LOCUS       NM_019412               5260 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus periaxin (Prx), transcript variant 2, mRNA.
ACCESSION   NM_019412
VERSION     NM_019412.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5260)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   2  (bases 1 to 5260)
  AUTHORS   Siems,S.B., Jahn,O., Eichel,M.A., Kannaiyan,N., Wu,L.M.N.,
            Sherman,D.L., Kusch,K., Hesse,D., Jung,R.B., Fledrich,R.,
            Sereda,M.W., Rossner,M.J., Brophy,P.J. and Werner,H.B.
  TITLE     Proteome profile of peripheral myelin in healthy mice and in a
            neuropathy model
  JOURNAL   Elife 9, e51406 (2020)
   PUBMED   32130108
  REMARK    GeneRIF: Proteome profile of peripheral myelin in healthy mice and
            in a neuropathy model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5260)
  AUTHORS   Maddala,R. and Rao,P.V.
  TITLE     Switching of alpha-Catenin From Epithelial to Neuronal Type During
            Lens Epithelial Cell Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 58 (9), 3445-3455 (2017)
   PUBMED   28692740
REFERENCE   4  (bases 1 to 5260)
  AUTHORS   Maddala,R., Walters,M., Brophy,P.J., Bennett,V. and Rao,P.V.
  TITLE     Ankyrin-B directs membrane tethering of periaxin and is required
            for maintenance of lens fiber cell hexagonal shape and mechanics
  JOURNAL   Am J Physiol Cell Physiol 310 (2), C115-C126 (2016)
   PUBMED   26538089
  REMARK    GeneRIF: Taken together, these observations reveal that AnkB is
            required for Prx membrane anchoring and for maintenance of lens
            fiber cell hexagonal geometry, membrane skeleton organization, and
            biomechanics.
REFERENCE   5  (bases 1 to 5260)
  AUTHORS   Wu,L.M., Williams,A., Delaney,A., Sherman,D.L. and Brophy,P.J.
  TITLE     Increasing internodal distance in myelinated nerves accelerates
            nerve conduction to a flat maximum
  JOURNAL   Curr Biol 22 (20), 1957-1961 (2012)
   PUBMED   23022068
REFERENCE   6  (bases 1 to 5260)
  AUTHORS   Gillespie,C.S., Sherman,D.L., Fleetwood-Walker,S.M., Cottrell,D.F.,
            Tait,S., Garry,E.M., Wallace,V.C., Ure,J., Griffiths,I.R., Smith,A.
            and Brophy,P.J.
  TITLE     Peripheral demyelination and neuropathic pain behavior in
            periaxin-deficient mice
  JOURNAL   Neuron 26 (2), 523-531 (2000)
   PUBMED   10839370
REFERENCE   7  (bases 1 to 5260)
  AUTHORS   Sherman,D.L. and Brophy,P.J.
  TITLE     A tripartite nuclear localization signal in the PDZ-domain protein
            L-periaxin
  JOURNAL   J Biol Chem 275 (7), 4537-4540 (2000)
   PUBMED   10671475
REFERENCE   8  (bases 1 to 5260)
  AUTHORS   Dytrych,L., Sherman,D.L., Gillespie,C.S. and Brophy,P.J.
  TITLE     Two PDZ domain proteins encoded by the murine periaxin gene are the
            result of alternative intron retention and are differentially
            targeted in Schwann cells
  JOURNAL   J Biol Chem 273 (10), 5794-5800 (1998)
   PUBMED   9488714
REFERENCE   9  (bases 1 to 5260)
  AUTHORS   Gillespie,C.S., Lee,M., Fantes,J.F. and Brophy,P.J.
  TITLE     The gene encoding the Schwann cell protein periaxin localizes on
            mouse chromosome 7 (Prx)
  JOURNAL   Genomics 41 (2), 297-298 (1997)
   PUBMED   9143514
REFERENCE   10 (bases 1 to 5260)
  AUTHORS   Scherer,S.S., Xu,Y.T., Bannerman,P.G., Sherman,D.L. and Brophy,P.J.
  TITLE     Periaxin expression in myelinating Schwann cells: modulation by
            axon-glial interactions and polarized localization during
            development
  JOURNAL   Development 121 (12), 4265-4273 (1995)
   PUBMED   8575326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045218.1, AJ222969.1 and AC158304.11.
            
            [WARNING] On Feb 4, 2025 this sequence was replaced by NM_019412.3.
            
            On Mar 18, 2008 this sequence version replaced NM_019412.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript but encodes the shorter isoform (S).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222969.1, CJ045218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               CJ045218.1         4-398
            396-804             AJ222969.1         395-803
            805-5260            AC158304.11        52417-56872         c
FEATURES             Location/Qualifiers
     source          1..5260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.91 cM"
     gene            1..5260
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="periaxin"
                     /db_xref="GeneID:19153"
                     /db_xref="MGI:MGI:108176"
     exon            1..42
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            43..86
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            87..185
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            186..312
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..732
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="isoform S is encoded by transcript variant 2"
                     /codon_start=1
                     /product="periaxin isoform S"
                     /protein_id="NP_062285.1"
                     /db_xref="CCDS:CCDS39849.1"
                     /db_xref="GeneID:19153"
                     /db_xref="MGI:MGI:108176"
                     /translation="MEARSRSAEELRRAELVEIIVETEAQTGVSGFNVAGGGKEGIFV
                     RELREDSPAAKSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPT
                     GDLALRPGTVSGYEMKGPRAKVAKLVRVLSPVPVQDSPSDRVAAAP"
     exon            313..469
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     exon            470..5260
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5241..5246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="hexamer: AATAAA"
     polyA_site      5260
                     /gene="Prx"
                     /gene_synonym="L-Periaxin"
                     /note="major polyA site"
ORIGIN      
        1 cagacagacc aaggagctct ggaggtgtct ggaggcccac cgagccccag acccaggagg
       61 cccaggaagc tggaagtgac cctcaggcag caagacctca aaggaagagt gagattcctg
      121 cttacagctg tgcatcaccc cgagtggggc tcctgtcagg agaaaaggcc atcactcaag
      181 aagcggctca gcggcagctg ctccatgagg agctgaaggt ggtcctgcag cagaaggagg
      241 agaggacacg ggagctcgag cccccaggtg actctctgca gagctatgga ggccaggagc
      301 cgcagcgctg aggagctgag acgggcggag ttggtggaga ttatcgtgga gaccgaggca
      361 cagaccgggg tcagcggctt caacgtagca ggcggcggca aagaaggaat ctttgtccgt
      421 gagctgcgag aggactcacc ggcagctaag agcctcagct tgcaagaagg ggaccagctg
      481 ctgagtgccc gtgtgttctt tgagaacttc aaatatgagg atgcacttcg cctgctgcaa
      541 tgcgcagagc cctacaaggt ctccttctgc ttgaagcgca ctgtgcccac cggggatctg
      601 gcactgaggc ccgggacggt gtctggatac gagatgaagg gcccacgggc caaagtggcc
      661 aagctggtac gcgtgcttag cccggtcccg gtccaggaca gccccagtga ccgggtcgct
      721 gctgcgccgt aaaccctact ccctttcact gtggcccact ttggccctct gtctgtcact
      781 aacccgacac taattcgccc tctgtccctt gttctctgct cctaaactcc actcctgtca
      841 aagggtgcac ctattggcag gtggttctca cccatcccca ccatgcaacc cgggctcatt
      901 aggggtcatg gagtcctgga aggccagatt ctagcccaat ggctgttggg ttactgagtg
      961 acccaagttt cttttcctct ctgggtcgca gtttccccaa ctctacaata aggatgttgg
     1021 gggaaattcc agaatttttg ggttcccatt gccacatccc tgtcccattg ccacatcact
     1081 gtgagattct gaatgactgt cattgccttc ctgaagtgac aggcaggaag gtggatgtgt
     1141 tttgggatat actctacccc aaacttctcc cagcctggta tactaggtgg gttatttttc
     1201 tatctactcc cagcctccca ctgtcccaca gcctcctgcc tctctcctct ctcctcagaa
     1261 catccagagt ctggcccctg tgaagaagaa gaagatggtg actggggccc tggggacccc
     1321 tgcagatttg gcccctgttg acgtcgagtt ctcttttccc aagttctccc gactgcgtcg
     1381 gggtctcaaa gccgaggctg tcaagggacc tgtcccagct gccccagccc gtcgccgcct
     1441 ccagctgcct cggctgcgtg tccgagaagt agctgaagag gcccaggtag cccgaatggc
     1501 tgctgctgct cctcccccaa ggaaggccaa ggcagaagct gaggcagcca caggagctgg
     1561 gttcacagcc cctcagttag agctagttgg gcctcggctg cctagtgccg aggtgggtgt
     1621 ccctcaggtc tcagttccca aggggacccc atcaacagag gcagccagcg gctttgccct
     1681 tcacctgcca acccttgggc taggtgcccc agctgcaccg gctgtggagc ccccagccac
     1741 gggaatccag gttccacaag tggaactccc caccctgccc tctctaccca ctcttcccac
     1801 acttccatgc ctggacaccc aggaaggagc tgcagtggta aaagtcccta ccctggatgt
     1861 ggcagctccg tctatggggg tggacctggc tttgccgggt gcagaggtgg aggcccaggg
     1921 agaggttcct gaagtggccc tcaagatgcc ccggctcagt ttcccccgtt ttgggattcg
     1981 ggggaaggaa gccactgaag ccaaagtagt caagggcagc cctgaggcca aagcaaaggg
     2041 tcccagactt cgaatgccca cctttgggct ttctctcctg gaaccccggc cctctggccc
     2101 tgaagctgtt gctgagagca agctgaagct acccaccctc aagatgccct ctttcggcat
     2161 tggtgtgact gggcctgagg tcaaggcacc caaggggccc gaagtaaagc tccctaaggt
     2221 tcctgaggtc aaactcccga aagtgcccga ggcagccatt ccagatgtgc aactccctga
     2281 ggtacagctg cccaaaatgt cagacatgaa acttccaaag atccctgaga tggttgtacc
     2341 cgacgttcgt cttccggaag tgcagctgcc caaagtccct gagatgaaag tcccagagat
     2401 gaagctcccg aaggtgcccg agatggccgt gcccgatgta caccttccag atgtacagct
     2461 cccgaaagtc ccagagatga agctcccgaa ggtgcccgag atggccgtgc ccgatgtaca
     2521 ccttccagat gtacagctcc cgaaagttcc agagatgaag ctaccagaga tgaagctccc
     2581 gaaggtgccg gagatggccg tgccggatgt acgactcccg gaagttcagc tgcccaaagt
     2641 gtctgaggtg aagctcccaa agatgcctga gatggccgtg cctgatgtcc acctcccgga
     2701 gctacaactt cccaaaatgt ccgaggtgaa gctcccaaag atgcccgaga tggccgtgcc
     2761 cgatgttcgc ctcccggaag ttcagctgcc caaagtgtca gagatgaaac tccctaagat
     2821 gccagagatg accatgcccg acattcgcct cccagaagtt cagttgccca aagtgcctga
     2881 cattaaactt cctgaaatga agcttccaga aataaaactc cccaaagtgc ctgacatggc
     2941 agtgcctgat gtcccccttc cagagctgca gctgcccaaa gtgtcggaca ttcggctgcc
     3001 tgaaatgcaa gtgtcacagg tcccagaggt gcagcttccc aagatgccag agatgaagtt
     3061 gtccaaggtt cctgaggtac agaggaaatc tgcaggggcg gagcaggcaa aagggactga
     3121 atttagtttc aagttgccca agatgaccat gcccaagttg gggaaagtgg gcaagcctgg
     3181 ggaggcaagt attgaggttc cagacaaact catgacactt ccctgtctgc agccagaggt
     3241 gggcactgag gcatcccatg ttggtgtccc ttccctctct ctcccctctg tggagcttga
     3301 cttgcctggg gccctgggcc tggagggaca agtccaagaa gctgtcccag gcaaagtgga
     3361 gaagccagag ggccccaggg tagcagtggg tgttggagag gtgggctttc gtgtgccctc
     3421 tgtggagatt gtcactcctc agctgcccac agttgaagtt gagaaagagc agctagagat
     3481 ggtggagatg aaagtcaaac cctcttccaa gttctctctg cccaaattcg gactttcagg
     3541 gcccaaagct gtcaagggag aggtggaggg gcctgggcga gccaccaagc tgaaggtttc
     3601 caagtttacc atctcacttc ccaaagctcg agcagggact gaggccgaag cgaagggagc
     3661 tggggaagcc gggttgctgc cagcgctgga tctgtccatc ccacagctca gcctggatgc
     3721 ccagctgccc tcaggcaagg tggaagtagc tgatagcaag cctaaatcgt ccagatttgc
     3781 tctgcccaag tttggggtga aaggccggga ctctgaggct gatgtactgg tggcagggga
     3841 ggctgagctt gagggaaagg gttggggctg ggatgggaag gtgaagatgc ccaagctgaa
     3901 aatgccatct tttgggttgt cccgaggaaa ggaagcagaa actcaggatg gacgtgtcag
     3961 ccccggggaa aagctggagg ccatagctgg gcagcttaag atccctgcgg tggaattggt
     4021 cacaccggga gctcaggaga cagagaaggt caccagtgga gtgaagccgt caggcctcca
     4081 ggtgtccacc actgggcagg tggttgcaga gggccaggag agtgtgcaga gggtgtccac
     4141 actaggtatc tctttgcccc aggtggaatt ggccagcttt ggggaggcag gccctgagat
     4201 cgtagcccct tctgcagagg gcacagcagg ctctagggtc caggtgccac aggtgatgct
     4261 ggagctacct ggaacccagg tggcaggggg tgatctgtta gtgggtgagg gcatcttcaa
     4321 gatgcccaca gtgacagtgc cccagctaga gctggatgtg gggctgggcc atgaagccca
     4381 ggctggtgaa gcagccaaga gtgagggtgg gataaagttg aagttgccca cactggggac
     4441 cggaagcaga ggagagggcg ttgagcccca gggccccgag gcccagcgca ccttccacct
     4501 ctcattgccc gatgtggaac tcacgtcacc agtgagtagc cacgctgagt accaggtagt
     4561 tgagggtgat ggggatggtg ggcacaaact caaggttcgg ctgcccctgt ttggtctggc
     4621 aaaggccaag gaagggatag aagttggaga aaaggctaag agtccaaagc tcaggctacc
     4681 ccgagtgggc ttcagccaga gtgagtcggt ctccggagaa ggctctccaa gtcctgagga
     4741 ggaggaagaa ggcagtgggg aaggggcttc cagtcgccgg ggtagggtaa gggtccgcct
     4801 gcctcgggta ggcttggctt ccccttctaa agtctctaag ggacaggagg gtgatgcaac
     4861 ctccaagtcc ccagttgggg agaagtcacc caaattccgt tttcctaggg tgtccttaag
     4921 ccccaaggcc cggagtggga gtagggaccg ggaagaaggt ggattcaggg tccgactgcc
     4981 cagtgtggga ttttcagaaa cagcagttcc aggttccacc aggattgagg gaacccaggc
     5041 tgctgccatc tgaagcccca ggacagctgt ggattccccc tcttgtcttt ccattcccca
     5101 gcctagcccc ccattttgtg tgtgacatta ctagcactaa tcctcagagg gcttgaaggt
     5161 gggtaactga ctcaggcagg agccagtggc ctgtgccacc tcattggcca aagtgcctgt
     5221 atatcatgtc aaactatggg aataaaataa ttcaaaagtt
//
