LOCUS       NP_932165               1391 aa            linear   ROD 04-FEB-2025
DEFINITION  periaxin isoform L [Mus musculus].
ACCESSION   NP_932165
VERSION     NP_932165.2
DBSOURCE    REFSEQ: accession NM_198048.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1391)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   2  (residues 1 to 1391)
  AUTHORS   Siems,S.B., Jahn,O., Eichel,M.A., Kannaiyan,N., Wu,L.M.N.,
            Sherman,D.L., Kusch,K., Hesse,D., Jung,R.B., Fledrich,R.,
            Sereda,M.W., Rossner,M.J., Brophy,P.J. and Werner,H.B.
  TITLE     Proteome profile of peripheral myelin in healthy mice and in a
            neuropathy model
  JOURNAL   Elife 9, e51406 (2020)
   PUBMED   32130108
  REMARK    GeneRIF: Proteome profile of peripheral myelin in healthy mice and
            in a neuropathy model.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1391)
  AUTHORS   Maddala,R. and Rao,P.V.
  TITLE     Switching of alpha-Catenin From Epithelial to Neuronal Type During
            Lens Epithelial Cell Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 58 (9), 3445-3455 (2017)
   PUBMED   28692740
REFERENCE   4  (residues 1 to 1391)
  AUTHORS   Maddala,R., Walters,M., Brophy,P.J., Bennett,V. and Rao,P.V.
  TITLE     Ankyrin-B directs membrane tethering of periaxin and is required
            for maintenance of lens fiber cell hexagonal shape and mechanics
  JOURNAL   Am J Physiol Cell Physiol 310 (2), C115-C126 (2016)
   PUBMED   26538089
  REMARK    GeneRIF: Taken together, these observations reveal that AnkB is
            required for Prx membrane anchoring and for maintenance of lens
            fiber cell hexagonal geometry, membrane skeleton organization, and
            biomechanics.
REFERENCE   5  (residues 1 to 1391)
  AUTHORS   Wu,L.M., Williams,A., Delaney,A., Sherman,D.L. and Brophy,P.J.
  TITLE     Increasing internodal distance in myelinated nerves accelerates
            nerve conduction to a flat maximum
  JOURNAL   Curr Biol 22 (20), 1957-1961 (2012)
   PUBMED   23022068
REFERENCE   6  (residues 1 to 1391)
  AUTHORS   Gillespie,C.S., Sherman,D.L., Fleetwood-Walker,S.M., Cottrell,D.F.,
            Tait,S., Garry,E.M., Wallace,V.C., Ure,J., Griffiths,I.R., Smith,A.
            and Brophy,P.J.
  TITLE     Peripheral demyelination and neuropathic pain behavior in
            periaxin-deficient mice
  JOURNAL   Neuron 26 (2), 523-531 (2000)
   PUBMED   10839370
REFERENCE   7  (residues 1 to 1391)
  AUTHORS   Sherman,D.L. and Brophy,P.J.
  TITLE     A tripartite nuclear localization signal in the PDZ-domain protein
            L-periaxin
  JOURNAL   J Biol Chem 275 (7), 4537-4540 (2000)
   PUBMED   10671475
REFERENCE   8  (residues 1 to 1391)
  AUTHORS   Dytrych,L., Sherman,D.L., Gillespie,C.S. and Brophy,P.J.
  TITLE     Two PDZ domain proteins encoded by the murine periaxin gene are the
            result of alternative intron retention and are differentially
            targeted in Schwann cells
  JOURNAL   J Biol Chem 273 (10), 5794-5800 (1998)
   PUBMED   9488714
REFERENCE   9  (residues 1 to 1391)
  AUTHORS   Gillespie,C.S., Lee,M., Fantes,J.F. and Brophy,P.J.
  TITLE     The gene encoding the Schwann cell protein periaxin localizes on
            mouse chromosome 7 (Prx)
  JOURNAL   Genomics 41 (2), 297-298 (1997)
   PUBMED   9143514
REFERENCE   10 (residues 1 to 1391)
  AUTHORS   Scherer,S.S., Xu,Y.T., Bannerman,P.G., Sherman,D.L. and Brophy,P.J.
  TITLE     Periaxin expression in myelinating Schwann cells: modulation by
            axon-glial interactions and polarized localization during
            development
  JOURNAL   Development 121 (12), 4265-4273 (1995)
   PUBMED   8575326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158304.11.
            
            On Mar 18, 2008 this sequence version replaced NP_932165.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (L).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222968.1, SRR14995044.113995.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.91 cM"
     Protein         1..1391
                     /product="periaxin isoform L"
                     /calculated_mol_wt=147499
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63425; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Region          31..85
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cd00136"
                     /db_xref="CDD:467153"
     Site            order(31..35,45,48,77,81,84..85)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          70..84
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BXM0"
                     /note="propagated from UniProtKB/Swiss-Prot (O55103.1)"
     Region          118..196
                     /region_name="Nuclear localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (O55103.1)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63425; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Region          432..719
                     /region_name="45 X 5 AA approximate tandem repeats of
                     [LVMGIED]-[PQSKHARMI]-[EDKLVTR]-[LIVMAP]-[AQKHRPEVSD],
                     that may have a tripeptide spacer of
                     [LVIDEA]-[PMSVI]-[KEATDQ]"
                     /note="propagated from UniProtKB/Swiss-Prot (O55103.1)"
     Region          433..547
                     /region_name="Cornifin"
                     /note="Cornifin (SPRR) family; pfam02389"
                     /db_xref="CDD:280537"
     Region          <434..764
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     Site            848
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63425; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            979
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1028
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63425; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Region          1267..1366
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55103.1)"
     Site            1279
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1285
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1293
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63425; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1337
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     Site            1369
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55103.1)"
     CDS             1..1391
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /coded_by="NM_198048.3:285..4460"
                     /note="isoform L is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21023.1"
                     /db_xref="GeneID:19153"
                     /db_xref="MGI:MGI:108176"
ORIGIN      
        1 mearsrsaee lrraelveii veteaqtgvs gfnvagggke gifvrelred spaakslslq
       61 egdqllsarv ffenfkyeda lrllqcaepy kvsfclkrtv ptgdlalrpg tvsgyemkgp
      121 rakvaklniq slapvkkkkm vtgalgtpad lapvdvefsf pkfsrlrrgl kaeavkgpvp
      181 aaparrrlql prlrvrevae eaqvarmaaa appprkakae aeaatgagft apqlelvgpr
      241 lpsaevgvpq vsvpkgtpst eaasgfalhl ptlglgapaa paveppatgi qvpqvelptl
      301 pslptlptlp cldtqegaav vkvptldvaa psmgvdlalp gaeveaqgev pevalkmprl
      361 sfprfgirgk eateakvvkg speakakgpr lrmptfglsl leprpsgpea vaesklklpt
      421 lkmpsfgigv tgpevkapkg pevklpkvpe vklpkvpeaa ipdvqlpevq lpkmsdmklp
      481 kipemvvpdv rlpevqlpkv pemkvpemkl pkvpemavpd vhlpdvqlpk vpemklpkvp
      541 emavpdvhlp dvqlpkvpem klpemklpkv pemavpdvrl pevqlpkvse vklpkmpema
      601 vpdvhlpelq lpkmsevklp kmpemavpdv rlpevqlpkv semklpkmpe mtmpdirlpe
      661 vqlpkvpdik lpemklpeik lpkvpdmavp dvplpelqlp kvsdirlpem qvsqvpevql
      721 pkmpemklsk vpevqrksag aeqakgtefs fklpkmtmpk lgkvgkpgea sievpdklmt
      781 lpclqpevgt eashvgvpsl slpsveldlp galglegqvq eavpgkvekp egprvavgvg
      841 evgfrvpsve ivtpqlptve vekeqlemve mkvkpsskfs lpkfglsgpk avkgevegpg
      901 ratklkvskf tislpkarag teaeakgage agllpaldls ipqlsldaql psgkvevads
      961 kpkssrfalp kfgvkgrdse advlvageae legkgwgwdg kvkmpklkmp sfglsrgkea
     1021 etqdgrvspg ekleaiagql kipavelvtp gaqetekvts gvkpsglqvs ttgqvvaegq
     1081 esvqrvstlg islpqvelas fgeagpeiva psaegtagsr vqvpqvmlel pgtqvaggdl
     1141 lvgegifkmp tvtvpqleld vglgheaqag eaakseggik lklptlgtgs rgegvepqgp
     1201 eaqrtfhlsl pdveltspvs shaeyqvveg dgdgghklkv rlplfglaka kegievgeka
     1261 kspklrlprv gfsqsesvsg egspspeeee egsgegassr rgrvrvrlpr vglaspskvs
     1321 kgqegdatsk spvgekspkf rfprvslspk arsgsrdree ggfrvrlpsv gfsetavpgs
     1381 triegtqaaa i
//
