LOCUS       NM_173347               3160 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus prune exopolyphosphatase (Prune1), mRNA.
ACCESSION   NM_173347
VERSION     NM_173347.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3160)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3160)
  AUTHORS   Wu,X., Simard,L.R. and Ding,H.
  TITLE     Generation of Conditional Knockout Alleles for PRUNE-1
  JOURNAL   Cells 12 (4), 524 (2023)
   PUBMED   36831191
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3160)
  AUTHORS   Nistala,H., Dronzek,J., Gonzaga-Jauregui,C., Chim,S.M.,
            Rajamani,S., Nuwayhid,S., Delgado,D., Burke,E., Karaca,E.,
            Franklin,M.C., Sarangapani,P., Podgorski,M., Tang,Y.,
            Dominguez,M.G., Withers,M., Deckelbaum,R.A., Scheonherr,C.J.,
            Gahl,W.A., Malicdan,M.C., Zambrowicz,B., Gale,N.W., Gibbs,R.A.,
            Chung,W.K., Lupski,J.R. and Economides,A.N.
  TITLE     NMIHBA results from hypomorphic PRUNE1 variants that lack
            short-chain exopolyphosphatase activity
  JOURNAL   Hum Mol Genet 29 (21), 3516-3531 (2021)
   PUBMED   33105479
REFERENCE   4  (bases 1 to 3160)
  AUTHORS   Carotenuto,M., de Antonellis,P., Chiarolla,C.M., Attanasio,C.,
            Damiani,V., Boffa,I., Aiese,N., Pedone,E., Accordi,B., Basso,G.,
            Navas,L., Imbimbo,C. and Zollo,M.
  TITLE     A therapeutic approach to treat prostate cancer by targeting
            Nm23-H1/h-Prune interaction
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 388 (2), 257-269 (2015)
   PUBMED   25138575
  REMARK    GeneRIF: A therapeutic approach to treat prostate cancer by
            targeting Nm23-H1/h-Prune interaction
REFERENCE   5  (bases 1 to 3160)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3160)
  AUTHORS   Carotenuto,P., Marino,N., Bello,A.M., D'Angelo,A., Di Porzio,U.,
            Lombardi,D. and Zollo,M.
  TITLE     PRUNE and NM23-M1 expression in embryonic and adult mouse brain
  JOURNAL   J Bioenerg Biomembr 38 (3-4), 233-246 (2006)
   PUBMED   17033939
REFERENCE   7  (bases 1 to 3160)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3160)
  AUTHORS   Forus,A., D'Angelo,A., Henriksen,J., Merla,G., Maelandsmo,G.M.,
            Florenes,V.A., Olivieri,S., Bjerkehagen,B., Meza-Zepeda,L.A., del
            Vecchio Blanco,F., Muller,C., Sanvito,F., Kononen,J., Nesland,J.M.,
            Fodstad,O., Reymond,A., Kallioniemi,O.P., Arrigoni,G., Ballabio,A.,
            Myklebost,O. and Zollo,M.
  TITLE     Amplification and overexpression of PRUNE in human sarcomas and
            breast carcinomas-a possible mechanism for altering the nm23-H1
            activity
  JOURNAL   Oncogene 20 (47), 6881-6890 (2001)
   PUBMED   11687967
REFERENCE   9  (bases 1 to 3160)
  AUTHORS   Reymond,A., Volorio,S., Merla,G., Al-Maghtheh,M., Zuffardi,O.,
            Bulfone,A., Ballabio,A. and Zollo,M.
  TITLE     Evidence for interaction between human PRUNE and nm23-H1 NDPKinase
  JOURNAL   Oncogene 18 (51), 7244-7252 (1999)
   PUBMED   10602478
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057546.1.
            
            On Dec 20, 2003 this sequence version replaced NM_173347.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057546.1, SRR1660821.35127.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3160
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..3160
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /note="prune exopolyphosphatase"
                     /db_xref="GeneID:229589"
                     /db_xref="MGI:MGI:1925152"
     exon            1..492
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1818
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /EC_number="3.6.1.1"
                     /note="protein prune homolog"
                     /codon_start=1
                     /product="exopolyphosphatase PRUNE1"
                     /protein_id="NP_775482.1"
                     /db_xref="CCDS:CCDS17610.1"
                     /db_xref="GeneID:229589"
                     /db_xref="MGI:MGI:1925152"
                     /translation="MEDYLQDCRAALQDSRPLHVVLGNEACDLDSMVSALALAFYLTK
                     TSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIPEPALIFRDEIDLLALHQAGQLTL
                     ILVDHHILPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVTERILQGA
                     PETLDRQTAALLHGTIILDCVNMDTNIGKATPKDSKYVEELEALFPDLPKRKDIFDSL
                     QKAKFDVSGLTTEQMLRKDQKTVYRQGTKVAISAIYMDLKAFLQRTDLFTDLSSFCHD
                     HSYDALVAMTIFFNTQNEPVRQLAIFCPHEALRMTICGILERSTSPPLKLTPIPSTSP
                     NLQAYHQGNTQVSRKKLLPVLQEALSAYLDSAKMASGQSEVAVGMSREQVDKDLDKAS
                     NSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKFSAEAVFEKCSQISLSQSARAC
                     TSNK"
     exon            493..585
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..788
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..973
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1132
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1227
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1386
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..3140
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3117..3122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /note="hexamer: ATTAAA"
     polyA_site      3140
                     /gene="Prune1"
                     /gene_synonym="9230112O05Rik; C130058A12; DRES-17; HTCD37;
                     Prune; Prune-M1; PRUNEM1"
                     /note="major polyA site"
ORIGIN      
        1 atttacatca atctcgaaca gattttcggt gtaatatatg gaaaggtact atacttagtc
       61 ctatctgcaa gttcagatgc cataaaggcg agttattgtg acacatacac aatttgcatg
      121 tcatagccct ccgaaaactg ctcacttgag gacaaacacg agctgctgga ctacatttcc
      181 caggaggcac cgcgatatac catactcctc cttgacgtcc catgagtctt tgggctcaga
      241 acccagcctc tgccgctggg gggcggggca acgccggact cccggagtgc cggattacgc
      301 acttcctcct ggggttcgga ggccgaaccc tttagtggcg ggttcgagtc ccgccccctg
      361 actctcggct ctagacccta ggtctagggc ggggtacatt ctgccgggtt acctctcctg
      421 gctgaggggc aacggcacac ctcgggcttt accatggagg actacctgca ggactgtcga
      481 gccgctttgc aggattccag gcctctacat gtcgtgctgg gaaatgaagc ctgcgactta
      541 gactccatgg tgtctgctct cgccttggcc ttctacctaa caaagacgtc tgaagctgaa
      601 gacatcttta taccagtttt aaatataaag cgttctgagc ttcctctgcg cggggacaat
      661 gtcttctttc tccaggaggt taagattcca gagccagccc tgatcttccg ggacgagatt
      721 gacctcctag ccctgcacca ggctggccag ctcaccctca tccttgttga ccaccatatt
      781 ttacccaaaa gcgatgcagc tctggaggag gccgtagcag aggtgctgga ccaccgacca
      841 attgagcaga aatactgtcc tccctgtcac gtttcagttg agctggtggg gtcctgtgcc
      901 accctggtga cagagagaat cctgcagggg gcaccagaga ccttggacag acaaactgca
      961 gccctactgc atggaaccat catcctggac tgtgtcaaca tggataccaa cattgggaag
     1021 gcaaccccaa aggacagcaa atatgtggaa gaactggaag cccttttccc agatctgccc
     1081 aaaagaaagg acatatttga ttccctgcag aaggccaagt ttgacgtctc aggactgacc
     1141 actgaacaga tgctcagaaa ggaccagaag acagtctaca gacagggcac caaggtggca
     1201 atcagtgcaa tctacatgga cttgaaggcc tttctgcagc ggacagacct cttcacagat
     1261 ctcagttctt tctgccatga tcacagctat gatgccctgg ttgccatgac tatctttttc
     1321 aacactcaaa atgagccagt acggcaatta gctatcttct gtccacacga ggcacttcga
     1381 atgacaatct gtggcatcct ggaacgatcc acctccccac ccctgaagct gacacctatc
     1441 ccaagcacct cccctaacct ccaggcctat caccaaggca acacccaggt ctctcggaag
     1501 aagctgctgc ctgtgctcca ggaagccctc tccgcatatc ttgactcagc gaagatggct
     1561 tcggggcagt ctgaggtagc tgtgggtatg tctagggagc aggtggacaa ggacttggac
     1621 aaggcaagta actccctgat ttctgggctg agtcaagatg aggaagaccc tccgctgcca
     1681 cccacgccta tgaacagctt ggtggatgag tgccctctgg atcaggggct gcctaagttc
     1741 tccgctgagg ctgtctttga gaagtgcagt cagatctcac tatcccagtc tgccagagcc
     1801 tgcacatcaa ataagtgacc attggaagta gggtggggaa gtgtggagga ggtgactggc
     1861 ctgcctcaaa tgcatgtttt gagatgtttg accacttcag caactacgtc agtggcttca
     1921 ggatcgggtg tactgttctc ataaccttgg gaggagaaag agaaagagag cggctgctgt
     1981 agggacagct ctctgcctct cctctcctgg ctctaccagt aagacaagat ttatttaatt
     2041 ttattattta atctgcactg attttcctgt ctttggtggg tacagtgtga taggaccact
     2101 gtcctggcag agcaggacta aaggaatgta gaccccatct cagtgtcttc agaaggactg
     2161 tgaacagagg cagcgtctgc catgaaacca gttcaccgct cctctccatg aattgacctt
     2221 ttcaattttt ttaaagttat ttttgagaca gagcctcatg tagcccaggc tggccttgag
     2281 ctctgtatgt atctgaggct agtcctgaat tcctaactct cctgagtgct gagattgtca
     2341 agcactgcat taaacctggc tggtctcttg tcttgacttc ctatatcttt ggctccttct
     2401 gtctcagaat gatgggaagc ctgacgggga cctgaggatt gaggtccttg ctttctcctg
     2461 gtggccatgg gacctcagag gcatttttgc caagagggca gaacctgact gagccctgga
     2521 tatcccctgt cttagtgggt ctgccaaggt cttgtcagtc tttttctggt tttgctcaag
     2581 ttgaagaatg cgtggagagt cttctggtga gacatcctct gtcccgggtc ccatttcccc
     2641 acctgtaact gaggttagga aaagatgtgc ccttccttcc tcccagcctt tctcccctct
     2701 gcttcctcat tacttttgtc ctccctggga gcgttcgcgc tctgggtcac tggattgttt
     2761 cgtgtttatg tgtgattgta ccaaggaact tagcctcatg tagcatgtac agggttgtaa
     2821 tggtgaccca gcagcgagct ctctcccagt aatttgttcc gcatgtgtag tctcccctcg
     2881 cctcccccac ctcccatccc ccttttttcc aatcaagctg tttcccctgt tcttacccta
     2941 tataagttgc aaacaatatc gctgaacagt agggtgtgtg gtggtttggg gcagtctgac
     3001 ttcactttag tgtatgacgt ctgtagccaa tgggaacgtg aaatattggt gcgatcactg
     3061 aaccaaaggg attgtgttct gtgactttgg tactttgttt tgcatttttg tttcatatta
     3121 aatactttct ttctgtttga aaaaaaaaaa aaaaaaaaaa
//
