LOCUS       NM_007676               2289 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus pregnancy specific beta-1-glycoprotein 16 (Psg16),
            transcript variant 2, mRNA.
ACCESSION   NM_007676 XM_984834
VERSION     NM_007676.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Phillips,J.M., Kuo,I.T., Richardson,C. and Weiss,S.R.
  TITLE     A novel full-length isoform of murine pregnancy-specific
            glycoprotein 16 (psg16) is expressed in the brain but does not
            mediate murine coronavirus (MHV) entry
  JOURNAL   J Neurovirol 18 (2), 138-143 (2012)
   PUBMED   22302612
  REMARK    GeneRIF: PSG16 does not mediate CEACAM1a-independent spread of
            murine coronavirus.
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Hirai,A., Ohtsuka,N., Ikeda,T., Taniguchi,R., Blau,D., Nakagaki,K.,
            Miura,H.S., Ami,Y., Yamada,Y.K., Itohara,S., Holmes,K.V. and
            Taguchi,F.
  TITLE     Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the
            resistance of mice to MHV infection: studies of mice with chimeric
            mCEACAM1a and mCEACAM1b
  JOURNAL   J Virol 84 (13), 6654-6666 (2010)
   PUBMED   20410265
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   McLellan,A.S., Fischer,B., Dveksler,G., Hori,T., Wynne,F., Ball,M.,
            Okumura,K., Moore,T. and Zimmermann,W.
  TITLE     Structure and evolution of the mouse pregnancy-specific
            glycoprotein (Psg) gene locus
  JOURNAL   BMC Genomics 6, 4 (2005)
   PUBMED   15647114
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Chen,D.S., Asanaka,M., Yokomori,K., Wang,F., Hwang,S.B., Li,H.P.
            and Lai,M.M.
  TITLE     A pregnancy-specific glycoprotein is expressed in the brain and
            serves as a receptor for mouse hepatitis virus
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12095-12099 (1995)
   PUBMED   8618851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030357.1, U34272.1 and CK021085.1.
            
            On Sep 6, 2007 this sequence version replaced NM_007676.3.
            
            Transcript Variant: This variant (2) lacks a 3' exon and its 3'
            terminal exon extends past a splice site that is used in variant 1.
            This results in a novel 3' coding region and 3' UTR, compared to
            variant 1. It encodes isoform 2 which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.43516.1, U34272.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1123              BC030357.1         11-1133
            1124-1728           U34272.1           1080-1684
            1729-2289           CK021085.1         50-610
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..2289
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /note="pregnancy specific beta-1-glycoprotein 16"
                     /db_xref="GeneID:26436"
                     /db_xref="MGI:MGI:1347249"
     exon            1..261
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /inference="alignment:Splign:2.1.0"
     exon            262..609
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1613
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /note="isoform 2 is encoded by transcript variant 2;
                     carcinoembryonic antigen 11; pregnancy specific
                     glycoprotein 16"
                     /codon_start=1
                     /product="pregnancy specific glycoprotein 16 isoform 2"
                     /protein_id="NP_031702.3"
                     /db_xref="CCDS:CCDS20861.2"
                     /db_xref="GeneID:26436"
                     /db_xref="MGI:MGI:1347249"
                     /translation="MGQMYSGREIVSSNGSLWIHNVTRKDTGLYTLRTVNRRGEIVST
                     SFTFLYVYTSLFICGRPSFPAKLTIESVPPSVAEGGSVLLRVHNLQDKLRGLSWYKGA
                     HVSRNLEIARQIIAKNSSVPGPAHSGRETVYSNGSLLLQNVTRNDTGFYTLQTLSRHR
                     KMELAHVQLQVDTSLSSCCDTLDSTQLIIDPMPRYAAEGESILLRVLNLPEDFQVFCW
                     YKGALIFQIFKIAEYSRARNSITKGPAQSRTERVYTNGSLLLQDVTEKDTGLYTLQTI
                     DRNFKIEKAHVQIQVNKPVTQPFMRVTDSTVRVQSSVVFTCFSDNTGVSIHWLFNNQS
                     LQLTERITLSPSKCQLRINPVRKEDGGEYQCEVFNLASSKSSLPVSLAVMNE"
     exon            610..969
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1329
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..2283
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1808..1813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /note="hexamer: AATAAA"
     polyA_site      1835
                     /gene="Psg16"
                     /gene_synonym="bCEA; Cea11; PSG"
                     /note="major polyA site"
ORIGIN      
        1 gcgcttacaa atgaggacat tttgggagtc ttgatacttg cagtatcatt atgagagtgg
       61 gtggacaggg tgaccagtgg gaagccagcc tcatctacgt ggtctctggt caatgtccag
      121 gaattatgaa gtgtttattg gctccacccg acttcaccgt tttaaacaca gagaaaccag
      181 gaaaaagcag ggcaagagct cgttgactcc ctggcttcaa tcatctgatg acctagatac
      241 cagcaagtga ccagctggtg gcctcccttt tagcctgctg gctcctgtcc accactgccc
      301 aggtcaccat tgaatcagtg cctttcaatg tggttgaagg agaaaatgtc cttcttcgtg
      361 ttgacaatct gccagagaat cttataacct tagcctggta cagagggctg aggaaaattg
      421 ttgtatacac actgaacact aaagtaagtg tgatggggca aatgtacagt ggtagagaga
      481 tagtgtccag caacgggtcc ctgtggatcc acaatgtcac ccggaaggac acaggactct
      541 acaccctacg gaccgtaaat agacgtggag aaattgtatc aacatcattc acgttcctct
      601 acgtgtacac ctctcttttc atctgtgggc gcccttcctt ccctgccaag ctcactattg
      661 aatcagtgcc gcccagcgtt gctgaagggg gaagcgttct tctccgtgtt cacaacctcc
      721 aggataagct tcgagggctt tcctggtaca aaggggcaca tgtgtctagg aaccttgaga
      781 ttgcccgaca gataatagcc aagaattcaa gtgtgccagg ccctgcccac agtggtagag
      841 agacagtgta cagcaatgga tccctgctgc tccagaatgt cacccggaat gacaccggat
      901 tctacaccct acaaactctg agtagacatc ggaaaatgga attagcacat gtgcaacttc
      961 aggtggacac ctccctttct tcatgctgtg acactcttga ctctacccaa ctcatcatcg
     1021 atccaatgcc acggtatgct gcagaagggg aaagcatcct tctccgtgtt cttaatctgc
     1081 ctgaagattt ccaagttttt tgctggtaca aaggagcatt gatcttccag atctttaaaa
     1141 ttgcagaata tagcagagcc aggaactcca tcaccaaggg gcctgctcaa agcagaacag
     1201 agagagtgta caccaatgga tctctcctgc tccaggatgt cactgagaaa gacacgggct
     1261 tgtatacact acaaacgata gacagaaatt tcaaaattga aaaagcacac gtgcaaatcc
     1321 aagtgaacaa gcctgtgaca cagcccttca tgagagtcac agacagcaca gttagagtac
     1381 agagctcagt ggtcttcact tgcttctcag acaacactgg ggtctccatc cattggctct
     1441 tcaacaatca gagtctgcag ctcacagaga ggatcacact ttccccatca aaatgccaac
     1501 tacgtataaa tcctgtcagg aaagaggatg gtggagagta tcaatgtgag gtcttcaacc
     1561 ttgccagctc gaaatccagt ctcccagtca gcctggccgt gatgaatgag tgacccctct
     1621 tctcatccta cagcaggggg aggcattcct ttgttaatag ggtacaaaat ggatgaaagt
     1681 tacatagtaa aaattgtcag tcaccagtca tgtaccacca gcatggtggc tcatgcctgt
     1741 agttctgaca tagcagtgtg tagaagaaca ggccatcatt ttaagtgaga cttggggtcc
     1801 aaaggaaaat aaagacatca gtatggtaaa cagtattgca aatgtgttaa gagtttaggt
     1861 tgtggatcta gtatatcact agccctgaga atccatggca actaggttca ggagtcccca
     1921 aacttcagga ttctctgagt gcccttttaa catggtacag tgtctgcacc gagacaaata
     1981 tgctctcata tactccaata gtgacaccta accccaaagc tacctggaca tcagtcaccc
     2041 atgggaagtg aggaagtgac agaagggact gcccatattt ctcagtgcac ataactggct
     2101 actagatagt tttgattcac agtttttttg atgcacagaa ttgaaatatt tttgtgtaaa
     2161 ggacaactgg agtgtttcta tcccaagggt ggcagtcaca gtgtgacctt gtacacaatt
     2221 ctttgtcata taaatataca taatatagat gatatatata aatatataat atatccaact
     2281 ctaaaaaaa
//
