LOCUS       NP_001038986             322 aa            linear   ROD 03-APR-2024
DEFINITION  serine protease 38 precursor [Mus musculus].
ACCESSION   NP_001038986 XP_911177 XP_993452 XP_997724
VERSION     NP_001038986.1
DBSOURCE    REFSEQ: accession NM_001045521.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 322)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (residues 1 to 322)
  AUTHORS   Skarnes,W.C., Rosen,B., West,A.P., Koutsourakis,M., Bushell,W.,
            Iyer,V., Mujica,A.O., Thomas,M., Harrow,J., Cox,T., Jackson,D.,
            Severin,J., Biggs,P., Fu,J., Nefedov,M., de Jong,P.J., Stewart,A.F.
            and Bradley,A.
  TITLE     A conditional knockout resource for the genome-wide study of mouse
            gene function
  JOURNAL   Nature 474 (7351), 337-342 (2011)
   PUBMED   21677750
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY736706.1, AL713994.15 and BY757078.1.
            
            On or before Sep 2, 2006 this sequence version replaced
            XP_911177.2, XP_997724.1, XP_993452.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145810.1, BC147400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.7 cM"
     Protein         1..322
                     /product="serine protease 38 precursor"
                     /note="serine protease MPN2; marapsin-2; protease, serine
                     38"
                     /calculated_mol_wt=32823
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2893
     mat_peptide     56..322
                     /product="Serine protease 38. /id=PRO_0000328823"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UKY7.1)"
                     /calculated_mol_wt=30021
     Region          58..287
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            order(96,146,241)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3UKY7.1)"
     Site            order(235,260,262)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     Site            250
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3UKY7.1)"
     Site            276
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3UKY7.1)"
     CDS             1..322
                     /gene="Prss38"
                     /gene_synonym="Gm249; Mpn2"
                     /coded_by="NM_001045521.1:24..992"
                     /db_xref="CCDS:CCDS36170.1"
                     /db_xref="GeneID:216797"
                     /db_xref="MGI:MGI:2685095"
ORIGIN      
        1 maaltsglgv lgyllfplll asptwvtsvs rrhpksqans lsgdvacgqp vlqgkllgge
       61 fardrkwpwq vslhysgfhi cggsilsayw vlsaahcfdr gkkletydiy vgitnlekan
      121 rhtqwfeiyq viihptfqmy hpiggdvalv qlksaivfsd fvlpiclpps dlylinlscw
      181 ttgwgmispq getgnellea qlpliprfqc qllyglssyl lpemlcaadi ktmknvcegd
      241 sgsplvckqn qtwlqigivs wgrgcaqply pgvfanvsyf lswiryhlqi ipnppqilps
      301 lssspkntli ifvtimghll vl
//
