LOCUS       NM_011645                812 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus serine protease 3 (Prss3), mRNA.
ACCESSION   NM_011645
VERSION     NM_011645.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Scavuzzo,M.A., Chmielowiec,J., Yang,D., Wamble,K., Chaboub,L.S.,
            Duraine,L., Tepe,B., Glasgow,S.M., Arenkiel,B.R., Brou,C.,
            Deneen,B. and Borowiak,M.
  TITLE     Pancreatic Cell Fate Determination Relies on Notch Ligand
            Trafficking by NFIA
  JOURNAL   Cell Rep 25 (13), 3811-3827 (2018)
   PUBMED   30590051
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Yamamoto-Tanaka,M., Motoyama,A., Miyai,M., Matsunaga,Y.,
            Matsuda,J., Tsuboi,R. and Hibino,T.
  TITLE     Mesotrypsin and caspase-14 participate in prosaposin processing:
            potential relevance to epidermal permeability barrier formation
  JOURNAL   J Biol Chem 289 (29), 20026-20038 (2014)
   PUBMED   24872419
  REMARK    GeneRIF: Mesotrypsin generated saposins A-D from prosaposin, and
            mature caspase-14 contributed to this process by activating
            mesotrypsinogen to mesotrypsin. Knockdown of these proteases
            markedly down-regulated saposin A synthesis in skin equivalent
            models.
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Budatha,M., Silva,S., Montoya,T.I., Suzuki,A., Shah-Simpson,S.,
            Wieslander,C.K., Yanagisawa,M., Word,R.A. and Yanagisawa,H.
  TITLE     Dysregulation of protease and protease inhibitors in a mouse model
            of human pelvic organ prolapse
  JOURNAL   PLoS One 8 (2), e56376 (2013)
   PUBMED   23437119
REFERENCE   6  (bases 1 to 812)
  AUTHORS   Sherwood,M.W., Prior,I.A., Voronina,S.G., Barrow,S.L.,
            Woodsmith,J.D., Gerasimenko,O.V., Petersen,O.H. and Tepikin,A.V.
  TITLE     Activation of trypsinogen in large endocytic vacuoles of pancreatic
            acinar cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5674-5679 (2007)
   PUBMED   17363470
  REMARK    GeneRIF: the initiation of acute pancreatitis depends on endocytic
            vacuole formation and trypsinogen activation in pancreatic acinar
            cells
REFERENCE   7  (bases 1 to 812)
  AUTHORS   Archer,H., Jura,N., Keller,J., Jacobson,M. and Bar-Sagi,D.
  TITLE     A mouse model of hereditary pancreatitis generated by transgenic
            expression of R122H trypsinogen
  JOURNAL   Gastroenterology 131 (6), 1844-1855 (2006)
   PUBMED   17087933
  REMARK    GeneRIF: These results underscore the importance of trypsinogen
            PRSS1 mutations as pathogenic mediators of hereditary pancreatitis
            and indicate that persistent pancreatic injury might be causally
            linked to chronic pancreatitis.
REFERENCE   8  (bases 1 to 812)
  AUTHORS   Chen,F., Rowen,L., Hood,L. and Rothenberg,E.V.
  TITLE     Differential transcriptional regulation of individual TCR V beta
            segments before gene rearrangement
  JOURNAL   J Immunol 166 (3), 1771-1780 (2001)
   PUBMED   11160223
REFERENCE   9  (bases 1 to 812)
  AUTHORS   Lu,X., Tumpey,T.M., Morken,T., Zaki,S.R., Cox,N.J. and Katz,J.M.
  TITLE     A mouse model for the evaluation of pathogenesis and immunity to
            influenza A (H5N1) viruses isolated from humans
  JOURNAL   J Virol 73 (7), 5903-5911 (1999)
   PUBMED   10364342
REFERENCE   10 (bases 1 to 812)
  AUTHORS   Stevenson,B.J., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     Sequence organisation and transcriptional regulation of the mouse
            elastase II and trypsin genes
  JOURNAL   Nucleic Acids Res 14 (21), 8307-8330 (1986)
   PUBMED   3641189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158659.6.
            
            On Sep 7, 2007 this sequence version replaced NM_011645.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098498.1, AK131862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC158659.6         72697-72752
            57-216              AC158659.6         73343-73502
            217-470             AC158659.6         75183-75436
            471-607             AC158659.6         75947-76083
            608-812             AC158659.6         76347-76551
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.5 cM"
     gene            1..812
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /note="serine protease 3"
                     /db_xref="GeneID:22073"
                     /db_xref="MGI:MGI:102758"
     exon            1..56
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..757
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /EC_number="3.4.21.4"
                     /note="trypsin 3; trypsinogen 15; protease, serine 3"
                     /codon_start=1
                     /product="mesotrypsin precursor"
                     /protein_id="NP_035775.1"
                     /db_xref="CCDS:CCDS20047.1"
                     /db_xref="GeneID:22073"
                     /db_xref="MGI:MGI:102758"
                     /translation="MNALLILALVGAAVAFPVDDDDKIVGGYTCQENSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNINVLEGNEQFVNAAKIIKHPNFNRK
                     TLNNDIMLLKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQC
                     LDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNRELQGIVSWGY
                     GCALPDNPGVYTKVCNYVDWIQDTIAAN"
     exon            57..216
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /inference="alignment:Splign:2.1.0"
     exon            217..470
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /inference="alignment:Splign:2.1.0"
     exon            471..607
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /inference="alignment:Splign:2.1.0"
     exon            608..812
                     /gene="Prss3"
                     /gene_synonym="MTG; Tb; Try3; TRY4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaccttct tccaccatga atgcactcct gatcctggcc cttgtgggag ctgctgttgc
       61 cttccccgtg gatgatgatg acaagatcgt tggaggatac acctgccaag agaattctgt
      121 cccctaccag gtgtccctga actctggcta ccacttctgt ggaggctccc tcatcaatga
      181 ccagtgggtg gtgtctgcag ctcactgcta caaaacccgc atccaagtga gattggggga
      241 gcacaacatc aacgtcctgg agggcaatga gcagtttgtc aatgctgcca agatcatcaa
      301 gcaccccaac ttcaatagga agacactgaa caacgacatt atgttgctca agctctcttc
      361 ccctgtgacc ctcaatgcca gagtggccac tgtggctctg cccagctcct gtgcacctgc
      421 tggcactcag tgtctcatct ctggctgggg caacactctt agctttggtg tcagtgaacc
      481 agacctgctc cagtgcctgg atgccccact gctgcctcag gctgactgtg aagcctccta
      541 tcctgggaag atcactggta acatggtctg tgctggcttc ctagagggag gcaaggattc
      601 ctgccagggt gactccggtg gccctgtggt ctgcaataga gaactccagg gtatagtctc
      661 ctggggctat ggctgtgccc tgccagacaa tcctggtgtg tacaccaagg tctgcaacta
      721 tgtggactgg attcaggaca caattgctgc caactagaaa ttcccattcc ctctgcagtc
      781 accataccaa taaagtgaaa ttttcttcag ca
//
