LOCUS       NM_001374208            1298 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus serine protease 47 (Prss47), transcript variant 1,
            mRNA.
ACCESSION   NM_001374208 XM_006517494
VERSION     NM_001374208.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154713.2.
            
            On Sep 12, 2019 this sequence version replaced XM_006517494.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.114615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC154713.2         155721-155930
            211-373             AC154713.2         156319-156481
            374-651             AC154713.2         158625-158902
            652-815             AC154713.2         161744-161907
            816-1298            AC154713.2         163022-163504
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.21 cM"
     gene            1..1298
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /note="serine protease 47"
                     /db_xref="GeneID:218304"
                     /db_xref="MGI:MGI:2685120"
     exon            1..210
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /inference="alignment:Splign:2.1.0"
     exon            211..373
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1133
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protease, serine 47"
                     /codon_start=1
                     /product="protease, serine 47 isoform 1"
                     /protein_id="NP_001361137.1"
                     /db_xref="CCDS:CCDS88474.1"
                     /db_xref="GeneID:218304"
                     /db_xref="MGI:MGI:2685120"
                     /translation="MVGKVFGGQDTLAGQWPWQASLLYRGVHLCGAVLIDTHWLASTA
                     HCFRNKSQAPEDYEVLLGNNQLYQETKHTQKISVNHIVSHPDFEKFHSFGSDIAMLQL
                     HLPINFTSYVVPACLPSKDTQLSNHTSCWITGWGMLSEDTKLLPPFSLQEGEVGIIDN
                     EFCNALYGQTPGQSRNYVYEEMLCAGGLSTGKSICRGDSGGPLICYHNSTWVLVGLAS
                     WGLDCRHPIYPSVFTRVAYFTDWISQVKRLTPLPEPVSVSLHTELQPTPLKAAGSPQP
                     CNILMAAQIWFLMLFILEAPQWTPE"
     exon            374..651
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /inference="alignment:Splign:2.1.0"
     exon            652..815
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1298
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1278..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /note="hexamer: AATAAA"
     polyA_site      1298
                     /gene="Prss47"
                     /gene_synonym="Gm274"
                     /note="major polyA site"
ORIGIN      
        1 aaaacggtgt ccagggctgt cccaatggtg ttggtagaga acatgggatt cctaagagta
       61 gggacaaaag agaacaaagc tccctgaagc ctagactgcc aactcctggg aacagttgaa
      121 tacaacctgc caagatctgg gacattaagc catgacattg agcacctaac atcagtaacc
      181 cataagactt ctagttcttt gatctgaaaa tttgtgggaa gccgaagatg gttgggaaag
      241 tgttcggtgg ccaggacaca ttggctggcc agtggccatg gcaggccagc ctgctgtacc
      301 ggggcgtgca tctctgtgga gctgtcctca ttgacaccca ctggctggct tccacagccc
      361 actgttttcg aaacaaatcc caggccccag aggactatga ggttctgttg gggaataatc
      421 agctgtacca ggaaacgaag cacactcaga agatttctgt gaatcatatc gtcagtcatc
      481 cagactttga gaagtttcat tcttttggaa gtgacattgc aatgctgcag ctgcatctgc
      541 ccataaactt cacatcctat gttgtacctg cctgtctccc atccaaagac acacagctct
      601 ccaaccacac atcctgttgg ataactggtt ggggaatgct ttctgaagac acaaaactgt
      661 taccaccatt ctcactccag gagggtgagg tgggcatcat tgacaatgag ttctgtaatg
      721 ccttgtacgg gcaaacacca ggccaaagca ggaactatgt atatgaggaa atgctgtgtg
      781 caggggggct ctccacagga aagtccatct gcaggggtga ctctgggggc cctctcatct
      841 gctaccacaa cagtacatgg gtcctggtag gactggccag ctggggcctg gattgccggc
      901 atcccattta ccccagcgtc ttcaccaggg tcgcctactt cactgactgg atcagccaag
      961 tcaagagact cactccactt ccagaacctg tatctgtgtc tcttcacaca gaacttcaac
     1021 ccacacctct gaaggctgct ggctccccac aaccctgcaa catccttatg gctgcacaaa
     1081 tctggttcct gatgttattt atccttgaag ctccacagtg gaccccagag tgaacaccag
     1141 gcctttaagc attattttca ggtttttttt ttttcctgag atacagcctc cactccttag
     1201 tttaccatct gcaccttttc ctcagcatat ctggccattc atggttacta ccccccaaaa
     1261 gcatagaaaa acctaccaat aaagcttatc tttcttca
//
