LOCUS       NM_009356               1301 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine protease 40 (Prss40), mRNA.
ACCESSION   NM_009356
VERSION     NM_009356.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1301)
  AUTHORS   Kohno,N., Yamagata,K., Yamada,S., Kashiwabara,S., Sakai,Y. and
            Baba,T.
  TITLE     Two novel testicular serine proteases, TESP1 and TESP2, are present
            in the mouse sperm acrosome
  JOURNAL   Biochem Biophys Res Commun 245 (3), 658-665 (1998)
   PUBMED   9588171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106841.11.
            
            On Aug 18, 2006 this sequence version replaced NM_009356.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008911.1, BC145989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC106841.11        5647-5860
            215-377             AC106841.11        6685-6847
            378-652             AC106841.11        8463-8737
            653-822             AC106841.11        10452-10621
            823-1301            AC106841.11        13781-14259
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 13.34 cM"
     gene            1..1301
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /note="serine protease 40"
                     /db_xref="GeneID:21756"
                     /db_xref="MGI:MGI:1270857"
     exon            1..214
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1137
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /EC_number="3.4.21.-"
                     /note="testicular serine protease 2; protease, serine 40"
                     /codon_start=1
                     /product="serine protease 40 precursor"
                     /protein_id="NP_033382.2"
                     /db_xref="CCDS:CCDS14870.1"
                     /db_xref="GeneID:21756"
                     /db_xref="MGI:MGI:1270857"
                     /translation="MCGIRAKKSGLGGYGAGLLAALLGVSFLSQHAQTAEHVTNAANN
                     TTIQIMKSTLSLSEVCGKTKFQGKIYGGQIAGAERWPWQASLRLYGRHICGAVLIDKN
                     WVLSAAHCFQRSQEPSDYHVMLGYTDLNSPTRYSRTMSVQKVIVHKDYNRFHTQGSDI
                     VLLQLRSSVEYSSHILPACVPEENIKIPKEKACWASGWGYLREDVRIPLPNELYEAEL
                     IIMSNDQCKGFFPPPVPGSGRSYYIYDDMVCAADYDMSKSICAGDSGGPLVCLLEGSW
                     YVVGLTSWSSTCEEPIVSPSVFARVSYFDKWIKDNKKSSSNSKPGESPHHPGSPENEN
                     PEGDNKNQGAVIKPTVCTALLLSQILLQQLI"
     exon            215..377
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..652
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..822
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1301
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /note="hexamer: AATAAA"
     polyA_site      1297
                     /gene="Prss40"
                     /gene_synonym="Tesp2"
                     /note="major polyA site"
ORIGIN      
        1 ggtcctgccc gggacccaga cacaagccgg ccagatgcca tgtgtggcat cagggccaaa
       61 aaatcgggcc tgggtggata cggggccggc ctgctggctg ctctgctcgg agtgagcttc
      121 ctgtcacagc atgcccagac cgcagaacac gtcaccaacg ctgcgaataa cactaccatc
      181 cagatcatga agtccactct atccctgtca gaggtatgtg gcaagaccaa attccaaggg
      241 aagatctatg gcggtcagat tgcaggggct gagcggtggc cgtggcaggc cagtctgcgc
      301 ttatatggca ggcacatctg tggagcagtt ctcatcgaca aaaactgggt actcagcgct
      361 gcccactgct tccaaagatc tcaagaacca agtgactacc atgtcatgct aggctacacc
      421 gacctgaaca gtcccaccag gtacagcagg acgatgtcag tgcagaaggt catcgttcac
      481 aaagactaca acagattcca cacccaagga agtgacattg tcctgctgca gctgcgttcc
      541 tctgtggagt acagctccca catcctccca gcctgtgtcc ctgaggaaaa cataaaaatc
      601 cccaaagaga aggcctgctg ggctagtggc tggggctatc tcagagagga cgtgcgaatt
      661 cctttgccta atgaactgta tgaagccgag ctcatcatca tgagtaatga ccagtgtaaa
      721 ggatttttcc caccaccagt tccgggatcc ggtagaagct actacatata tgatgatatg
      781 gtgtgtgctg ctgactatga catgtcaaaa tccatctgcg caggagattc tgggggcccc
      841 cttgtctgct tactggaagg ctcctggtac gtggtagggc taaccagctg gagctctaca
      901 tgtgaagaac caatcgtcag ccccagtgtc tttgccaggg tctcctactt tgacaagtgg
      961 attaaagata acaagaaatc atcatccaac tcaaagccag gggagtcccc tcaccatcca
     1021 ggatcccctg agaatgaaaa tcccgagggc gacaataaaa accaaggtgc tgttatcaag
     1081 ccgacggtgt gcacagccct gctgctctcc cagatcctcc tgcaacagtt gatttagttc
     1141 agggatctgt gatggagcca cggggcctta gacagccaga atgtcctgca agccacctca
     1201 ctgagcactg tcattcatgc ctccatcagt gtgccactct tgccctaggc caggcaaaac
     1261 aaagaatgaa aactaaagaa taaaactaaa aactaaagaa a
//
