LOCUS       NM_001310539            1590 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine protease 54 (Prss54), mRNA.
ACCESSION   NM_001310539 XM_006531367
VERSION     NM_001310539.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1590)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1590)
  AUTHORS   Shen,C., Xiong,W., Li,C., Ge,H., Shen,Y., Tang,L., Zhang,H., Lu,S.,
            Fei,J. and Wang,Z.
  TITLE     Testis-specific serine protease PRSS54 regulates acrosomal granule
            localization and sperm head morphogenesis in micedagger
  JOURNAL   Biol Reprod 107 (4), 1139-1154 (2022)
   PUBMED   35863763
  REMARK    GeneRIF: Testis-specific serine protease PRSS54 regulates acrosomal
            granule localization and sperm head morphogenesis in micedagger.
REFERENCE   3  (bases 1 to 1590)
  AUTHORS   Holcomb,R.J., Oura,S., Nozawa,K., Kent,K., Yu,Z., Robertson,M.J.,
            Coarfa,C., Matzuk,M.M., Ikawa,M. and Garcia,T.X.
  TITLE     The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are
            dispensable for male mouse fertilitydagger
  JOURNAL   Biol Reprod 102 (1), 84-91 (2020)
   PUBMED   31403672
  REMARK    GeneRIF: The testis-specific serine proteases PRSS44, PRSS46, and
            PRSS54 are dispensable for male mouse fertilitydagger.
REFERENCE   4  (bases 1 to 1590)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY716181.1, AC102555.11 and BC145787.1.
            
            On Jul 15, 2015 this sequence version replaced XM_006531367.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145787.1, SRR5189685.183677.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BY716181.1         68-125
            59-152              AC102555.11        195941-196034       c
            153-1590            BC145787.1         1-1438
FEATURES             Location/Qualifiers
     source          1..1590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..1590
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /note="serine protease 54"
                     /db_xref="GeneID:70993"
                     /db_xref="MGI:MGI:1918243"
     exon            1..245
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /inference="alignment:Splign:2.1.0"
     exon            246..340
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1431
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /note="plasma kallikrein-like protein 4; protease, serine
                     54"
                     /codon_start=1
                     /product="inactive serine protease 54"
                     /protein_id="NP_001297468.1"
                     /db_xref="CCDS:CCDS80916.1"
                     /db_xref="GeneID:70993"
                     /db_xref="MGI:MGI:1918243"
                     /translation="MAEMRGMLLMLLYISHSSSAICGIQKATIADKLKENLVSSTEFP
                     WVVSIQDKQYTHLAFGCILSEFWILSTASALQHRKEVIAVVGISNMDPRKTDHREYSV
                     NTIIPHENFDNVSMGNNIALLKTESAMHFNDLVQAICFLGKKLHKPPALKNCWVAGWN
                     PTSATGNHMTMSILRRISVKDIEVCPLRRHQKTECASHTKEPNNVCLGEPGSPMMCQA
                     KKLDLWILRGLLAYGGDSCPGLFLYTSVADYSDWITAKTRKAGPSLSSLHLWEKLVFE
                     LPFHESNIALTTNSFSIHTYAEWPHSYSQGQRMSTKSNKQKDAGQNFRVNRQPETSGP
                     SKVAIQPMYYDYYGGEAGEGGAVAGQNRLHWSQERILMSFVLVFLGSGV"
     exon            341..512
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..771
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /inference="alignment:Splign:2.1.0"
     exon            772..900
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1590
                     /gene="Prss54"
                     /gene_synonym="4931432M23Rik; Klkbl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttttatgg ctatagagtc aaagcaaggg ttgaattcca caaatcaaaa gccaaccctt
       61 tttagagaac caactctcta gcacaaccag ggcccccagg ctgctctgag aagacaactg
      121 gaaaaaaaaa aaaaaaaaag cagactacct tctctccttg ggccatctca cagccaagta
      181 tccggagcca gacagcctct tccttgtcca tacctgctca gaatccagcg ctggggatgt
      241 gacagctgct catggtgctc gctgtgcttc tctctgggga tggcagagat gcgagggatg
      301 ctgctgatgc tgctgtacat atcccactcg tcatctgcca tttgcggcat ccagaaagcc
      361 accatcgcgg acaagttaaa ggagaacctc gtgagcagca ccgagttccc ctgggtggtg
      421 tccatccagg acaagcagta cacccacctg gctttcggct gcattctcag cgagttctgg
      481 atcctcagca ccgcctccgc tctccagcac aggaaggagg ttattgctgt tgttggtata
      541 tctaacatgg atccccgaaa gactgaccac agagagtatt cagtcaatac catcatcccc
      601 catgagaact ttgacaacgt ctcaatgggc aataacatag ccctcctgaa gacagaatcc
      661 gccatgcatt tcaacgacct ggtccaggcc atctgcttcc tgggcaaaaa gctacataag
      721 ccaccagcct tgaagaactg ctgggtagca ggatggaatc ccacgtctgc aacaggaaat
      781 cacatgacaa tgagtatcct gaggagaatc tccgtgaagg acattgaagt gtgtccctta
      841 cgtagacacc agaaaacaga atgtgccagt cacacaaagg aacccaacaa tgtttgcctg
      901 ggggaaccag gaagccctat gatgtgccag gcaaagaagc tggatctctg gatcctgaga
      961 ggactcctgg cctatggagg cgactcgtgc cctggcctgt ttctgtacac cagtgtggca
     1021 gactacagcg actggatcac ggccaagacg aggaaggctg gcccttccct gtcctcgctc
     1081 cacctctggg agaagttggt ctttgagctc ccctttcacg aatcaaatat tgccctgaca
     1141 acgaattcgt tttctataca tacctatgct gaatggcccc actcctactc ccaagggcaa
     1201 agaatgtcca ctaagtccaa caagcagaag gatgctgggc agaacttcag ggtaaacagg
     1261 caaccggaaa ccagcgggcc ttcgaaggtg gctattcagc ccatgtacta cgactactac
     1321 ggtggggagg caggggaagg tggggctgtg gctggccaga acaggctgca ttggtctcaa
     1381 gaaaggatct tgatgtcctt cgtgcttgtt ttcttgggca gcggagtcta gctaggagct
     1441 aacctactac cactgagaag aagctcagag cgcaaggcgc taggtgcctg ccgtactgtt
     1501 ctggtgtctg ctcttgatgg gtgccccctg ggtggccatg ggcaggccca cggcagcgcc
     1561 aggctggctc tcctccctct gtcccactcc
//
