LOCUS       NM_178738               2525 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus serine protease 35 (Prss35), mRNA.
ACCESSION   NM_178738
VERSION     NM_178738.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Li,Y., Zhong,X. and Yang,F.
  TITLE     Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice
            by regulating the C3/MMPs/prss axis
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (7), 4823-4831 (2024)
   PUBMED   38157023
  REMARK    GeneRIF: Silencing HE4 alleviates the renal fibrosis in lupus
            nephritis mice by regulating the C3/MMPs/prss axis.
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Van Hove,L., Lecomte,K., Roels,J., Vandamme,N., Vikkula,H.K.,
            Hoorens,I., Ongenae,K., Hochepied,T., Donati,G., Saeys,Y.,
            Quist,S.R., Watt,F.M., van Loo,G. and Hoste,E.
  TITLE     Fibrotic enzymes modulate wound-induced skin tumorigenesis
  JOURNAL   EMBO Rep 22 (5), e51573 (2021)
   PUBMED   33780134
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Hoffmann,S., Schmitteckert,S., Raedecke,K., Rheinert,D.,
            Diebold,S., Roeth,R., Weiss,B., Granzow,M., Niesler,B.,
            Griesbeck,A., Eckstein,V., Zimmermann,W.H., Just,S. and
            Rappold,G.A.
  TITLE     Network-driven discovery yields new insight into Shox2-dependent
            cardiac rhythm control
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (4-5), 194702 (2021)
   PUBMED   33706013
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Nakajima,K., Ono,M., Radovic,U., Dizdarevic,S., Tomizawa,S.I.,
            Kuroha,K., Nagamatsu,G., Hoshi,I., Matsunaga,R., Shirakawa,T.,
            Kurosawa,T., Miyazaki,Y., Seki,M., Suzuki,Y., Koseki,H.,
            Nakamura,M., Suda,T. and Ohbo,K.
  TITLE     Lack of whey acidic protein (WAP) four-disulfide core domain
            protease inhibitor 2 (WFDC2) causes neonatal death from respiratory
            failure in mice
  JOURNAL   Dis Model Mech 12 (11) (2019)
   PUBMED   31562139
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Letra,A., Menezes,R., Fonseca,R.F., Govil,M., McHenry,T.,
            Murphy,M.J., Hennebold,J.D., Granjeiro,J.M., Castilla,E.E.,
            Orioli,I.M., Martin,R., Marazita,M.L., Bjork,B.C. and Vieira,A.R.
  TITLE     Novel cleft susceptibility genes in chromosome 6q
  JOURNAL   J Dent Res 89 (9), 927-932 (2010)
   PUBMED   20511563
REFERENCE   7  (bases 1 to 2525)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2525)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2525)
  AUTHORS   Wahlberg,P., Nylander,A., Ahlskog,N., Liu,K. and Ny,T.
  TITLE     Expression and localization of the serine proteases
            high-temperature requirement factor A1, serine protease 23, and
            serine protease 35 in the mouse ovary
  JOURNAL   Endocrinology 149 (10), 5070-5077 (2008)
   PUBMED   18566130
  REMARK    GeneRIF: HtrA1 and PRSS35 may be involved in ovulation and corpus
            luteum formation and regression, and that PRSS23 may play a role in
            follicular atresia
REFERENCE   10 (bases 1 to 2525)
  AUTHORS   Miyakoshi,K., Murphy,M.J., Yeoman,R.R., Mitra,S., Dubay,C.J. and
            Hennebold,J.D.
  TITLE     The identification of novel ovarian proteases through the use of
            genomic and bioinformatic methodologies
  JOURNAL   Biol Reprod 75 (6), 823-835 (2006)
   PUBMED   16870946
  REMARK    GeneRIF: Prss35 mRNA levels increased around the time of ovulation
            and remained elevated in the developing corpus luteum
            GeneRIF: Mouse ortholog of human PRSS35 is an ovary-selectively
            expressed gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB659182.1 and BC075675.1.
            
            On Nov 1, 2007 this sequence version replaced NM_178738.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031411.1, AK031644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BB659182.1         1-31
            32-2525             BC075675.1         1-2494
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.58 cM"
     gene            1..2525
                     /gene="Prss35"
                     /gene_synonym="6030424L22Rik; P3D9"
                     /note="serine protease 35"
                     /db_xref="GeneID:244954"
                     /db_xref="MGI:MGI:2444800"
     exon            1..174
                     /gene="Prss35"
                     /gene_synonym="6030424L22Rik; P3D9"
                     /inference="alignment:Splign:2.1.0"
     exon            175..2525
                     /gene="Prss35"
                     /gene_synonym="6030424L22Rik; P3D9"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1425
                     /gene="Prss35"
                     /gene_synonym="6030424L22Rik; P3D9"
                     /note="inactive serine protease 35; protease, serine 35"
                     /codon_start=1
                     /product="inactive serine protease 35 precursor"
                     /protein_id="NP_848853.2"
                     /db_xref="CCDS:CCDS40714.1"
                     /db_xref="GeneID:244954"
                     /db_xref="MGI:MGI:2444800"
                     /translation="MENTLLWLVILIPGWALSDGSETELDFTWHLSRIPQVVSENTIH
                     LASPTFQADAGVVKATVCGIECQEELPAPSLSQLEESLSYETIFENGTRTLTRVKVQG
                     LVLEPTRNSSVKGAHPRRRRQVYGTDSRFSILDKRFATNFPFNTAVKLSTGCSGTLVS
                     PNHVLTAAHCVHDGKDYVKGSKKLRVGVLKMRNKGGRKKRRGSKRSRREAESAGQSQA
                     HLRESTTQRPGKKSRRGPRVTQGRPSFQWTRVKSTHIPKGWVRGENGGLALDYDYALL
                     ELKRAHKQQHMELGVSPTITKLPGGRIHFSGFDNDRDEQLVYRFCSVSEESNDLLYQY
                     CDAEAGSTGSGIYLRLKEPGQKNWKRKIVAVYSGHQWVDVHGVQKDYNVAVRITPLKY
                     AQICLWIHGNAANCAYG"
ORIGIN      
        1 tcagtgcagc agccccactc tcgcctggtc ccggactcgg ggaagctccg ctgagaggac
       61 cctgcactct gctgcccact aggctcctgg caccttccgt agccagtgtc tgcatccacc
      121 cggatccttg ctgggcagcg cccctgggac gggaggatac agtaagcatc tcagagggca
      181 aaatagaaga acaagatgga aaatacgtta ctctggttgg taattttaat ccctggatgg
      241 gccctctctg atgggtcgga aacagaacta gacttcacgt ggcacttgag cagaataccc
      301 caggttgtga gtgagaacac tatccatctt gccagcccca cgttccaggc ggatgctggg
      361 gtggtgaagg ccacagtgtg tggcatcgaa tgtcaggaag agctcccggc tcccagcctt
      421 tcccagttgg aagagtccct atcctatgag accatcttcg agaatggcac ccgaacctta
      481 accagggtga aagttcaagg tctggtcctg gaacccactc ggaacagcag cgtaaaagga
      541 gcacacccta ggagaaggag gcaggtgtat ggtacggaca gcaggttcag catcttagac
      601 aaaaggttcg cgaccaattt cccttttaat acagcagtga agctatccac cggctgcagc
      661 ggtaccctcg tttcccccaa ccatgtgctc acagctgccc actgtgtcca cgatgggaag
      721 gactatgtca aaggcagtaa aaagctgagg gtgggagtgc tgaagatgag aaacaaagga
      781 ggtcgcaaga aacgcagagg ttccaaaagg agccggagag aagcagagag tgctggtcaa
      841 agtcaggcgc atcttcggga gagcaccacc caaagaccgg ggaaaaaatc caggcgtggt
      901 ccaagagtca cccaaggaag gccttccttc caatggaccc gcgtcaagag cacccacatt
      961 cccaaaggct gggtgagggg agagaatggg ggcctggcct tggactacga ctacgcgctc
     1021 ctggagctga agcgcgcaca caagcaacag cacatggagc tgggagtcag ccccaccatc
     1081 accaagctgc cgggaggccg gatccacttc tctggatttg acaacgacag ggatgaacag
     1141 ttggtgtatc ggttttgcag cgtttctgag gaatccaatg acctcctgta tcagtattgc
     1201 gatgctgagg caggctccac aggctcgggg atctacctga ggctcaaaga accaggccaa
     1261 aaaaattgga agcgcaagat cgtcgcggtc tactcgggcc accagtgggt ggatgtgcac
     1321 ggagttcaga aggactataa cgtggctgtg cgcatcactc cgctcaagta cgcccagatt
     1381 tgcctctgga tccacggaaa cgctgccaac tgtgcttacg gctgagggaa aactgaagcg
     1441 agcttcatgc acatcttgaa tcccagagaa agccagctct cattgagaga ccactcatga
     1501 gctatgcata ggcttggact aacagtggtt tttacagcgt tttttttaca gacgtccttt
     1561 atcaaagtta ggttactttt gcacagttaa aatgttagtt acagatactg aaactagatg
     1621 gcacttcagc gacaagtata tattctttat atggtgataa gtttcgtttt gggggaaacc
     1681 atttgtttac ttgggccttt tggaatacca gacactcttt aaaacatcaa accagaactg
     1741 tgatgtgact tctcaatgga ctagctcttg agtcctactc taggaagaac ctaggaggat
     1801 gtagttctat gttcaacctc tatggaaaat aggaagattc acagtaacac cgttagaatc
     1861 aggggagaca ggaggtttag tttgcaatgt gatgaaatgc tatttcattc ttgccttcag
     1921 tgtttatatg tgtcttctct tggtactgag aaactcattt caagaactat agatcaaaac
     1981 atataaaaat tacaaatcaa atatactagt gagctgcata aacaaaactc gtaactatgg
     2041 ctttaaaaac ccaacactga aaaagtaaaa cgtaaaaaca aaattctagg cctttaggcc
     2101 caggcttggg aatgtggtct ttgtgactca atgctccaag gtatgctaat cataaaacag
     2161 atagcaacat ccctccaccc acccacttcc tgggttctag gagtattcat tcaaagaaag
     2221 tcaccctgac ccaccctgac cattgctgga acccactatg caaaggtgct attgttaggg
     2281 gctcttagaa actgtcttga gaaataaccc acacaatcac caggtattcc ttgtgacact
     2341 tgtgactttg cacttccttg tgactcttaa ctggtatttt tggtatgttc caacaacgcc
     2401 tttcccacct ccttgagttg tggtttcttc ctttaaatac ccccttactc agctactcgg
     2461 ggccccacgg tcctctaccc ctgcgtggtg tatgaccgtg ggcccaagag cgctcttgaa
     2521 taaaa
//
