LOCUS       NM_028707               4628 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pleckstrin and Sec7 domain containing 2 (Psd2),
            transcript variant 1, mRNA.
ACCESSION   NM_028707
VERSION     NM_028707.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   Saegusa,S., Fukaya,M., Kakegawa,W., Tanaka,M., Katsumata,O.,
            Sugawara,T., Hara,Y., Itakura,M., Okubo,T., Sato,T., Yuzaki,M. and
            Sakagami,H.
  TITLE     Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for
            Arf6, exhibit lower Purkinje cell synaptic density but normal
            cerebellar motor functions
  JOURNAL   PLoS One 14 (5), e0216960 (2019)
   PUBMED   31095630
  REMARK    GeneRIF: EFA6C, a guanine nucleotide exchange factor for Arf6,
            plays ancillary roles in cerebellar development and motor functions
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4628)
  AUTHORS   Kinoshita-Kawada,M., Hasegawa,H., Hongu,T., Yanagi,S., Kanaho,Y.,
            Masai,I., Mishima,T., Chen,X., Tsuboi,Y., Rao,Y., Yuasa-Kawada,J.
            and Wu,J.Y.
  TITLE     A crucial role for Arf6 in the response of commissural axons to
            Slit
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30674481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4628)
  AUTHORS   Ueda,T., Hanai,A., Takei,T., Kubo,K., Ohgi,M., Sakagami,H.,
            Takahashi,S., Shin,H.W. and Nakayama,K.
  TITLE     EFA6 activates Arf6 and participates in its targeting to the
            Flemming body during cytokinesis
  JOURNAL   FEBS Lett 587 (11), 1617-1623 (2013)
   PUBMED   23603394
REFERENCE   5  (bases 1 to 4628)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   6  (bases 1 to 4628)
  AUTHORS   Sakagami,H., Suzuki,H., Kamata,A., Owada,Y., Fukunaga,K.,
            Mayanagi,H. and Kondo,H.
  TITLE     Distinct spatiotemporal expression of EFA6D, a guanine nucleotide
            exchange factor for ARF6, among the EFA6 family in mouse brain
  JOURNAL   Brain Res 1093 (1), 1-11 (2006)
   PUBMED   16707115
REFERENCE   7  (bases 1 to 4628)
  AUTHORS   Matsuya,S., Sakagami,H., Tohgo,A., Owada,Y., Shin,H.W.,
            Takeshima,H., Nakayama,K., Kokubun,S. and Kondo,H.
  TITLE     Cellular and subcellular localization of EFA6C, a third member of
            the EFA6 family, in adult mouse Purkinje cells
  JOURNAL   J Neurochem 93 (3), 674-685 (2005)
   PUBMED   15836626
  REMARK    Erratum:[J Neurochem. 2005 Nov;95(4):1215]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066026.1 and BC066036.1.
            
            On Jan 24, 2014 this sequence version replaced NM_028707.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066026.1, BC065055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4607              BC066026.1         1-4607
            4608-4628           BC066036.1         4364-4384
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.34 cM"
     gene            1..4628
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /note="pleckstrin and Sec7 domain containing 2"
                     /db_xref="GeneID:74002"
                     /db_xref="MGI:MGI:1921252"
     exon            1..390
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            391..792
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1242
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1437
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1518
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1631
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1690
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1780
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1824
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2015
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2086
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2244
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2389
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2533
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..4610
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /note="hexamer: AATAAA"
     polyA_site      4610
                     /gene="Psd2"
                     /gene_synonym="6330404E20Rik; EFA6C"
                     /note="major polyA site"
ORIGIN      
        1 gcttatgctg aagccggtgg ccgtgttctg gtgggtgggc gccccgcaca aggtcgggcg
       61 cttgtgccca ggcgccgcgg gtgggccctc ctggtggcca cggtcccctc caggctgcgg
      121 gcgcgccggc agtctctccc ccgcccccct cccgcccttc ttgtccttcc cgctcctccc
      181 tccctccttc tctgctctgt tccctcctcc tgcagtccgt cccctccttc tctgcccagc
      241 ctctccacag ccgaggctcc aacacctgag gggacagaag cgaagcgaac gcggggagct
      301 ccaacaggcg gcggcacggg accgcgggtc caggggtggc ctccgcatgg ccccaccgtg
      361 agaggggacc cagcggctgg gacacgagcg ccctaggggc tggcagggac gggtggaaac
      421 agtgaccgac atggatgaag agaagctccc atgtgagctg cacaaggaag ggagtgctac
      481 ccaggaggac cacggcctgg agcccgaaga ggagcctggg ctccagaatg gaacagcagc
      541 cagcgaaggc ctgagcagcc acatcagcgg cccaggcggt gagaagacct tagagggtac
      601 catggagcct gtgagaggcc cagatgtggc cctgcctggc cttaacctct ctttgaccaa
      661 tggcctggct ttgggacaag atgggaacat tttggaagat tccatagaat ttaagacctg
      721 gagaagcgga ccagcagagg aggaggatgt ccctgggagt ccctgtccag atgctgggga
      781 ccctcagctg gggctggatt gtcctggcga accagatgta cgtgatggct tcagtgccac
      841 ttttgagaag attctggagt cggagctact gcggggcacc cagtatagca gcctggactc
      901 tttagatgtg ctgagtctca ctgacgagag tgacagctgt gtcagcttcg aggcccccct
      961 tacacctctc atccagcaga gggctcgaga tagccccgag gccggggctg ggctgggcaa
     1021 tggggacatg gggcctgaag gggatctggg ggcaactggt ggttgtgatg gggaactagg
     1081 cagtcccctg aggcggtcca tctctagcag ccgctcagag aatgtcttga gccacctgtc
     1141 tctcacctcg gtgcccaatg ggttccatga agatgggcct gggggctcgg gaggggacga
     1201 tgaggacgat gaggacacgg acaagttgct gaactctgcc agtgacacca gccttaagga
     1261 tggcctgtcg gactcggact cggagctgag cagctctgag gggctggagc ctggcagcac
     1321 agatccactg gccaacgggt gccagggggt cagcgaagcc gctcgcaggc tggcccgacg
     1381 gctctaccat cttgaaggtt tccagcgctg tgatgtagct cggcagctgg gcaagaacaa
     1441 tgagttcagc aggctggttg ctggggagta cctcagtttc ttcgacttct caggcctcac
     1501 tttggacaga gcactcagaa ccttcctgaa ggccttcccg ctgatggggg agacacagga
     1561 acgagaacga gtccttaccc acttctctcg ccggtactgc cagtgtaacc cagacgacag
     1621 cacatcagaa gatgggatcc acacgctcac ctgcgccctg atgctgctca acacagacct
     1681 gcatggacac aacattggca agaagatgtc ctgccagcaa ttcattgcca acttggacca
     1741 gctgaacgat ggccaagact ttgccaaaga ccttttgaag acactttaca actccatcaa
     1801 gaacgaaaag ctggaatggg ccattgatga ggatgagctg aggaaatccc tgtctgagct
     1861 ggtggatgac aagtttggga cgggcacaaa gaaggtgact cggatcttgg atggtggcaa
     1921 tccattcctg gatgtcccgc aggctctcaa cgctaccacc tacaagcatg gcgtgctgac
     1981 ccggaagact catgcggaca tggatggcaa gaggacaccc cgtgggaggc gtggctggaa
     2041 gaaattctat gcagtgctca aagggaccat cctgtacctg cagaaggatg agtacaggct
     2101 tgacaaggct ctgtctgagg gggacctgaa gaatgccatc cgtgtgcacc acgctctggc
     2161 caccagggct tctgactaca gtaagaagtc caacgtgctc aagctgaaga cagcagactg
     2221 gagggtgttc ctcttccagg caccgagcaa ggaagagatg ttgtcctgga tcctgaggat
     2281 caacctagta gccgccatct tctcagcacc agccttccca gcagccgtca gctccatgaa
     2341 gaagttttgt cgacccctgc tgccctcctg taccacccgc ctctgccagg aggagcagct
     2401 gcggtctcat gagaataagt tgaggcaggt gactgcagag ctggctgagc acaggtgtca
     2461 cccactggag agaggcctca agtctaagga agcagaagag taccgtctga aggaacacta
     2521 tctcaccttt gagaaaagcc gttatgagac ctatattcac ctcctggccg tgaaaatcaa
     2581 agtgggctca gatgacctgg agcggattga ggcacggctg gctactatag aaggggatga
     2641 cccagctctc cggaaaacac actcaagccc cgccctcagc ctgggccacg ggcctgtgac
     2701 tggcagcaaa gccacaaagg atacctctgc atctgatact tagctagtgt ggctgtgcag
     2761 gccctagagg caggcaaatg tccccagagg ggtcagtgag cacaattcca gccagggatt
     2821 gcttggaccg agctccaggc agttaacagg caaccagagg ggtgtggaga gccctgtgcc
     2881 caaggagatg gagatgtcac tcatgacgct gatcttcttg catcctggac catcgctggc
     2941 ctagaccctc tcctagccct gctgccctcc agtcatgggg ccagacatgc tctagagctg
     3001 gacaagtctg tcactgttgc tctttcccag gctcccttct catcaggctc ctccctcgtc
     3061 ctgtatttgt gagggtgggt ctggactctg gatttcagct tggctatcca ccctttctcc
     3121 tctttcctct cagttgacca gcagcaggtc tatggaccac cagcaacctt tgcaaccggc
     3181 ccagttctcc tgcctcacgt tgcaataatc tggggcctaa cctccactca gtgccaagct
     3241 gattccacac atgcgtgtgt cccctttctc ctttcatccc ctgaggcctc tccagcctct
     3301 tttttataca gacacacaca cacacacaca cacacacaca caatatatat atatatgtaa
     3361 agtactcatt taaagaaggg ttggaaacta ctaccgacta gagggtgaaa ccagaaaaag
     3421 gaaaactcct gacttggagc ctggcctgct atggaggaag cctgcagggg gccctgcact
     3481 gctctgacac tggatgggag gatgaagacc ctctgtgttt ttgccttttc cttttccggc
     3541 tgacttgtga ctcacaatca cttttccagt tgatgctttt ggactggaca ggatgcctgc
     3601 gtgtgtgtca cctcctctgt cccaggggtg tcctgtgggt tgagtgcctt gggggcacac
     3661 ctctgtttgc ttttgatctt cttgtgaata ctgccaaggt ctccgagctc cagtgatgcc
     3721 ctctgcacag acctcctggc agtaaggaag gacactacct agctgagcgt catcctccgg
     3781 caagcccagg ctgggcggta gagtagggtt aaggaagctg ttagtttgtg gtctcgggga
     3841 gaaggtagag tgacaaggtt ttgattagtg ataatccttt ccttttccta gcaaatcaga
     3901 aagcctaagc taaggaccca gttgagagtc gagacacatg tctctcacgg gttgacatcc
     3961 tttgaacacc gcatcactta gagcaacaag tgagtctcgg ggataggccc ccttgacaca
     4021 gctaccacga gccaatcttg cctattgttt ggccaacggt ttgcagtctt gggtgacata
     4081 atctttgcaa ctaagtgctt atcacttcaa atccactccc atctgatgca gggagctggg
     4141 agtttgtgga gaggtgtagt ggggttgaaa tccaaattgc ttaaattgga ttagctgaag
     4201 tgcgtttgat aaccaaacca tctggcccct ttgttttgct caggggaaac aaatgctcgt
     4261 ttgaatgaga tcagaaaggc aatttagggg gcagcaaaga gatctcagtt ctttgtccag
     4321 ctgcctgaaa gtcctttgat tttccagcca gtgtcccact ctctgtgtca tgggtggggg
     4381 acagtagagg tgaagttctt tagcctcaga cacgcgtgat tccccaagca ctagttgtgc
     4441 ctcccatcag taaagacatt ttttagttcg cttccttaat tgtataattc tttatttgta
     4501 aattatatac atgtactact gtactaaaat attatgtaca ttataaaaca tacacaaaaa
     4561 tagaaattta aaaaagatga gatgaaaata aatctaaatc aaagttctaa aaaaaaaaaa
     4621 aaaaaaaa
//
