LOCUS       NM_001001650            1187 bp    mRNA    linear   ROD 09-AUG-2024
DEFINITION  Mus musculus serine protease 48 (Prss48), transcript variant 1,
            mRNA.
ACCESSION   NM_001001650 XM_355442
VERSION     NM_001001650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1187)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1187)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   3  (bases 1 to 1187)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133508.3.
            
            On Jun 20, 2019 this sequence version replaced NM_001001650.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.48599.1, BN000135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC133508.3         161234-161316
            84-128              AC133508.3         162835-162879
            129-291             AC133508.3         163221-163383
            292-551             AC133508.3         165452-165711
            552-718             AC133508.3         166387-166553
            719-1187            AC133508.3         169685-170153
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.83 cM"
     gene            1..1187
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /note="serine protease 48"
                     /db_xref="GeneID:368202"
                     /db_xref="MGI:MGI:2685865"
     exon            1..83
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..979
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /EC_number="3.4.21.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; epidermis-specific serine protease-like
                     protein; protease, serine 48"
                     /codon_start=1
                     /product="serine protease 48 isoform 1 precursor"
                     /protein_id="NP_001001650.1"
                     /db_xref="CCDS:CCDS17444.1"
                     /db_xref="GeneID:368202"
                     /db_xref="MGI:MGI:2685865"
                     /translation="MGPAGLKVLLLLFLGAFQGSFTKKKNLQSVCGRPVHTGRIVGGQ
                     DAALGRWPWQVSLRFDYTHSCGGSLISDHWVLTAAHCIKKTWYSFLYSVWLGSIDREY
                     SSTGKEYYVSRIAIPDKHRHTEADIALLKLSSRVTFSSVILPICLPNISKQLTVPASC
                     WVTGWGQNQEGHYPSTLQELEVPVISSEACEQLYNPIGVFLPDLERVIKEDMFCAGER
                     QSRKDSCKGDSGGPLSCHIDGVWRLMGVVSWGLECGKDLPGVYTNVTYYQKWISAIIS
                     RAPPGWGGDSTHMTSCSLLCYFLWLSWDPPEPLALA"
     exon            84..128
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /inference="alignment:Splign:2.1.0"
     exon            129..291
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /inference="alignment:Splign:2.1.0"
     exon            292..551
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /inference="alignment:Splign:2.1.0"
     exon            552..718
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1187
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1160..1165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /note="hexamer: AATAAA"
     regulatory      1164..1169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /note="hexamer: AATAAG"
     polyA_site      1180
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
     polyA_site      1187
                     /gene="Prss48"
                     /gene_synonym="Esspl; Gm1019"
                     /note="major polyA site"
ORIGIN      
        1 gagtcccgga agccggaagt actgcaatga ggacagaagc atgggccctg ctggccttaa
       61 ggttctgctg ctgctttttc tgggagcttt ccagggctct tttaccaaaa agaaaaactt
      121 gcaatcagta tgtggacgac ctgtacacac tggacgcatt gtgggtggcc aagatgctgc
      181 tttggggcgc tggccctggc aggtgagcct gcgttttgac tacacccatt cttgtggagg
      241 ttctctcatc agtgaccact gggtgctgac ggcagcacac tgcataaaaa agacctggta
      301 cagttttcta tacagtgtgt ggcttggatc catcgataga gagtactcaa gcacaggcaa
      361 agaatactat gtgtccagaa tcgccatccc cgacaaacac cgccacacag aagcagacat
      421 cgccctgctg aagctgtctt cccgggtcac cttctcatcg gtcattctgc ccatctgctt
      481 gcccaatatc tcaaagcagc tgacagttcc agcttcttgc tgggtgactg gatggggaca
      541 aaatcaggaa ggtcactacc cctctaccct ccaagaactt gaagtgcctg tcatttccag
      601 tgaggcgtgt gaacaactct acaacccaat tggtgtcttc ctcccggatc tggagcgggt
      661 catcaaggaa gacatgttct gtgctggtga gaggcagtcg aggaaggata gctgcaaggg
      721 cgattctgga gggcctctgt cctgtcacat tgatggtgtc tggaggctga tgggtgtggt
      781 aagctggggt ttggaatgcg gtaaggatct tccgggagtc tacaccaacg tgacctacta
      841 ccaaaagtgg atcagtgcta ttatctcgag agctcctccg ggctggggtg gtgacagcac
      901 ccacatgact tcctgttccc tactatgtta ctttctctgg ctctcctggg atcctcccga
      961 gcctttggcc ctagcgtaat accaagtcaa tccaggagct gctgctgttg gggaactcac
     1021 gggatggggt gtgtggagaa taaagcctta gcggagaact catgagacag tcgctgcgat
     1081 gcctggatga ctgcctttat gtatgtgctt gcaaggttct tgctttgtgt atgtttcagt
     1141 agttggaatg caaacagcta ataaataagg ctaccacttc tgtgcaa
//
