LOCUS       NM_001379522            1135 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus serine protease 55 (Prss55), transcript variant 2,
            mRNA.
ACCESSION   NM_001379522 XM_030248022
VERSION     NM_001379522.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1135)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1135)
  AUTHORS   Zhu,F., Li,W., Zhou,X., Chen,X., Zheng,M., Cui,Y., Liu,X., Guo,X.
            and Zhu,H.
  TITLE     PRSS55 plays an important role in the structural differentiation
            and energy metabolism of sperm and is required for male fertility
            in mice
  JOURNAL   J Cell Mol Med 25 (4), 2040-2051 (2021)
   PUBMED   33417308
  REMARK    GeneRIF: PRSS55 plays an important role in the structural
            differentiation and energy metabolism of sperm and is required for
            male fertility in mice.
REFERENCE   3  (bases 1 to 1135)
  AUTHORS   Kobayashi,K., Endo,T., Matsumura,T., Lu,Y., Yu,Z., Matzuk,M.M. and
            Ikawa,M.
  TITLE     Prss55 but not Prss51 is required for male fertility in micedagger
  JOURNAL   Biol Reprod 103 (2), 223-234 (2020)
   PUBMED   32301961
  REMARK    GeneRIF: Prss55 but not Prss51 is required for male fertility in
            micedagger.
REFERENCE   4  (bases 1 to 1135)
  AUTHORS   Shang,X., Shen,C., Liu,J., Tang,L., Zhang,H., Wang,Y., Wu,W.,
            Chi,J., Zhuang,H., Fei,J. and Wang,Z.
  TITLE     Serine protease PRSS55 is crucial for male mouse fertility via
            affecting sperm migration and sperm-egg binding
  JOURNAL   Cell Mol Life Sci 75 (23), 4371-4384 (2018)
   PUBMED   30032357
  REMARK    GeneRIF: Data show that serine protease 55 (PRSS55) plays vital
            roles in regulating male fertility including in vivo sperm
            migration and in vitro sperm-egg interaction
REFERENCE   5  (bases 1 to 1135)
  AUTHORS   Khan,M., Jabeen,N., Khan,T., Hussain,H.M.J., Ali,A., Khan,R.,
            Jiang,L., Li,T., Tao,Q., Zhang,X., Yin,H., Yu,C., Jiang,X. and
            Shi,Q.
  TITLE     The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2
            are dispensable for fertility in mice
  JOURNAL   Sci Rep 8 (1), 4975 (2018)
   PUBMED   29563520
  REMARK    GeneRIF: Study of the mouse Tex37 and Prss55 - genes evolutionarily
            conserved in eutherians (including human) found that these genes
            had a testis-enriched expression pattern in mice, but they are not
            individually essential for spermatogenesis, testis development and
            male fertility in mice in laboratory conditions.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166997.1.
            
            On Apr 7, 2020 this sequence version replaced XM_030248022.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.72689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC166997.1         117006-117202
            198-390             AC166997.1         120565-120757
            391-638             AC166997.1         122973-123220
            639-781             AC166997.1         125193-125335
            782-1135            AC166997.1         126622-126975
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.35 cM"
     gene            1..1135
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /note="serine protease 55"
                     /db_xref="GeneID:71037"
                     /db_xref="MGI:MGI:1918287"
     exon            1..197
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1108
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable serine protease UNQ9391/PRO34284 homolog;
                     protease, serine 55"
                     /codon_start=1
                     /product="serine protease 55 isoform 2"
                     /protein_id="NP_001366451.1"
                     /db_xref="GeneID:71037"
                     /db_xref="MGI:MGI:1918287"
                     /translation="MLVCGLLSLWPELLTRAGQSGYLLSSPPFILSICECGVRPLYDS
                     RIQYSRIIEGQEAELGEFPWQVSIQESDHHFCGGSILSEWWILTVAHCFYAQELSPTD
                     LRVRVGTNDLTTSPVELEVTTIIRHKGFKRLNMDNDIALLLLAKPLTFNELTVPICLP
                     LWPAPPSWHECWVAGWGVTNSTDKESMSTDLMKVPMRIIEWEECLQMFPSLTTNMLCA
                     SYGNESYDACQGDSGGPLVCTTDPGSRWYQVGIISWGKSCGKKGFPGIYTVLAKYTLW
                     IEKIAQTEGKPLDFRGQSSSNKKKNRQNNQLSKSPALNCPQSWLLPCLLSFALLRALS
                     NWK"
     exon            198..390
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            391..638
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            639..781
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1135
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1135
                     /gene="Prss55"
                     /gene_synonym="4933401F05Rik"
                     /note="major polyA site"
ORIGIN      
        1 actattctgt cagcctggcc tccaacacac agcacagcca gagccatgat cctgccctcc
       61 atcctgctac ttgttgccca caccctggaa gcaaatgttg gtatgtggac tcctctccct
      121 ctggccagag ctgctgaccc gggcaggtca gtcaggatac ctgctctcct cgcctccctt
      181 catcctatca atatgtgagt gtggtgtgag acccctgtat gatagcagaa ttcaatactc
      241 caggatcata gaagggcagg aggctgagct gggtgagttt ccatggcagg tgagcattca
      301 ggaaagtgac caccatttct gcggcggctc cattctcagt gagtggtgga tcctcaccgt
      361 ggcccactgc ttctatgctc aggagctttc cccaacagat ctcagagtca gagtgggaac
      421 caatgactta actacttcac ccgtggaact agaggtcacc accataatcc ggcacaaagg
      481 ctttaaacgg ctgaacatgg acaacgacat tgccttgttg ctgctagcca agcccttgac
      541 gttcaatgag ctgacggtgc ccatctgcct tcctctctgg cccgcccctc ccagctggca
      601 cgaatgctgg gtggcaggat ggggcgtaac caactcaact gacaaggaat ctatgtcaac
      661 ggatctgatg aaggtgccca tgcgtatcat agagtgggag gaatgcttac agatgtttcc
      721 cagcctcacc acaaacatgc tgtgtgcctc atatggtaat gagagctacg atgcttgcca
      781 gggtgacagt gggggaccgc ttgtctgcac cacagatcct ggcagtaggt ggtaccaggt
      841 gggcatcatc agctggggca agagctgtgg aaaaaaaggc ttcccaggga tatatactgt
      901 attggcaaag tataccctgt ggattgagaa aatagcccag acagagggga agcccctgga
      961 ttttagaggt cagagctcct ctaacaagaa gaaaaacaga cagaacaatc agctctccaa
     1021 atccccagcc ctgaactgcc cccaaagctg gctcctgccc tgtctgctgt cctttgcact
     1081 gcttagagcc ttgtccaact ggaaataaaa caatgcagtc tctgatccac cctaa
//
