LOCUS       NM_178372               1216 bp    mRNA    linear   ROD 23-AUG-2023
DEFINITION  Mus musculus serine protease 34 (Prss34), mRNA.
ACCESSION   NM_178372
VERSION     NM_178372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Iki M, Tanaka K, Deki H, Fujimaki M, Sato S, Yoshikawa S, Yamanishi
            Y and Karasuyama H.
  TITLE     Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated,
            delayed-onset allergic inflammation in mice
  JOURNAL   Blood 128 (25), 2909-2918 (2016)
   PUBMED   27789480
  REMARK    GeneRIF: basophil tryptase mMCP-11 is a crucial effector molecule
            for the induction of immunoglobulin E-mediated chronic allergic
            inflammation.
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Yamagishi H, Mochizuki Y, Hamakubo T, Obata K, Ugajin T, Sato S,
            Kawano Y, Minegishi Y and Karasuyama H.
  TITLE     Basophil-derived mouse mast cell protease 11 induces microvascular
            leakage and tissue edema in a mast cell-independent manner
  JOURNAL   Biochem Biophys Res Commun 415 (4), 709-713 (2011)
   PUBMED   22086176
  REMARK    GeneRIF: basophil-derived mMCP-11 can induce microvascular leakage
            via prostaglandins in a mast cell-independent manner, and may
            contribute to the development of basophil-mediated inflammatory
            responses.
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Ugajin T, Kojima T, Mukai K, Obata K, Kawano Y, Minegishi Y, Eishi
            Y, Yokozeki H and Karasuyama H.
  TITLE     Basophils preferentially express mouse Mast Cell Protease 11 among
            the mast cell tryptase family in contrast to mast cells
  JOURNAL   J Leukoc Biol 86 (6), 1417-1425 (2009)
   PUBMED   19703899
  REMARK    GeneRIF: basophils rather than mast cells are the major source of
            mMCP-11.
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C,
            Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D,
            Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N,
            Kimata K, Hayashizaki Y and Sekiguchi K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   5  (bases 1 to 1216)
  AUTHORS   Tang L and Rancourt DE.
  TITLE     Murine implantation serine proteinases 1 and 2: structure, function
            and evolution
  JOURNAL   Gene 364, 30-36 (2005)
   PUBMED   16257142
REFERENCE   6  (bases 1 to 1216)
  AUTHORS   Wong GW, Yasuda S, Morokawa N, Li L and Stevens RL.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY261775.1.
            
            On Jun 3, 2003 this sequence version replaced NM_178372.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY261775.1, AK081986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1216
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /note="serine protease 34"
                     /db_xref="GeneID:328780"
                     /db_xref="MGI:MGI:2681414"
     exon            1..173
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1057
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /note="mast cell protease 11; protease, serine 34"
                     /codon_start=1
                     /product="mastin precursor"
                     /protein_id="NP_848459.1"
                     /db_xref="CCDS:CCDS28514.1"
                     /db_xref="GeneID:328780"
                     /db_xref="MGI:MGI:2681414"
                     /translation="MCLGMLWLLFLSLPCLGNTMPLTLDLGSGQGLVGIVGGCPVSAS
                     RFPWQVSLRLYDMEHSRWEHECGGSLIHPQWVLTAAHCVRPKEVEAYGVRVQVGQLRL
                     YENDQLMKVVKIIRHPKFSEKLSARGGADIALLKLDTRVVLSEHVYPVSLPAASLRIS
                     SKKTCWVAGWGVIENYMPLPPPYHLREVAVPIVENNDCEQKYQTNSSSDSTTRIIKDD
                     MLCAGKEGRDSCKADSGGPLVCRWNCSWVQVGVVSWGIGCGLPDFPGVYTRVMSYVSW
                     IKCYVPTFLEPLKGPDGIHTTEETPATHIDPFTPPSGPASLS"
     exon            174..354
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /inference="alignment:Splign:2.1.0"
     exon            355..629
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /inference="alignment:Splign:2.1.0"
     exon            630..793
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1216
                     /gene="Prss34"
                     /gene_synonym="C130091P12; Mcp11; mMcp-11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagagag tggagtacaa ctgttccaat ccattagcac ctctgccctc aggtctcctg
       61 gctgccgaag tcagtatttg ggaccagaaa tctctgtgat atgtgcttgg ggatgctctg
      121 gctcctgttc ctcagtctcc cctgcctggg gaacacgatg cctctgactc ttgaccttgg
      181 ctcaggacag gggttggtag gcatcgtcgg gggctgccct gtctcagcca gccggttccc
      241 gtggcaggtc agcttgaggc tctacgacat ggagcacagc agatgggaac acgagtgtgg
      301 cggttccctc atccatcctc agtgggtgct aactgctgct cactgtgtga ggccgaaaga
      361 ggtggaggcc tatggagtta gagtccaagt tgggcagcta aggctttatg aaaacgacca
      421 gctgatgaaa gtggtcaaga tcatccgcca ccccaagttt agtgagaagc tgtctgcccg
      481 tgggggtgcg gacattgctc tgctgaaact agacacccga gttgtgctgt ctgagcatgt
      541 ctaccccgtt tccctccctg ctgcctccct gaggatctcc tctaagaaga cctgctgggt
      601 ggctggctgg ggtgtcatcg agaactacat gccactgccc ccaccctacc acctgaggga
      661 agtggcggtc cccatcgtgg aaaacaatga ctgtgagcag aagtaccaga ccaattcttc
      721 ctcggacagc actaccagga tcatcaaaga cgacatgctt tgtgctggga aggagggcag
      781 ggactcttgc aaggctgact ctgggggccc attggtatgc aggtggaact gttcctgggt
      841 ccaggtgggt gtggtcagct ggggcatagg ctgcgggctt cctgacttcc ctggtgtata
      901 cacccgggtg atgagctacg tgtcctggat caaatgctat gtccccacgt tcctagaacc
      961 tttgaagggg ccagatggga ttcatacaac agaggagacc ccagccactc atattgatcc
     1021 attcactcct ccttctggtc cagcctcact ttcttaaacc tccctattct atggtagtga
     1081 aactaccttg tgctcctggc ctggagtcta tggtgtccct taactctggg aaggaggggg
     1141 ataaaactac atctcaaaag tagctggaag cccatattcc ctccttacca tgtttcccat
     1201 taaatgatgg agtgtc
//
