LOCUS       NM_001081268            2531 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine protease 53 (Prss53), mRNA.
ACCESSION   NM_001081268 XM_620568
VERSION     NM_001081268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2531)
  AUTHORS   Mori,M., Liu,C., Yoshizawa,T., Miyahara,H., Dai,J., Igarashi,Y.,
            Cui,X., Li,Y., Kang,X. and Higuchi,K.
  TITLE     Polygenic control of the wavy coat of the NCT mouse: involvement of
            an intracisternal A particle insertional mutation of the protease,
            serine 53 (Prss53) gene, and a modifier gene
  JOURNAL   Mamm Genome 33 (3), 451-464 (2022)
   PUBMED   35067752
  REMARK    GeneRIF: Polygenic control of the wavy coat of the NCT mouse:
            involvement of an intracisternal A particle insertional mutation of
            the protease, serine 53 (Prss53) gene, and a modifier gene.
REFERENCE   3  (bases 1 to 2531)
  AUTHORS   Mizusawa,N., Harada,N., Iwata,T., Ohigashi,I., Itakura,M. and
            Yoshimoto,K.
  TITLE     Identification of protease serine S1 family member 53 as a
            mitochondrial protein in murine islet beta cells
  JOURNAL   Islets 14 (1), 1-13 (2022)
   PUBMED   34636707
  REMARK    GeneRIF: Identification of protease serine S1 family member 53 as a
            mitochondrial protein in murine islet beta cells.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149222.4.
            
            On Feb 6, 2007 this sequence version replaced XM_620568.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220244.1, AK131611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC149222.4         63092-63203
            113-133             AC149222.4         64305-64325
            134-296             AC149222.4         64421-64583
            297-562             AC149222.4         64863-65128
            563-717             AC149222.4         65262-65416
            718-937             AC149222.4         65548-65767
            938-1088            AC149222.4         66413-66563
            1089-1330           AC149222.4         66644-66885
            1331-1476           AC149222.4         66967-67112
            1477-1693           AC149222.4         67318-67534
            1694-2531           AC149222.4         67781-68618
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.81 cM"
     gene            1..2531
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /note="serine protease 53"
                     /db_xref="GeneID:330657"
                     /db_xref="MGI:MGI:2652890"
     exon            1..112
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1713
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /note="polyserase-3; polyserine protease 3; Bc039632-like
                     protein; protease, serine 53"
                     /codon_start=1
                     /product="serine protease 53 precursor"
                     /protein_id="NP_001074737.1"
                     /db_xref="CCDS:CCDS52409.1"
                     /db_xref="GeneID:330657"
                     /db_xref="MGI:MGI:2652890"
                     /translation="MRQSWRPELLIVGAVVVIEGLQAAQRACGQRGPGPPEPQEGNTL
                     PGEWPWQASVRRQGVHICSGSLVADTWVLTAAHCFEKMATAELSSWSVVLGSLKQEGQ
                     SPGAEEVGVAALQLPKAYNHYSQGSDLALLQLTHPTVQTTLCLPQPTYHFPFGASCWA
                     TGWDQNTSDVSRTLRNLRLRLISRPTCNCLYNRLHQRLLSNPARPGMLCGGAQPGEQG
                     PCQGDSGGPVMCREPDGHWVQVGIISFTSKCAQEDTPVLLTDMAVHSSWLQAHVHEAA
                     FLVQAPGVVKMSDENSCVACGSLRSAGPQAGALSQWPWDARLKHHGKLACGGALVSEV
                     VVLTAAHCFIGRQTLEEWSVGLGAGPEEWGLKQLILHGAYTHPEGGYDVAFLLLAQPV
                     TLGPGLRPLCLPYADHHLPDGEHGWVLGLTQKAGINYPQTVPVTVLGPMACSRQHAAP
                     GGTGIPILPGMVCTTVVGEPPHCEGLSGAPLVHEIRGTWFLVGLHSFGDTCQSSAKPA
                     VFAALSAYEDWISNLDWQVYFAEEPEPEAETGSCLVNSSQPASC"
     exon            113..133
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            134..296
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            297..562
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            563..717
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            718..937
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1088
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1330
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1476
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1693
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..2531
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /note="hexamer: AGTAAA"
     polyA_site      2123
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /note="major polyA site"
ORIGIN      
        1 gggagaccca ggtggccttt ctgacagccg gagcactgag tggcctggag cagcatgagg
       61 cagagctgga gaccagagct gcttattgtg ggagctgtgg tcgtgataga gggtcttcaa
      121 gcagctcagc gtgcatgcgg gcagcgtggc cctggccctc cagagcccca ggaaggcaac
      181 acattacctg gtgaatggcc ctggcaggcc agtgtgaggc gacagggtgt acacatctgc
      241 agtggctcct tggtggcaga cacttgggtc ctcacagctg ctcactgctt tgaaaagatg
      301 gccacagcag aactgagctc ctggtccgtg gtcctgggtt ctctcaagca ggaggggcag
      361 agcccggggg ctgaggaggt gggagttgct gccctgcagt tgcccaaggc ctataaccac
      421 tatagccagg gatcagatct ggccctgctc cagctcaccc accccaccgt tcagacaacc
      481 ctctgcttgc cccaacccac ctaccacttc ccctttggag cttcttgctg ggccactggc
      541 tgggaccaga acaccagtga tgtttccaga accctacgga atctgcgcct ccgtctcatc
      601 agccgcccca cttgtaactg tctctacaat cggttgcacc agaggttgct gtccaaccca
      661 gcaagacctg ggatgctctg tgggggtgca cagcctgggg aacaggggcc ctgccaggga
      721 gattctgggg gacctgtgat gtgccgtgag cctgatggac actgggtcca ggttggaatc
      781 attagtttca catcaaaatg tgcccaagag gacacccctg tgctgttgac tgacatggca
      841 gtacacagtt catggctgca ggcccatgtt cacgaggcag ctttcttggt gcaggcccca
      901 ggagttgtga agatgagcga cgagaacagc tgtgtagcat gtggctcctt gaggagtgca
      961 ggaccccagg caggagcgct ctctcagtgg ccctgggatg ccaggctgaa gcaccacggg
     1021 aagctggctt gtggtggagc tctggtatcg gaggtggtgg tgctgacggc tgctcactgc
     1081 tttatcgggc gccaaaccct agaggaatgg agcgtaggac tgggggctgg accagaggaa
     1141 tggggcctga agcaactcat tctgcacggg gcctacaccc acccagaagg cggctatgat
     1201 gtggccttcc tgctgctggc tcagcctgtg acattgggcc ctggcctaag gcccctctgc
     1261 ttgccctatg ctgaccacca cctgcctgat ggtgaacatg gctgggttct tgggctgacc
     1321 caaaaagcag gcatcaacta cccccagaca gtacctgtga cagtcctggg gccgatggcc
     1381 tgtagcagac agcatgcagc tcctgggggc acaggcatcc ccatcctgcc agggatggta
     1441 tgcaccactg tcgtgggtga gccccctcac tgtgagggcc tctctggggc gccacttgta
     1501 catgagatca ggggcacatg gttcctggtt ggactgcaca gctttggaga cacctgtcaa
     1561 agctctgcaa agcctgcagt ttttgcagca ctctctgcct acgaggactg gatcagcaat
     1621 ctagactggc aggtctactt cgctgaggag ccagagcctg aggctgagac tggaagctgc
     1681 ttggtcaact cgagccaacc agccagttgt tgactggtga ctctagttta ctcacaggac
     1741 gccagaaacg ccagacaact cccacgtcaa cacccagttc tacactcctg cccctcccct
     1801 cccggtcttg tggttcccag ccctgaggca ggtccaacag ctggctggct ggctgagaat
     1861 gagcctgccc agagatgctt ttcatgtgtg ccatggcccc gcccccaagt tctgctttcc
     1921 aacagagatg tctccagtat tccctagcca atccttcaga tataaccaca ccagtagctg
     1981 ttgtgaaaaa aaaagttgtt ttttttttcc ttgggggtgg ggggtttggg gagcaatttc
     2041 cttttttaaa acttaaattg ttacaaaata gattttagaa aataagttac aaactatagt
     2101 aaaaggctcc cctgtcacag gcagctttcg caccagtggt tctctctgat ctgcctctcc
     2161 ctgggtgaga atctggctct ctctgcattt tggcagagtc tggccctgga aaatcatggt
     2221 gacaaagggt tgggaaggag atccttcatc cttcatgggc acagacatga agactacctc
     2281 atgcccttct tgggggaaaa agccagatta gggtcctctt cgtgggaaga ggagatgggg
     2341 atgcccaagc aactcctgag caaaatgagg agagcaagcc tctccctgcc tgccccatcc
     2401 ttcagtcaac tgttctttgg agacctgtca ttcagaggga gagactgagg tctgcaggcc
     2461 actggggtga ggggttcgga agcgaggctg tagaggaatc ctctctgctt gctgctggtg
     2521 ccactgaggc t
//
