LOCUS       NM_153099               1595 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus serine protease 42 (Prss42), mRNA.
ACCESSION   NM_153099
VERSION     NM_153099.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Satoh,Y., Takei,N., Kawamura,S., Takahashi,N., Kotani,T. and
            Kimura,A.P.
  TITLE     A novel testis-specific long noncoding RNA, Tesra, activates the
            Prss42/Tessp-2 gene during mouse spermatogenesisdagger
  JOURNAL   Biol Reprod 100 (3), 833-848 (2019)
   PUBMED   30379984
  REMARK    GeneRIF: These results proposed a potential function of an lncRNA,
            Tesra, in transcriptional activation and suggest a novel
            relationship between an lncRNA and an enhancer.
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Yoneda,R., Satoh,Y., Yoshida,I., Kawamura,S., Kotani,T. and
            Kimura,A.P.
  TITLE     A genomic region transcribed into a long noncoding RNA interacts
            with the Prss42/Tessp-2 promoter in spermatocytes during mouse
            spermatogenesis, and its flanking sequences can function as
            enhancers
  JOURNAL   Mol Reprod Dev 83 (6), 541-557 (2016)
   PUBMED   27111572
  REMARK    GeneRIF: data therefore identified the direct interaction of a
            genomic region in the lncRNA-HSVIII locus with the Prss42/Tessp-2
            promoter in spermatocytes, and suggested that sequences adjacent to
            the lncRNA function as enhancers for the Prss42/Tessp-2 gene.
REFERENCE   3  (bases 1 to 1595)
  AUTHORS   Yoneda,R., Takahashi,T., Matsui,H., Takano,N., Hasebe,Y.,
            Ogiwara,K. and Kimura,A.P.
  TITLE     Three testis-specific paralogous serine proteases play different
            roles in murine spermatogenesis and are involved in germ cell
            survival during meiosis
  JOURNAL   Biol Reprod 88 (5), 118 (2013)
   PUBMED   23536369
  REMARK    GeneRIF: These results strongly suggest that the three paralogous
            Prss/Tessp proteases play different roles in spermatogenesis and
            that Prss42/Tessp-2 and Prss43/Tessp-3 are required for germ cell
            survival during meiosis.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB052292.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052292.1, BC060984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.79 cM"
     gene            1..1595
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /note="serine protease 42"
                     /db_xref="GeneID:235628"
                     /db_xref="MGI:MGI:2665280"
     exon            1..224
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1021
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /EC_number="3.4.21.-"
                     /note="testis serine protease 2; protease, serine 42"
                     /codon_start=1
                     /product="serine protease 42 precursor"
                     /protein_id="NP_694739.1"
                     /db_xref="CCDS:CCDS23572.1"
                     /db_xref="GeneID:235628"
                     /db_xref="MGI:MGI:2665280"
                     /translation="MASGGGSLGLIVFLLLLQPKPCEAWAAASVLSTSGFPSGFSEAP
                     RDNPPPPTRVRMSKATTRSPFMNFSLVCGQPFMKIMGGVDAEEGKWPWQVSVRVRHMH
                     VCGGSLINSQWVLTAAHCIYSRIQYNVKVGDRSVYRQNTSLVIPIKTIFVHPKFSTTI
                     VVKNDIALLKLQHPVNFTTNIYPVCIPSESFPVKAGTKCWVTGWGKLVPGAPDVPTEI
                     LQEVDQNVILYEECNEMLKKATSSSVDLVKRGMVCGYKERGKDACQGDSGGPMSCEFE
                     NKWVQVGVVSWGISCGRKGYPGVYTDVAFYSKWLIAVVNQADCLHPVVFLVLLLCSLT
                     S"
     exon            225..381
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..644
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..805
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1555
                     /gene="Prss42"
                     /gene_synonym="Tessp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctacgtgat gacatggcgt ccggaggtgg ctccctgggc ctcatagtct tcctcttgct
       61 ccttcagcca aagccctgcg aggcctgggc agccgcctct gtactctcta cttccggttt
      121 cccctcaggg tttagtgaag ccccgaggga caacccaccg ccacccaccc gggtgcgcat
      181 gtccaaggct accacccgct ctcctttcat gaacttttcc ttagtgtgtg gccaaccctt
      241 tatgaagatc atgggagggg tagacgctga agaggggaag tggccttggc aggtgagcgt
      301 tcgggtcagg cacatgcatg tctgtggagg ttccctcatc aattcccagt gggtgctgac
      361 tgccgcccat tgtatttaca gccgaatcca gtacaacgtc aaggtgggcg atcggagtgt
      421 ctaccgacag aatacaagtc tggtgattcc catcaagacc atctttgtcc accctaagtt
      481 ctcaacaact atcgtcgtta aaaatgatat tgctcttctc aagctccaac accctgtgaa
      541 tttcaccact aacatatacc ctgtctgcat cccttcagag agttttcctg taaaagctgg
      601 gaccaaatgt tgggtgacag gatggggaaa actagtgcca ggcgcaccgg atgttccgac
      661 agaaatcctc caggaggtgg accaaaatgt catcctttat gaggaatgta atgagatgct
      721 gaagaaagct acctcaagtt ctgtggatct cgtcaagaga ggcatggtct gtggctataa
      781 agaaagagga aaggacgcct gccagggaga ttctggaggc ccgatgtcct gtgaatttga
      841 aaacaaatgg gtgcaggtag gagttgtgag ctggggcatc agctgtggtc gcaaaggata
      901 ccctggagtt tatacagacg ttgccttcta cagcaagtgg ctaattgccg tggtgaacca
      961 ggcagattgt ttgcatccag tggtcttcct cgtcttactg ctgtgttcgc tgacctcatg
     1021 acatcctgtg gacacggtga tctcattcct atcctcttta gagcccctct tgtttgacct
     1081 tcccaatgcc ctttcttcaa atcccttgcc ccagagagag ccacagtgaa atatgtcggg
     1141 gatctgagag acttgaaagt gttctgcctg gtgctctggt caccatcctt ggccacagca
     1201 ctcctgagtt gtgctctgcc tggcagtaac gaaggttagt cagttccagt tagaagacaa
     1261 actggcctgc caggtcaatc gcagtgacct cagcaaggat gtcatcaggg gaggggcaag
     1321 tgctaggcat agctgtggtt tcagggaact cacctcagac tgtcacacta gatctagctt
     1381 ggtgatcaca cacacacaca cacacacaca cacacacaca cacacacaga gcgcttatgt
     1441 gtcctaacta taattgtttt ctttatacat ctttatctat gactttgtaa agttacattt
     1501 catatagaat gtaatttgca accatgttca aagataaagt gaaactgaaa aaataaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
