LOCUS       NM_175485               8764 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus protogenin (Prtg), mRNA.
ACCESSION   NM_175485
VERSION     NM_175485.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8764)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8764)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   4  (bases 1 to 8764)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8764)
  AUTHORS   Draganova,K., Zemke,M., Zurkirchen,L., Valenta,T., Cantu,C.,
            Okoniewski,M., Schmid,M.T., Hoffmans,R., Gotz,M., Basler,K. and
            Sommer,L.
  TITLE     Wnt/beta-catenin signaling regulates sequential fate decisions of
            murine cortical precursor cells
  JOURNAL   Stem Cells 33 (1), 170-182 (2015)
   PUBMED   25182747
REFERENCE   6  (bases 1 to 8764)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   7  (bases 1 to 8764)
  AUTHORS   Liu,L., He,B., Liu,W.M., Zhou,D., Cox,J.V. and Zhang,X.A.
  TITLE     Tetraspanin CD151 promotes cell migration by regulating integrin
            trafficking
  JOURNAL   J Biol Chem 282 (43), 31631-31642 (2007)
   PUBMED   17716972
REFERENCE   8  (bases 1 to 8764)
  AUTHORS   Hou,J., Charters,A.M., Lee,S.C., Zhao,Y., Wu,M.K., Jones,S.J.,
            Marra,M.A. and Hoodless,P.A.
  TITLE     A systematic screen for genes expressed in definitive endoderm by
            Serial Analysis of Gene Expression (SAGE)
  JOURNAL   BMC Dev Biol 7, 92 (2007)
   PUBMED   17683524
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8764)
  AUTHORS   Vesque,C., Anselme,I., Couve,E., Charnay,P. and
            Schneider-Maunoury,S.
  TITLE     Cloning of vertebrate Protogenin (Prtg) and comparative expression
            analysis during axis elongation
  JOURNAL   Dev Dyn 235 (10), 2836-2844 (2006)
   PUBMED   16881056
  REMARK    GeneRIF: Protogenin expression is restricted to posterior neural
            plate and mesoderm, with an anterior limit at the level of the
            rhombencephalon.
REFERENCE   10 (bases 1 to 8764)
  AUTHORS   Yamaza,H., Matsuo,K., Kiyoshima,T., Shigemura,N., Kobayashi,I.,
            Wada,H., Akamime,A. and Sakai,H.
  TITLE     Detection of differentially expressed genes in the early
            developmental stage of the mouse mandible
  JOURNAL   Int J Dev Biol 45 (4), 675-680 (2001)
   PUBMED   11461004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY630257.1, CT027588.10 and AC158997.2.
            
            On Jul 26, 2007 this sequence version replaced NM_175485.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ360114.1, AY630257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AY630257.1         71-563
            494-520             CT027588.10        80044-80070         c
            521-2087            AY630257.1         591-2157
            2088-2088           CT027588.10        30928-30928         c
            2089-4231           AY630257.1         2159-4301
            4232-8764           AC158997.2         54883-59415
FEATURES             Location/Qualifiers
     source          1..8764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..8764
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /note="protogenin"
                     /db_xref="GeneID:235472"
                     /db_xref="MGI:MGI:2444710"
     exon            1..259
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..3759
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /note="shen-dan; protein Shen-Dan; protogenin homolog
                     (Gallus gallus)"
                     /codon_start=1
                     /product="protogenin precursor"
                     /protein_id="NP_780694.3"
                     /db_xref="CCDS:CCDS23331.1"
                     /db_xref="GeneID:235472"
                     /db_xref="MGI:MGI:2444710"
                     /translation="MAPPVRPGMLPLLLLLLLPPLGSVPGVWSFSELFFMKEPQDATV
                     TRKDPVVLDCQAHGEGPIKVTWLKNGAKLSENKRIQVLSNGSLYISEVEGRRGEQSDE
                     GFYQCLAVNKYGAILSQKAHLTLSTISAFEVHPVSTEVHEGGVARFSCKISSTPPAVI
                     TWEFNRTALPTTMDRVTALPSGVLQIYDVGPEDAGNYRCVAATIAHKRKSMEASLTIV
                     AANETRSFYMPTIIASPQNVTASLHQTVVLECMATGYPRPIISWSRLDHKSIDVFNTR
                     VLGNGNLIISDVKLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPR
                     AGTARFVCQAEGIPSPKMSWLKNGRRIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAE
                     NSQGSVLSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHY
                     MKAEGLNNEEYQVVLGNDTTHYIIDDLEPDSNYTFYIVAYMPLGASQMSDHVTQNTLE
                     DVPLRPPEISLTSRSPTDILVSWLPIPAKYRRGQVVLYRLSFRLSTENAIQVVELPGT
                     VHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLN
                     CTTISVRWLQDTEDPAAIRGYKLFYKEEGQQEHGPIFLDTGDLLYTLSGLDPRRKYHV
                     RLLAYNNMEEGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPA
                     FTTAQVINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSS
                     PWSPVVYHSTLPEAPTGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKA
                     WIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKDAS
                     ESNQRPKRLDSSNAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKS
                     SASKTAQSGTQPLSQASASVAAGSDMGKNLERATETAESLVPMMPSSFIDAKGGTDLI
                     INSYGPIIKNNTKKKWLFFQDTKKIKVEQTQRRFTQAVCFYQPGTTVLISDEDSPGSP
                     GQTASFPRPFGATALDTEHSANSEGSHETGDSGRFSHESNDEIHLSSVISSTPPTSNP
                     LAGGDSDGDAAPKKHGDPAQPLPAEQTSAPQTSAGLRYAAEGFPV"
     exon            260..562
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            563..707
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            708..841
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..979
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1138
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1298
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1546
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1711
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2017
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2206
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2302
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2489
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2617
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2788
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2971
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3092
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3255
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3360
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..8764
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8659..8664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /note="hexamer: AATAAA"
     polyA_site      8692
                     /gene="Prtg"
                     /gene_synonym="A230098A12Rik; Igdcc5"
                     /note="major polyA site"
ORIGIN      
        1 tggacgcggc gcgcgtggtc cccgcggcct ggcgcactcg cggggctccg tgcgcctgca
       61 agcggcgcgt cgccttccca cgccggagca gcgggttgca gcaggagctg cgggtccagg
      121 agagcagcgg gagcagcggg cgcgggcgaa cagcccggga gcatgcccgc gcagccccgc
      181 tgaatggcgc ctcccgtgcg cccggggatg ctgcccctgc tgctgttgct gctactgccg
      241 ccgctcggct cggttccagg agtgtggagc tttagcgaac tgtttttcat gaaagaacca
      301 caggatgcaa cagtcacaag gaaagaccca gtcgttttag attgccaggc acacggagaa
      361 ggccccatta aggtcacatg gttgaaaaat ggagcaaaat tgtccgaaaa taaacggatc
      421 caggttctat ctaacggctc tctatacatc agtgaggtgg aaggcaggag gggagagcaa
      481 tcggatgaag gattttatca gtgtttggca gtgaacaaat acggggccat tcttagtcag
      541 aaagctcatc tgacattgtc aactatctct gcgtttgaag tccatccagt gtctactgag
      601 gtccatgaag gaggagttgc tagattttca tgcaagattt catcaacgcc gcctgcagtc
      661 ataacatggg aatttaatag aacagccctg cctacaacca tggacagggt gactgccctg
      721 ccatcaggag tgttgcagat ctacgacgtt ggcccggagg atgctgggaa ttaccgctgt
      781 gttgcagcta ctatagctca taagaggaaa agcatggagg cttcgctaac catagttgca
      841 gctaatgaga ccagatcctt ctacatgcca accattatag ccagtccaca gaatgtaacc
      901 gcatctctac atcagacagt tgtgctagag tgtatggcca caggatatcc cagacccatc
      961 atttcctgga gccgtcttga tcacaagtcc attgatgtct tcaacactcg ggtacttgga
     1021 aatggcaacc tcattatatc agatgtcaag ctgcagcatg ctggagtgta tgtttgtcgg
     1081 gccaccaccc caggcacacg taacttcaca gttgctatgg caacgttaac tgtattagct
     1141 cctccttcat ttgtcgaatg gcctgaaagt ttaacaaggc cacgagctgg cactgcacga
     1201 tttgtgtgcc aagcagaagg aattccctca cccaaaatgt cctggttgaa aaatgggaga
     1261 aggatacatt caaatggcag gattaaaatg tacaacagca aattggtcat taatcagatt
     1321 atcccggaag acgatgctat ctatcagtgc atggctgaaa acagccaagg atctgttctg
     1381 tctcgagcca gactgactgt ggtaatgtcg gaagatagac ccagcgctcc ttacaacgtt
     1441 catgctgaga ccatgtcgag ctctgctatc cttctggctt gggagagacc actgtacaat
     1501 tcagacaagg tcatcgccta ctctgtacac tacatgaagg cggaaggttt aaataacgag
     1561 gaatatcagg tggtccttgg aaacgacacg actcattaca tcattgatga cttagaaccc
     1621 gacagcaact atactttcta cattgtggcg tacatgccgc tgggggccag ccagatgtcg
     1681 gatcatgtga cacagaacac gctagaagat gtgcccctaa gacctcccga aattagcttg
     1741 acgagtcgaa gtcccaccga cattctcgtc tcctggctgc caatcccggc caagtaccgg
     1801 cggggccaag tggtgctgta ccgcctgtcc ttccgcctga gcactgagaa cgccatccaa
     1861 gttgtagaac tcccggggac cgtgcacgag taccttctgg aaggcctgaa gccagacagt
     1921 gtctatctgg ttcggattac tgcagctacc cgtgtggggc tgggagagtc gtcggtgtgg
     1981 acctcacaca ggacgcccaa ggctacgagc gtgaaagccc cgaagtctcc tgaactgcat
     2041 ttggaaccac tgaattgtac taccatctct gtgaggtggc tgcaagacac agaggacccg
     2101 gccgctattc ggggctacaa gctgttttat aaagaggaag ggcagcaaga acacggacct
     2161 atcttcctag acaccggtga cctgctgtat acgctcagtg gcttggaccc cagaagaaaa
     2221 taccacgtga ggctcctggc ttacaacaac atggaagaag gctaccaggc cgaccagact
     2281 gtcagcactc ccggatgcgt gtccgtccgt gatcgcatgg tccctccacc accgccaccc
     2341 caccatctct acgcgaaggc gaatacctcc tcttccatct tcctgcactg gaggaggcct
     2401 gcgttcacca ccgcccaagt cattaactac accatccgct gtaaccctgt tggcctgcag
     2461 aatgcctctc tggttctcta cctgcaaaca tcagaaaccc acatgctggt ccaaggacta
     2521 gaaccaaaca ccaagtatga atttgctgtc cgactgcatg tggatcagct gtccagtccc
     2581 tggagtcctg tggtctacca ttctacattg ccagaagcac ccacaggccc cccggtaggg
     2641 gtaaaggtga ccctgataga agacgacact gcccttgttt cctggaaacc cccagatggc
     2701 ccagagacag tggtgacacg ctacaccatc ttgtatgctt ccaggaaggc ctggattgcg
     2761 ggagagtggc aggttcttca ccgagaaggg gcaatcacca tggctttgct ggaaaacctg
     2821 gtggcaggga acgtgtacat tgtcaagata tctgcgtcca acgaggtggg agaagggccc
     2881 ttttcaaact ccgtggagct ggccgtcctc cccaaggatg cttcagagtc gaaccagagg
     2941 cccaagcgtt tggattcttc caatgccaaa gtttattccg gctattacca tctggaccaa
     3001 aagtcaatga cgggcatcgc agtaggcgtt ggcatagcct tgacctgtat cctcatctgt
     3061 gttctcatct tgatctaccg aagcaaagcc aggaagtcat ccgcctctaa gacagcgcag
     3121 agtggaaccc agccgttatc ccaagccagt gcctctgtag cagcagggag tgacatgggg
     3181 aagaacctgg agagagctac agagactgca gagtccttgg tacccatgat gcccagcagc
     3241 ttcattgacg cgaagggagg gactgacctg atcatcaata gctacggtcc tataattaaa
     3301 aacaacacta agaaaaagtg gctttttttc caagacacta agaaaatcaa agttgaacag
     3361 actcaaagaa gatttactca ggccgtctgc ttttaccagc cgggcaccac cgtgctgatc
     3421 agcgatgaag attcccccgg ctccccaggc cagaccgcca gcttcccaag accttttggg
     3481 gctactgccc ttgacacaga gcattcagcg aacagtgaag gcagccatga gacaggggat
     3541 tccggaaggt tttcccatga gtccaatgat gagatacacc tgtcctccgt catcagcagc
     3601 acgcccccca cctcgaatcc cctcgctggt ggcgattctg atggggatgc tgcaccgaag
     3661 aagcacggag accctgcgca gcccttgcca gctgagcaga cctcagctcc gcagacatct
     3721 gcggggctgc gatatgctgc cgagggtttt ccggtctaga cagccacgct cagggattca
     3781 caacaagcac ctgttcgaag gacaatgagc agggagccaa agccttttgt gaaaatcttg
     3841 atgtcttact gtttattgtt tgttttgttt gtttgttttt tatctttttt tttaaactat
     3901 ttttaagctt acgaattttg aatgtttcaa ctgtcaacaa tgtgaaaaag ggcagtcaag
     3961 atgcttgact ggactctaag ataaatcact ggagcggagg gaagactgcc taagccctct
     4021 gctgaatagc tacctcagtt tgctgtgggc agactctgaa gacaactgtg ctgccttctt
     4081 cgagtgctgg tttctctcag tggcataacc agcgggactt gctagtgacg ctgtgtgtcc
     4141 attgtgtgtg tgctgtgtgt gactgaagga gtccgatagg taggagagga aagatgttga
     4201 tctgaagctc tgattttttt tttttttttt taaagaaccg tgataatgta acacctctgg
     4261 ctgtgaggag aaaatatggg agtatattta tttgaatgga agaaacaaat acgtctcttt
     4321 ggagaagaga acattccata gtacataggg gatcgtgtcc ttgcaaagct gttgggtttg
     4381 ggacaccaga gcaggagaat tttgctccag cctgcatcag cctgccctca gcctgcaaaa
     4441 ccacctttcc ctttgctcca cagccggcca agggctgcgc tgtcttgtgg aacgttttca
     4501 aagtttacag agctagctgc aaaatacaat gtaggaaagt ggattttttt tttaatggtt
     4561 cagattttct tttttaaaat ctcagtttgg cttcaaatgg ggcaaagaag aaatgttatt
     4621 aaatattaag aatgaagata aacgaaacag tagagattaa gacagacttg aggttttcat
     4681 aatagcagtg ccttccattg tgagaaattt tgccttatac ctttttaata ttcacgaaga
     4741 tgtttaggaa aaaaggtacc aaaaatttgc cttaaaaaaa aaaaagcttg gatcttagcg
     4801 atagctgtgc tatctggcac cttgatgaag ctgctctctt tttgaagctc aggtttgctc
     4861 cctatcaccc tggcggctga actctggctt cgtagcccac taacactcca gaagcgagtt
     4921 cattctctgg tttaaaatca acaaattgtc tcctcttctg atccggcagc cttctccgtc
     4981 acaaggcaac atgctaggtg ccgagccacg tgggaaggac aaagactgag ctgtgaaaag
     5041 aagaaacaag tccttagcct tttaaaatca tgagttttgc cctccctgaa atttttttgg
     5101 aagtggcttt gaattgcatt ttaaaagaaa agccctccgt gggttttccc ttgaaaccgt
     5161 ccctccatgc acagacaagg caggtcctgc caaatggtgt tatcacccca gtgtcatcta
     5221 ttgcgaaagc ctgacactgc cacagttttc atcgtcattc taagttttgt gccaaattgg
     5281 actttcttag aagcccaggc actactcagc acagttctgt cccattcacc atgggcttct
     5341 cggcaaaatg gggggaaaaa agaaagaaga aagaaaaaaa aaaaaagcag agctttaggt
     5401 aaacagtcgg aggggagaaa aaatggcttc cttcccctgc cttcgcgctc ctgtttatac
     5461 tacctccttt ttaaagttat tctagtgtta ttgttctttc ctgtactcag ggactttttt
     5521 gttactcttg agctcatgtt gcatgggcgg gtgcattgac agggtatggt ggtgtttggt
     5581 tcgtaagtag aagtacgtgg gccaacttct ctcagtatct aaaatgaagg gcacaatggg
     5641 atcacaagtc agaagcaaac agatcgaaaa ggggaaagca ggtttaaggc catgcatatt
     5701 taaaccgtgt tccctgcctg gatcatccga aaggctggga caggacattt ctggaagaac
     5761 gtgctctgtt taatgataaa taggccctta gttatgatag gtctttagct tataattatt
     5821 tactagttca ttttttgttc ttatacagac ttttctgtca attctgttac caaagaattt
     5881 tcagtagaca gtaaaatttc tatgataagt accttaaatc caattcacta gaaacagata
     5941 tagactcgaa tataaacaat ttctaaccct aatctgaagg gtttatattg atagttaaaa
     6001 ttaattaggc tagtgacata aactacctta ccgtcaccag agtttaaaat aaattttaat
     6061 ttccttgcca gcatatggtt acaaactctt taaactgtaa ggtttttttt ttctccagca
     6121 agtaacgaaa ccttcaactc tatagtatta atgtattttc taattgttga aattacttgt
     6181 tggagagaaa aaaataaata ttactactaa tgtcatggac taaagtattt aatgttcaac
     6241 agaggtttta ggcttggtga aagccagcct ctctgaagtc tgaagtacga aattccaact
     6301 aaagtgtgaa ggttatcatg tcttcctcga ggtttcatta ttcatcgtat tcaactccaa
     6361 ataagctgac atgcaaatta gaaactgttt cattttccaa aaacgtattt gctggaagcg
     6421 gtgataacct ggctgcctgt cattttttaa tgtcaaatat tacaatatac tgctcatcgg
     6481 tattttcata ccaaagacca ttaaaatata tagtttagcc tgtaagtaaa gatgagcagg
     6541 tttaaagtaa atttatttag aaacagatag ggaatatagc tttagtggca aaaagaaaat
     6601 atcaaaaggc taagtttaca tagttaaaag caatacagtt atattggtat ttatcagtgt
     6661 tttttattcg agtactttat atcagcaaat taaaaagaaa ttaaaaacca aagatattta
     6721 aggttacctc agaatatagg aaagtttagc tgtacattga actgttgttt gttgttttgt
     6781 gttaacaaac tgtctctcca gaacctctcc tctgtgcaga cagcgtcctg aggatttatt
     6841 tccatggtgt ctgctcactc agtctcaggt gtgtttttac tacatggtgt gctgcttcca
     6901 tacagcctgt gagggtgata ggtcggcaga gagagcatca ggcttgtctg tattgtggga
     6961 acccctacat cattctaagt cgtctgcatt cctatgtaaa gtccttctct agatactcag
     7021 acagcttgag gaaaccaaaa ggtgccactg ttcggacggg cagtgctttg ggttcaaata
     7081 cggttcctaa atcataagat tttcattgcg tcgaaaagct ggctttcgat ctcaagtgaa
     7141 accctgttaa agtgccaggg ggtgagatgc tcctgatgtg tttgttagaa gctctcttgc
     7201 ctttacctca gacacgagca atggcagcaa tgcagcagag actggggtac gcactgctgt
     7261 ctctcttctg caggacttct gcaaacagca taaaaaaggc tcatagctga ccagtcagga
     7321 gcaccgctta agtccccgcc attggaaaca gtgcttcctg tcatcgaagg ctggggtggt
     7381 tcactcctgt catcaattgc agcagtcgga ggaagggggc agcatgcatt ttaggaagtc
     7441 agagcctgct gtaattcatg gttcgattct gtacatttgc atatcatcag atgtccattt
     7501 tgaataccag atgtggaaaa agagtttgaa ctgtattgta aagagctggt acctgaagca
     7561 accatgtatt ttgcaagatt ttcttcctga aaatttacta catgcatcac tgataaaatt
     7621 gctttggtag aagtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaatcact cctgggctgt
     7681 gtgagcacag agtggtgggt tctggagacc accacccata tctgtctgtc taattgtgaa
     7741 ttttgttgac atttagaagg caaccatagg ttttatgcca ggttgtccat gctcaggaca
     7801 caagttcaca ggctatcgcc atgcttctgt tacaggctta tctagcagac gggtactgaa
     7861 ttcattttct tgcaattttt ctaacaaacc agcacgaact tagtgtctgt aaacagcacc
     7921 gcacagtgtt gaaggtctgt aggtcagaac tctttctttt tgaggcagtt tcctgctgta
     7981 aaaccctctc tgtcctggaa cctgctgtat gtataaacca ggctggcttt gaaccagtgg
     8041 ggaccctgct gcctcagcct atctttaaaa aacaaaactg cttttcaatg ggtttttctt
     8101 atttgccctg tcctgtagta tctggtccat tcccaaacta aaacccttcc tgcagataag
     8161 cctgaacaca gatgtgcctc tgcctcttag tagggcttag gagatatatt aagaaaatgt
     8221 gtctgtcagt tactgttgtt ggacaaaagt ttatgtctgt atgtgtagga attttttttc
     8281 tatttcaaag atgtgaattt aatgaagtgt gggagccagt taagttattt tctgtagtgg
     8341 gtgttctggg tcctgccact ctctgcttcc ttgtaagggc accatttcct ggcttcctgg
     8401 tggactgtgg agctgggtta cattcgattt ctgcttgtct caggggacca gctctgcagg
     8461 ctccatctca tgaagaaagt gaatgtttgc cttgattttg aatgtatttt taaaaatgtc
     8521 ttcttaaaac atattttttg tttaataatg tgggtttgtt ttcttttcct agcatgatag
     8581 taaatattgc ttagtacccc acatccctac cctacccctg gaagtttata ttctacccta
     8641 caggtcatgc caaaaatgaa taaaagttta aatgccaaaa tgtttattga aactgctgtc
     8701 tacatattga ttgattgcac agtttaaata aaacctttcc ttagttttaa aaaaacaaaa
     8761 acaa
//
