LOCUS       NM_025582                810 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peroxiredoxin like 2B (Prxl2b), mRNA.
ACCESSION   NM_025582
VERSION     NM_025582.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 810)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 810)
  AUTHORS   Bertrand,J.A., Woodward,D.F., Sherwood,J.M., Spenlehauer,A.,
            Silvestri,C., Piscitelli,F., Marzo,V.D., Yamazaki,M., Sakimura,K.,
            Inoue,Y., Watanabe,K. and Overby,D.R.
  TITLE     Deletion of the gene encoding prostamide/prostaglandin F synthase
            reveals an important role in regulating intraocular pressure
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 165, 102235 (2021)
   PUBMED   33418484
  REMARK    GeneRIF: Deletion of the gene encoding prostamide/prostaglandin F
            synthase reveals an important role in regulating intraocular
            pressure.
REFERENCE   3  (bases 1 to 810)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 810)
  AUTHORS   Yasuda,S., Hasegawa,T., Hosono,T., Satoh,M., Watanabe,K., Ono,K.,
            Shimizu,S., Hayakawa,T., Yamaguchi,T., Suzuki,K. and Sato,Y.
  TITLE     AW551984: a novel regulator of cardiomyogenesis in pluripotent
            embryonic cells
  JOURNAL   Biochem J 437 (2), 345-355 (2011)
   PUBMED   21554246
REFERENCE   5  (bases 1 to 810)
  AUTHORS   Yoshikawa,K., Takei,S., Hasegawa-Ishii,S., Chiba,Y., Furukawa,A.,
            Kawamura,N., Hosokawa,M., Woodward,D.F., Watanabe,K. and Shimada,A.
  TITLE     Preferential localization of prostamide/prostaglandin F synthase in
            myelin sheaths of the central nervous system
  JOURNAL   Brain Res 1367, 22-32 (2011)
   PUBMED   20950588
REFERENCE   6  (bases 1 to 810)
  AUTHORS   Moriuchi,H., Koda,N., Okuda-Ashitaka,E., Daiyasu,H., Ogasawara,K.,
            Toh,H., Ito,S., Woodward,D.F. and Watanabe,K.
  TITLE     Molecular characterization of a novel type of
            prostamide/prostaglandin F synthase, belonging to the
            thioredoxin-like superfamily
  JOURNAL   J Biol Chem 283 (2), 792-801 (2008)
   PUBMED   18006499
REFERENCE   7  (bases 1 to 810)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 810)
  AUTHORS   Suzuki-Yamamoto,T., Sugimoto,Y., Ichikawa,A. and Ishimura,K.
  TITLE     Co-localization of prostaglandin F synthase, cyclooxygenase-1 and
            prostaglandin F receptor in mouse Leydig cells
  JOURNAL   Histochem Cell Biol 128 (4), 317-322 (2007)
   PUBMED   17674023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607032.16.
            
            On Jan 24, 2023 this sequence version replaced NM_025582.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030453.1, BU559784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL607032.16        115149-115271       c
            124-328             AL607032.16        114682-114886       c
            329-380             AL607032.16        114334-114385       c
            381-444             AL607032.16        113712-113775       c
            445-520             AL607032.16        113555-113630       c
            521-639             AL607032.16        113246-113364       c
            640-810             AL607032.16        112633-112803       c
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 85.67 cM"
     gene            1..810
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /note="peroxiredoxin like 2B"
                     /db_xref="GeneID:66469"
                     /db_xref="MGI:MGI:1913719"
     exon            1..123
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..666
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /EC_number="1.11.1.20"
                     /note="prostamide/PGF synthase; prostamide/PG F synthase;
                     family with sequence similarity 213, member B"
                     /codon_start=1
                     /product="prostamide/prostaglandin F synthase"
                     /protein_id="NP_079858.2"
                     /db_xref="CCDS:CCDS19016.1"
                     /db_xref="GeneID:66469"
                     /db_xref="MGI:MGI:1913719"
                     /translation="MNVVDLGRVGACVLKHAVTGEAVELRSLWQEKACVVAGLRRFGC
                     MVCRWIAQDLSNLRSILDQHDVRLVGVGPEALGLQEFLDGGYFSGELYLDESKQIYKE
                     LGFKRYNSLSILPAALGKPVRDVASKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLL
                     HFIQKSPGDYVPQENILQALGISAEVCSSKPPQCDEEVCGR"
     exon            124..328
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            329..380
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            381..444
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            445..520
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            521..639
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     exon            640..810
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      789..794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /note="hexamer: ATTAAA"
     polyA_site      810
                     /gene="Prxl2b"
                     /gene_synonym="2810405K02Rik; Fam213b; PM/PGFS"
                     /note="major polyA site"
ORIGIN      
        1 agagtgagcc tccccaggct gcgagaaggg accgtggagc agaaagggac ggaggaggcc
       61 atgaatgtgg tggaccttgg tcgcgtagga gcgtgtgtct tgaaacatgc agtgactggg
      121 gaggctgtgg agctgcggag cctatggcag gagaaagctt gtgtggtggc cggtctgcga
      181 cgcttcggct gcatggtgtg ccgctggatc gcccaggacc tcagcaacct ccggagcatc
      241 ctggaccaac acgatgtgcg cctggtgggc gtggggcctg aggccctggg cctgcaggag
      301 tttctggatg gtggttactt ctcaggagaa ctctaccttg atgagagcaa gcaaatctat
      361 aaggagctgg gcttcaagcg gtacaacagc ttaagcatcc taccagctgc cctgggaaaa
      421 cctgttcgtg atgtagcctc caaggctaaa gctgttggta tccaggggaa cctgtctggt
      481 gacctgctgc aaagtggagg gctgctggtg gtcagcaagg gtggcgacaa ggtactgttg
      541 cacttcatcc agaagtcccc gggtgactat gttccccagg agaacatcct gcaggccttg
      601 ggtatctctg cagaggtttg ctccagcaag ccaccccagt gtgatgaaga ggtgtgtggg
      661 aggtgacacg cacagcctga ggacccggag gcatctgtaa ccttggatgt gtttggaaca
      721 caaagaatcc ctgtggagcc actgagccag gacgttggac cttgttcatc tttcaacagc
      781 aatgagccat taaagtgcag gtcctgggca
//
