LOCUS       NM_175020                987 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus serine protease 58 (Prss58), mRNA.
ACCESSION   NM_175020
VERSION     NM_175020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Park,S., Shimada,K., Fujihara,Y., Xu,Z., Shimada,K., Larasati,T.,
            Pratiwi,P., Matzuk,R.M., Devlin,D.J., Yu,Z., Garcia,T.X.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched
            genes are dispensable for male fecundity
  JOURNAL   Biol Reprod 103 (2), 195-204 (2020)
   PUBMED   32561905
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161887.5.
            
            On May 2, 2007 this sequence version replaced NM_175020.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075754.1, BC048599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC161887.5         196944-197059       c
            117-201             AC161887.5         196726-196810       c
            202-340             AC161887.5         194399-194537       c
            341-597             AC161887.5         193977-194233       c
            598-737             AC161887.5         192267-192406       c
            738-987             AC161887.5         191934-192183       c
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.94 cM"
     gene            1..987
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /note="serine protease 58"
                     /db_xref="GeneID:232717"
                     /db_xref="MGI:MGI:3608323"
     exon            1..116
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            117..201
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..887
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /EC_number="3.4.21.4"
                     /note="putative inactive serine protease 58; putative
                     trypsin-X3; protease, serine 58"
                     /codon_start=1
                     /product="putative inactive serine protease 58 precursor"
                     /protein_id="NP_778185.1"
                     /db_xref="CCDS:CCDS20040.1"
                     /db_xref="GeneID:232717"
                     /db_xref="MGI:MGI:3608323"
                     /translation="MKLAFLCILSTLLRTFAYNPDHIAGTTPPYLVYLKSDYLPCTGV
                     LIHPLWVITAAHCNLPNLQVILGITNPADPMERDVEVSDYEKIFHHPNFLVSSISHDL
                     LLIKLKRRIKHSNYAKAVKLPQHIVSVNAMCSVSTWAYNLCDVTKDPDSLQTVNVTVI
                     SKAECRNAYKAFDITENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLR
                     ADVGIYASIFHYLPWIEDTMKNN"
     exon            202..340
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..597
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..737
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..987
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      945..950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /note="hexamer: ATTAAA"
     polyA_site      980
                     /gene="Prss58"
                     /gene_synonym="1700020H15; Tryx3"
                     /note="major polyA site"
ORIGIN      
        1 cttcctgcac aagtcaaaga gcaggaggct gtggagactt tgtgaacatc tctcttggat
       61 taagtaactt cttcaaaaga agacaaaatt gagatctaga cagcgtgagt gatcagagac
      121 actgagctaa aacccatctc aaaacagctt tcaacatcat aatgaagtta gccttcctct
      181 gcattctttc aaccctgctt cgtacctttg cctataatcc agatcacata gctggcacca
      241 cgccccccta cttggtctac ctgaagtctg attacttgcc ctgcactgga gtcctgatcc
      301 atcctttgtg ggtgatcaca gctgcacact gcaatttacc gaaccttcaa gtgattcttg
      361 ggataacaaa tccagcagat cccatggaaa gggatgtgga ggtgtctgac tatgaaaaaa
      421 tattccatca tccaaacttc ttggtctctt ctatttcaca tgacctcctg ttaatcaaac
      481 tgaaaagacg gattaaacat agtaactacg caaaagctgt caaactgcct caacacatcg
      541 tgtctgtgaa tgccatgtgc tccgtgtcta cctgggccta caatctatgt gacgtcacca
      601 aagaccctga ctcactgcag accgtgaatg tcactgtaat ctctaaggct gagtgccgta
      661 atgcctataa agcctttgac atcacagaaa acatgatctg cgtaggcatc gtgccagggc
      721 ggaggctgcc ttgcaaggaa gtcacggctg ccccagcagt ctgcaacggg gtactttatg
      781 gaatcttgtc ttatgcagat ggctgtgttt tgagagctga tgttggcatc tatgctagca
      841 tctttcacta cttgccctgg attgaagata ccatgaaaaa taactgagct cccacaacag
      901 gaggaattct gaaacatgtg acaaggcaca tccacaccct cacaattaaa ggaaatgggc
      961 tcattagacc gtgcgaggca caccggc
//
