LOCUS       NM_025498                671 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus presenilin enhancer gamma secretase subunit (Psenen),
            transcript variant 1, mRNA.
ACCESSION   NM_025498
VERSION     NM_025498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 671)
  AUTHORS   Serneels,L., Bammens,L., Zwijsen,A., Tolia,A., Chavez-Gutierrez,L.
            and De Strooper,B.
  TITLE     Functional and topological analysis of PSENEN, the fourth subunit
            of the gamma-secretase complex
  JOURNAL   J Biol Chem 300 (1), 105533 (2024)
   PUBMED   38072061
  REMARK    GeneRIF: Functional and topological analysis of PSENEN, the fourth
            subunit of the gamma-secretase complex.
REFERENCE   2  (bases 1 to 671)
  AUTHORS   Klein,M., Kaleem,A., Oetjen,S., Wunkhaus,D., Binkle,L.,
            Schilling,S., Gjorgjieva,M., Scholz,R., Gruber-Schoffnegger,D.,
            Storch,S., Kins,S., Drewes,G., Hoffmeister-Ullerich,S., Kuhl,D. and
            Hermey,G.
  TITLE     Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome
            system
  JOURNAL   Autophagy 18 (9), 2068-2085 (2022)
   PUBMED   34964690
REFERENCE   3  (bases 1 to 671)
  AUTHORS   Xia,Y., Zhang,Y., Xu,M., Zou,X., Gao,J., Ji,M.H. and Chen,G.
  TITLE     Presenilin enhancer 2 is crucial for the transition of apical
            progenitors into neurons but into not basal progenitors in the
            developing hippocampus
  JOURNAL   Development 149 (10) (2022)
   PUBMED   35575074
  REMARK    GeneRIF: Presenilin enhancer 2 is crucial for the transition of
            apical progenitors into neurons but into not basal progenitors in
            the developing hippocampus.
REFERENCE   4  (bases 1 to 671)
  AUTHORS   Dave,J.M., Chakraborty,R., Ntokou,A., Saito,J., Saddouk,F.Z.,
            Feng,Z., Misra,A., Tellides,G., Riemer,R.K., Urban,Z., Kinnear,C.,
            Ellis,J., Mital,S., Mecham,R., Martin,K.A. and Greif,D.M.
  TITLE     JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and
            stenosis in elastin deficiency
  JOURNAL   J Clin Invest 132 (5) (2022)
   PUBMED   34990407
REFERENCE   5  (bases 1 to 671)
  AUTHORS   Wang,H., Liu,M., Ye,Z., Zhou,C., Bi,H., Wang,L., Zhang,C., Fu,H.,
            Shen,Y., Yang,J.J., Hu,Y. and Chen,G.
  TITLE     Akt Regulates Sox10 Expression to Control Oligodendrocyte
            Differentiation via Phosphorylating FoxO1
  JOURNAL   J Neurosci 41 (39), 8163-8180 (2021)
   PUBMED   34385359
REFERENCE   6  (bases 1 to 671)
  AUTHORS   Fraering,P.C., Ye,W., Strub,J.M., Dolios,G., LaVoie,M.J.,
            Ostaszewski,B.L., van Dorsselaer,A., Wang,R., Selkoe,D.J. and
            Wolfe,M.S.
  TITLE     Purification and characterization of the human gamma-secretase
            complex
  JOURNAL   Biochemistry 43 (30), 9774-9789 (2004)
   PUBMED   15274632
REFERENCE   7  (bases 1 to 671)
  AUTHORS   Culvenor,J.G., Ilaya,N.T., Ryan,M.T., Canterford,L., Hoke,D.E.,
            Williamson,N.A., McLean,C.A., Masters,C.L. and Evin,G.
  TITLE     Characterization of presenilin complexes from mouse and human brain
            using Blue Native gel electrophoresis reveals high expression in
            embryonic brain and minimal change in complex mobility with
            pathogenic presenilin mutations
  JOURNAL   Eur J Biochem 271 (2), 375-385 (2004)
   PUBMED   14717705
REFERENCE   8  (bases 1 to 671)
  AUTHORS   Takasugi,N., Tomita,T., Hayashi,I., Tsuruoka,M., Niimura,M.,
            Takahashi,Y., Thinakaran,G. and Iwatsubo,T.
  TITLE     The role of presenilin cofactors in the gamma-secretase complex
  JOURNAL   Nature 422 (6930), 438-441 (2003)
   PUBMED   12660785
REFERENCE   9  (bases 1 to 671)
  AUTHORS   Luo,W.J., Wang,H., Li,H., Kim,B.S., Shah,S., Lee,H.J.,
            Thinakaran,G., Kim,T.W., Yu,G. and Xu,H.
  TITLE     PEN-2 and APH-1 coordinately regulate proteolytic processing of
            presenilin 1
  JOURNAL   J Biol Chem 278 (10), 7850-7854 (2003)
   PUBMED   12522139
REFERENCE   10 (bases 1 to 671)
  AUTHORS   De Strooper,B., Annaert,W., Cupers,P., Saftig,P., Craessaerts,K.,
            Mumm,J.S., Schroeter,E.H., Schrijvers,V., Wolfe,M.S., Ray,W.J.,
            Goate,A. and Kopan,R.
  TITLE     A presenilin-1-dependent gamma-secretase-like protease mediates
            release of Notch intracellular domain
  JOURNAL   Nature 398 (6727), 518-522 (1999)
   PUBMED   10206645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167970.4 and BC081443.1.
            
            On Jun 5, 2018 this sequence version replaced NM_025498.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081443.1, BI554957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC167970.4         57087-57104
            19-671              BC081443.1         1-653
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.6 cM"
     gene            1..671
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /note="presenilin enhancer gamma secretase subunit"
                     /db_xref="GeneID:66340"
                     /db_xref="MGI:MGI:1913590"
     exon            1..153
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..296
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..541
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /note="presenilin enhancer protein 2; presenilin enhancer
                     2 homolog"
                     /codon_start=1
                     /product="gamma-secretase subunit PEN-2"
                     /protein_id="NP_079774.1"
                     /db_xref="CCDS:CCDS21099.1"
                     /db_xref="GeneID:66340"
                     /db_xref="MGI:MGI:1913590"
                     /translation="MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLA
                     PAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLGTP"
     exon            297..401
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..671
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      650..655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /note="hexamer: AATAAA"
     polyA_site      671
                     /gene="Psenen"
                     /gene_synonym="1700023M09Rik; Pen-2; Pen2"
                     /note="major polyA site"
ORIGIN      
        1 agcgcatgcg tacaacgtag cggagggggt ggggtgcgag gggggctggg caggagaaga
       61 aaaaaaaaag cgacaacaaa ctccactgaa aactgcggca tctcccgcaa atctcccgca
      121 aaggaatcca ggcagaaggg ataaaccgca ctggggcgtg gttgctcgtg atcttgcgtc
      181 tgtcatttgg gtcttgctct gcagaccctt aggaccaccg ggctccagcg caactatgaa
      241 cttggagcgg gtatccaatg aggagaagtt gaacctgtgc cggaagtact atcttggtgg
      301 atttgcgttc ctgccttttc tttggttagt caacattttc tggttcttca gagaggcgtt
      361 cctcgcccca gcctacacag agcagagcca aatcaaaggc tatgtttggc gctcagctgt
      421 gggcttcctc ttctgggtga tcattctcgc cacctggatc accatcttcc agatctaccg
      481 gccccgctgg ggcgctcttg gggactacct ctccttcacc attcccctgg gcactcccta
      541 acaacttcat aagctgctga tctgttcttt ctcccaggat gaaggcttct ctgctctagg
      601 ctttccctca gaccctgaag acatctgttt ctcatttccc atctgcccca ataaaggacc
      661 ctaactttaa a
//
