LOCUS       NM_027464               1615 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus peroxiredoxin like 2A (Prxl2a), transcript variant 7,
            mRNA.
ACCESSION   NM_027464
VERSION     NM_027464.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Guo,F., He,H., Fu,Z.C., Huang,S., Chen,T., Papasian,C.J.,
            Morse,L.R., Xu,Y., Battaglino,R.A., Yang,X.F., Jiang,Z., Xin,H.B.
            and Fu,M.
  TITLE     Adipocyte-derived PAMM suppresses macrophage inflammation by
            inhibiting MAPK signalling
  JOURNAL   Biochem J 472 (3), 309-318 (2015)
   PUBMED   26438880
  REMARK    GeneRIF: results suggest that adipocyte-derived PAMM may suppress
            macrophage activation by inhibiting MAPK signalling pathway.
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Jedrychowski,M.P., Liu,L., Laflamme,C.J., Karastergiou,K.,
            Meshulam,T., Ding,S.Y., Wu,Y., Lee,M.J., Gygi,S.P., Fried,S.K. and
            Pilch,P.F.
  TITLE     Adiporedoxin, an upstream regulator of ER oxidative folding and
            protein secretion in adipocytes
  JOURNAL   Mol Metab 4 (11), 758-770 (2015)
   PUBMED   26629401
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Xu,Y., Morse,L.R., da Silva,R.A., Odgren,P.R., Sasaki,H.,
            Stashenko,P. and Battaglino,R.A.
  TITLE     PAMM: a redox regulatory protein that modulates osteoclast
            differentiation
  JOURNAL   Antioxid Redox Signal 13 (1), 27-37 (2010)
   PUBMED   19951071
  REMARK    GeneRIF: The PAMM is a redox regulatory protein that modulates
            osteoclast differentiation in vitro. PAMM expression may affect
            bone resorption in vivo and help to maintain bone mass.
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154597.2, BB851890.1, CX238562.1, AK017688.1 and AI840708.1.
            
            On Oct 24, 2015 this sequence version replaced NM_027464.3.
            
            Transcript Variant: This variant (7) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (c) is
            shorter at the N-terminus compared to isoform a. Variants 6, 7, and
            8 all encode the same isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056635.1, AK017688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC154597.2         98354-98382         c
            30-497              BB851890.1         2-469
            498-592             CX238562.1         489-583
            593-1295            AK017688.1         536-1238
            1296-1615           AI840708.1         1-320               c
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     gene            1..1615
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /note="peroxiredoxin like 2A"
                     /db_xref="GeneID:70564"
                     /db_xref="MGI:MGI:1917814"
     exon            1..136
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /inference="alignment:Splign:2.1.0"
     exon            137..299
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..811
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /note="isoform c is encoded by transcript variant 7;
                     UPF0765 protein C10orf58 homolog; peroxiredoxin-like 2
                     activated in M-CSF stimulated monocytes; family with
                     sequence similarity 213, member A; redox-regulatory
                     protein PAMM; redox-regulatory protein FAM213A;
                     Adiporedoxin"
                     /codon_start=1
                     /product="peroxiredoxin-like 2A isoform c"
                     /protein_id="NP_081740.2"
                     /db_xref="CCDS:CCDS26957.1"
                     /db_xref="GeneID:70564"
                     /db_xref="MGI:MGI:1917814"
                     /translation="MGMWSIGVGAVGAAAVALLLANTDMFLSKPRKAALEYLEDIDLK
                     TLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVV
                     KEQVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMFMGLIRLGVWYNSFRAWNGGFS
                     GNLEGEGFILGGVFVIGSGKQGILLEHREKEFGDRVNPLSVLEAVKKIKLQTPASGRS
                     "
     exon            300..391
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /inference="alignment:Splign:2.1.0"
     exon            392..532
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /inference="alignment:Splign:2.1.0"
     exon            533..697
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1600
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="Prxl2a"
                     /gene_synonym="5730469M10Rik; Adrx; Fam213a; Pamm"
                     /note="major polyA site"
ORIGIN      
        1 gctgagctgc gcaggcgcgg ggagacctta gtctcacccg ccctcaaaac tgcactacaa
       61 ccgaggaggc acctgcgtcc gctggcgcag ctcaggggcc agtgaggtcc acggaggcgg
      121 ggtccttggg gcgcaggacc caagtttctt ctccatgggt atgtggtcca tcggtgtggg
      181 agctgtgggg gccgctgctg tggcactgct cctggccaac acagacatgt ttctgtccaa
      241 gccccgaaaa gcagcactgg aatatttgga agacatagac ctgaaaacac tggagaaaga
      301 accaaggaca ttcaaagcaa aggagctgtg ggagaagaac ggggctgtga ttatggctgt
      361 acgcaggcca ggctgctttc tctgccgagc ggaagcagca gacctgatgt ccttgaagcc
      421 caagttggat gagctaggtg tccctctcta tgcggtggtg aaggagcagg tgaagagaga
      481 agtggaagat ttccaacctt acttcaaagg ggaaatcttc ctggatgaaa agaaaaaatt
      541 ctatggtcca gagaggcgga agatgatgtt catgggcctc atccgattgg gggtgtggta
      601 taactccttt cgagcctgga atggaggctt ctctggaaac ctagaaggcg aaggcttcat
      661 ccttggagga gtttttgtga taggatctgg aaaacagggc atccttcttg agcaccgaga
      721 aaaagaattt ggagacagag tgaacccact ctctgttctg gaggctgtaa agaaaatcaa
      781 gctacagact ccagcgtccg ggagaagctg atcctgtaca gctgctggct gggagagaac
      841 gcacggggcc tgtgctgtgt tcatcagatg agctgtgctt tccccagggc cccaagagcc
      901 agaaggccct tgcaccatat ttactaagaa ttggtgatgc attttaacat tgtctgttta
      961 ggtcccagag cctttaacat tccgtttagg cccagtaggg caaatagggt cccagacaga
     1021 acagagttca atctaacaaa ccagtgagag ttatttgagg aaagatctag aaaatttaat
     1081 gtttaaagtt tactgctgaa gcttctttca aaggaatatg tcctaagtgc cggtatttga
     1141 agtgaagttt attttcatgc ctagttaaaa aacaaacaaa caaacaaaca aacctgaaat
     1201 ctgagaaaag tgcggctaag aaacagctca gtggtggagc atttacctaa catgcacatg
     1261 gccctaagtg ggatacccag acagacagac agacagacac acacacacac acacacacac
     1321 acacacacac actctctctc tctctcctaa gaaaagctga tggctgactt gataattaga
     1381 gaattatcct tttgtttgat gtgttttctg ttaacaactt gttacttaag gtcagagtac
     1441 cacataaagc aattgctgtg ctgtgttctt ggataaatta cacaggtaaa ttacaaagtg
     1501 aaggttctgt ggtcttccct tatagacgca gagatttgct tccttgggaa aaactgtcac
     1561 ctgggaaact gtcacctcta ataaaaatat tcaccaggaa aaaaaaaaaa aaaaa
//
