LOCUS       NM_133351               1841 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus serine protease 8 (prostasin) (Prss8), transcript
            variant 1, mRNA.
ACCESSION   NM_133351
VERSION     NM_133351.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Ehret,E., Stroh,S., Auberson,M., Ino,F., Jager,Y., Maillard,M.,
            Szabo,R., Bugge,T.H., Frateschi,S. and Hummler,E.
  TITLE     Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and
            CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
  JOURNAL   Cells 12 (19), 2342 (2023)
   PUBMED   37830556
  REMARK    GeneRIF: Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8
            and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Ishii,T., Miyasato,Y., Ichijo,M., Uchimura,K. and Furuya,F.
  TITLE     Membrane protease prostasin promotes insulin secretion by
            regulating the epidermal growth factor receptor pathway
  JOURNAL   Sci Rep 13 (1), 9086 (2023)
   PUBMED   37277555
  REMARK    GeneRIF: Membrane protease prostasin promotes insulin secretion by
            regulating the epidermal growth factor receptor pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Vuagniaux,G., Vallet,V., Jaeger,N.F., Pfister,C., Bens,M.,
            Farman,N., Courtois-Coutry,N., Vandewalle,A., Rossier,B.C. and
            Hummler,E.
  TITLE     Activation of the amiloride-sensitive epithelial sodium channel by
            the serine protease mCAP1 expressed in a mouse cortical collecting
            duct cell line
  JOURNAL   J Am Soc Nephrol 11 (5), 828-834 (2000)
   PUBMED   10770960
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Ashby,B.
  TITLE     Co-expression of prostaglandin receptors with opposite effects: a
            model for homeostatic control of autocrine and paracrine signaling
  JOURNAL   Biochem Pharmacol 55 (3), 239-246 (1998)
   PUBMED   9484788
  REMARK    Review article
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Hogan,M.E., King,L.E. Jr. and Sundberg,J.P.
  TITLE     Defects of pelage hairs in 20 mouse mutations
  JOURNAL   J Invest Dermatol 104 (5 Suppl), 31S-32S (1995)
   PUBMED   7738386
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   MacSwiney,F.J. and Wallace,M.E.
  TITLE     Genetics of warfarin-resistance in house mice of three separate
            localities
  JOURNAL   J Hyg (Lond) 80 (1), 69-75 (1978)
   PUBMED   621381
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Wallace,M.E. and MacSwiney,F.J.
  TITLE     A major gene controlling warfarin-resistance in the house mouse
  JOURNAL   J Hyg (Lond) 76 (2), 173-181 (1976)
   PUBMED   1063212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            On Jun 8, 2022 this sequence version replaced NM_133351.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038244.1, AF378085.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AC149222.4         23968-24264
            298-315             AC149222.4         24488-24505
            316-478             AC149222.4         26091-26253
            479-750             AC149222.4         26792-27063
            751-917             AC149222.4         27151-27317
            918-1841            AC149222.4         27422-28345
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.84 cM"
     gene            1..1841
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /note="serine protease 8 (prostasin)"
                     /db_xref="GeneID:76560"
                     /db_xref="MGI:MGI:1923810"
     exon            1..297
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1232
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /note="prostasin; channel activating protease 1; serine
                     protease 8; protease, serine 8 (prostasin)"
                     /codon_start=1
                     /product="prostasin precursor"
                     /protein_id="NP_579929.1"
                     /db_xref="CCDS:CCDS40147.1"
                     /db_xref="GeneID:76560"
                     /db_xref="MGI:MGI:1923810"
                     /translation="MALRVGLGLGQLEAVTILLLLGLLQSGIRADGTEASCGAVIQPR
                     ITGGGSAKPGQWPWQVSITYDGNHVCGGSLVSNKWVVSAAHCFPREHSREAYEVKLGA
                     HQLDSYSNDTVVHTVAQIITHSSYREEGSQGDIALIRLSSPVTFSRYIRPICLPAANA
                     SFPNGLHCTVTGWGHVAPSVSLQTPRPLQQLEVPLISRETCSCLYNINAVPEEPHTIQ
                     QDMLCAGYVKGGKDACQGDSGGPLSCPMEGIWYLAGIVSWGDACGAPNRPGVYTLTST
                     YASWIHHHVAELQPRVVPQTQESQPDGHLCNHHPVFSSAAAPKLLRPVLFLPLGLTLG
                     LLSLA"
     exon            298..315
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..478
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..750
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..917
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1841
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /note="hexamer: AATAAA"
     polyA_site      1731
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /note="major polyA site"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="Prss8"
                     /gene_synonym="2410039E18Rik; CAP1; fr; mCAP1"
                     /note="major polyA site"
ORIGIN      
        1 agaacaggtc cacgctggtc actgcagaga gactaaaggt gtgtcccgtc ttccccctgg
       61 ccattttctg ccgagaagcc tgcttcacct tcccagccta gatcctggga ttcctcactc
      121 tgatcccaca cctagatcct gccttcaaaa ccagccttct ggttcttccc tttctaccta
      181 ggggctcctt cggggggccc ttgtcctagg ccatggccct aagggtgggc ctgggacttg
      241 ggcagctgga agctgtgacc attctgctcc ttctcggatt gctccagtcg ggaatccgag
      301 ctgacgggac tgaagcctcc tgtggtgccg tcatccagcc acgcatcacc ggtggtggca
      361 gtgcaaagcc cggtcagtgg ccctggcagg tcagcatcac ctacgatggc aaccatgttt
      421 gtggcgggtc gctcgtgtca aataaatggg tggtgtctgc tgctcactgc ttccccagag
      481 aacacagcag ggaagcgtat gaggtgaagc tgggggccca ccagctagac tcctacagca
      541 atgacactgt ggtccacaca gtggctcaga tcatcaccca ctcaagctac cgagaagagg
      601 gctcccaggg ggacatcgcg ctcatccgcc tcagcagtcc tgtcaccttc tcccgctaca
      661 tcagacccat ctgcctccct gcagccaatg cctcctttcc caacggcctt cactgtactg
      721 tcacgggatg gggtcatgtg gctccttcag tgagcctcca gacccctagg cctctgcagc
      781 agctcgaggt accactcatc agccgggaaa cctgtagctg cctgtacaac attaatgcgg
      841 tgcctgaaga accgcacact atccagcagg acatgctgtg tgctggctat gtgaagggag
      901 gcaaggatgc ctgccagggt gactctgggg gcccactctc ttgtcccatg gagggcatct
      961 ggtacttggc aggcattgtg agttggggtg atgcctgtgg tgcccccaac aggcctggag
     1021 tatacactct gacttctacc tatgcttcct ggatccacca ccatgtggca gagctccagc
     1081 ctcgagttgt cccccagact caggagtccc agccggatgg ccacctctgc aaccatcatc
     1141 ctgtcttcag ctcagcggca gccccgaaat tgttaaggcc cgtacttttc ctgccacttg
     1201 gtctgaccct gggcctcttg tctttggctt gaacattaag ctatttaacc ctcaaagttg
     1261 accatgcttc caggaccaca gcacacccaa ggacatgtgc ctgtccggga gggcagcatg
     1321 ccgacttgat ctttgagccc actcgtctgc atttgttctt tgggattata taatctaggg
     1381 ccaagaagtt tactgcctgt ggagcgggca ggaactctag ccacctttct ctgttacctg
     1441 cagctgattg gcaaggctcc tatggagctc ccagaagcct cagctaggaa aatgagccct
     1501 cacttcagcc tgtatctagc acgtggggca gctgcctagc tgactgctgc acaaggctga
     1561 ctctgggctc tacccaccct gcctgatgag cccttcactt tgtcctcttc ctgcctcctg
     1621 ggctctgcct taatctcctg gactccggag gactgagccc ccaccggagc tggctggggc
     1681 ttgggtcagg gtgaggaata aaaggagcga ggaatcaatg tttttaacac agctggctgt
     1741 ctgtgagatg aaatgaagaa taccaccctt tggcatctct gcgtacctcc aaagtccagt
     1801 gcaccagcag attttacttt atgaataaat gacacaaaac a
//
