LOCUS       NM_001355232            5164 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pleckstrin and Sec7 domain containing 4 (Psd4),
            transcript variant 3, mRNA.
ACCESSION   NM_001355232 XM_011239049
VERSION     NM_001355232.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5164)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5164)
  AUTHORS   Kinoshita-Kawada,M., Hasegawa,H., Hongu,T., Yanagi,S., Kanaho,Y.,
            Masai,I., Mishima,T., Chen,X., Tsuboi,Y., Rao,Y., Yuasa-Kawada,J.
            and Wu,J.Y.
  TITLE     A crucial role for Arf6 in the response of commissural axons to
            Slit
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30674481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5164)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 5164)
  AUTHORS   Sakagami,H., Suzuki,H., Kamata,A., Owada,Y., Fukunaga,K.,
            Mayanagi,H. and Kondo,H.
  TITLE     Distinct spatiotemporal expression of EFA6D, a guanine nucleotide
            exchange factor for ARF6, among the EFA6 family in mouse brain
  JOURNAL   Brain Res 1093 (1), 1-11 (2006)
   PUBMED   16707115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150238.1 and AL732528.12.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001355232.2.
            
            On Sep 13, 2017 this sequence version replaced XM_011239049.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150238.1, AK169859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1531              AK150238.1         2-1532
            1532-1532           AL732528.12        77781-77781
            1533-3153           AK150238.1         1534-3154
            3154-5164           AL732528.12        87562-89572
FEATURES             Location/Qualifiers
     source          1..5164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.38 cM"
     gene            1..5164
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="pleckstrin and Sec7 domain containing 4"
                     /db_xref="GeneID:215632"
                     /db_xref="MGI:MGI:2674093"
     exon            1..94
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            95..1113
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..3216
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="pleckstrin homology and SEC7 domain-containing
                     protein 4; SEC7 homolog; exchange factor for ARF6 B;
                     exchange factor for ADP-ribosylation factor guanine
                     nucleotide factor 6 B"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 4"
                     /protein_id="NP_001342161.1"
                     /db_xref="CCDS:CCDS15737.1"
                     /db_xref="GeneID:215632"
                     /db_xref="MGI:MGI:2674093"
                     /translation="MMGDHLRPMECLNICLEDNLQPCPEAYPSEIHGHPGPSEPCQEH
                     TCPFDPPESARPDAPHGNSGVESTHLENCLVQVQARQASASLRSLEDNSSLGSPQQNQ
                     SSSTQVVFWAGILQAQMCVLDLEEELEKTEGLRAELRCCIPPPSKDLLGDEGLSPSRP
                     EEDEDSGDDSSGPEEENQTWPREKIPGSSLEWGAEEDSIFFDNPLFLESPCSDTSTEG
                     ECFSWGYPNSHPDMKTWHQSPQTLDSPLQKGTGLWRQENELDLGSDTADHGGCSTPPF
                     PVPSYKMHPCLALGSTEGDPTVPPDQEGETSCEDDLGHGSPKAPFVDHELIQESDNFE
                     FDLRPATTHPVQPWGSQTSQSLSDLTQPILEDLQREDPSRSQETLISQNRGERDAGCF
                     QEPVFCTLAPWGSQTSLLEPNCPESEGRGSGPQPSPVSSQDSSPRVLLHSPKWPQDAS
                     HLLQKDRSELSSLKEEETEEVPSLRQEAECEDTSRSEDASANQHHVHLASAEGLPESP
                     MPQAQSPEEGWRPSSSREKLANDIRNDKGAWNLALRLYQLNGFRKSEVAAHLRKNNDF
                     SRAVAEAYLSFFQFEGQSLDRALRGFLQALVLSGETQERERILYQFSKRFHYCNPGAF
                     PSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFVTNLNGLQDGRNFPKELLKALYWS
                     IRSEKLEWAIDEEDADRPEKDQPSPSAGKISSPFLQMAQDPTMPTYKQGILARKMHHI
                     ADGKKTPWGKRGWKMFHTLLRGMVLYFLKGEGQWLDGESLVGHMVDEPVGVHHSLASP
                     ATHYTKKPHVFQLRTADWRLYLFQAPTAKEMASWIARINLAAATHSAPPFPAAVGSQR
                     RFVRPILPMSPVQSSLEEQHRSHENCLDAASDDLLDLQRNLPERRGRSRELEEYRLRK
                     EYLEHEKTRYETYVQLLVARLHFPLGDLALWEDQLGKETDGSQEPRPSLKKSHSSPSL
                     HQEEAPTTAKVKRNISERRTYRKIIPKRNRNQL"
     exon            1114..1242
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1351
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1706
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1886
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1967
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2080
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2139
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2229
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2273
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2434
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2505
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2669
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2814
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2958
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..5164
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4525..4530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="hexamer: AATAAA"
     regulatory      4529..4534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="hexamer: AATAGA"
     polyA_site      4544
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="major polyA site"
     polyA_site      4547
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="major polyA site"
     regulatory      4701..4706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="hexamer: ATTACA"
     polyA_site      4738
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="major polyA site"
     regulatory      5130..5135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
                     /note="hexamer: ATTAAA"
     polyA_site      5153
                     /gene="Psd4"
                     /gene_synonym="EFA6B"
ORIGIN      
        1 agtcgctgca tttgcaggcg ggcaagtacg cagcagttaa gttcctgggg aagggggatc
       61 ggatcgaatc ggatcggatc cggagagcct gaaggctaga tatggatttc caccttggct
      121 tgtgcaccta ctaatttgtg agatgggatt gtgaaaacag atgctaccaa gggcttctgc
      181 tcaaccatca ctctgtggat gatgggggac cacctcagac ccatggaatg tctcaatatt
      241 tgcttggaag acaacttaca accctgtcca gaagcatatc caagtgaaat acatggccat
      301 ccaggccctt ctgaaccttg ccaggaacat acctgtccgt ttgacccccc agaatctgcc
      361 agacctgatg ctcctcatgg taactctggt gtggagtcca ctcatctaga aaactgcttg
      421 gtgcaggtac aggctaggca ggcctcagca tcactgaggt cactggagga caacagctct
      481 ttggggagtc cacagcaaaa ccagagctca tccacccagg tggtattctg ggctggcatc
      541 ctgcaggccc agatgtgtgt cctggacctg gaggaggagc tggagaaaac agagggactc
      601 agagcagaac tcaggtgctg catcccacca ccctctaagg acctccttgg agatgaaggt
      661 ctgagcccca gccgacccga ggaggatgaa gactctggag atgacagcag tgggcctgag
      721 gaggagaacc agacctggcc aagggagaaa attccaggct cctccctaga gtggggtgct
      781 gaggaggaca gtatcttctt tgataatccc ctcttcctgg agagcccttg ctcagacacc
      841 agcactgaag gagaatgctt ttcctggggg tacccgaatt cccacccaga catgaagacc
      901 tggcatcaga gccctcaaac tctggactct cctctccaaa aaggcacagg gctctggagg
      961 caagaaaatg agctggattt ggggagcgac actgctgacc atggtgggtg ttccacccct
     1021 ccattccctg tgccttccta taagatgcac ccctgcttgg ccttaggatc cactgaaggg
     1081 gatcccacgg tacctcctga tcaggagggt gagacttctt gtgaagatga tcttggccat
     1141 ggctcaccta aagcaccctt tgtagaccat gaattgatcc aagaatcaga taactttgaa
     1201 tttgacctta gacctgccac aacacatcct gtacagcctt ggggttcaca gacatcccaa
     1261 agcctttctg acctgactca acccatactt gaggacctgc agagagaaga tccttccagg
     1321 tcccaggaaa ctcttatctc ccagaacaga ggtgagaggg atgctggctg tttccaggag
     1381 cccgtgttct gcactttggc cccctggggg agccaaacct ctttactgga gcctaactgc
     1441 ccagaatctg agggtagagg ctctggcccc cagcccagcc cagtgtcttc ccaggatagc
     1501 agcccacggg ttctgctgca cagccccaag tggccacaag atgcctcaca ccttctccag
     1561 aaggatagat cagagttgag ctccctaaag gaagaggaga cagaggaggt cccaagcctg
     1621 aggcaggagg cagaatgtga agatacatcc agaagtgaag atgcttcagc caaccagcac
     1681 catgttcact tggcttctgc agaagggctt cctgagagcc ccatgcccca agctcaatct
     1741 ccagaggaag gctggaggcc atcatcgtct agagagaagt tggctaatga catcagaaat
     1801 gacaagggag catggaacct agccctgcgc ctctatcaac tgaatggttt tcggaagtct
     1861 gaagtagctg cccacctacg caagaacaat gacttcagca gggctgtagc cgaggcctac
     1921 ttgtctttct tccagttcga aggtcagagc ctggacagag ccctccgtgg tttcctccag
     1981 gccctggtgc tcagtggaga gactcaggag cgggaacgaa ttctctacca gttttccaaa
     2041 cgtttccatt actgcaatcc tggagccttc ccctcagtag attctgttca cacgttgacc
     2101 tgtgcaatca tgctccttaa cacagaccta catgggcaga acattggcaa gagcatgagc
     2161 tgtcaggaat ttgtaaccaa cttgaatggc ctgcaggatg gcaggaactt ccccaaagag
     2221 ctgctgaagg ccctctactg gtctatccgc agtgagaagc tcgaatgggc tatagatgaa
     2281 gaagatgcag acagacccga gaaggaccaa ccctctccct cagctggcaa gataagcagc
     2341 cccttcctgc agatggctca ggatcccacg atgcccacct ataagcaggg cattctggct
     2401 cggaagatgc atcacattgc tgatggcaag aagactccat ggggcaaacg aggctggaag
     2461 atgtttcaca ccttactgag agggatggtc ctctacttcc tgaagggaga gggccaatgg
     2521 ctggatggag agagtttggt aggacatatg gtggatgagc ctgtgggagt acaccactca
     2581 ctagccagcc cagccaccca ctacaccaag aagccacatg tcttccagct tcggactgca
     2641 gactggcgtc tctacctctt ccaggcacct actgccaaag aaatggcttc ctggattgcg
     2701 cgaatcaacc tggcggctgc cacccactca gcacctcctt ttccggctgc agtgggctcc
     2761 caacgcagat tcgtgaggcc catcctgccc atgagcccgg tgcagagctc cctggaggag
     2821 cagcatcgat cccacgagaa ctgcctggat gctgcctcag atgacctgtt ggatttgcag
     2881 aggaacctgc cggagcgacg gggccgcagc cgcgagctgg aggaataccg cttacggaag
     2941 gagtatctgg agcacgagaa aactcgatat gagacctacg tacagcttct ggtggcccgc
     3001 ctacacttcc ctttggggga cctggctctg tgggaagatc agcttgggaa ggaaactgac
     3061 ggttctcagg agcccaggcc aagcctgaag aagtcccact caagcccatc actgcaccag
     3121 gaggaggccc ccaccacagc caaggtgaaa cgcaacatct cagagcgcag aacctaccgg
     3181 aagatcattc ccaagaggaa ccgcaatcag ctgtgaagct gttaccctct cagacactga
     3241 ccactgctcc ggggtggacc tgagatgcag ccttatgtgc caggaccatg gtgaaggata
     3301 aggcatctct gattctttgc tgaaggacgg ggctgatttc tctgtgtccc cgttccctgg
     3361 ctctttagaa ctgccttaat cttgccatac ttgcttctgt cccccatggt ggttcctcca
     3421 tcaccctaac cctgatcact caagagcaag gttgagtgag aaattggctc cacttgcgga
     3481 atttgtcccc catgcactct ctcctctgaa acacggggcc tgggttgctg ggaggtcgct
     3541 tgaggaagtc tagctaggac tgttcactgg gaacagtctt actttgggaa ttaggtgacc
     3601 tagcaggaga tggtcccaga agcataggga aggacctctt gggaattcct aagcaccatc
     3661 ttgtaagcag ggttactctg gcactgccca gtagaggaca gcttctaaca agagtccttg
     3721 gtaagttcag gactcaggga tgctgtgggg ctccaagctt cagatcttct gactgcttta
     3781 tcctacaacc agccaaacaa agcccttccc gggacaggga gtacatgaaa aggctgcgtg
     3841 cctaattgtt gttaatcaac agagcagagc ttgtggcctg agccagggtc aataggagtg
     3901 ggggcctcta gagctctatg gagaaccctt ggaacaagga gcctttgttt cctgagagta
     3961 atcagggtag cttttctagg gggtgaaggt ggtgacagtt ctccttggga gtctgcctgg
     4021 cagtgggagt ggagattgga ggcctgggtt ctcactgctt tctgtagtca cccccatccc
     4081 acctccacct tcaatatccc tcaaagctgc agtcctgagg gttgacagga cctatttctc
     4141 attcctgggg cagctcccag gctcttgctg ccctgccttg ggaaatcccc ttgcacttct
     4201 ttttggcttc ttcccaggta tgcctgttct ccaggggagg ttctggagac tcggagactt
     4261 agggctgtgt ctgtgaggag gaggctggcc tgagggagca gccacattgt ctctgctcag
     4321 ccatgtgtgc aaagaggttg ctggccaaat ggaagcctct gctgctcacc cttcagctgg
     4381 cacattgcct ctcctgcctt cctgctgggc cacacatcct cccttccaat aatgcttaga
     4441 gcaccacaaa gcggagctgg tccttagggc caggggactc tctggccagg gcctggggct
     4501 ggcctttgca cccaatgggt gtgcaataaa tagaacctac cacagaagtg ggtgagtgtg
     4561 agtgtgtgtg tgtgtaaggg ggagtcagtc aggtagccgt ggccacctgc agtgtgtcag
     4621 gctatagctt cctttgcccc ctttgtgata gtatgtctgt gtctgtgtcc tgcatgttca
     4681 tgtgtgtacc ccaacataca attacaagct acttaagctc gggaacattt ttcatccact
     4741 tactgtgttt ttcatttcac agatgttatg ggactcctta catggccagt actaggggat
     4801 ttgaaatgag caaaatgtcc ctgacctcat aaattgggag tcttgcccac tgtttcatag
     4861 ctgtcagtat taagatacac attatctttc tggggagcat ttattcctac tcctgcctca
     4921 caaccagaga tctaatctgc agacctgtca ggtggatatg tatgcatgtt tgaaacatac
     4981 atatgctaaa ccgagattta gcagaaatta acagccacac aagagtccaa cttgtctgat
     5041 tgtacagagg agaacactta gcatgggtag atatgacatg gccaggattg atgcttccca
     5101 gcgtgggcat gactgggttt ttggacctca ttaaacactt atcctatcca gaagaaaagt
     5161 taaa
//
