LOCUS       NP_001074737             552 aa            linear   ROD 30-APR-2024
DEFINITION  serine protease 53 precursor [Mus musculus].
ACCESSION   NP_001074737 XP_620568
VERSION     NP_001074737.1
DBSOURCE    REFSEQ: accession NM_001081268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 552)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 552)
  AUTHORS   Mori,M., Liu,C., Yoshizawa,T., Miyahara,H., Dai,J., Igarashi,Y.,
            Cui,X., Li,Y., Kang,X. and Higuchi,K.
  TITLE     Polygenic control of the wavy coat of the NCT mouse: involvement of
            an intracisternal A particle insertional mutation of the protease,
            serine 53 (Prss53) gene, and a modifier gene
  JOURNAL   Mamm Genome 33 (3), 451-464 (2022)
   PUBMED   35067752
  REMARK    GeneRIF: Polygenic control of the wavy coat of the NCT mouse:
            involvement of an intracisternal A particle insertional mutation of
            the protease, serine 53 (Prss53) gene, and a modifier gene.
REFERENCE   3  (residues 1 to 552)
  AUTHORS   Mizusawa,N., Harada,N., Iwata,T., Ohigashi,I., Itakura,M. and
            Yoshimoto,K.
  TITLE     Identification of protease serine S1 family member 53 as a
            mitochondrial protein in murine islet beta cells
  JOURNAL   Islets 14 (1), 1-13 (2022)
   PUBMED   34636707
  REMARK    GeneRIF: Identification of protease serine S1 family member 53 as a
            mitochondrial protein in murine islet beta cells.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149222.4.
            
            On Feb 6, 2007 this sequence version replaced XP_620568.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220244.1, AK131611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.81 cM"
     Protein         1..552
                     /product="serine protease 53 precursor"
                     /note="polyserase-3; polyserine protease 3; Bc039632-like
                     protein; protease, serine 53"
                     /calculated_mol_wt=56427
     sig_peptide     1..23
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q571E5.2)"
                     /calculated_mol_wt=2565
     mat_peptide     24..552
                     /product="Serine protease 53. /id=PRO_0000316764"
                     /note="propagated from UniProtKB/Swiss-Prot (Q571E5.2)"
                     /calculated_mol_wt=56427
     Region          27..46
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q571E5.2)"
     Region          45..271
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            order(77,128,224)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(218,244,246)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     Region          311..522
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            order(341,382,477)
                     /site_type="active"
                     /db_xref="CDD:238113"
     CDS             1..552
                     /gene="Prss53"
                     /gene_synonym="mFLJ00289; Pol3s"
                     /coded_by="NM_001081268.1:55..1713"
                     /db_xref="CCDS:CCDS52409.1"
                     /db_xref="GeneID:330657"
                     /db_xref="MGI:MGI:2652890"
ORIGIN      
        1 mrqswrpell ivgavvvieg lqaaqracgq rgpgppepqe gntlpgewpw qasvrrqgvh
       61 icsgslvadt wvltaahcfe kmataelssw svvlgslkqe gqspgaeevg vaalqlpkay
      121 nhysqgsdla llqlthptvq ttlclpqpty hfpfgascwa tgwdqntsdv srtlrnlrlr
      181 lisrptcncl ynrlhqrlls nparpgmlcg gaqpgeqgpc qgdsggpvmc repdghwvqv
      241 giisftskca qedtpvlltd mavhsswlqa hvheaaflvq apgvvkmsde nscvacgslr
      301 sagpqagals qwpwdarlkh hgklacggal vsevvvltaa hcfigrqtle ewsvglgagp
      361 eewglkqlil hgaythpegg ydvaflllaq pvtlgpglrp lclpyadhhl pdgehgwvlg
      421 ltqkaginyp qtvpvtvlgp macsrqhaap ggtgipilpg mvcttvvgep phceglsgap
      481 lvheirgtwf lvglhsfgdt cqssakpavf aalsayedwi snldwqvyfa eepepeaetg
      541 sclvnssqpa sc
//
