LOCUS       NM_177698              11327 bp    mRNA    linear   ROD 28-DEC-2022
DEFINITION  Mus musculus pleckstrin and Sec7 domain containing 3 (Psd3),
            transcript variant 2, mRNA.
ACCESSION   NM_177698 XM_006509615
VERSION     NM_177698.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11327)
  AUTHORS   Mancina RM, Sasidharan K, Lindblom A, Wei Y, Ciociola E,
            Jamialahmadi O, Pingitore P, Andreasson AC, Pellegrini G, Baselli
            G, Mannisto V, Pihlajamaki J, Karja V, Grimaudo S, Marini I,
            Maggioni M, Becattini B, Tavaglione F, Dix C, Castaldo M, Klein S,
            Perelis M, Pattou F, Thuillier D, Raverdy V, Dongiovanni P,
            Fracanzani AL, Stickel F, Hampe J, Buch S, Luukkonen PK, Prati D,
            Yki-Jarvinen H, Petta S, Xing C, Schafmayer C, Aigner E, Datz C,
            Lee RG, Valenti L, Linden D and Romeo S.
  TITLE     PSD3 downregulation confers protection against fatty liver disease
  JOURNAL   Nat Metab 4 (1), 60-75 (2022)
   PUBMED   35102341
  REMARK    GeneRIF: PSD3 downregulation confers protection against fatty liver
            disease.
REFERENCE   2  (bases 1 to 11327)
  AUTHORS   Kinoshita-Kawada M, Hasegawa H, Hongu T, Yanagi S, Kanaho Y, Masai
            I, Mishima T, Chen X, Tsuboi Y, Rao Y, Yuasa-Kawada J and Wu JY.
  TITLE     A crucial role for Arf6 in the response of commissural axons to
            Slit
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30674481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11327)
  AUTHORS   Fukaya M, Ohta S, Hara Y, Tamaki H and Sakagami H.
  TITLE     Distinct subcellular localization of alternative splicing variants
            of EFA6D, a guanine nucleotide exchange factor for Arf6, in the
            mouse brain
  JOURNAL   J Comp Neurol 524 (13), 2531-2552 (2016)
   PUBMED   27241101
  REMARK    GeneRIF: Genetic variants of EFA6D were found to be distributed in
            overlapping patterns throughout the subcellular brain.
REFERENCE   4  (bases 1 to 11327)
  AUTHORS   Harrow JL, Steward CA, Frankish A, Gilbert JG, Gonzalez JM,
            Loveland JE, Mudge J, Sheppard D, Thomas M, Trevanion S and Wilming
            LG.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (bases 1 to 11327)
  AUTHORS   Ueda T, Hanai A, Takei T, Kubo K, Ohgi M, Sakagami H, Takahashi S,
            Shin HW and Nakayama K.
  TITLE     EFA6 activates Arf6 and participates in its targeting to the
            Flemming body during cytokinesis
  JOURNAL   FEBS Lett 587 (11), 1617-1623 (2013)
   PUBMED   23603394
REFERENCE   6  (bases 1 to 11327)
  AUTHORS   Sakagami H, Suzuki H, Kamata A, Owada Y, Fukunaga K, Mayanagi H and
            Kondo H.
  TITLE     Distinct spatiotemporal expression of EFA6D, a guanine nucleotide
            exchange factor for ARF6, among the EFA6 family in mouse brain
  JOURNAL   Brain Res 1093 (1), 1-11 (2006)
   PUBMED   16707115
REFERENCE   7  (bases 1 to 11327)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125262.9, AB220685.1, AK122405.1, CX568292.1, AK147606.1,
            AK032036.1 and BM898780.1.
            
            [WARNING] On Apr 17, 2023 this sequence was replaced by
            NM_177698.6.
            
            On Jul 30, 2020 this sequence version replaced NM_177698.4.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB220685.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC125262.9         118175-118187
            14-4364             AB220685.1         1-4351
            4365-8627           AK122405.1         1758-6020
            8628-9258           CX568292.1         146-776
            9259-10508          AK147606.1         7145-8394
            10509-11326         AK032036.1         1766-2583
            11327-11327         BM898780.1         21-21               c
FEATURES             Location/Qualifiers
     source          1..11327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     gene            1..11327
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /note="pleckstrin and Sec7 domain containing 3"
                     /db_xref="GeneID:234353"
                     /db_xref="MGI:MGI:1918215"
     exon            1..455
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..3439
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /note="isoform 2 is encoded by transcript variant 2; PH
                     and SEC7 domain-containing protein 3; guanine nucleotide
                     exchange factor for ADP ribosylation factor 6; pleckstrin
                     homology and SEC7 domain-containing protein 3; exchange
                     factor for ARF6 D; exchange factor for ADP-ribosylation
                     factor guanine nucleotide factor 6 D"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 3 isoform
                     2"
                     /protein_id="NP_808366.2"
                     /db_xref="CCDS:CCDS40355.3"
                     /db_xref="GeneID:234353"
                     /db_xref="MGI:MGI:1918215"
                     /translation="MGNCWSYSNLCDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASL
                     DFDAKSPPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQEQSLQPIDSLISALK
                     ATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPL
                     SAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVPESACPVSSSSAGS
                     HNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGEEAESRH
                     PPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSP
                     MPLGESGEDDVFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDV
                     YSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSV
                     GGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAFWGSRDRCFAEGKTT
                     GVDAGSEMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGKN
                     NEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNP
                     DTITSKDGVHCLTCAMMLLNTDLHGHVNIGKKMTCQEFITNLQGVNEGGDFSKDLLKA
                     LYNSIKNEKLEWAVDDEEKKKSPSEGTDEKANGTHPKTISRIGSTTNPFLDIPHDPNA
                     AVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKSLSDEDL
                     KNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVF
                     SAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKK
                     VKAKDVDEYKLKDHYLEFEKTRYEIYVSVLKEGGKELLTTDGNEPVGLKKSHSSPSLN
                     PDASPVTAKVKRNVSERKDHRPETPGIKQKVT"
     exon            456..1521
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1914
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2121
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2202
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2315
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2374
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2377
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2467
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2511
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2705
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2776
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2934
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3079
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3223
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..11327
                     /gene="Psd3"
                     /gene_synonym="4931420C21Rik; D430018P08; EFA6D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcctctg ccggcttcct gctgctgcac tgggggaatg gttacattaa agctaactcc
       61 cgacatctca gttatctcct tggaagtagt tttgacaatt atagaaaagc cccacagtgg
      121 ctgtcttcgg taagctacca aggtagagag cgaccgaggc tgagcacagc aggagagcgg
      181 gctgctctgc ctttgtgagg ggctgaggcg gcagttcctg ggctcggctc agctctggtt
      241 ccaagtgctc aaagtgcttc catttacatc accgtgtgca gtgcagggca agaggggcct
      301 ccaggaaatt tgaaactaat ttgcttccag ttgactagaa cagcacattt tgcattagct
      361 tgcttctttt ctcgttaact tttctcaagc gttaaactga tgaactgggc attttctatg
      421 atcaatgggt aactgctgga gctacagtaa tctctgtgat catggaggaa gcactttact
      481 cccaccgact gtcacaaatg aatttccaga atatgggacc atggaagaag gaggggaagg
      541 cctcagagcc tctctagact ttgatgcaaa gtctccacca tgccgcttgc ctgggcagca
      601 ggcagtccac cttcttgcgg gacaagactc tatacttaac agtgttacag aaggaccaaa
      661 cgacgcccca cagtgtcacc ctcaggaaca aagtttacaa cccatcgact ctttaatttc
      721 tgctctgaaa gctacggaag ccagaatagc ttcaggaaca tttcaagcta caaaggtact
      781 ggacaaagat gctaactttt cagtttacca ggtggataaa gaactgagta ctgccagtca
      841 taagccacag agagcccata gaacatttcc tgttggccca ggaaaatcac cagatatacc
      901 tctttcagcg gaagtaccaa cggaggaaaa cttgtctttg cacatccagg aggatctgtc
      961 tgcactctta cctgaagaag ctcaagcaca tcggtcccag ataactaatt acaggaggca
     1021 ggggcctctc cgtgtgccag agtcagcatg tcctgtgtcc tcaagctcag cagggagcca
     1081 taaccctgtg gacagagttg gtgctttaag agagcagagg tctgaccttg gaagagagca
     1141 ccctagaggc tatgatcggg gaggctccat ggggcgccaa ggccggatca aacatgtaga
     1201 atttcaagga gtagagatac tgtggacagg agaggaggct gagagccgac atccaccaga
     1261 aaggacagcc tcgcctgtga gcaaggagtt tgccaaacgg ccaagtcatt ctagcccagc
     1321 ttgtggtgtg tgtagcacct ccactcattt aactggggat gtttgggatg aaacttgcaa
     1381 agccccttcc gaaaggccgg gcacaagcgc aggcacactg tcccctatgc ctctcggtga
     1441 gagtggagag gatgacgtct ttctgagaga aagcaaagaa caccttgagg agaactttgc
     1501 tatacaggga gacaaagaaa ggattctcga tcaagaggag caccttaggg gagatgatga
     1561 tattcttggg cctggatata cggaggactc cactgatgtg tacagcagcc aattcgaaac
     1621 tattttggac aacacttccc tatactacag tgcagagtca ttagagacac tgtattcgga
     1681 accggatagc tattttagct ttgaaatgcc gcttactcca atgatacagc agcgcattaa
     1741 agaaggcggt cagttcttgg agaggacctc tgtgggagga cagcatgatg tgctgagtgt
     1801 gtcagcagat ggtgggatag tgatgggcta ttctgcaggg atcaccaacg gattgcacga
     1861 ttctgccaac tctgtctaca ccagaggccc tcaagagatt gccttctggg gaagtaggga
     1921 ccgttgcttt gctgagggga aaacaacagg agtagatgct ggttctgaaa tggggagcac
     1981 tgacattctg gaaaaggaga ccacagaaag tctcagcaat gggaccaaca gcaatgtgga
     2041 agcagctaaa agattggcca aacgcttgta tcatctagac agattcaaga gatcggacgt
     2101 tgcaaaacat ctaggcaaaa acaatgaatt tagcaagcta gttgcagagg agtatctgaa
     2161 gttttttgat ttcacgggga tgacgctgga tcagtctctc aggtattttt taaaagcatt
     2221 ttctcttgtg ggagaaaccc aggagcgtga gagagtatta atacattttt ccaatagata
     2281 tttttcttgt aatccagaca ctatcacctc aaaagatgga gttcattgcc tcacctgtgc
     2341 tatgatgctg ctcaacacag atctgcatgg ccatgtgaat attggaaaga agatgacttg
     2401 ccaggagttc attacaaatc tccaaggagt aaatgaaggt ggggatttct ccaaggatct
     2461 tctgaaagct ctgtacaact caatcaagaa cgagaagctt gaatgggcag tagatgatga
     2521 agagaaaaaa aaatccccct cagaaggtac tgatgagaag gctaatggaa cgcacccaaa
     2581 gactatcagt cgtattggga gtacaacgaa cccatttttg gacattcctc atgacccgaa
     2641 tgctgctgta tacaaaagtg gatttttggc tcgtaaaatc cacgcagaca tggatggaaa
     2701 gaagactcca agaggaaagc gaggatggaa aaccttttat gctgtcctga agggaaccgt
     2761 tctttactta cagaaggatg agtataagcc agagaagtct ctgtccgatg aagacttgaa
     2821 gaatgcggtg agtgtgcacc acgctctggc gtccaaggcc actgactatg agaagaagcc
     2881 gaacgtgttt aaactcaaga ctgcggactg gagggtcttg cttttccaaa cccagagtcc
     2941 agaggaaatg caaggctgga taaacaaaat taactgtgtg gcagctgtgt tttctgcacc
     3001 gcctttccca gcagccattg gctctcagaa gaagtttagc cgcccacttc tgccagccac
     3061 tacaacaaaa ttatcccagg aggagcagct gaagtcccat gaaagcaagc tgaagcagat
     3121 caccactgag ctggctgagc atcgctcata tcccccagac aagaaggtca aagccaagga
     3181 tgttgatgag tacaagctga aagaccacta tctggagttc gagaaaaccc gttatgagat
     3241 ttatgtcagc gttctgaaag aaggaggcaa agagctcctg actaccgatg gaaatgagcc
     3301 cgtgggactg aagaagtcac actcaagtcc ctccctcaac ccagatgcat ctccagtcac
     3361 tgccaaggtc aagcgcaacg tgtcagagag aaaagaccac cgacctgaaa caccgggcat
     3421 taagcaaaaa gttacttaga atccatccgc ggccaggagg tgctggtcat ggaacaaaat
     3481 agggtttttc aagatctttc tggtaatccg tgaatatatt taaaaaacag tctgtgacta
     3541 aacggtgcat tagtaacctt ttctattata tatttttgtt agtttctgta caggtgtctt
     3601 tgctcttgag ttcctttgct ttgatgattt ggacaacttt ataactaatg caccttttgt
     3661 gaggaggagg aggagggcta cagatccttt ctcttcggct ttctcttatt tgcacttcta
     3721 tacagttatt ttgtgtatta ccaatcagtt gttgtatttt tttttaggtt taaattttta
     3781 atccattgtg aaacccataa ctggacaagc attgtgcttt tagtaaatcc tagactttac
     3841 atgtgaaatc ctgcccagtc acggaggtga agttgaaagt tcatagttgc tcacatgaaa
     3901 atggcagcgc tgggagtcga ggtgtcccaa gataggacac ttctgcgttc ttcctggcac
     3961 ctgttgttgg tgctggacac aggacaaaag ggagcacgag gatgacagga ctggagacct
     4021 tagggaggca caggagtttg tctcaggtgt gcattccatt ccagccatgc aagggaattc
     4081 agaagtggag tcatcttgct tgaagggagc ctgaggatgg cttgatcccg agccactttt
     4141 gttttctaaa ggctggtggc agtaatcagc tctttggaac tgtagcagta ggatgtatgg
     4201 tcttctatag aaatgttacc tcactcccat ggaatctaga ctaggaatca aaatcatctc
     4261 tgtgattgat acctttccat ccaggaatag attcatttaa catagatgta caggcataga
     4321 tcatgtcctg gttgaaacaa aacaatgttg gaaatgaata ccaccttccc ccacacatac
     4381 tcttctcttt cttttctata tcaagacaaa taaggagcaa cacagatgca gttcttcatc
     4441 aagatcaggc catcagacgg gctatgaaat cagtctgatc acagtgaccg aggatggagg
     4501 ggtctgatgt atgagcagcg tcttagctta ttctcatctc cacctctaca gcggtcttgc
     4561 tatgccacta ttaagattgc tcctggaatt acttgtatac atttaatctt atttttttcc
     4621 tgcattcaaa atggtttcac tttacagtca aagcagtccc tttacaattt aaagtattaa
     4681 gtagagtatt gtctgtagag gaagaaaaag gcgtaaaagg tgaacttcct ctgtggctga
     4741 aaactgtcca gtttccagcc ttgaaactgt attctctaaa actactatct tcccatcaaa
     4801 atatcttcaa aaactaacag gatgacattt agatattctt tattctcctt aaatatttcc
     4861 tctatttcga cttggttagt tgaaggtact atgaccagag aatcagctgc tcttgcatga
     4921 atagcatgat tctagtaagt tagagtaagc ctgttaaaaa atcccggtag tttatagaga
     4981 catctcgtta ggatgtacta gcatttagtc acaggactgt gtgttagcct gtacttcttt
     5041 cacctctgta catgcccacc ttgcttgtgc cccggaatag taacacttct ctccaatacg
     5101 gtagctgctt gcttcatggt attttgccac actattggaa aaacttccct aaacttctat
     5161 cttgtttaag taaaggcagt gatttaattt atatctcaga accatgaagc gaatatgata
     5221 gttaacattg tggctccata tacctgaact atttcatagc atcctagtga atccaatatt
     5281 ccccaagcaa gttgcctttc ttctagaagg tgaactatca ctgtctgctt tttgcctaag
     5341 tatttgtaat ccctgaaggg aaaggtacca agaccttgga gtcttgagca tcatcttaga
     5401 gcatcagtag ctgaacagtt aacatgtcta aatgtgtttg tccacagtgt gtgctatatg
     5461 tatagaatgt ttgtgtgtac ttatgtagag tatctaatat acattgaatg gtaccttgct
     5521 gcagagtttc tgacatggag aattgtctag gactaccctt agcattagct ctgccactgt
     5581 tcctgttaca ggactcacta gtgttggctc tagagcttct ggacatgctt atagataatc
     5641 agatcacaaa ggcactttta aagctgtgga ctactctgtc tacatcattt atcttgaaaa
     5701 ataactgaag cagtcttttg tgagtcagaa tcccagcctg ccctagtgta atgctgtcta
     5761 cctttgggga taggctaaaa atgtgtcttc cctgaggcct ctggaaggat gctgcattct
     5821 cagatctgat gggactctaa gagtctggcc catagtcagc cccatttctc ccacagtatt
     5881 gattcctaag aaatggaagg tggtccattg aacagctctg ctaagcctgt tgcccagtac
     5941 acggtaccgg gagctcttgt ccctttcctt tccatggtac ttcatcctgt ccctcctata
     6001 cctactgtca tccctacctc ggtgccctgg agtcttggaa ttcctctcca tatgataaag
     6061 cattatttat cttacattaa taccttaaag gatggttctt agtattgaaa atatgaacaa
     6121 gacatcaaaa gactttgatg atagtcttgt tgaaaaactg accattgaag taccccttgt
     6181 ataaaatctg tgtgtatctt gggcttcacc cctaccccca catgctagct tctaaaaaga
     6241 tttaccagga acccagtttt aaaaattcta cttagagtcc ttgttttatt ggtatatcgt
     6301 tagcatttct gaaaatgttt ttctaaaagt ctatataatt tatctaactc ttagtaatgc
     6361 ctaattaagt caactgttac ttatttatgt ttccattatt ccaaaggaaa ccagcatgta
     6421 gaagactcct ctggttgaaa tagcttatag gttatatgta actttttaaa attgtgctta
     6481 gatagagcca ttttctcatg caacgatctt gtatagtgtg taaggtgctc tgtgcccctc
     6541 tgttttttcc cctcatcctg aaggtaagga ctatttccaa ggcaaatgta gtgtaaggga
     6601 attggttctg aaagaggaaa acttactggt tttcaaggcc cagctagggt tgtgttctaa
     6661 tctccttggg aagttgagag caggaaggta caaaggttct tcttcgcctt ctgccccttt
     6721 atcatgtaaa gaacaaggat gaaggaccat gctctgaaat aagaaaagac cgtcctgaaa
     6781 tactcatcat ctgtcttttt tattagaagt caattttcca ttgtctttcc aaataagaga
     6841 gaccttagag gaagttagct gaacatggaa atttaattct ttggcttttt ttttctatta
     6901 atcatcagtt caaccttgct tggcattaag tttgttagtt ctgaacacct aagtatttgt
     6961 ggcttagcta ttatggatac aagatatttt tcagaccagc agccacgttc ctggttttgg
     7021 cagaaaatga tagtgttgta gttcaagtag cagtgtattt tccctataaa gctcacacta
     7081 gcaccgaagc agaatcatag catcagttaa acatatactg cagttcaaga atgataatgc
     7141 atcttggggt ctgaggcata tcagctcttg tttcagagca tctgtgttac tcagacagaa
     7201 acagaccaga cagttttaca ggctccagca cctctttctt accttcattc acccaggcca
     7261 ggcagctggt aaattagcag aagtctcggc acccatttga catccgttgt catcatgcct
     7321 tccagaggac tctatcaagc cacaaaaact aatccctggc atattacaga ggtactttgt
     7381 cactgcactt cctttcagac tccatttcat ccttcatact taacaggact gatatctgag
     7441 gtcattctca ttctgtatct atagtgggca tcttatagca gttggctcat tgcatgtgga
     7501 gagaatgtca gtaaatactt gaatctgcat ggcagtttgc tgacgtgtat gcaagagcaa
     7561 ggagcgagga atgcagcaag ttacttgtac atacagtagg tttccttagg tcttgtgggc
     7621 acatcccttg taatttatat gtatatctgt tgtactgaag catttgggga aatacttgta
     7681 tagaaagtat gtatgtcata tgtcaaagga aatgctttct gtcccctgcc aatgttgtat
     7741 ttgtgggtat ttatagttgt atgtatgtat gtacatcaat gtgtagattg tgtatcagta
     7801 tatggtatat gtatgttgaa attatttttg tcttttagca accagtataa tatgaaaaga
     7861 aagtttaaaa acctcatagg aatgactata tagtacagtt gttgagaatt catacagtgg
     7921 tatcatttta ttaaacttaa attcaaatga tattttgatt aaatttttag taagacttta
     7981 cactagaaaa ttccatcttt aagctttgaa ttaccagggc aaaaaaaaaa tgactttaaa
     8041 ctaaacttgt gaatctattg aagtgtacag tgtgcaatac agtgagaact cattataata
     8101 taggaaatac agcagaagtg gaggggaaat ccagcctggg ccgtcttagc aactttagta
     8161 ttaagagcac ttaaaaataa agttgagctg ataacttagg gcttattaca aaaggtgatg
     8221 ctttcaagct cacgttcttt attgttgtaa ttagtccaga aaaaaataca tagctttctg
     8281 aagaactaag taactaccca gtgtatcttc tatgtgctgg tgtgtatttt agagtagatc
     8341 actctcctgg tgccgcatct ttaccctctt tgatacaaaa gaatatcaca gatactgaag
     8401 tctatcaggg catcccaaga tcgggtactg tattccaggt ttgcaattgc acaaattaac
     8461 agctagtgtt gtaggtaaaa ggacttaagg aacaggttag actttattta atatttttat
     8521 acttcaatct cttttttcct gactctcccc aaagaagagc cactggcctt agttgtttaa
     8581 tgttattgct tatattataa agtgtaaata gtaactaaag ttttattaac cagcatgttt
     8641 ggtatattta aagcagtgac tgagtgtgtt tgagtgtgtg gttgagtgca gtgcctgttg
     8701 gaatgcactg cctcatgtct ccatgtctga gtcagagaat tagaagtgtg gggtctcaga
     8761 ctccacttca gctccaggct acagtcctgt attggcagtt acacttgagt ttagtttttt
     8821 attaactcct cagtctcaaa ctatttttta taaattatat ttctcgattt ggttttatgt
     8881 gtgatcggct ggctctgtgg ataatcagca gggcttctgc aagaatattt ccttctaaga
     8941 attccctggg atttgcagaa aacagccatc gattcataaa ttgagtagta gaactaaggt
     9001 atgttttagg tcgtagctac ttgaaaagtt ttaattttaa tatgaagcca tgaaagttgt
     9061 aaagccaagt aatcatttga catggataat aatattcaca ctagagagta tatatgcaca
     9121 ttaaattttt atgtcattag aatacttttt taagctttag gaataagagt aattagacca
     9181 aattaaagtg caggggtgag ctggctgttt tccacctgga gtagtcatgt attattaaat
     9241 cttcaactaa gagatgcaaa actgagtaac taactgctcc cttaggtgtt taaggagaag
     9301 attgacaggc atagaacctc atctgtgtat gtacacacac acacacacag agagagagag
     9361 agagagagag agagagagag agagagagag agaggacgag aaaaaagttt taagctatac
     9421 aaatgtatta tcttaagaca ccaagggcca gagtattcta gaggtgatga atggaggcag
     9481 tggaaactgt atcatagatg tattccaaga accaggggaa atgatggagt gctggtgtct
     9541 gactctgaga gagggcgggg acggatgctg cgtcctgcta gtggatacca acttgaagga
     9601 attcttgtga cccataggca gtgactccag aatcccccac tagcactctg cagatcattt
     9661 ctttcagagg agagtgtaaa tggagaagcc atattacctt cagagcccaa ggtgtggttt
     9721 gcctgccatg gcttctcaga tgtaggtgaa agagtttgca ctgaactgtg ctaaaacagc
     9781 ggagcgttgt ccacaggcca ggatcttcag gatgaaaaca ggctggaacc caaacacaat
     9841 gcacttttgc aggggagagc tcagctctga taataagcat gttgacttca atttggaaag
     9901 cactggtgaa tggagagaac tttggaggtt cacttagagt tcccccattg gtctatatca
     9961 gtctttgaac ccaccctcaa gtcccagcct caaggctcaa tgaaaaatct catggcaggt
    10021 gtgaggctca ctgctctggg tgtgaggcta gggcagtgga gagcagggtg atcttacctc
    10081 gcagaagcgt ccccttggcc ttcttctcca cttgggcttc tgctcagcag caggaatatt
    10141 ccgggttcca ggttcattag gaatccagct gtcccagtgg cttgaccctg tttaggcaag
    10201 atatcagctc tgagggtgac ccggtcacag aggaaggcaa gtttgacaag atcctgcagt
    10261 ttgaagcaaa actgtgtttt gtctttttca agaaacaaat gggcgcattg agttttggtc
    10321 agtgtcagag gatatctttc tctttgctcc cagatttcca gaaatggata atgttttcat
    10381 ttctgtggga agggtcaaga aacataaaat tgctcaacag tgctcagctc cctgagagtt
    10441 gttgagcgaa ggccgacatg cctccctgca tcctcttcta cctcaagttt ttggaactga
    10501 attctgggac agaaatttac acaagaagcc atgttgccag ccctggttac tgtgggatgc
    10561 acattgggat gacagtcttt atctttaaga taaacaggag ctgggctttg acagcctact
    10621 gcccagttta tatctactgt agtttcaaat gattggcaat gcatagcatt ccttaccttc
    10681 aaagttttct ccattggtca tttctgtatc actgcggttc tggtgtcata tgcccctgca
    10741 aattgtgaaa gtagttagtg acaaaatacc cccccctttt cagtggccaa acggtcagct
    10801 gtagccgacc tgggaaagct agtggtacca caccatgtac tgaaaacctg ttccttatca
    10861 cacactagac tcaagaaatg ccacctctga atggtgccat tcaaggtgat agtggtttga
    10921 acggaacagt aatctatgtg gatattgtta aagtgtttaa agaatatttt gaaaattaag
    10981 tttacatttt acaattgctt tatttttatt gaaataattg tatatagcta ttaccctatt
    11041 tccctgttat taaaggtaac ccttgccttg aagacaagtg ggccagcgga tatgtataga
    11101 agatgtgatg tagacaagta tctttctcta ttgtgtaaat ggtcatgaat ataaccgtcc
    11161 ctggattttt ataagttgag ggcattttgt tgttttacga caacaaaatt tattgcattt
    11221 gaaatggttt ttatgtaata gaaatcatgc aaacagtgaa ggattataaa atggtatatg
    11281 taaatgtata aactttagaa agaaataaat acaacaaatt tcaatca
//
