LOCUS       NM_027084               2179 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus serine protease 56 (Prss56), mRNA.
ACCESSION   NM_027084 XM_487606 XM_906114
VERSION     NM_027084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2179)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2179)
  AUTHORS   Perrin,S., Protic,S., Bretegnier,V., Laurendeau,I., de
            Lageneste,O.D., Panara,N., Ruckebusch,O., Luka,M., Masson,C.,
            Maillard,T., Coulpier,F., Pannier,S., Wicart,P., Hadj-Rabia,S.,
            Radomska,K.J., Zarhrate,M., Menager,M., Vidaud,D., Topilko,P.,
            Parfait,B. and Colnot,C.
  TITLE     MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1
            loss in Schwann cells and skeletal stem/progenitor cells
  JOURNAL   Sci Transl Med 16 (753), eadj1597 (2024)
   PUBMED   38924432
  REMARK    Erratum:[Sci Transl Med. 2024 Aug 28;16(762):eads3171. doi:
            10.1126/scitranslmed.ads3171. PMID: 39196963]
REFERENCE   3  (bases 1 to 2179)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2179)
  AUTHORS   Koli,S., Labelle-Dumais,C., Zhao,Y., Paylakhi,S. and Nair,K.S.
  TITLE     Identification of MFRP and the secreted serine proteases PRSS56 and
            ADAMTS19 as part of a molecular network involved in ocular growth
            regulation
  JOURNAL   PLoS Genet 17 (3), e1009458 (2021)
   PUBMED   33755662
  REMARK    GeneRIF: Identification of MFRP and the secreted serine proteases
            PRSS56 and ADAMTS19 as part of a molecular network involved in
            ocular growth regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2179)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   6  (bases 1 to 2179)
  AUTHORS   Soundararajan,R., Won,J., Stearns,T.M., Charette,J.R., Hicks,W.L.,
            Collin,G.B., Naggert,J.K., Krebs,M.P. and Nishina,P.M.
  TITLE     Gene profiling of postnatal Mfrprd6 mutant eyes reveals
            differential accumulation of Prss56, visual cycle and
            phototransduction mRNAs
  JOURNAL   PLoS One 9 (10), e110299 (2014)
   PUBMED   25357075
  REMARK    GeneRIF: Transcripts of Prss56, a gene associated with
            angle-closure glaucoma, posterior microphthalmia and myopia, were
            increased in Mfrprd6 eyes by 17-fold.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2179)
  AUTHORS   Nair,K.S., Hmani-Aifa,M., Ali,Z., Kearney,A.L., Ben Salem,S.,
            Macalinao,D.G., Cosma,I.M., Bouassida,W., Hakim,B., Benzina,Z.,
            Soto,I., Soderkvist,P., Howell,G.R., Smith,R.S., Ayadi,H. and
            John,S.W.
  TITLE     Alteration of the serine protease PRSS56 causes angle-closure
            glaucoma in mice and posterior microphthalmia in humans and mice
  JOURNAL   Nat Genet 43 (6), 579-584 (2011)
   PUBMED   21532570
REFERENCE   8  (bases 1 to 2179)
  AUTHORS   Gal,A., Rau,I., El Matri,L., Kreienkamp,H.J., Fehr,S., Baklouti,K.,
            Chouchane,I., Li,Y., Rehbein,M., Fuchs,J., Fledelius,H.C.,
            Vilhelmsen,K., Schorderet,D.F., Munier,F.L., Ostergaard,E.,
            Thompson,D.A. and Rosenberg,T.
  TITLE     Autosomal-recessive posterior microphthalmos is caused by mutations
            in PRSS56, a gene encoding a trypsin-like serine protease
  JOURNAL   Am J Hum Genet 88 (3), 382-390 (2011)
   PUBMED   21397065
REFERENCE   9  (bases 1 to 2179)
  AUTHORS   Orr,A., Dube,M.P., Zenteno,J.C., Jiang,H., Asselin,G., Evans,S.C.,
            Caqueret,A., Lakosha,H., Letourneau,L., Marcadier,J., Matsuoka,M.,
            Macgillivray,C., Nightingale,M., Papillon-Cavanagh,S., Perry,S.,
            Provost,S., Ludman,M., Guernsey,D.L. and Samuels,M.E.
  TITLE     Mutations in a novel serine protease PRSS56 in families with
            nanophthalmos
  JOURNAL   Mol Vis 17, 1850-1861 (2011)
   PUBMED   21850159
REFERENCE   10 (bases 1 to 2179)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102611.10, JF698684.1, JF323950.1 and D18648.1.
            
            On Sep 1, 2015 this sequence version replaced NM_027084.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF323950.1, JF698684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC102611.10        141581-141759
            180-1994            JF698684.1         1-1815
            1995-2178           JF323950.1         1816-1999
            2179-2179           D18648.1           71-71
FEATURES             Location/Qualifiers
     source          1..2179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.07 cM"
     gene            1..2179
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /note="serine protease 56"
                     /db_xref="GeneID:69453"
                     /db_xref="MGI:MGI:1916703"
     exon            1..285
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1994
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /note="protease, serine 56"
                     /codon_start=1
                     /product="serine protease 56 precursor"
                     /protein_id="NP_081360.1"
                     /db_xref="CCDS:CCDS59538.1"
                     /db_xref="GeneID:69453"
                     /db_xref="MGI:MGI:1916703"
                     /translation="MPLAMLLLLLLLLSPDSQTAHGHPLYTRLSPGALQVLSAQGTQA
                     LQAAQRSAQWAIKRVLMEIQHRLHECQGPGRPRPQAPLLQDPPEPVQCGERHQGVANT
                     TRAHGRIVGGSTAPSGAWPWLVRLQLGGLPLCGGVLVAASWVLTAAHCFAGASNELLW
                     TVMLAEGPQGEQAEEVQVNRILPHPKFDPQTFHNDLALVQLWTPVSPEGPARPICLPQ
                     GSREPPAGTPCAIAGWGALFEDGPESEAVREARVPLLSADTCQKVLGPGLRPSTMLCA
                     GYLAGGIDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVTVFKD
                     WLQEQMSAGPSTREPSCRELLNWNAREEEPFTDAPGLCAFYARQCLGSESSCARLALQ
                     QCLQRRRRCELRSLAHTLLGLLRGAQELLGPRPGLRRGVSAPARSAPSLQELPGHNPR
                     EQRLYSGSRIAGTWLQKPKPERRPETKGCPGLEPLQQKLAAIQRAHAWILQIPAEHLA
                     MNFHEVLADLGSKTLTGLFRAWVRAGLGDQRVVFSGLVGLEPSTLAHSLPRLLVQALK
                     AFRSASLTEGEPQAPWIGADQGQRLGKERQGQLQPPVP"
     exon            286..393
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            394..447
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            448..637
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            638..737
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            738..897
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1040
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1203
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1383
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1548
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1611
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1718
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2179
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2179
                     /gene="Prss56"
                     /gene_synonym="1700027L20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggctcccag gaggtgaggg ccaggtgagg tgcggaccat tagaagtgag tagtttagtg
       61 taagacaacg ggatcagatg gtttgaggga cacaaagtct gtgggcagga agaatcacag
      121 gagagggtag agtccaggaa taaagaggac agggtctccc gccttggccc caggtcacca
      181 tgccgctggc tatgttgttg ctgctgctgc tgctactgtc cccagactcc caaactgccc
      241 atgggcatcc actgtacacg cgcctgtccc ccggcgccct gcaagtttta tctgcccagg
      301 ggactcaggc attgcaggct gcccagagga gtgcccagtg ggccataaag cgcgtgttga
      361 tggagatcca gcacagacta catgaatgcc aaggacctgg acgccctaga cctcaagccc
      421 ccctcctcca ggacccaccg gagccagtac aatgtggaga aagacatcaa ggcgttgcca
      481 acacgacccg ggctcacggc cgcatagtcg gtggcagcac ggctccctcg ggggcctggc
      541 cttggctagt gaggctgcaa cttggagggt tgcctctgtg cgggggtgtc ctggtagcag
      601 catcctgggt gctcacggct gcacattgct tcgccggtgc ctcgaatgag cttctgtgga
      661 ctgtgatgct cgccgagggg cctcaggggg agcaagcgga agaagtgcag gtgaaccgca
      721 tcttgcccca ccctaagttt gacccgcaga cttttcacaa tgacctggcc ttggtacagt
      781 tgtggacgcc tgtgagccca gaggggcctg cgcgccccat ttgccttccc cagggttctc
      841 gggagcctcc tgccggcacc ccctgcgcca ttgcaggctg gggggctctc ttcgaagacg
      901 ggcctgagtc tgaggcagtg agggaggccc gcgttccgct gctcagtgca gacacctgtc
      961 aaaaggtcct ggggcctggg ctgcggccca gcaccatgct ctgcgctggt tacctggcag
     1021 ggggcatcga ctcatgccag ggtgactccg ggggcccttt aacctgttcc gagcccggcc
     1081 cgcgccccag agaggtcctc tttggagtca cttcttgggg agatggctgt ggggaaccag
     1141 ggaagcctgg ggtctacacc cgtgtgaccg tgttcaaaga ctggctgcag gagcagatga
     1201 gcgcgggccc ctccactcgc gagcctagct gcagagaact tctaaattgg aacgctcggg
     1261 aagaggagcc gttcacggac gccccgggcc tctgtgcctt ctatgcgcgc cagtgcctag
     1321 ggtccgagag ctcctgtgcg cgcctagcgc tccaacagtg tctgcagcgc aggcgacggt
     1381 gcgagctacg gtcactggcg cacaccctgc ttggtctgct gcggggcgcc caggagctgc
     1441 tcggcccccg gccaggattg cggcgtggag tctccgcgcc cgctcgctcc gcgccgtcgc
     1501 tccaggagct tcccggtcac aatccccgag aacagcggtt atactcagga tcgcgaattg
     1561 cgggaacctg gctccagaaa ccaaagccgg agcggcgccc ggaaacaaag ggctgccctg
     1621 ggctggagcc tctgcaacag aagttagcgg ctattcagcg agcgcatgct tggatcctac
     1681 agatcccagc tgagcacttg gccatgaact ttcatgaggt gctggcagat ctgggctcca
     1741 agacactgac aggactcttc agagcttggg tgagggccgg tttgggggac cagcgtgtgg
     1801 tcttcagtgg cctagtgggc ttggaacctt ccacactggc tcatagtctc ccccggctac
     1861 tagtgcaggc cctgaaggcc ttccgctcag cttccctgac agaaggagag ccccaggcac
     1921 cctggatagg tgctgatcaa ggacagaggc tgggaaagga gcgccagggc caactccagc
     1981 ctcctgttcc ctgaaccagg caaccctgtg atggtcacac tgtcctgggg gctaaagcgg
     2041 ttgtgtgaga catacaaagt ctctctattc cagttgatct tggatgtgtg gatagagtgg
     2101 ggatcctgga tctcactcat cttcttcaat gtgtcaccag acacgcatgg ctgctttaat
     2161 aaatgttatt tatactcta
//
