LOCUS       NM_001362271            2706 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus presenilin 1 (Psen1), mRNA.
ACCESSION   NM_001362271 XM_006515605
VERSION     NM_001362271.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Yang,H., Yang,J., Park,N., Hwang,D.S., Park,S.Y., Kim,S. and Bae,H.
  TITLE     Adoptive Transfer of CX3CR1-Transduced Tregs Homing to the
            Forebrain in Lipopolysaccharide-Induced Neuroinflammation and 3xTg
            Alzheimer's Disease Models
  JOURNAL   Int J Mol Sci 25 (24), 13682 (2024)
   PUBMED   39769442
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Wang,Z.J., Han,W.N., Chai,S.F., Li,Y., Fu,C.J., Wang,C.F.,
            Cai,H.Y., Li,X.Y., Wang,X., Holscher,C. and Wu,M.N.
  TITLE     Semaglutide promotes the transition of microglia from M1 to M2 type
            to reduce brain inflammation in APP/PS1/tau mice
  JOURNAL   Neuroscience 563, 222-234 (2024)
   PUBMED   39547338
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Del Rosario Hernandez,T., Joshi,N.R., Gore,S.V., Kreiling,J.A. and
            Creton,R.
  TITLE     Combining supervised and unsupervised analyses to quantify
            behavioral phenotypes and validate therapeutic efficacy in a triple
            transgenic mouse model of Alzheimer's disease
  JOURNAL   Biomed Pharmacother 181, 117718 (2024)
   PUBMED   39637754
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Wu,C.Y., Zhang,Y., Howard,P., Huang,F. and Lee,R.H.
  TITLE     ACSL3 is a promising therapeutic target for alleviating anxiety and
            depression in Alzheimer's disease
  JOURNAL   Geroscience (2024) In press
   PUBMED   39532829
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2706)
  AUTHORS   Blankenship,H.E., Carter,K.A., Pham,K.D., Cassidy,N.T.,
            Markiewicz,A.N., Thellmann,M.I., Sharpe,A.L., Freeman,W.M. and
            Beckstead,M.J.
  TITLE     VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to
            casein kinase 2-dependent SK channel dysfunction
  JOURNAL   Nat Commun 15 (1), 9673 (2024)
   PUBMED   39516200
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2706)
  AUTHORS   Cribbs,D.H., Chen,L.S., Bende,S.M. and LaFerla,F.M.
  TITLE     Widespread neuronal expression of the presenilin-1 early-onset
            Alzheimer's disease gene in the murine brain
  JOURNAL   Am J Pathol 148 (6), 1797-1806 (1996)
   PUBMED   8669467
REFERENCE   7  (bases 1 to 2706)
  AUTHORS   Amson,R.B., Nemani,M., Roperch,J.P., Israeli,D., Bougueleret,L., Le
            Gall,I., Medhioub,M., Linares-Cruz,G., Lethrosne,F., Pasturaud,P.,
            Piouffre,L., Prieur,S., Susini,L., Alvaro,V., Millasseau,P.,
            Guidicelli,C., Bui,H., Massart,C., Cazes,L., Dufour,F.,
            Bruzzoni-Giovanelli,H., Owadi,H., Hennion,C., Charpak,G.,
            Telerman,A. et al.
  TITLE     Isolation of 10 differentially expressed cDNAs in p53-induced
            apoptosis: activation of the vertebrate homologue of the drosophila
            seven in absentia gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 3953-3957 (1996)
   PUBMED   8632996
REFERENCE   8  (bases 1 to 2706)
  AUTHORS   Takahashi,H., Murayama,M., Takashima,A., Mercken,M., Nakazato,Y.,
            Noguchi,K. and Imahori,K.
  TITLE     Molecular cloning and expression of the rat homologue of
            presenilin-1
  JOURNAL   Neurosci Lett 206 (2-3), 113-116 (1996)
   PUBMED   8710164
REFERENCE   9  (bases 1 to 2706)
  AUTHORS   Pericak-Vance,M.A. and Haines,J.L.
  TITLE     Genetic susceptibility to Alzheimer disease
  JOURNAL   Trends Genet 11 (12), 504-508 (1995)
   PUBMED   8533168
  REMARK    Review article
REFERENCE   10 (bases 1 to 2706)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY318326.1, AK134615.1, AK148101.1 and BU757833.1.
            
            On Apr 11, 2018 this sequence version replaced XM_006515605.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148101.1, SRR1660821.36641.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY318326.1         2-52
            52-1708             AK134615.1         3-1659
            1709-2251           AK148101.1         1659-2201
            2252-2706           BU757833.1         1-455               c
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.84 cM"
     gene            1..2706
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /note="presenilin 1"
                     /db_xref="GeneID:19164"
                     /db_xref="MGI:MGI:1202717"
     exon            1..142
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            143..209
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            210..349
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1666
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /EC_number="3.4.23.-"
                     /codon_start=1
                     /product="presenilin-1 precursor"
                     /protein_id="NP_001349200.1"
                     /db_xref="CCDS:CCDS26030.1"
                     /db_xref="GeneID:19164"
                     /db_xref="MGI:MGI:1202717"
                     /translation="MTEIPAPLSYFQNAQMSEDSHSSSAIRSQNDSQERQQQHDRQRL
                     DNPEPISNGRPQSNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKS
                     VSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVIMTILLVVLYKYRCYK
                     VIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYVTVALLIWNFGVVGMIAIHWKGP
                     LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQ
                     ERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVPKNPKYNTQRAERETQDSGSGNDDG
                     GFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIFYSVL
                     VGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATD
                     YLVQPFMDQLAFHQFYI"
     exon            350..600
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            601..742
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            743..810
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1031
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1130
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1217
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1391
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1510
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..2690
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /note="hexamer: ATTAAA"
     polyA_site      2690
                     /gene="Psen1"
                     /gene_synonym="Ad3h; PS-1; PS1; S182"
                     /note="major polyA site"
ORIGIN      
        1 agttgcgaca ccggtgagac ctctagggcg gggcctagga cgacctgctc cgtgggccgc
       61 gagtattcgt cggaaacaaa acagcggcag ctgaggcgga aacctaggct gcgagccggc
      121 cgcccgggcg cggagagaga aggaaccaac acaagacagc agcccttcga ggtctttagg
      181 cagcttggag gagaacacat gagagaaaga atcccaagag gttttgtttt ctttgagaag
      241 gtatttctgt ccagctgctc caatgacaga gatacctgca cctttgtcct acttccagaa
      301 tgcccagatg tctgaggaca gccactccag cagcgccatc cggagccaga atgacagcca
      361 agaacggcag cagcagcatg acaggcagag acttgacaac cctgagccaa tatctaatgg
      421 gcggccccag agtaactcaa gacaggtggt ggaacaagat gaggaggaag acgaagagct
      481 gacattgaaa tatggagcca agcatgtcat catgctcttt gtccccgtga ccctctgcat
      541 ggtcgtcgtc gtggccacca tcaaatcagt cagcttctat acccggaagg acggtcagct
      601 aatctacacc ccattcacag aagacactga gactgtaggc caaagagccc tgcactcgat
      661 cctgaatgcg gccatcatga tcagtgtcat tgtcattatg accatcctcc tggtggtcct
      721 gtataaatac aggtgctaca aggtcatcca cgcctggctt attatttcat ctctgttgtt
      781 gctgttcttt ttttcgttca tttacttagg ggaagtattt aagacctaca atgtcgccgt
      841 ggactacgtt acagtagcac tcctaatctg gaattttggt gtggtcggga tgattgccat
      901 ccactggaaa ggcccccttc gactgcagca ggcgtatctc attatgatca gtgccctcat
      961 ggccctggta tttatcaagt acctccccga atggaccgca tggctcatct tggctgtgat
     1021 ttcagtatat gatttggtgg ctgttttatg tcccaaaggc ccacttcgta tgctggttga
     1081 aacagctcag gaaagaaatg agactctctt tccagctctt atctattcct caacaatggt
     1141 gtggttggtg aatatggctg aaggagaccc agaagcccaa aggagggtac ccaagaaccc
     1201 caagtataac acacaaagag cggagagaga gacacaggac agtggttctg ggaacgatga
     1261 tggtggcttc agtgaggagt gggaggccca aagagacagt cacctggggc ctcatcgctc
     1321 cactcccgag tcaagagctg ctgtccagga actttctggg agcattctaa cgagtgaaga
     1381 cccggaggaa agaggagtaa aacttggact gggagatttc attttctaca gtgttctggt
     1441 tggtaaggcc tcagcaaccg ccagtggaga ctggaacaca accatagcct gctttgtagc
     1501 catactgatc ggcctgtgcc ttacattact cctgctcgcc attttcaaga aagcgttgcc
     1561 agccctcccc atctccatca ccttcgggct cgtgttctac ttcgccacgg attaccttgt
     1621 gcagcccttc atggaccaac ttgcattcca tcagttttat atctagcctt tctgcagtta
     1681 gaacatggat gtttcttctt tgattatcaa aaacacaaaa acagagagca agcccgagga
     1741 ggagactggt gactttcctg tgtcctcagc taacaaaggc aggactccag ctggacttct
     1801 gcagcttcct tccgagtctc cctagccacc cgcactactg gactgtggaa ggaagcgtct
     1861 acagagaacg gtttccaaca tccatcgctg cagcagacgg tgtccctcag tgacttgaga
     1921 gacaaggaca aggaaatgtg ctgggccaag gagctgccgt gctctgctag ctttgacccg
     1981 tgggcatgga gatttacccg cactgtgaac tctctaaagg ttaaacaaag tgaggtgaac
     2041 caaacagagc tgccatcttc cacaccatgt tggaaataaa acacgtccta gctgaaccct
     2101 tactgtccag gaggttccgt gtggaggtgg cactgggccg ggcctccctc tcaggctcct
     2161 ttgctgccca cttgtaagtt taaataagga caccgcccta cacaaacctc acccctgtca
     2221 catcagtgac tctgaccact tttgttctca aactctctca ctattatctg tggttgccgt
     2281 ttcttcccaa ggccagcctg gacgaatttg gggttgctct atcctgagag ttgtaacctc
     2341 aacttccaaa gtttatattt tcttgaaatg atggatctat tgctcaacag tccctgtcat
     2401 ccttaagtga cttctgggtt tcccacaaat tcctcacttt tagacacact ctaagcttac
     2461 ttctggcctg gatgcttcct ctccctgtct ctcccttgcc ccacagcggt tccctgacag
     2521 cagacaaggc agctctggga ggtagctagt atccaataac ccaggggttt cctcatgtga
     2581 tgcaaatact acgtgtccaa ccaatcagtg ctgtcaacgg gctgccatag ctccttcgat
     2641 ggcaaatagg atgtgtgccc aaagaattaa agcgatgagt ggctggtgaa aaaaaaaaaa
     2701 aaaaaa
//
