LOCUS       NM_001417656            1100 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus serine protease 37 (Prss37), transcript variant 2,
            mRNA.
ACCESSION   NM_001417656 XM_006506525
VERSION     NM_001417656.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Xiong,W., Ge,H., Shen,C., Li,C., Zhang,X., Tang,L., Shen,Y., Lu,S.,
            Zhang,H. and Wang,Z.
  TITLE     PRSS37 deficiency leads to impaired energy metabolism in testis and
            sperm revealed by DIA-based quantitative proteomic analysis
  JOURNAL   Reprod Sci 30 (1), 145-168 (2023)
   PUBMED   35471551
  REMARK    GeneRIF: PRSS37 deficiency leads to impaired energy metabolism in
            testis and sperm revealed by DIA-based quantitative proteomic
            analysis.
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Xiong,W., Shen,C., Li,C., Zhang,X., Ge,H., Tang,L., Shen,Y., Lu,S.,
            Zhang,H., Han,M., Zhang,A., Wang,J., Wu,Y., Fei,J. and Wang,Z.
  TITLE     Dissecting the PRSS37 interactome and potential mechanisms leading
            to ADAM3 loss in PRSS37-null sperm
  JOURNAL   J Cell Sci 134 (10) (2021)
   PUBMED   34028541
  REMARK    GeneRIF: Dissecting the PRSS37 interactome and potential mechanisms
            leading to ADAM3 loss in PRSS37-null sperm.
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Shen,C., Wang,J., Zhuang,H., Liu,J., Wang,X., Chen,X., Wu,Z.,
            Wu,W., Wu,Y., Sun,Y., Yan,H., Fei,J., Kuang,Y. and Wang,Z.
  TITLE     Establishment, characterization, and application of
            pAcr-SP-NTP-EGFP transgenic mice in visualizing the
            oviduct-migrating ability of sperm from Prss37-null mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 47 (6), 466-473 (2015)
   PUBMED   25921412
  REMARK    GeneRIF: interstrain hybridization obtained Prss37(-/-)EGFP(tg/+)
            males produced sperm with impaired oviduct-migrating ability as
            visualized under fluorescence microscope, compared with
            Prss37(+/+)EGFP(tg/+) counterparts
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Shen,C., Kuang,Y., Liu,J., Feng,J., Chen,X., Wu,W., Chi,J.,
            Tang,L., Wang,Y., Fei,J. and Wang,Z.
  TITLE     Prss37 is required for male fertility in the mouse
  JOURNAL   Biol Reprod 88 (5), 123 (2013)
   PUBMED   23553430
  REMARK    GeneRIF: Prss37 deficiency causes the absence of mature Adam3 in
            sperm and a defect in sperm migration from uterus into oviduct,
            which mainly accounts for male infertility of Prss37-null mice
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155653.4.
            
            On Mar 7, 2023 this sequence version replaced XM_006506525.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.243378.1,
                                           SRR17784644.1103929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC155653.4         14947-15030
            85-312              AC155653.4         15171-15398
            313-454             AC155653.4         16616-16757
            455-708             AC155653.4         18077-18330
            709-845             AC155653.4         18946-19082
            846-1100            AC155653.4         19354-19608
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.82 cM"
     gene            1..1100
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /note="serine protease 37"
                     /db_xref="GeneID:67690"
                     /db_xref="MGI:MGI:1914940"
     exon            1..84
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..312
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..992
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /note="probable inactive trypsin-X2; probable inactive
                     serine protease 37; protease, serine 37"
                     /codon_start=1
                     /product="probable inactive serine protease 37 precursor"
                     /protein_id="NP_001404585.1"
                     /db_xref="GeneID:67690"
                     /db_xref="MGI:MGI:1914940"
                     /translation="MKLIIYLTILAGTALVTHSSVQKEDHAPYLAYLKSNFNPCVGVL
                     IKASWVLAPSHCYLPNLRVMLGNFKSRVRDGTEQTIYPIQIIRYWNYSHTAPQDDLML
                     IKLAKPATFNHKVQVLPIATTNVRPGTVCTLSGLDWSQENNGRHPDLRQNLEAPVMTD
                     KDCQKTQQGSSHRNSLCVRFVKVFSRIFGEVAVATVICKNKLQGIEVGHFMGGDVGIY
                     TNIYSYVPWIEKTTKEKMT"
     exon            313..454
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..708
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..845
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1100
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1065..1070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /note="hexamer: AATAAA"
     polyA_site      1100
                     /gene="Prss37"
                     /gene_synonym="1700016G05Rik; Tryx2"
                     /note="major polyA site"
ORIGIN      
        1 aaaccattaa gggcatgctc tccctgagcc aaggtagaga atcctgttcc tcacagctct
       61 gtgctcagaa actctgcaag aaagtcccag tagaagcata ctctcctgtt tctcagtctt
      121 cctatctgga gttttctcca cctgctgatt ttgcctagag cccttaccta tccaaacctg
      181 ctggctccgg tagacatccc ccaggagaca agtgagcaga agattccggc ctctgctgat
      241 cttctttcta tacctcgaaa ggaaagagct ggaccatcat gaaacttatt atctatctca
      301 ccatcctagc tggaacagct ttagtcactc actcatctgt gcagaaagag gaccatgctc
      361 cctacttagc atacctcaag tctaacttca atccctgcgt gggtgtcctc atcaaagcca
      421 gctgggtgct ggccccatct cactgctatt taccaaatct gagggtgatg ttgggaaatt
      481 tcaagagcag agtcagagat gggacagagc agacaattta tcccatccag attatccgct
      541 actggaacta cagccacaca gccccacagg atgacctcat gcttattaaa ctagctaagc
      601 ctgccacctt caaccacaaa gtccaggttc ttcccatagc caccactaat gtccggccag
      661 gcactgtctg tacactttca ggtttggact ggagtcaaga aaacaatggc aggcaccctg
      721 acttacggca gaacctggaa gctcccgtga tgacggacaa agactgccag aaaactcaac
      781 aaggaagcag ccacagaaac tccttatgtg tcagatttgt gaaagtattc agccgaattt
      841 ttggggaggt tgctgtagct actgtcattt gtaaaaacaa gctccaggga attgaagttg
      901 gacacttcat gggaggggac gttggcatct ataccaacat ttactcatat gtaccatgga
      961 ttgagaaaac cactaaggag aagatgacat gatgccctgc ttttccctcc gcatctcatt
     1021 gcctctgcca ttgactgaag gagcttacat ggtccctaaa ctcaaataaa ctctccaaac
     1081 agaaagtttg gaatgcagca
//
