LOCUS       NP_082903               1024 aa            linear   ROD 28-APR-2025
DEFINITION  PH and SEC7 domain-containing protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_082903 XP_484810
VERSION     NP_082903.2
DBSOURCE    REFSEQ: accession NM_028627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1024)
  AUTHORS   Chomphoo,S., Sakagami,H., Kondo,H. and Hipkaeo,W.
  TITLE     Localization of EFA6A, an exchange factor for Arf6, in Z-lines and
            sarcoplasmic reticulum membranes in addition to myofilaments in
            I-domains of skeletal myofibers of peri-natal mice
  JOURNAL   Acta Histochem 126 (5-7), 152187 (2024)
   PUBMED   39126836
  REMARK    GeneRIF: Localization of EFA6A, an exchange factor for Arf6, in
            Z-lines and sarcoplasmic reticulum membranes in addition to
            myofilaments in I-domains of skeletal myofibers of peri-natal mice.
REFERENCE   2  (residues 1 to 1024)
  AUTHORS   Fukaya,M., Ibuchi,K., Sugawara,T., Itakura,M., Ito,A.,
            Shiroshima,T., Hara,Y., Okamoto,H., Luton,F. and Sakagami,H.
  TITLE     EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA
            Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
  JOURNAL   Traffic 25 (5), e12936 (2024)
   PUBMED   38725127
  REMARK    GeneRIF: EFA6A, an Exchange Factor for Arf6, Regulates
            NGF-Dependent TrkA Recycling From Early Endosomes and Neurite
            Outgrowth in PC12 Cells.
REFERENCE   3  (residues 1 to 1024)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1024)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1024)
  AUTHORS   Chomphoo,S., Sakagami,H., Kondo,H. and Hipkaeo,W.
  TITLE     Discrete localization patterns of Arf6, and its activators EFA6A
            and BRAG2, and its effector PIP5kinasegamma on myofibrils of
            myotubes and plasma membranes of myoblasts in developing skeletal
            muscles of mice
  JOURNAL   Acta Histochem 122 (3), 151513 (2020)
   PUBMED   32059926
REFERENCE   6  (residues 1 to 1024)
  AUTHORS   Sakagami,H., Honma,T., Sukegawa,J., Owada,Y., Yanagisawa,T. and
            Kondo,H.
  TITLE     Somatodendritic localization of EFA6A, a guanine nucleotide
            exchange factor for ADP-ribosylation factor 6, and its possible
            interaction with alpha-actinin in dendritic spines
  JOURNAL   Eur J Neurosci 25 (3), 618-628 (2007)
   PUBMED   17298598
  REMARK    GeneRIF: EFA6A may form a protein complex with alpha-actinin and
            activate ARF6 in close proximity of the actin cytoskeleton and
            membrane proteins in the dendritic spines
REFERENCE   7  (residues 1 to 1024)
  AUTHORS   Sakagami,H., Suzuki,H., Kamata,A., Owada,Y., Fukunaga,K.,
            Mayanagi,H. and Kondo,H.
  TITLE     Distinct spatiotemporal expression of EFA6D, a guanine nucleotide
            exchange factor for ARF6, among the EFA6 family in mouse brain
  JOURNAL   Brain Res 1093 (1), 1-11 (2006)
   PUBMED   16707115
  REMARK    GeneRIF: determined the complete primary sequence of mouse EFA6D
            encoding a protein of 1004 amino acids with a calculated molecular
            weight of 111,207 Da.
REFERENCE   8  (residues 1 to 1024)
  AUTHORS   Decressac,S., Franco,M., Bendahhou,S., Warth,R., Knauer,S.,
            Barhanin,J., Lazdunski,M. and Lesage,F.
  TITLE     ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a
            GDP/GTP exchange factor for ARF6
  JOURNAL   EMBO Rep 5 (12), 1171-1175 (2004)
   PUBMED   15540117
REFERENCE   9  (residues 1 to 1024)
  AUTHORS   Rieger,D.K., Reichenberger,E., McLean,W., Sidow,A. and Olsen,B.R.
  TITLE     A double-deletion mutation in the Pitx3 gene causes arrested lens
            development in aphakia mice
  JOURNAL   Genomics 72 (1), 61-72 (2001)
   PUBMED   11247667
REFERENCE   10 (residues 1 to 1024)
  AUTHORS   Perletti,L., Talarico,D., Trecca,D., Ronchetti,D.,
            Fracchiolla,N.S., Maiolo,A.T. and Neri,A.
  TITLE     Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10,
            which contains Sec7 and pleckstrin-homology domains
  JOURNAL   Genomics 46 (2), 251-259 (1997)
   PUBMED   9417912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057353.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XP_484810.1, NP_082903.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057353.1, SRR7345562.1506395.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.8 cM"
     Protein         1..1024
                     /product="PH and SEC7 domain-containing protein 1 isoform
                     1"
                     /note="pleckstrin and Sec7 domain containing homolog; PH
                     and SEC7 domain-containing protein 1; pleckstrin homology
                     and SEC7 domain-containing protein 1; exchange factor for
                     ARF6 A; exchange factor for ADP-ribosylation factor
                     guanine nucleotide factor 6"
                     /calculated_mol_wt=109556
     Region          67..96
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Site            126
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Region          154..195
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Site            156
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Region          250..277
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Region          307..401
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Region          434..536
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Region          542..708
                     /region_name="Sec7"
                     /note="Sec7 domain; Domain named after the S. cerevisiae
                     SEC7 gene product. The Sec7 domain is the central domain
                     of the guanine-nucleotide-exchange factors (GEFs) of the
                     ADP-ribosylation factor family of small GTPases (ARFs) .
                     It carries the exchange factor...; cd00171"
                     /db_xref="CDD:238100"
     Site            order(616..623,652..665)
                     /site_type="active"
                     /note="active site/putative ARF binding site [active]"
                     /db_xref="CDD:238100"
     Site            720
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5DTT2.2)"
     Region          753..877
                     /region_name="PH_EFA6"
                     /note="Exchange Factor for ARF6 Pleckstrin homology (PH)
                     domain; cd13295"
                     /db_xref="CDD:270107"
     Region          976..1024
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DTT2.2)"
     CDS             1..1024
                     /gene="Psd"
                     /gene_synonym="1110007H17Rik; A930015K15; Efa6; Efa6a;
                     mKIAA2011; Psdl"
                     /coded_by="NM_028627.2:214..3288"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS29875.1"
                     /db_xref="GeneID:73728"
                     /db_xref="MGI:MGI:1920978"
ORIGIN      
        1 maqgamrfcs egdcaisppr cprrwlpegp vpqsppasmy gstgslirrv vgpgprgrdl
       61 grvtapctpl rappsphiap spwgpssptg qpppgaqssv vifrfvekas vrplnglpas
      121 gglsrswdlg gisaprptpa lgpgcnrklr leastsdplp agggsvlpgs rdpsrgplvp
      181 pqigadglys slpnglggtp ehlamhfrgp adtgflnqgd twssprevss haqriarakw
      241 effygsldap ssgakppeqv lpsrgvgskq gsgvavgraa kysetdldkv plrcyretdi
      301 devlaereea dsaiesqpss egphgtaqpp asrpspcpgp ssslgsgned deaggeedvd
      361 devfeasega rpgdhmphsg llkspvpfll gtspsadgpd sfscvfeail eshrakgtsy
      421 sslasleala spgptqspff tfemppqppa prpdppapap laplepdsgt ssaadgpwtq
      481 rreveesdag atlaprkelp spshsedsfg lgaaplgsep plsqlvsdsd seldsterla
      541 lgstdtlsng qkadleaaqr lakrlyrldg frkadvarhl gknndfsklv ageylkffvf
      601 tgmtldqalr vflkelalmg etqerervla hfsqryfqcn pealssedga htltcalmll
      661 ntdlhghnig krmtcgdfig nleglndggd fprellkaly ssikneklqw aideeelrrs
      721 lseladpnpk vikrvsggsg sssspfldlt pepgaavykh galvrkvhad pdcrktprgk
      781 rgwksfhgil kgmilylqke eyqpgkalse aelknaisih halatrasdy skrphvfylr
      841 tadwrvflfq apsleqmqsw itrinvvaam fsappfpaav ssqkkfsrpl lpsaatrlsq
      901 eeqvrtheak lkamaselre hraahlgkka rgkeadeqrq keaylefeks rygtyaallr
      961 vkmkaaseel dtieaalaqa gstedgcppp hsspslrpkp tsqpraqrpg setragagst
     1021 rpkp
//
