LOCUS       NM_053260               1185 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus serine protease 29 (Prss29), mRNA.
ACCESSION   NM_053260 XM_914731
VERSION     NM_053260.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Kelleher,A.M., Allen,C.C., Davis,D.J. and Spencer,T.E.
  TITLE     Prss29 Cre recombinase mice are useful to study adult uterine gland
            function
  JOURNAL   Genesis 60 (10-12), e23493 (2022)
   PUBMED   35866844
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Dhakal,P. and Spencer,T.E.
  TITLE     Generation and analysis of Prss28 and Prss29 deficient mice using
            CRISPR-Cas9 genome-editing
  JOURNAL   Mol Reprod Dev 88 (7), 482-489 (2021)
   PUBMED   33973295
  REMARK    GeneRIF: Generation and analysis of Prss28 and Prss29 deficient
            mice using CRISPR-Cas9 genome-editing.
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Piccirilli,D., Baldini,E., Massimiani,M., Camaioni,A., Salustri,A.,
            Bernardini,R., Centanni,M., Ulisse,S., Moretti,C. and Campagnolo,L.
  TITLE     Thyroid hormone regulates protease expression and activation of
            Notch signaling in implantation and embryo development
  JOURNAL   J Endocrinol 236 (1), 1-12 (2018)
   PUBMED   28993437
  REMARK    GeneRIF: Hypothyroidism induces a significant reduction of
            proteases Isp1 and Isp2 gene expression and Notch signaling.
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Kelleher,A.M., Peng,W., Pru,J.K., Pru,C.A., DeMayo,F.J. and
            Spencer,T.E.
  TITLE     Forkhead box a2 (FOXA2) is essential for uterine function and
            fertility
  JOURNAL   Proc Natl Acad Sci U S A 114 (6), E1018-E1026 (2017)
   PUBMED   28049832
REFERENCE   5  (bases 1 to 1185)
  AUTHORS   Sharma,N., Fahr,J., Renaux,B., Saifeddine,M., Kumar,R.,
            Nishikawa,S., Mihara,K., Ramachandran,R., Hollenberg,M.D. and
            Rancourt,D.E.
  TITLE     Implantation serine proteinase 2 is a monomeric enzyme with mixed
            serine proteolytic activity and can silence signalling via
            proteinase activated receptors
  JOURNAL   Biochem Cell Biol 91 (6), 487-497 (2013)
   PUBMED   24219291
  REMARK    GeneRIF: ISP2 is a monomeric enzyme with mixed serine proteolytic
            activity and can silence signaling via proteinase activated
            receptors.
REFERENCE   6  (bases 1 to 1185)
  AUTHORS   O'Sullivan,C.M., Tang,L., Xu,H., Liu,S. and Rancourt,D.E.
  TITLE     Origin of the murine implantation serine proteinase subfamily
  JOURNAL   Mol Reprod Dev 69 (2), 126-136 (2004)
   PUBMED   15293213
REFERENCE   7  (bases 1 to 1185)
  AUTHORS   Wong,G.W., Yasuda,S., Morokawa,N., Li,L. and Stevens,R.L.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
REFERENCE   8  (bases 1 to 1185)
  AUTHORS   Huang,Z.P., Yu,H., Yang,Z.M., Shen,W.X., Wang,J. and Shen,Q.X.
  TITLE     Uterine expression of implantation serine proteinase 2 during the
            implantation period and in vivo inhibitory effect of its antibody
            on embryo implantation in mice
  JOURNAL   Reprod Fertil Dev 16 (3), 379-384 (2004)
   PUBMED   15304212
  REMARK    GeneRIF: ISP2 may play an important role during embryo
            implantation.
REFERENCE   9  (bases 1 to 1185)
  AUTHORS   O'Sullivan,C.M., Liu,S.Y., Karpinka,J.B. and Rancourt,D.E.
  TITLE     Embryonic hatching enzyme strypsin/ISP1 is expressed with ISP2 in
            endometrial glands during implantation
  JOURNAL   Mol Reprod Dev 62 (3), 328-334 (2002)
   PUBMED   12112596
  REMARK    GeneRIF: the ISP1 and ISP2 genes are co-expressed within the
            endometrial gland
REFERENCE   10 (bases 1 to 1185)
  AUTHORS   O'Sullivan,C.M., Liu,S.Y., Rancourt,S.L. and Rancourt,D.E.
  TITLE     Regulation of the strypsin-related proteinase ISP2 by progesterone
            in endometrial gland epithelium during implantation in mice
  JOURNAL   Reproduction 122 (2), 235-244 (2001)
   PUBMED   11467974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK144368.1 and
            BX632512.1.
            
            On Jan 18, 2008 this sequence version replaced NM_053260.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144368.1, SRR5189676.32197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-968               AK144368.1         2-969
            969-1185            BX632512.1         1-217               c
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1185
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /note="serine protease 29"
                     /db_xref="GeneID:114662"
                     /db_xref="MGI:MGI:2149952"
     exon            1..164
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1004
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /note="implantation serine protease 2; ISP-2; strypsin-2;
                     strypsin-related protein; tryptase-like proteinase;
                     implantation serine proteinase 2; protease, serine 29"
                     /codon_start=1
                     /product="serine protease 29 precursor"
                     /protein_id="NP_444490.2"
                     /db_xref="CCDS:CCDS28516.1"
                     /db_xref="GeneID:114662"
                     /db_xref="MGI:MGI:2149952"
                     /translation="MLIQLCLTLFFLGCSIAGTPAPGPEGVLMGIVGGHSAPQGKWPW
                     QVSLRIYRYYWAFWVHNCGGSIIHPQWVLTAAHCIRERDADPSVFRIRVGEAYLYGGK
                     ELLSVSRVIIHPDFVHAGLGSDVALLQLAVSVQSFPNVKPVKLPSESLEVTKKDVCWV
                     TGWGAVSTHRSLPPPYRLQQVQVKIIDNSLCEEMYHNATRHRNRGQKLILKDMLCAGN
                     QGQDSCYGDSGGPLVCNVTGSWTLVGVVSWGYGCALRDFPGVYARVQSFLPWITQQMQ
                     RFS"
     exon            165..225
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..406
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..672
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..839
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1181
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1159..1164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1177
                     /gene="Prss29"
                     /gene_synonym="Isp2; mISP-2"
                     /note="major polyA site"
ORIGIN      
        1 ggggaccatc tgtcttgctt ctatctggga catacttctg acactgagtc cccaagaacc
       61 tgtatcctgg acaatcctgg gcacacccac atcttttggg gggctctcat aaacgtcctg
      121 tgagtggttc tcataggaga gaacctggtt tttctggagc caagatgctg atccagctgt
      181 gcctgaccct cttctttctt gggtgctcca ttgctggaac cccagcacct gggcctgagg
      241 gcgttctgat gggcatcgtg gggggtcata gtgccccaca ggggaagtgg ccatggcagg
      301 tcagcctgag gatctataga tactactggg ccttctgggt gcacaactgt gggggctcca
      361 tcatccaccc acagtgggtg ctgactgctg cccactgcat tcgtgagaga gatgccgacc
      421 catcagtctt tcggatccgt gttggggagg cgtacctcta tgggggcaag gagctgctga
      481 gtgtgagccg ggtcatcatc cacccagact ttgtccacgc tggcctgggt tcagatgtgg
      541 ctctgctcca gctggcagtg tctgtacaat cctttcctaa tgtcaagcca gtcaagctgc
      601 cctctgagtc tcttgaggtc accaagaagg atgtgtgctg ggtgaccggc tggggtgcag
      661 tgagcacaca caggtcgctg cctcctccct accgcctaca gcaggtgcag gtaaagataa
      721 ttgacaactc actttgtgag gagatgtacc acaatgccac caggcaccgc aatcgtggcc
      781 agaaactgat cctaaaggac atgttatgtg caggcaacca gggccaagat tcctgctatg
      841 gtgactcagg tggccctctg gtctgcaatg tgacaggctc ctggaccctg gtgggagtgg
      901 tgagctgggg ctatggctgt gccctcaggg acttccctgg ggtctatgca cgtgtacagt
      961 ccttcctgcc ctggatcacg cagcagatgc agaggttctc ctgagcccag ctgctggcct
     1021 cgtggccatc agatgaggat aggtcggctt tggtcacgat tccagagtgg acggccaggg
     1081 tttaggctct ggagtgtagg tgaccagggc accgagcatt agctactgaa ggacatggct
     1141 cagtttcctg gcttcctaaa taaagatatg tttgttgcac aaaaa
//
