LOCUS       NM_028216                876 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus prostate stem cell antigen (Psca), mRNA.
ACCESSION   NM_028216
VERSION     NM_028216.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Guo,W., Li,L., He,J., Liu,Z., Han,M., Li,F., Xia,X., Zhang,X.,
            Zhu,Y., Wei,Y., Li,Y., Aji,R., Dai,H., Wei,H., Li,C., Chen,Y.,
            Chen,L. and Gao,D.
  TITLE     Single-cell transcriptomics identifies a distinct luminal
            progenitor cell type in distal prostate invagination tips
  JOURNAL   Nat Genet 52 (9), 908-918 (2020)
   PUBMED   32807988
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Dong,B., Vold,S., Olvera-Jaramillo,C. and Chang,H.
  TITLE     Functional redundancy of frizzled 3 and frizzled 6 in planar cell
            polarity control of mouse hair follicles
  JOURNAL   Development 145 (19) (2018)
   PUBMED   30237242
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Xin,L., Lawson,D.A. and Witte,O.N.
  TITLE     The Sca-1 cell surface marker enriches for a prostate-regenerating
            cell subpopulation that can initiate prostate tumorigenesis
  JOURNAL   Proc Natl Acad Sci U S A 102 (19), 6942-6947 (2005)
   PUBMED   15860580
  REMARK    GeneRIF: Sca-1-enriched prostate-regenerating cells possess
            multiple stem/progenitor cell properties
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Watabe,T., Lin,M., Ide,H., Donjacour,A.A., Cunha,G.R., Witte,O.N.
            and Reiter,R.E.
  TITLE     Growth, regeneration, and tumorigenesis of the prostate activates
            the PSCA promoter
  JOURNAL   Proc Natl Acad Sci U S A 99 (1), 401-406 (2002)
   PUBMED   11752398
  REMARK    GeneRIF: This transgenic system helps define the range of cellular
            changes associated with altered expression of PSCA, shows that
            transcriptional control is a major component regulating PSCA
            levels.
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Yang,D., Holt,G.E., Velders,M.P., Kwon,E.D. and Kast,W.M.
  TITLE     Murine six-transmembrane epithelial antigen of the prostate,
            prostate stem cell antigen, and prostate-specific membrane antigen:
            prostate-specific cell-surface antigens highly expressed in
            prostate cancer of transgenic adenocarcinoma mouse prostate mice
  JOURNAL   Cancer Res 61 (15), 5857-5860 (2001)
   PUBMED   11479226
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Ross,S., Spencer,S.D., Lasky,L.A. and Koeppen,H.
  TITLE     Selective expression of murine prostate stem cell antigen in fetal
            and adult tissues and the transgenic adenocarcinoma of the mouse
            prostate model of prostate carcinogenesis
  JOURNAL   Am J Pathol 158 (3), 809-816 (2001)
   PUBMED   11238029
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Reiter,R.E., Gu,Z., Watabe,T., Thomas,G., Szigeti,K., Davis,E.,
            Wahl,M., Nisitani,S., Yamashiro,J., Le Beau,M.M., Loda,M. and
            Witte,O.N.
  TITLE     Prostate stem cell antigen: a cell surface marker overexpressed in
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1735-1740 (1998)
   PUBMED   9465086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008851.1, EH109693.1 and AF319173.1.
            
            On Oct 31, 2009 this sequence version replaced NM_028216.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF319173.1, BQ218635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK008851.1         1-24
            25-132              EH109693.1         22-129
            133-876             AF319173.1         121-864
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.26 cM"
     gene            1..876
                     /gene="Psca"
                     /gene_synonym="2210408B04Rik"
                     /note="prostate stem cell antigen"
                     /db_xref="GeneID:72373"
                     /db_xref="MGI:MGI:1919623"
     exon            1..68
                     /gene="Psca"
                     /gene_synonym="2210408B04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..388
                     /gene="Psca"
                     /gene_synonym="2210408B04Rik"
                     /codon_start=1
                     /product="prostate stem cell antigen precursor"
                     /protein_id="NP_082492.1"
                     /db_xref="CCDS:CCDS27526.1"
                     /db_xref="GeneID:72373"
                     /db_xref="MGI:MGI:1919623"
                     /translation="MKTVFFLLLATYLALHPGAALQCYSCTAQMNNRDCLNVQNCSLD
                     QHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYYLGKKNITCCYSDLCNVNGAHTLKP
                     PTTLGLLTVLCSLLLWGSSRL"
     exon            69..176
                     /gene="Psca"
                     /gene_synonym="2210408B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            177..856
                     /gene="Psca"
                     /gene_synonym="2210408B04Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgctcact gcaaccatga agaccgtctt ctttctcctg ctggccacct acttagccct
       61 gcatccaggt gctgctctgc agtgctattc atgcacagca cagatgaaca acagagactg
      121 tctgaatgta cagaactgca gcctggacca gcacagttgc tttacatcgc gcatccgggc
      181 cattggactc gtgacagtta tcagtaaggg ctgcagctca cagtgtgagg atgactcgga
      241 gaactactat ttgggcaaga agaacatcac gtgctgctac tctgacctgt gcaatgtcaa
      301 cggggcccac accctgaagc cacccaccac cctggggctg ctgaccgtgc tctgcagcct
      361 gttgctgtgg ggctccagcc gtctgtaggc tctgggagag ccctaccata gcccgattgt
      421 gaagggatga gctgcacctc cacccccacc cccacacagg agcaaccacc accaccactc
      481 ttaactccca catagggctg gcctccctca ccccaacccc ttccaccagg gccctttctc
      541 ctctctgctg ctatttccac agctagcgct tggcccaccc caccccatca gcactgtgcc
      601 ctaccaagtt ctgctcagat gcttcagctg aaggactccc tcgccaccct actctccagg
      661 gcctgagcca gtgtgcacag cagcacttgg ggaggggcct ggtagaggct gagatgggat
      721 ggactgagca gaaatggagc tgggaggtgg gtgtgaggca ccaggagtcc caggagatga
      781 tgcctggtgg gggacatgct ctccgtttat agagctccag gatacaacag tcgtgtaata
      841 aatacctgct gagtaaaaaa aaaaaaaaaa aaaaaa
//
