LOCUS       NM_001347631             917 bp    mRNA    linear   ROD 23-AUG-2023
DEFINITION  Mus musculus serine protease 51 (Prss51), transcript variant 2,
            mRNA.
ACCESSION   NM_001347631 XM_006518311
VERSION     NM_001347631.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 917)
  AUTHORS   Kobayashi K, Endo T, Matsumura T, Lu Y, Yu Z, Matzuk MM and Ikawa
            M.
  TITLE     Prss55 but not Prss51 is required for male fertility in micedagger
  JOURNAL   Biol Reprod 103 (2), 223-234 (2020)
   PUBMED   32301961
  REMARK    GeneRIF: Prss55 but not Prss51 is required for male fertility in
            micedagger.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005740.1 and AV172114.1.
            
            On Dec 3, 2016 this sequence version replaced XM_006518311.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, and
            uses an alternate splice site in the 5' coding region relative to
            variant 1. These differences cause translation initiation at a
            downstream start codon and result in an isoform (2) with a shorter
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-915               AK005740.1         48-962
            916-917             AV172114.1         311-312
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.35 cM"
     gene            1..917
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /note="serine protease 51"
                     /db_xref="GeneID:100504162"
                     /db_xref="MGI:MGI:1921465"
     exon            1..127
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            128..208
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            209..468
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..911
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protease, serine 51"
                     /codon_start=1
                     /product="serine protease-like protein 51 isoform 2"
                     /protein_id="NP_001334560.1"
                     /db_xref="CCDS:CCDS84145.1"
                     /db_xref="GeneID:100504162"
                     /db_xref="MGI:MGI:1921465"
                     /translation="MGIKTFSDTNLERKQVQKIIAHRDYKPPDLDSDLCLLLLATPIQ
                     FNKDKMPICLPQRENSWDRCWMSEWAYTHGHGSAKGSNMHLKKLRVVQISWRTCAKRV
                     TQLSRNMLCAWKEVGTNGKCQGDSGAPMVCANWETRRLFQVGVFSWGITSGSRGRPGI
                     FVSVAQFIPWILEETQREGRALALSKASKSLLAGSPRYHPILLSMGSQILLAAIFSDD
                     KSNC"
     exon            469..611
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..917
                     /gene="Prss51"
                     /gene_synonym="1700007N14Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcaagact actgcatgtg tgttcactgt ggtgtgtttg ctacacatat agttttctac
       61 tcttacaaaa agctttgtga tgggaaatgg agacctgtag tatttcccta ccattgttcc
      121 tctgcataat cagttctgtg tggccacaga cctgccttcc caaactcatc atggctgcca
      181 ttgcgggagc tgcttgaggt ccagcatgat tagaactggt agcagtcaat gtcactgtgg
      241 tcatgggaat caagactttc agtgacacca acttagagag aaaacaagtg cagaagatca
      301 ttgctcacag agactacaaa ccgcccgacc ttgacagcga cctctgcctg ctcctacttg
      361 ccacgccaat ccaattcaat aaagacaaaa tgcccatctg cctgccacag agggagaact
      421 cctgggaccg gtgctggatg tcagagtggg catatactca tggccatggt tcagccaaag
      481 gctcaaacat gcacctgaag aagctcaggg tggttcagat tagctggagg acatgtgcca
      541 agagggtgac tcagctctcc aggaacatgc tttgtgcttg gaaggaagtg ggcaccaacg
      601 gcaagtgcca gggagacagc ggggcaccca tggtctgtgc taactgggag actcggagac
      661 tctttcaagt gggtgtcttc agctggggca taacttcagg atccaggggg aggccaggca
      721 tttttgtgtc tgtggctcag tttatcccat ggatcctgga ggagacacaa agggagggac
      781 gagcccttgc cctctcaaag gcctcaaaaa gtctcttggc tggcagtcca cgctaccatc
      841 ccatattgct aagcatgggc tctcaaatac tgcttgctgc catattttct gatgataaat
      901 caaattgcta agctctg
//
