LOCUS       NM_198048               4668 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus periaxin (Prx), transcript variant 1, mRNA.
ACCESSION   NM_198048
VERSION     NM_198048.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4668)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   2  (bases 1 to 4668)
  AUTHORS   Siems,S.B., Jahn,O., Eichel,M.A., Kannaiyan,N., Wu,L.M.N.,
            Sherman,D.L., Kusch,K., Hesse,D., Jung,R.B., Fledrich,R.,
            Sereda,M.W., Rossner,M.J., Brophy,P.J. and Werner,H.B.
  TITLE     Proteome profile of peripheral myelin in healthy mice and in a
            neuropathy model
  JOURNAL   Elife 9, e51406 (2020)
   PUBMED   32130108
  REMARK    GeneRIF: Proteome profile of peripheral myelin in healthy mice and
            in a neuropathy model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4668)
  AUTHORS   Maddala,R. and Rao,P.V.
  TITLE     Switching of alpha-Catenin From Epithelial to Neuronal Type During
            Lens Epithelial Cell Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 58 (9), 3445-3455 (2017)
   PUBMED   28692740
REFERENCE   4  (bases 1 to 4668)
  AUTHORS   Maddala,R., Walters,M., Brophy,P.J., Bennett,V. and Rao,P.V.
  TITLE     Ankyrin-B directs membrane tethering of periaxin and is required
            for maintenance of lens fiber cell hexagonal shape and mechanics
  JOURNAL   Am J Physiol Cell Physiol 310 (2), C115-C126 (2016)
   PUBMED   26538089
  REMARK    GeneRIF: Taken together, these observations reveal that AnkB is
            required for Prx membrane anchoring and for maintenance of lens
            fiber cell hexagonal geometry, membrane skeleton organization, and
            biomechanics.
REFERENCE   5  (bases 1 to 4668)
  AUTHORS   Wu,L.M., Williams,A., Delaney,A., Sherman,D.L. and Brophy,P.J.
  TITLE     Increasing internodal distance in myelinated nerves accelerates
            nerve conduction to a flat maximum
  JOURNAL   Curr Biol 22 (20), 1957-1961 (2012)
   PUBMED   23022068
REFERENCE   6  (bases 1 to 4668)
  AUTHORS   Gillespie,C.S., Sherman,D.L., Fleetwood-Walker,S.M., Cottrell,D.F.,
            Tait,S., Garry,E.M., Wallace,V.C., Ure,J., Griffiths,I.R., Smith,A.
            and Brophy,P.J.
  TITLE     Peripheral demyelination and neuropathic pain behavior in
            periaxin-deficient mice
  JOURNAL   Neuron 26 (2), 523-531 (2000)
   PUBMED   10839370
REFERENCE   7  (bases 1 to 4668)
  AUTHORS   Sherman,D.L. and Brophy,P.J.
  TITLE     A tripartite nuclear localization signal in the PDZ-domain protein
            L-periaxin
  JOURNAL   J Biol Chem 275 (7), 4537-4540 (2000)
   PUBMED   10671475
REFERENCE   8  (bases 1 to 4668)
  AUTHORS   Dytrych,L., Sherman,D.L., Gillespie,C.S. and Brophy,P.J.
  TITLE     Two PDZ domain proteins encoded by the murine periaxin gene are the
            result of alternative intron retention and are differentially
            targeted in Schwann cells
  JOURNAL   J Biol Chem 273 (10), 5794-5800 (1998)
   PUBMED   9488714
REFERENCE   9  (bases 1 to 4668)
  AUTHORS   Gillespie,C.S., Lee,M., Fantes,J.F. and Brophy,P.J.
  TITLE     The gene encoding the Schwann cell protein periaxin localizes on
            mouse chromosome 7 (Prx)
  JOURNAL   Genomics 41 (2), 297-298 (1997)
   PUBMED   9143514
REFERENCE   10 (bases 1 to 4668)
  AUTHORS   Scherer,S.S., Xu,Y.T., Bannerman,P.G., Sherman,D.L. and Brophy,P.J.
  TITLE     Periaxin expression in myelinating Schwann cells: modulation by
            axon-glial interactions and polarized localization during
            development
  JOURNAL   Development 121 (12), 4265-4273 (1995)
   PUBMED   8575326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045218.1, AJ222968.1 and AC158304.11.
            
            [WARNING] On Feb 4, 2025 this sequence was replaced by NM_198048.3.
            
            On Mar 18, 2008 this sequence version replaced NM_198048.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (L).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               CJ045218.1         4-398
            396-833             AJ222968.1         395-832
            834-4668            AC158304.11        52417-56251         c
FEATURES             Location/Qualifiers
     source          1..4668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.91 cM"
     gene            1..4668
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="periaxin"
                     /db_xref="GeneID:19153"
                     /db_xref="MGI:MGI:108176"
     exon            1..42
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            43..86
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            87..185
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            186..312
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..4461
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="isoform L is encoded by transcript variant 1"
                     /codon_start=1
                     /product="periaxin isoform L"
                     /protein_id="NP_932165.2"
                     /db_xref="CCDS:CCDS21023.1"
                     /db_xref="GeneID:19153"
                     /db_xref="MGI:MGI:108176"
                     /translation="MEARSRSAEELRRAELVEIIVETEAQTGVSGFNVAGGGKEGIFV
                     RELREDSPAAKSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPT
                     GDLALRPGTVSGYEMKGPRAKVAKLNIQSLAPVKKKKMVTGALGTPADLAPVDVEFSF
                     PKFSRLRRGLKAEAVKGPVPAAPARRRLQLPRLRVREVAEEAQVARMAAAAPPPRKAK
                     AEAEAATGAGFTAPQLELVGPRLPSAEVGVPQVSVPKGTPSTEAASGFALHLPTLGLG
                     APAAPAVEPPATGIQVPQVELPTLPSLPTLPTLPCLDTQEGAAVVKVPTLDVAAPSMG
                     VDLALPGAEVEAQGEVPEVALKMPRLSFPRFGIRGKEATEAKVVKGSPEAKAKGPRLR
                     MPTFGLSLLEPRPSGPEAVAESKLKLPTLKMPSFGIGVTGPEVKAPKGPEVKLPKVPE
                     VKLPKVPEAAIPDVQLPEVQLPKMSDMKLPKIPEMVVPDVRLPEVQLPKVPEMKVPEM
                     KLPKVPEMAVPDVHLPDVQLPKVPEMKLPKVPEMAVPDVHLPDVQLPKVPEMKLPEMK
                     LPKVPEMAVPDVRLPEVQLPKVSEVKLPKMPEMAVPDVHLPELQLPKMSEVKLPKMPE
                     MAVPDVRLPEVQLPKVSEMKLPKMPEMTMPDIRLPEVQLPKVPDIKLPEMKLPEIKLP
                     KVPDMAVPDVPLPELQLPKVSDIRLPEMQVSQVPEVQLPKMPEMKLSKVPEVQRKSAG
                     AEQAKGTEFSFKLPKMTMPKLGKVGKPGEASIEVPDKLMTLPCLQPEVGTEASHVGVP
                     SLSLPSVELDLPGALGLEGQVQEAVPGKVEKPEGPRVAVGVGEVGFRVPSVEIVTPQL
                     PTVEVEKEQLEMVEMKVKPSSKFSLPKFGLSGPKAVKGEVEGPGRATKLKVSKFTISL
                     PKARAGTEAEAKGAGEAGLLPALDLSIPQLSLDAQLPSGKVEVADSKPKSSRFALPKF
                     GVKGRDSEADVLVAGEAELEGKGWGWDGKVKMPKLKMPSFGLSRGKEAETQDGRVSPG
                     EKLEAIAGQLKIPAVELVTPGAQETEKVTSGVKPSGLQVSTTGQVVAEGQESVQRVST
                     LGISLPQVELASFGEAGPEIVAPSAEGTAGSRVQVPQVMLELPGTQVAGGDLLVGEGI
                     FKMPTVTVPQLELDVGLGHEAQAGEAAKSEGGIKLKLPTLGTGSRGEGVEPQGPEAQR
                     TFHLSLPDVELTSPVSSHAEYQVVEGDGDGGHKLKVRLPLFGLAKAKEGIEVGEKAKS
                     PKLRLPRVGFSQSESVSGEGSPSPEEEEEGSGEGASSRRGRVRVRLPRVGLASPSKVS
                     KGQEGDATSKSPVGEKSPKFRFPRVSLSPKARSGSRDREEGGFRVRLPSVGFSETAVP
                     GSTRIEGTQAAAI"
     exon            313..469
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            470..666
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            667..4668
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4649..4654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="hexamer: AATAAA"
     polyA_site      4668
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="major polyA site"
ORIGIN      
        1 cagacagacc aaggagctct ggaggtgtct ggaggcccac cgagccccag acccaggagg
       61 cccaggaagc tggaagtgac cctcaggcag caagacctca aaggaagagt gagattcctg
      121 cttacagctg tgcatcaccc cgagtggggc tcctgtcagg agaaaaggcc atcactcaag
      181 aagcggctca gcggcagctg ctccatgagg agctgaaggt ggtcctgcag cagaaggagg
      241 agaggacacg ggagctcgag cccccaggtg actctctgca gagctatgga ggccaggagc
      301 cgcagcgctg aggagctgag acgggcggag ttggtggaga ttatcgtgga gaccgaggca
      361 cagaccgggg tcagcggctt caacgtagca ggcggcggca aagaaggaat ctttgtccgt
      421 gagctgcgag aggactcacc ggcagctaag agcctcagct tgcaagaagg ggaccagctg
      481 ctgagtgccc gtgtgttctt tgagaacttc aaatatgagg atgcacttcg cctgctgcaa
      541 tgcgcagagc cctacaaggt ctccttctgc ttgaagcgca ctgtgcccac cggggatctg
      601 gcactgaggc ccgggacggt gtctggatac gagatgaagg gcccacgggc caaagtggcc
      661 aagctgaaca tccagagtct ggcccctgtg aagaagaaga agatggtgac tggggccctg
      721 gggacccctg cagatttggc ccctgttgac gtcgagttct cttttcccaa gttctcccga
      781 ctgcgtcggg gtctcaaagc cgaggctgtc aagggacctg tcccagctgc cccagcccgt
      841 cgccgcctcc agctgcctcg gctgcgtgtc cgagaagtag ctgaagaggc ccaggtagcc
      901 cgaatggctg ctgctgctcc tcccccaagg aaggccaagg cagaagctga ggcagccaca
      961 ggagctgggt tcacagcccc tcagttagag ctagttgggc ctcggctgcc tagtgccgag
     1021 gtgggtgtcc ctcaggtctc agttcccaag gggaccccat caacagaggc agccagcggc
     1081 tttgcccttc acctgccaac ccttgggcta ggtgccccag ctgcaccggc tgtggagccc
     1141 ccagccacgg gaatccaggt tccacaagtg gaactcccca ccctgccctc tctacccact
     1201 cttcccacac ttccatgcct ggacacccag gaaggagctg cagtggtaaa agtccctacc
     1261 ctggatgtgg cagctccgtc tatgggggtg gacctggctt tgccgggtgc agaggtggag
     1321 gcccagggag aggttcctga agtggccctc aagatgcccc ggctcagttt cccccgtttt
     1381 gggattcggg ggaaggaagc cactgaagcc aaagtagtca agggcagccc tgaggccaaa
     1441 gcaaagggtc ccagacttcg aatgcccacc tttgggcttt ctctcctgga accccggccc
     1501 tctggccctg aagctgttgc tgagagcaag ctgaagctac ccaccctcaa gatgccctct
     1561 ttcggcattg gtgtgactgg gcctgaggtc aaggcaccca aggggcccga agtaaagctc
     1621 cctaaggttc ctgaggtcaa actcccgaaa gtgcccgagg cagccattcc agatgtgcaa
     1681 ctccctgagg tacagctgcc caaaatgtca gacatgaaac ttccaaagat ccctgagatg
     1741 gttgtacccg acgttcgtct tccggaagtg cagctgccca aagtccctga gatgaaagtc
     1801 ccagagatga agctcccgaa ggtgcccgag atggccgtgc ccgatgtaca ccttccagat
     1861 gtacagctcc cgaaagtccc agagatgaag ctcccgaagg tgcccgagat ggccgtgccc
     1921 gatgtacacc ttccagatgt acagctcccg aaagttccag agatgaagct accagagatg
     1981 aagctcccga aggtgccgga gatggccgtg ccggatgtac gactcccgga agttcagctg
     2041 cccaaagtgt ctgaggtgaa gctcccaaag atgcctgaga tggccgtgcc tgatgtccac
     2101 ctcccggagc tacaacttcc caaaatgtcc gaggtgaagc tcccaaagat gcccgagatg
     2161 gccgtgcccg atgttcgcct cccggaagtt cagctgccca aagtgtcaga gatgaaactc
     2221 cctaagatgc cagagatgac catgcccgac attcgcctcc cagaagttca gttgcccaaa
     2281 gtgcctgaca ttaaacttcc tgaaatgaag cttccagaaa taaaactccc caaagtgcct
     2341 gacatggcag tgcctgatgt cccccttcca gagctgcagc tgcccaaagt gtcggacatt
     2401 cggctgcctg aaatgcaagt gtcacaggtc ccagaggtgc agcttcccaa gatgccagag
     2461 atgaagttgt ccaaggttcc tgaggtacag aggaaatctg caggggcgga gcaggcaaaa
     2521 gggactgaat ttagtttcaa gttgcccaag atgaccatgc ccaagttggg gaaagtgggc
     2581 aagcctgggg aggcaagtat tgaggttcca gacaaactca tgacacttcc ctgtctgcag
     2641 ccagaggtgg gcactgaggc atcccatgtt ggtgtccctt ccctctctct cccctctgtg
     2701 gagcttgact tgcctggggc cctgggcctg gagggacaag tccaagaagc tgtcccaggc
     2761 aaagtggaga agccagaggg ccccagggta gcagtgggtg ttggagaggt gggctttcgt
     2821 gtgccctctg tggagattgt cactcctcag ctgcccacag ttgaagttga gaaagagcag
     2881 ctagagatgg tggagatgaa agtcaaaccc tcttccaagt tctctctgcc caaattcgga
     2941 ctttcagggc ccaaagctgt caagggagag gtggaggggc ctgggcgagc caccaagctg
     3001 aaggtttcca agtttaccat ctcacttccc aaagctcgag cagggactga ggccgaagcg
     3061 aagggagctg gggaagccgg gttgctgcca gcgctggatc tgtccatccc acagctcagc
     3121 ctggatgccc agctgccctc aggcaaggtg gaagtagctg atagcaagcc taaatcgtcc
     3181 agatttgctc tgcccaagtt tggggtgaaa ggccgggact ctgaggctga tgtactggtg
     3241 gcaggggagg ctgagcttga gggaaagggt tggggctggg atgggaaggt gaagatgccc
     3301 aagctgaaaa tgccatcttt tgggttgtcc cgaggaaagg aagcagaaac tcaggatgga
     3361 cgtgtcagcc ccggggaaaa gctggaggcc atagctgggc agcttaagat ccctgcggtg
     3421 gaattggtca caccgggagc tcaggagaca gagaaggtca ccagtggagt gaagccgtca
     3481 ggcctccagg tgtccaccac tgggcaggtg gttgcagagg gccaggagag tgtgcagagg
     3541 gtgtccacac taggtatctc tttgccccag gtggaattgg ccagctttgg ggaggcaggc
     3601 cctgagatcg tagccccttc tgcagagggc acagcaggct ctagggtcca ggtgccacag
     3661 gtgatgctgg agctacctgg aacccaggtg gcagggggtg atctgttagt gggtgagggc
     3721 atcttcaaga tgcccacagt gacagtgccc cagctagagc tggatgtggg gctgggccat
     3781 gaagcccagg ctggtgaagc agccaagagt gagggtggga taaagttgaa gttgcccaca
     3841 ctggggaccg gaagcagagg agagggcgtt gagccccagg gccccgaggc ccagcgcacc
     3901 ttccacctct cattgcccga tgtggaactc acgtcaccag tgagtagcca cgctgagtac
     3961 caggtagttg agggtgatgg ggatggtggg cacaaactca aggttcggct gcccctgttt
     4021 ggtctggcaa aggccaagga agggatagaa gttggagaaa aggctaagag tccaaagctc
     4081 aggctacccc gagtgggctt cagccagagt gagtcggtct ccggagaagg ctctccaagt
     4141 cctgaggagg aggaagaagg cagtggggaa ggggcttcca gtcgccgggg tagggtaagg
     4201 gtccgcctgc ctcgggtagg cttggcttcc ccttctaaag tctctaaggg acaggagggt
     4261 gatgcaacct ccaagtcccc agttggggag aagtcaccca aattccgttt tcctagggtg
     4321 tccttaagcc ccaaggcccg gagtgggagt agggaccggg aagaaggtgg attcagggtc
     4381 cgactgccca gtgtgggatt ttcagaaaca gcagttccag gttccaccag gattgaggga
     4441 acccaggctg ctgccatctg aagccccagg acagctgtgg attccccctc ttgtctttcc
     4501 attccccagc ctagcccccc attttgtgtg tgacattact agcactaatc ctcagagggc
     4561 ttgaaggtgg gtaactgact caggcaggag ccagtggcct gtgccacctc attggccaaa
     4621 gtgcctgtat atcatgtcaa actatgggaa taaaataatt caaaagtt
//
