LOCUS       NM_011178                974 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus proteinase 3 (Prtn3), mRNA.
ACCESSION   NM_011178
VERSION     NM_011178.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Liu,H., Sun,L., Zhao,H., Zhao,Z., Zhang,S., Jiang,S., Cheng,T.,
            Wang,X., Wang,T., Shao,Y., Zhu,H., Han,H., Cao,Y., Jiang,E., Cao,Y.
            and Xu,Y.
  TITLE     Proteinase 3 depletion attenuates leukemia by promoting myeloid
            differentiation
  JOURNAL   Cell Death Differ 31 (6), 697-710 (2024)
   PUBMED   38589495
  REMARK    GeneRIF: Proteinase 3 depletion attenuates leukemia by promoting
            myeloid differentiation.
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Kawataka,M., Ouhara,K., Kobayashi,E., Shinoda,K., Tobe,K.,
            Fujimori,R., Mizuno,N., Sugiyama,E., Ozawa,T. and Kishi,H.
  TITLE     N-glycan in the variable region of monoclonal ACPA (CCP-Ab1)
            promotes the exacerbation of experimental arthritis
  JOURNAL   Rheumatology (Oxford) 62 (12), 3968-3977 (2023)
   PUBMED   36944270
  REMARK    GeneRIF: N-glycan in the variable region of monoclonal ACPA
            (CCP-Ab1) promotes the exacerbation of experimental arthritis.
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Ugur,M., Labios,R.J., Fenton,C., Knopper,K., Jobin,K., Imdahl,F.,
            Golda,G., Hoh,K., Grafen,A., Kaisho,T., Saliba,A.E., Grun,D.,
            Gasteiger,G., Bajenoff,M. and Kastenmuller,W.
  TITLE     Lymph node medulla regulates the spatiotemporal unfolding of
            resident dendritic cell networks
  JOURNAL   Immunity 56 (8), 1778-1793 (2023)
   PUBMED   37463581
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Ortega-Gomez,A. and Soehnlein,O.
  TITLE     Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic Lesions
  JOURNAL   Thromb Haemost 120 (6), 994-997 (2020)
   PUBMED   32403136
  REMARK    GeneRIF: Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic
            Lesions.
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Mirea,A.M., Stienstra,R., Kanneganti,T.D., Tack,C.J., Chavakis,T.,
            Toonen,E.J.M. and Joosten,L.A.B.
  TITLE     Mice Deficient in the IL-1beta Activation Genes Prtn3, Elane, and
            Casp1 Are Protected Against the Development of Obesity-Induced
            NAFLD
  JOURNAL   Inflammation 43 (3), 1054-1064 (2020)
   PUBMED   32002713
  REMARK    GeneRIF: Mice Deficient in the IL-1beta Activation Genes Prtn3,
            Elane, and Casp1 Are Protected Against the Development of
            Obesity-Induced NAFLD.
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Sturrock,A., Franklin,K.F., Wu,S. and Hoidal,J.R.
  TITLE     Characterization and localization of the genes for mouse
            proteinase-3 (Prtn3) and neutrophil elastase (Ela2)
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 104-108 (1998)
   PUBMED   9925946
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Jenne,D.E., Frohlich,L., Hummel,A.M. and Specks,U.
  TITLE     Cloning and functional expression of the murine homologue of
            proteinase 3: implications for the design of murine models of
            vasculitis
  JOURNAL   FEBS Lett 408 (2), 187-190 (1997)
   PUBMED   9187364
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.
  TITLE     Secretory granule proteases in rat mast cells. Cloning of 10
            different serine proteases and a carboxypeptidase A from various
            rat mast cell populations
  JOURNAL   J Exp Med 185 (1), 13-29 (1997)
   PUBMED   8996238
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Aveskogh,M., Lutzelschwab,C., Huang,M.R. and Hellman,L.
  TITLE     Characterization of cDNA clones encoding mouse proteinase 3
            (myeloblastine) and cathepsin G
  JOURNAL   Immunogenetics 46 (3), 181-191 (1997)
   PUBMED   9211743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151846.3.
            
            On Jan 31, 2022 this sequence version replaced NM_011178.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U97073.1, U43525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC151846.3         120257-120334       c
            79-244              AC151846.3         119406-119571       c
            245-386             AC151846.3         118822-118963       c
            387-617             AC151846.3         117834-118064       c
            618-974             AC151846.3         116825-117181       c
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..974
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /note="proteinase 3"
                     /db_xref="GeneID:19152"
                     /db_xref="MGI:MGI:893580"
     exon            1..78
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..776
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /EC_number="3.4.21.76"
                     /note="myeloblastin"
                     /codon_start=1
                     /product="myeloblastin precursor"
                     /protein_id="NP_035308.2"
                     /db_xref="CCDS:CCDS23993.1"
                     /db_xref="GeneID:19152"
                     /db_xref="MGI:MGI:893580"
                     /translation="MAGSYPSPKGIHPFLLLALVVGGAVQASKIVGGHEARPHSRPYV
                     ASLQLSRFPGSHFCGGTLIHPRFVLTAAHCLQDISWQLVTVVLGAHDLLSSEPEQQKF
                     TISQVFQNNYNPEENLNDVLLLQLNRTASLGKEVAVASLPQQDQTLSQGTQCLAMGWG
                     RLGTQAPTPRVLQELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLICNGILHGV
                     DSFVIRECASLQFPDFFARVSMYVDWIQNVLRGAEP"
     exon            79..244
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /inference="alignment:Splign:2.1.0"
     exon            245..386
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /inference="alignment:Splign:2.1.0"
     exon            387..617
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..974
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      950..955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /note="hexamer: AATAAA"
     polyA_site      974
                     /gene="Prtn3"
                     /gene_synonym="mPR3; PR-3; PR3"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctggc catggctgga agctacccat cccccaaggg gatccatccc ttcctgctgc
       61 ttgccctggt ggttggtggc gcagtccagg cctccaagat tgtaggtggg cacgaggctc
      121 ggccccactc tcggccttat gtggcatccc tgcagctgag caggttccct gggagccact
      181 tctgtggtgg caccctgatc cacccgagat tcgtgctgac agccgcccac tgcctgcagg
      241 acatctcctg gcagcttgtg acagtggtgc tgggtgccca cgacctgctg agctcggagc
      301 ctgagcagca gaagttcacc atcagtcagg tcttccagaa caattacaac cccgaggaga
      361 acctcaatga cgtgcttctc ctccagctaa accggacagc ctccctgggc aaggaggtgg
      421 cggtggcttc tctgccccag caggaccaga ctctgtccca gggcacccag tgcctggcca
      481 tgggctgggg tcgcctgggc acccaagcac ccacgccccg tgtgctgcag gaactgaacg
      541 tcacggtggt caccttccta tgccgggaac acaacgtgtg cacgctggtg ccacggaggg
      601 cagcaggcat atgcttcgga gactcgggcg gccccttgat ctgcaatggc attcttcatg
      661 gagtggactc cttcgtgatc cgcgaatgcg cctccctcca gttccctgat ttcttcgccc
      721 gggtgtccat gtatgtggac tggattcaaa acgtgctgcg gggcgcagag ccctgaggtg
      781 cccttctgcg ctccaggcag cctaaagctg gggcgaccag caggctctag tgggaaaaaa
      841 atggagtggg gtggactaga cctttccagg cttttctttc acccacgcac ccacccacgc
      901 agcaccccct ggagtggagt cagctctgtt ccctattcca tatgacctca ataaaaactg
      961 agacatattt aaaa
//
