LOCUS       NM_028627               3950 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus pleckstrin and Sec7 domain containing (Psd),
            transcript variant 1, mRNA.
ACCESSION   NM_028627 XM_484810
VERSION     NM_028627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3950)
  AUTHORS   Chomphoo,S., Sakagami,H., Kondo,H. and Hipkaeo,W.
  TITLE     Localization of EFA6A, an exchange factor for Arf6, in Z-lines and
            sarcoplasmic reticulum membranes in addition to myofilaments in
            I-domains of skeletal myofibers of peri-natal mice
  JOURNAL   Acta Histochem 126 (5-7), 152187 (2024)
   PUBMED   39126836
  REMARK    GeneRIF: Localization of EFA6A, an exchange factor for Arf6, in
            Z-lines and sarcoplasmic reticulum membranes in addition to
            myofilaments in I-domains of skeletal myofibers of peri-natal mice.
REFERENCE   2  (bases 1 to 3950)
  AUTHORS   Fukaya,M., Ibuchi,K., Sugawara,T., Itakura,M., Ito,A.,
            Shiroshima,T., Hara,Y., Okamoto,H., Luton,F. and Sakagami,H.
  TITLE     EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA
            Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
  JOURNAL   Traffic 25 (5), e12936 (2024)
   PUBMED   38725127
  REMARK    GeneRIF: EFA6A, an Exchange Factor for Arf6, Regulates
            NGF-Dependent TrkA Recycling From Early Endosomes and Neurite
            Outgrowth in PC12 Cells.
REFERENCE   3  (bases 1 to 3950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3950)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3950)
  AUTHORS   Chomphoo,S., Sakagami,H., Kondo,H. and Hipkaeo,W.
  TITLE     Discrete localization patterns of Arf6, and its activators EFA6A
            and BRAG2, and its effector PIP5kinasegamma on myofibrils of
            myotubes and plasma membranes of myoblasts in developing skeletal
            muscles of mice
  JOURNAL   Acta Histochem 122 (3), 151513 (2020)
   PUBMED   32059926
REFERENCE   6  (bases 1 to 3950)
  AUTHORS   Sakagami,H., Honma,T., Sukegawa,J., Owada,Y., Yanagisawa,T. and
            Kondo,H.
  TITLE     Somatodendritic localization of EFA6A, a guanine nucleotide
            exchange factor for ADP-ribosylation factor 6, and its possible
            interaction with alpha-actinin in dendritic spines
  JOURNAL   Eur J Neurosci 25 (3), 618-628 (2007)
   PUBMED   17298598
  REMARK    GeneRIF: EFA6A may form a protein complex with alpha-actinin and
            activate ARF6 in close proximity of the actin cytoskeleton and
            membrane proteins in the dendritic spines
REFERENCE   7  (bases 1 to 3950)
  AUTHORS   Sakagami,H., Suzuki,H., Kamata,A., Owada,Y., Fukunaga,K.,
            Mayanagi,H. and Kondo,H.
  TITLE     Distinct spatiotemporal expression of EFA6D, a guanine nucleotide
            exchange factor for ARF6, among the EFA6 family in mouse brain
  JOURNAL   Brain Res 1093 (1), 1-11 (2006)
   PUBMED   16707115
  REMARK    GeneRIF: determined the complete primary sequence of mouse EFA6D
            encoding a protein of 1004 amino acids with a calculated molecular
            weight of 111,207 Da.
REFERENCE   8  (bases 1 to 3950)
  AUTHORS   Decressac,S., Franco,M., Bendahhou,S., Warth,R., Knauer,S.,
            Barhanin,J., Lazdunski,M. and Lesage,F.
  TITLE     ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a
            GDP/GTP exchange factor for ARF6
  JOURNAL   EMBO Rep 5 (12), 1171-1175 (2004)
   PUBMED   15540117
REFERENCE   9  (bases 1 to 3950)
  AUTHORS   Rieger,D.K., Reichenberger,E., McLean,W., Sidow,A. and Olsen,B.R.
  TITLE     A double-deletion mutation in the Pitx3 gene causes arrested lens
            development in aphakia mice
  JOURNAL   Genomics 72 (1), 61-72 (2001)
   PUBMED   11247667
REFERENCE   10 (bases 1 to 3950)
  AUTHORS   Perletti,L., Talarico,D., Trecca,D., Ronchetti,D.,
            Fracchiolla,N.S., Maiolo,A.T. and Neri,A.
  TITLE     Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10,
            which contains Sec7 and pleckstrin-homology domains
  JOURNAL   Genomics 46 (2), 251-259 (1997)
   PUBMED   9417912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057353.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_484810.1, NM_028627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057353.1, SRR7345562.1506395.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2001              BC057353.1         1-2001
            2002-3586           BC057353.1         2003-3587
            3587-3950           BC057353.1         3589-3952
FEATURES             Location/Qualifiers
     source          1..3950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.8 cM"
     gene            1..3950
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /note="pleckstrin and Sec7 domain containing"
                     /db_xref="GeneID:73728"
                     /db_xref="MGI:MGI:1920978"
     exon            1..73
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            74..129
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            130..867
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3288
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin and Sec7 domain containing homolog; PH and SEC7
                     domain-containing protein 1; pleckstrin homology and SEC7
                     domain-containing protein 1; exchange factor for ARF6 A;
                     exchange factor for ADP-ribosylation factor guanine
                     nucleotide factor 6"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 1 isoform
                     1"
                     /protein_id="NP_082903.2"
                     /db_xref="CCDS:CCDS29875.1"
                     /db_xref="GeneID:73728"
                     /db_xref="MGI:MGI:1920978"
                     /translation="MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTG
                     SLIRRVVGPGPRGRDLGRVTAPCTPLRAPPSPHIAPSPWGPSSPTGQPPPGAQSSVVI
                     FRFVEKASVRPLNGLPASGGLSRSWDLGGISAPRPTPALGPGCNRKLRLEASTSDPLP
                     AGGGSVLPGSRDPSRGPLVPPQIGADGLYSSLPNGLGGTPEHLAMHFRGPADTGFLNQ
                     GDTWSSPREVSSHAQRIARAKWEFFYGSLDAPSSGAKPPEQVLPSRGVGSKQGSGVAV
                     GRAAKYSETDLDKVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPHGTAQPPASRP
                     SPCPGPSSSLGSGNEDDEAGGEEDVDDEVFEASEGARPGDHMPHSGLLKSPVPFLLGT
                     SPSADGPDSFSCVFEAILESHRAKGTSYSSLASLEALASPGPTQSPFFTFEMPPQPPA
                     PRPDPPAPAPLAPLEPDSGTSSAADGPWTQRREVEESDAGATLAPRKELPSPSHSEDS
                     FGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLY
                     RLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQE
                     RERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNL
                     EGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRVSGGSG
                     SSSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQ
                     KEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQ
                     MQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAM
                     ASELREHRAAHLGKKARGKEADEQRQKEAYLEFEKSRYGTYAALLRVKMKAASEELDT
                     IEAALAQAGSTEDGCPPPHSSPSLRPKPTSQPRAQRPGSETRAGAGSTRPKP"
     exon            868..970
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1325
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1766
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1961
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2042
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2155
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2214
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2304
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2348
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2539
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2610
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2768
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2913
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3057
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3900
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3880..3884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
     polyA_site      3900
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 cgcttgcgca ttacgacaaa tctggcgctg tccccttcag cacctcgcgg aactcgcgcc
       61 acccctcccc gcgctgagcg gggcccagcc tctctgcctc tcttcgattc cagctcctga
      121 cgagcagcgg cctgtctgaa gagcatgcag cccccttact ccctgcctgg cctcgccatc
      181 cctgcccccc cagcctgacc ccccggctcc agcatggccc agggtgccat gcgcttctgc
      241 tcagaaggcg actgtgccat ctccccacca cgatgtcctc gtcgctggct ccccgaaggc
      301 ccagtgcccc aaagtccccc agccagcatg tatggcagca caggatccct tatacgacga
      361 gtggtgggcc caggtcctcg aggccgggat ctgggacgtg tgacagcacc ttgtacccct
      421 ctgcgagccc ctccctcacc ccatatagct ccctcaccct ggggaccctc ttcacccact
      481 gggcagcctc caccaggggc acagagttct gtggtcatct tccgttttgt ggagaaggcc
      541 agtgtgaggc cactgaatgg cctacctgct tctggaggcc tgagtcggag ctgggacctg
      601 ggcgggattt ctgcccccag gcccacccca gcccttggac ctggctgcaa ccggaagttg
      661 cggctagagg catccacatc agacccactc ccagctggag gaggctctgt tcttcctggc
      721 agcagggacc cctcacgtgg accattggtc ccaccccaga tcggggcaga tgggctttac
      781 tcctccctcc ccaatgggct gggggggacc cctgagcacc tggccatgca cttccgagga
      841 cctgcagaca ccggattcct aaaccagggg gacacctggt cctccccccg ggaagtctcc
      901 tctcatgccc agagaatcgc tcgagccaag tgggaattct tctatggctc cttggacgcc
      961 cccagctcag gtgctaagcc cccagagcag gtcctcccat cacgtggggt gggctccaag
     1021 caaggctctg gggtggctgt ggggcgagca gccaagtact ccgagacaga cctggacaag
     1081 gtgcccctga ggtgctaccg agagactgac atcgatgagg tgctggctga gcgggaggag
     1141 gccgactctg ccattgagag tcagcccagc tctgagggcc cccatggcac tgcccaacca
     1201 cctgcctcac gacctagccc atgccctggc ccttcttcca gtctgggcag tggcaacgaa
     1261 gatgatgagg caggaggtga agaggatgtg gatgatgagg tgttcgaggc ctcggagggg
     1321 gcccggccag gggaccacat gcctcactct gggcttctca agtcaccagt acccttcctg
     1381 cttgggacca gcccctcagc ggatgggcct gactccttca gttgtgtgtt tgaagctatc
     1441 ttggagtcac accgggccaa gggcacctcc tatagtagcc ttgcctccct ggaggcactg
     1501 gcctcacctg gcccaaccca gagccccttc ttcacctttg agatgcctcc ccagccccca
     1561 gctcccaggc ctgacccacc tgcacctgcc ccacttgccc ctcttgaacc tgattctggc
     1621 accagctctg ctgctgatgg tccttggacc cagagaaggg aggtggaaga gtcagatgct
     1681 ggggccacgc tggccccaag gaaggagctt cctagtccct cccactctga ggatagcttt
     1741 gggctggggg cagcacccct aggcagtgaa ccacccctaa gtcagctggt atccgactca
     1801 gactcagagc tggacagcac agagcggctg gccctgggaa gcacagacac cttgtccaat
     1861 ggacagaaag cagatttgga ggctgcacag cgcctagcca agaggctata ccgactcgat
     1921 ggcttcagga aggccgatgt ggcacggcat ctgggcaaga acaatgactt cagcaaattg
     1981 gtggctggcg agtatctgaa gttttttgtc ttcacgggca tgactctgga ccaagctctc
     2041 agggtatttc taaaggagct ggccttaatg ggtgagaccc aggagcggga gcgtgtactg
     2101 gcccacttct cccagcgata tttccagtgt aatcctgaag ccctgtcctc agaggacggt
     2161 gctcacacgc tgacctgtgc cctcatgctc ctcaacacag atctccatgg ccataacatt
     2221 gggaagcgca tgacctgtgg ggacttcatc ggaaacctgg agggcctcaa tgatggtggc
     2281 gacttcccca gggagctgct caaggccttg tacagctcca tcaagaatga aaaattgcaa
     2341 tgggccatag acgaggagga gctgcgacgg tctctgtccg agttggccga tcctaacccc
     2401 aaggtcatca agcgggtcag cggaggcagt ggcagcagtt ccagcccctt cctggacctg
     2461 actcctgagc ccggggcagc tgtctacaag cacggggccc tggtgcgaaa ggtgcacgca
     2521 gaccctgact gcaggaagac acctcgtggc aagcggggct ggaagagctt ccacgggatc
     2581 ctcaagggca tgatcctcta cctgcagaag gaggagtatc agcctgggaa ggctctttcc
     2641 gaggcagagc tgaagaatgc tatcagcatc caccacgccc tggctacccg cgccagcgat
     2701 tatagcaaga gaccacacgt cttctacctg cgcacagctg actggcgggt cttcctcttc
     2761 caggctccga gcctggagca aatgcagtcc tggatcactc gcatcaatgt ggtggctgcc
     2821 atgttttctg cacccccctt cccagctgct gttagctccc agaagaaatt cagccgccct
     2881 ctgctgccca gtgctgccac ccgcctctcc caggaggagc aggtgaggac ccatgaggcc
     2941 aagctgaagg ccatggccag cgagctgaga gagcaccggg ctgcacatct gggaaagaag
     3001 gcccgaggca aggaggcgga tgagcagcgg cagaaggagg cctacctgga gtttgagaaa
     3061 tcccgctacg gcacctatgc agcactgctt cgagtcaaga tgaaggcagc cagcgaggag
     3121 ctggacacca tagaggcagc cctggcccag gctgggagca cggaggatgg atgccctccg
     3181 cctcactcca gtccttccct gcggcccaag cccaccagcc agccccgggc tcagcgtcct
     3241 ggctcagaaa cccgggctgg agcaggcagt acaaggccaa agccctgagc agggcatagg
     3301 agcgatgggg gcagtgcccg ctgggcacct gcatgatgac atacacggtc ctgcctgagc
     3361 tcagctagcc tcgggccagc cacgagggcc tcctggtcca gggcccgacc gcgccggacg
     3421 cggtgtccgg ggcagggcag ggctgagccg ggcctcagag cctaggctga gggcctctca
     3481 gagaccccct ttttgtgata atgttttgca ctttttcgta caggaagggt gggaggggcc
     3541 catgccccta atttttgatg ggggtttcct ttcctttcct tctttctttt ttttttttct
     3601 tccttttttt tttcgtgggg gaggcctgat caagtttctg ctttctgctg agaccacctc
     3661 acccttacac cagcaacacc cctccatcct ggggcctggc tcagacagaa gccaggagtt
     3721 ggggctgagc tggtccccct attcctcccc aagggctcac ctctctcttt gcagagacag
     3781 aggaagggca tccactttga ggccccatcc acaggctggg gtggcacggc ctgcttccct
     3841 tctttggtgg gccctaccct ttgtacagcc tccaccctca ttaaaactgc tctgaattgc
     3901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
