LOCUS       NM_001319147            3028 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus serine protease 36 (Prss36), mRNA.
ACCESSION   NM_001319147
VERSION     NM_001319147.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3028)
  AUTHORS   Camerer,E., Barker,A., Duong,D.N., Ganesan,R., Kataoka,H.,
            Cornelissen,I., Darragh,M.R., Hussain,A., Zheng,Y.W.,
            Srinivasan,Y., Brown,C., Xu,S.M., Regard,J.B., Lin,C.Y.,
            Craik,C.S., Kirchhofer,D. and Coughlin,S.R.
  TITLE     Local protease signaling contributes to neural tube closure in the
            mouse embryo
  JOURNAL   Dev Cell 18 (1), 25-38 (2010)
   PUBMED   20152175
REFERENCE   3  (bases 1 to 3028)
  AUTHORS   Cal,S., Quesada,V., Llamazares,M., Diaz-Perales,A., Garabaya,C. and
            Lopez-Otin,C.
  TITLE     Human polyserase-2, a novel enzyme with three tandem serine
            protease domains in a single polypeptide chain
  JOURNAL   J Biol Chem 280 (3), 1953-1961 (2005)
   PUBMED   15536082
  REMARK    Erratum:[J Biol Chem. 2018 Jul 27;293(30):11784. doi:
            10.1074/jbc.AAC118.004649.. PMID: 30054290]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC149222.4         7337-7650
            315-353             AC149222.4         7973-8011
            354-389             AC149222.4         8189-8224
            390-552             AC149222.4         8663-8825
            553-833             AC149222.4         9140-9420
            834-1000            AC149222.4         12859-13025
            1001-1250           AC149222.4         17224-17473
            1251-1380           AC149222.4         17608-17737
            1381-1619           AC149222.4         18059-18297
            1620-1783           AC149222.4         18397-18560
            1784-2021           AC149222.4         19435-19672
            2022-2163           AC149222.4         19782-19923
            2164-2429           AC149222.4         20230-20495
            2430-2551           AC149222.4         20570-20691
            2552-3028           AC149222.4         20948-21424
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.84 cM"
     gene            1..3028
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /note="serine protease 36"
                     /db_xref="GeneID:77613"
                     /db_xref="MGI:MGI:1924863"
     exon            1..314
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2836
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /note="polyserase-2 protein; polyserine protease 2;
                     protease, serine 36"
                     /codon_start=1
                     /product="polyserase-2 precursor"
                     /protein_id="NP_001306076.1"
                     /db_xref="CCDS:CCDS52410.2"
                     /db_xref="GeneID:77613"
                     /db_xref="MGI:MGI:1924863"
                     /translation="MSHHLFLPVVIMVVSPIPPGAFQDSVVSPTQGEFEDLDCGRPEP
                     SSRIVGGSDAHPGTWPWQVSLHQGGGHICGGSLIAPSWVLSAAHCFVTNGTLEPADEL
                     SVLLGVHSQDGPLEGAHMRSVATILIPDNYSTVELGADLALLRLASPAKLGPSVRPVC
                     LPRASHLFAHGTACWATGWGDVQEAVPLPLPWVLQEVELRLLGEAACQCLYSRPGPFN
                     LTFQLLPGMLCAGYPAGRRDTCQGDSGGPLVCEDGGRWFLAGITSFGFGCGRRNRPGV
                     FTAVAPYESWIREHVMGSEPGPVFPSQLQKPQSGPWEPREENCTFAQPECGKAPRPGT
                     WPWEAQVTVPGSTPCYGALVSDRWVLAPASCFLDSPHDFETWRVLLPSRPEEERVARL
                     VAHENASRDFASDLALLQLRTRVNLTAAPSAVCLPHHEHYFLPGSHCRLARWGRGELA
                     PGSSAQLEAQLLNGWWCHCLYGRQGETVPRPGDPPHLLCPAYQEEEEAGLCWKDSSWS
                     LLCREEGTWFLAGYRTLSDGCLRPRAFSPMQTHGPWIRHVTQGAYLEDQLTWDWGPEG
                     EETEKQTCPTHTEHGACGLRPKSTPAGVLWPWLTEVHVTGDRVCTGILVAPGWVLAAT
                     HCILRLGSTTVPYIEVYLGRAGVSSLPQGHQVSRSVVSIRLPRHLGLRPPLALLELNS
                     RVEPSPSALPICLHPGGIPSGASCWVLGWKNPQDRVPVVAAVSILTPRLCHCLYPGIL
                     TPGTFCVLYSEGQEDRCEVTSAPPLLCQTEEGPWVLVGMAVRGNRELFAAIGPEATWI
                     SQTVGEAHFLHLGGSSYWSPEGSDLCPQDLAGSASSPKVTALLLLLLLAPLIPR"
     exon            315..353
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            354..389
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..552
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            553..833
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1250
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1380
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1619
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1783
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..2021
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2163
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2429
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2551
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..3028
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3028
                     /gene="Prss36"
                     /gene_synonym="C330007D15Rik"
                     /note="major polyA site"
ORIGIN      
        1 atccaacagg tgtcctggag tgaggacacc gccctacctc cactctgagc ctccagatat
       61 gtgagatgca ccagaattca gggtggggcc tttgacctcc ctattttccc ctttcaggcc
      121 cagatcctct cagattccca cagatgggct ccagccaggg agggtggggc tacccctggg
      181 accatcagga ggaaccagct acatagtccg gtgacagagt ggtggcagga agcagcctct
      241 cacctgcctc tgtgcctcca gctgacttta gtagaccatg tcccatcacc tgtttctccc
      301 agttgtaatc atggtggtca gtcccatccc tccaggagcc ttccaggact cagtggtcag
      361 tcctacccaa ggagaatttg aagacctaga ctgcggccgc cctgagccct cttcccgcat
      421 tgtggggggc tcggacgctc atcctggcac ttggccatgg caggtgagcc tgcatcaagg
      481 tgggggccac atctgcgggg gctccctcat cgccccttcc tgggtcctct ccgctgctca
      541 ctgtttcgtg acgaatggaa ccttggagcc cgcggacgaa ttgtcagttc tgctgggcgt
      601 gcactcccag gacgggcccc tggaaggagc gcacatgcgc tcagtggcca ccatcctgat
      661 accggacaac tacagcacag tggaactggg cgcagacttg gctctgctgc gcctggcctc
      721 gccagccaag ctgggcccct ctgtgcggcc ggtctgcctg cctcgtgcct cgcacctctt
      781 cgctcacgga actgcctgct gggccactgg ttggggggac gtccaggagg ctgtccctct
      841 gcctctgccc tgggttctac aggaagtgga gctaaggttg ctgggagagg ctgcctgtca
      901 atgtctctac agccgtcctg gccctttcaa cctgactttc cagctgttgc cagggatgtt
      961 gtgtgctggc tatccagcgg gacgaaggga tacctgccag ggtgactctg ggggaccgct
     1021 ggtctgtgag gacggaggcc gatggttcct ggccggaatc accagctttg gctttggctg
     1081 tggacggagg aaccgccctg gggtcttcac tgcagtggct ccctatgagt cgtggattcg
     1141 ggaacacgtg atgggttcag aacctgggcc tgtctttccc agccagctcc agaagccaca
     1201 gtcaggaccc tgggagccca gagaagaaaa ctgtaccttt gctcaaccag agtgcgggaa
     1261 ggctccgagg ccggggacct ggccctggga ggcccaagtg accgtaccag gctccacacc
     1321 ctgctatgga gctctggtgt ctgacagatg ggtcttggca cccgccagct gctttctgga
     1381 ctcaccccac gattttgaga cctggcgggt gctgctgccc tcccgtccgg aggaggagag
     1441 ggtggcgcgc ctcgtggcgc acgagaacgc ttccagggac ttcgcttcgg acctggcgct
     1501 gctgcagctg aggacgcgcg tgaacctgac cgcggccccg agtgccgtgt gcctgcccca
     1561 ccacgaacac tattttctgc ccgggagcca ctgccgcctg gctcgctggg gacgcgggga
     1621 actcgccccg ggctccagcg cgcagctgga ggcgcagctg ttgaacggct ggtggtgtca
     1681 ttgcctgtac ggccgccagg gggagaccgt gccgcggcca ggagacccgc cgcacttgct
     1741 ttgtcccgcc taccaggagg aggaagaggc gggcctatgt tggaaagatt ccagttggag
     1801 ccttctgtgc cgtgaggagg ggacctggtt cctggcagga tacagaaccc tctcagatgg
     1861 ttgtctccga ccccgagcct tttccccaat gcagactcat ggtccgtgga tccgtcatgt
     1921 gactcaggga gcttacctgg aggaccagct aacctgggac tggggccctg aaggggagga
     1981 gaccgagaaa cagacttgtc ccacacatac tgagcacggt gcctgtggcc taaggccaaa
     2041 atccactcca gctggtgtgt tgtggccctg gctgacggag gtgcatgtga ctggtgatag
     2101 agtctgcact gggattctgg tggccccagg ctgggtccta gcagccactc actgtattct
     2161 caggctgggc tctacaacag tgccctacat tgaagtatat cttggccggg caggggtcag
     2221 ctccctccca cagggccacc aggtatctcg gtctgtcgtc agcatccgtc tgccccggca
     2281 cttaggactt agaccccccc tggctctact ggagctgaac tctcgggtgg agccctcccc
     2341 atcagctctt cccatctgcc tacacccagg gggtattcct tcaggggcca gctgctgggt
     2401 tttgggctgg aagaacccac aggacagagt tcctgtagtt gctgctgtct ccatcttgac
     2461 accacgactc tgtcactgcc tctatccggg tattctgact cctgggacct tctgtgtcct
     2521 ctattcagag ggacaggagg atagatgtga ggtcacctca gcacctcccc tcctgtgcca
     2581 gactgaggaa ggtccctggg ttctcgtggg catggctgtt cgaggaaacc gggagctgtt
     2641 tgcagccatt ggccctgaag ctacatggat atcgcaaacc gtgggagaag cccattttct
     2701 tcatctcggt ggctcctcct actggtctcc tgaaggcagt gacctctgcc cccaagactt
     2761 agcagggtct gctagctccc ctaaggtcac tgctctgctt ctgctcctcc tcctggctcc
     2821 actgatccct cgctgagagc ccggctccta ttcacaccac ccatcagggc tggaatgtgg
     2881 ctcaaccggc cagctcccgg gcctgaagag ggcctcttcc acctctactg catcagcttt
     2941 cagataattg gacctcagtg ctggctactt taaatctaag aatccttggg ggtggaggag
     3001 gaacagacaa taaaaatgta aatacaga
//
