LOCUS       NM_053259               1190 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus serine protease 28 (Prss28), mRNA.
ACCESSION   NM_053259
VERSION     NM_053259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Dhakal,P. and Spencer,T.E.
  TITLE     Generation and analysis of Prss28 and Prss29 deficient mice using
            CRISPR-Cas9 genome-editing
  JOURNAL   Mol Reprod Dev 88 (7), 482-489 (2021)
   PUBMED   33973295
  REMARK    GeneRIF: Generation and analysis of Prss28 and Prss29 deficient
            mice using CRISPR-Cas9 genome-editing.
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Piccirilli,D., Baldini,E., Massimiani,M., Camaioni,A., Salustri,A.,
            Bernardini,R., Centanni,M., Ulisse,S., Moretti,C. and Campagnolo,L.
  TITLE     Thyroid hormone regulates protease expression and activation of
            Notch signaling in implantation and embryo development
  JOURNAL   J Endocrinol 236 (1), 1-12 (2018)
   PUBMED   28993437
  REMARK    GeneRIF: Hypothyroidism induces a significant reduction of
            proteases Isp1 and Isp2 gene expressions and Notch signaling.
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Sharma,N., Kumar,R., Renaux,B., Saifeddine,M., Nishikawa,S.,
            Mihara,K., Ramachandran,R., Hollenberg,M.D. and Rancourt,D.E.
  TITLE     Implantation serine proteinase 1 exhibits mixed substrate
            specificity that silences signaling via proteinase-activated
            receptors
  JOURNAL   PLoS One 6 (11), e27888 (2011)
   PUBMED   22132161
  REMARK    GeneRIF: ISP1 might signal to cells by cleaving and activating
            proteinase-activated receptors (PARs) and therefore assessed PARs
            1, 2 and 4 as potential ISP1 targets.
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Khalife,M., Young,R., Passet,B., Halliez,S., Vilotte,M.,
            Jaffrezic,F., Marthey,S., Beringue,V., Vaiman,D., Le Provost,F.,
            Laude,H. and Vilotte,J.L.
  TITLE     Transcriptomic analysis brings new insight into the biological role
            of the prion protein during mouse embryogenesis
  JOURNAL   PLoS One 6 (8), e23253 (2011)
   PUBMED   21858045
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Sharma,N., Liu,S., Tang,L., Irwin,J., Meng,G. and Rancourt,D.E.
  TITLE     Implantation Serine Proteinases heterodimerize and are critical in
            hatching and implantation
  JOURNAL   BMC Dev Biol 6, 61 (2006)
   PUBMED   17156484
  REMARK    GeneRIF: ISP1 plays a critical role in embryo hatching and
            implantation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Tang,L. and Rancourt,D.E.
  TITLE     Murine implantation serine proteinases 1 and 2: structure, function
            and evolution
  JOURNAL   Gene 364, 30-36 (2005)
   PUBMED   16257142
  REMARK    GeneRIF: organization, structure and postulated function of the
            implantation serine proteinase (ISP1 and 2) genes.
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   O'Sullivan,C.M., Tang,L., Xu,H., Liu,S. and Rancourt,D.E.
  TITLE     Origin of the murine implantation serine proteinase subfamily
  JOURNAL   Mol Reprod Dev 69 (2), 126-136 (2004)
   PUBMED   15293213
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Wong,G.W., Yasuda,S., Morokawa,N., Li,L. and Stevens,R.L.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
REFERENCE   9  (bases 1 to 1190)
  AUTHORS   O'Sullivan,C.M., Liu,S.Y., Karpinka,J.B. and Rancourt,D.E.
  TITLE     Embryonic hatching enzyme strypsin/ISP1 is expressed with ISP2 in
            endometrial glands during implantation
  JOURNAL   Mol Reprod Dev 62 (3), 328-334 (2002)
   PUBMED   12112596
  REMARK    GeneRIF: the ISP1 and ISP2 genes are co-expressed within the
            endometrial gland
REFERENCE   10 (bases 1 to 1190)
  AUTHORS   O'Sullivan,C.M., Rancourt,S.L., Liu,S.Y. and Rancourt,D.E.
  TITLE     A novel murine tryptase involved in blastocyst hatching and
            outgrowth
  JOURNAL   Reproduction 122 (1), 61-71 (2001)
   PUBMED   11425330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144498.1 and AC122454.4.
            
            On Sep 22, 2006 this sequence version replaced NM_053259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144498.1, SRR5189676.31630.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK144498.1         2-5
            5-5                 AC122454.4         95928-95928
            6-1190              AK144498.1         7-1191
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1190
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /note="serine protease 28"
                     /db_xref="GeneID:114661"
                     /db_xref="MGI:MGI:2149951"
     exon            1..161
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..986
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /note="implantation serine protease 1; ISP-1; strypsin;
                     protease, serine 28; tryptase-like proteinase;
                     implantation serine proteinase 1"
                     /codon_start=1
                     /product="serine protease 28 precursor"
                     /protein_id="NP_444489.2"
                     /db_xref="CCDS:CCDS28515.1"
                     /db_xref="GeneID:114661"
                     /db_xref="MGI:MGI:2149951"
                     /translation="MFRLLLLALSCLESTVFMASVSISRSKPVGIVGGQCTPPGKWPW
                     QVSLRMYSYEVNSWVHICGGSIIHPQWILTAAHCIQSQDADPAVYRVQVGEVYLYKEQ
                     ELLNISRIIIHPDYNDVSKRFDLALMQLTALLVTSTNVSPVSLPKDSSTFDSTDQCWL
                     VGWGNLLQRVPLQPPYQLHEVKIPIQDNKSCKRAYRKKSSDEHKAVAIFDDMLCAGTS
                     GRGPCFGDSGGPLVCWKSNKWIQVGVVSKGIDCSNNLPSIFSRVQSSLAWIHQHIQ"
     exon            162..222
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..403
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..669
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..833
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1190
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss28"
                     /gene_synonym="Isp1; mIsp-1"
                     /note="putative"
ORIGIN      
        1 ggaaattgtc tgtctttctc ccacccaaga tatacatctg tcattgagtc tctaaaattt
       61 gtgccatagg caatctggat gcacccacct acttgggggg ctctcataaa cgccctgtga
      121 gtggttctca taggagagaa actggtgttt ctggagccaa gatgttcaga ctgttgctcc
      181 tggctctctc ctgtctggaa agtaccgtgt tcatggcctc tgtatctatc tccagaagca
      241 agccagtggg cattgtgggg ggtcaatgta ccccaccagg gaagtggcca tggcaggtca
      301 gcctaagaat gtacagttac gaggtgaact cctgggtgca catctgtggg ggctccatca
      361 tccaccctca gtggattctg actgctgctc actgcatcca aagtcaggac gccgacccag
      421 ccgtataccg ggtccaggtg ggggaagtat acctctataa ggagcaggaa cttctgaaca
      481 tcagcaggat catcatccac cctgactaca acgatgttag taagaggttt gacttggccc
      541 tgatgcagtt gactgccctc ctggtcacat ccacaaatgt cagtccagtc tctctgccaa
      601 aagacagctc aaccttcgac tccactgacc agtgttggct ggttggctgg ggcaaccttc
      661 tccaacgtgt gcctctgcag cctccctatc aactgcatga ggtgaagatc ccaattcagg
      721 acaacaagag ctgtaagcgg gcttatagga agaagtcatc cgacgagcac aaagctgtgg
      781 ccatctttga cgacatgctt tgtgctggca cctcaggccg aggcccctgt tttggtgact
      841 ctgggggtcc cttggtctgc tggaagagca acaagtggat acaggtgggc gtggtcagca
      901 aggggatcga ttgcagcaac aatctgccat caatcttctc aagagtccag agctccttag
      961 cctggatcca tcaacacatc cagtagacga gtccaccagc tgctgaccat catcagagac
     1021 agcttcatgg ctcctctgtt ctttacttcc tggacccttc cttgctcgcc ctgccctctt
     1081 ccctggcctg tccttcccca ctgacaagga tgtccagcaa accccagtgt ggggttgggc
     1141 tgctgtattg gggtgtggct gtatttgtct caataaactg gcagtaaacg
//
