LOCUS       NM_177420               2172 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus phosphoserine aminotransferase 1 (Psat1), transcript
            variant 1, mRNA.
ACCESSION   NM_177420 XM_129211
VERSION     NM_177420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2172)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2172)
  AUTHORS   Ciuffoli,V., Feng,X., Jiang,K., Acevedo-Luna,N., Ko,K.D.,
            Wang,A.H.J., Riparini,G., Khateb,M., Glancy,B., Dell'Orso,S. and
            Sartorelli,V.
  TITLE     Psat1-generated alpha-ketoglutarate and glutamine promote muscle
            stem cell activation and regeneration
  JOURNAL   Genes Dev 38 (3-4), 151-167 (2024)
   PUBMED   38453480
  REMARK    GeneRIF: Psat1-generated alpha-ketoglutarate and glutamine promote
            muscle stem cell activation and regeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2172)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   5  (bases 1 to 2172)
  AUTHORS   Radzishevsky,I., Odeh,M., Bodner,O., Zubedat,S., Shaulov,L.,
            Litvak,M., Esaki,K., Yoshikawa,T., Agranovich,B., Li,W.H.,
            Radzishevsky,A., Gottlieb,E., Avital,A. and Wolosker,H.
  TITLE     Impairment of serine transport across the blood-brain barrier by
            deletion of Slc38a5 causes developmental delay and motor
            dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2302780120 (2023)
   PUBMED   37812701
REFERENCE   6  (bases 1 to 2172)
  AUTHORS   White,J.K., Gerdin,A.K., Karp,N.A., Ryder,E., Buljan,M.,
            Bussell,J.N., Salisbury,J., Clare,S., Ingham,N.J., Podrini,C.,
            Houghton,R., Estabel,J., Bottomley,J.R., Melvin,D.G., Sunter,D.,
            Adams,N.C., Tannahill,D., Logan,D.W., Macarthur,D.G., Flint,J.,
            Mahajan,V.B., Tsang,S.H., Smyth,I., Watt,F.M., Skarnes,W.C.,
            Dougan,G., Adams,D.J., Ramirez-Solis,R., Bradley,A. and Steel,K.P.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
REFERENCE   7  (bases 1 to 2172)
  AUTHORS   Seo,J., Fortuno,E.S. 3rd, Suh,J.M., Stenesen,D., Tang,W.,
            Parks,E.J., Adams,C.M., Townes,T. and Graff,J.M.
  TITLE     Atf4 regulates obesity, glucose homeostasis, and energy expenditure
  JOURNAL   Diabetes 58 (11), 2565-2573 (2009)
   PUBMED   19690063
REFERENCE   8  (bases 1 to 2172)
  AUTHORS   Furuya,S., Yoshida,K., Kawakami,Y., Yang,J.H., Sayano,T., Azuma,N.,
            Tanaka,H., Kuhara,S. and Hirabayashi,Y.
  TITLE     Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice:
            changes in gene expression and associated regulatory networks
            resulting from serine deficiency
  JOURNAL   Funct Integr Genomics 8 (3), 235-249 (2008)
   PUBMED   18228065
REFERENCE   9  (bases 1 to 2172)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 2172)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032487.1, AK167044.1 and AV166058.1.
            
            On Apr 19, 2011 this sequence version replaced NM_177420.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032487.1, BC004827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AK032487.1         2-64
            64-2162             AK167044.1         2-2100
            2163-2172           AV166058.1         284-293
FEATURES             Location/Qualifiers
     source          1..2172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 10.86 cM"
     gene            1..2172
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /note="phosphoserine aminotransferase 1"
                     /db_xref="GeneID:107272"
                     /db_xref="MGI:MGI:2183441"
     exon            1..196
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1249
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /EC_number="2.6.1.52"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endometrial progesterone-induced protein;
                     phosphohydroxythreonine aminotransferase"
                     /codon_start=1
                     /product="phosphoserine aminotransferase isoform 1"
                     /protein_id="NP_803155.1"
                     /db_xref="CCDS:CCDS29681.1"
                     /db_xref="GeneID:107272"
                     /db_xref="MGI:MGI:2183441"
                     /translation="MEATKQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSH
                     RSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVPLNLIGLKAGRSADYV
                     VTGAWSAKAAEEAKKFGTVNIVHPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGV
                     EFDFVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLG
                     FSLRECPSVLDYKVQAGNNSLYNTPPCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQ
                     MIYEIIDNSQGFYVCPVERQNRSRMNIPFRIGNAKGDEALEKRFLDKAVELNMISLKG
                     HRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMHQL"
     exon            197..257
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            258..327
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            328..533
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            534..706
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            707..876
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1005
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1143
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..2172
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /note="hexamer: ATTAAA"
     polyA_site      2165
                     /gene="Psat1"
                     /gene_synonym="D8Ertd814e; EPIP; PSA; Psat"
                     /note="major polyA site"
ORIGIN      
        1 agtgagcggc ctgagacagc gaaccaatgg agcgccgact cagcaggctg aagcccgctc
       61 tgcctttgca tccggagacg cgggctgttc gcgtggtctc tgctcctgcc acttcccctg
      121 ctgtcgcctt agcaccatgg aagccaccaa gcaagtggtt aactttgggc ccgggcctgc
      181 caagctgcca cactcggtat tgttggagat ccagaagcag ctactagact acagaggact
      241 cggcatcagt gtgctcgaaa tgagtcacag gtcatcagat tttgccaaga ttattggcaa
      301 tacagagaat cttgtgaggg aattgctagc tgttcccaac aactacaagg tgatctttgt
      361 acaaggaggt gggtctggcc agttcagtgc tgtcccctta aatctgattg gcctgaaagc
      421 tggaaggagt gctgactacg tggtgaccgg agcttggtca gctaaggctg cggaagaagc
      481 caagaagttt ggaacggtga acattgtcca ccctaaactt ggaagttaca caaaaattcc
      541 agacccaagc acctggaacc tcaacccgga cgcctcctat gtatacttct gtgcaaacga
      601 gactgtgcac ggggtggagt ttgacttcgt acctgacgtc aagggagcgg tgctggtctg
      661 tgacatgtcc tcaaacttct tatccaggcc ggtggatgtt tccaagtttg gtgtgatttt
      721 cgctggtgct cagaagaatg ttggctctgc cggggtgacg gtggtgattg tccgggatga
      781 cctgctgggg ttctcgctca gagagtgccc atcagtcctt gactacaaag tgcaggctgg
      841 gaacaactct ttgtataaca cacctccgtg cttcagcatc tacgtcatgg gcatggtcct
      901 ggaatggatc aagaacaacg gcggggccgc agccatggag aagctcagct ccatcaaatc
      961 ccaaatgatt tatgagatca ttgataattc tcaaggattt tatgtatgcc cagtggagcg
     1021 ccagaataga agcaggatga acatcccatt tcgcattggc aacgccaaag gagacgaagc
     1081 tttggaaaag cggtttcttg acaaggcggt agaactcaac atgatctcct tgaaggggca
     1141 caggtcagtg ggaggcattc gtgcctctct gtataacgct gtcacaaccg aagacgttga
     1201 gaagctggcg gccttcatga agaatttctt ggagatgcat cagctgtgaa catgaccagc
     1261 cacgctctgc ctgtgagcag cacgcagcgt cgtttagagt aacttgggat tgactacaga
     1321 aacttaacag acatggattt ttttttccca aatacatgct tattacagat tcctttctca
     1381 aagaataacg actaaacatc agggcactgc agagctgagg aaactcccag ctaacagcca
     1441 ccttcattct catgtgacct ggaagcattt tgaaagcttt ctttcctgtt gctcttctaa
     1501 atgaattcag cctgtcagcc atctttgctg cccccttctc taggtggact gccttgggct
     1561 ttgccctgct ggttccaact ggttattatt aggaggttgg aggccctgtg ggctggattg
     1621 acagcagtga gtttgctggg ttctgcagca gttggttcaa gtcaacagcg actcacgagc
     1681 gttttggatc tgtgtactgc aattcccata aagagatagg tgtgttatgc tgtgtttatg
     1741 tagtgggtat tgttttaaac accgtacggt ttatgcctat gcctttatat ttctaatgaa
     1801 acagttttgt tcagcccatg actttgtgca tgactgtcgt ccgttctagt cacctgtgct
     1861 ctccatctac tgccttttaa agctgcgtca tgagaaggat ctacacgttc caccatgact
     1921 ctcgtttctt gccacaagta gaagaaatgg ttgattcttt gcttttcggt taggccgtta
     1981 aacaaaactc agtcacaccc ctgccttcca ccctcaaact gtgatcacgt ggctgttctt
     2041 gtagtttaac cagggcaaca ctatatattc caggtctata cattgctgag gtctttttct
     2101 ggttgttcat gtatcagtgt tttcaatcga ctgcatggaa aacattaaag tcctaagtca
     2161 tctaagccat tc
//
