LOCUS       NP_775608                424 aa            linear   ROD 30-APR-2024
DEFINITION  serine/threonine-protein kinase H1 [Mus musculus].
ACCESSION   NP_775608
VERSION     NP_775608.1
DBSOURCE    REFSEQ: accession NM_173432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 424)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 424)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 424)
  AUTHORS   Burnicka-Turek,O., Steimle,J.D., Huang,W., Felker,L., Kamp,A.,
            Kweon,J., Peterson,M., Reeves,R.H., Maslen,C.L., Gruber,P.J.,
            Yang,X.H., Shendure,J. and Moskowitz,I.P.
  TITLE     Cilia gene mutations cause atrioventricular septal defects by
            multiple mechanisms
  JOURNAL   Hum Mol Genet 25 (14), 3011-3028 (2016)
   PUBMED   27340223
REFERENCE   4  (residues 1 to 424)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (residues 1 to 424)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (residues 1 to 424)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   7  (residues 1 to 424)
  AUTHORS   Paronetto,M.P., Giorda,E., Carsetti,R., Rossi,P., Geremia,R. and
            Sette,C.
  TITLE     Functional interaction between p90Rsk2 and Emi1 contributes to the
            metaphase arrest of mouse oocytes
  JOURNAL   EMBO J 23 (23), 4649-4659 (2004)
   PUBMED   15526037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC050128.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050128.1, AK166338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.06 cM"
     Protein         1..424
                     /product="serine/threonine-protein kinase H1"
                     /EC_number="2.7.11.1"
                     /note="PSK-H1; Mutant line 1230"
                     /calculated_mol_wt=47964
     Region          59..79
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YA2.3)"
     Region          96..355
                     /region_name="STKc_PSKH1"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     kinase H1; cd14087"
                     /db_xref="CDD:270989"
     Site            order(104..108,112,125,127,156,172..175,179,181,217..218,
                     220,222..223,225,238..239,242,258..262,264)
                     /site_type="active"
                     /db_xref="CDD:270989"
     Site            order(104..107,112,125,127,156,172..175,179,222..223,225,
                     238..239)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270989"
     Site            order(108,179,181,217..218,220,222,242,258..262,264)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270989"
     Site            order(238..248,250..262)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270989"
     Region          378..408
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YA2.3)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91YA2.3)"
     Site            381
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91YA2.3)"
     CDS             1..424
                     /gene="Pskh1"
                     /gene_synonym="b2b1230Clo; E130013P03Rik"
                     /coded_by="NM_173432.2:138..1412"
                     /db_xref="CCDS:CCDS22619.1"
                     /db_xref="GeneID:244631"
                     /db_xref="MGI:MGI:3528383"
ORIGIN      
        1 mgcgtskvlp eppkdvqldl vkkvepfsgt kndvykhfit evdsvgplka gfpatsqyap
       61 pcpgvpntgh tappsepprr arvakyrakf dprvtakydi kaligrgsfs rvvrvehrat
      121 rqpyaikmie tkyregrevc eselrvlrrv rhaniiqlve vfetqervym vmelatggel
      181 fdriiakgsf terdatrvlq mvldgvrylh algithrdlk penllyyhpg tdskiiitdf
      241 glasarkkgd dclmkttcgt peyiapevlv rkpytnsvdm walgviayil lsgtmpfedd
      301 nrtrlyrqil rgkysylgep wpsvsnlakd fidrlltvdp garmtalqal rhpwvvsmaa
      361 sssmknlhrs isqnllkras srcqstkssq strssrstrs nksrrvrere lrelnlryqq
      421 qyng
//
