LOCUS       NM_175440               1149 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus serine protease 27 (Prss27), mRNA.
ACCESSION   NM_175440 XM_916545
VERSION     NM_175440.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Bolt,C.C., Negi,S., Guimaraes-Camboa,N., Zhang,H., Troy,J.M.,
            Lu,X., Kispert,A., Evans,S.M. and Stubbs,L.
  TITLE     Tbx18 Regulates the Differentiation of Periductal Smooth Muscle
            Stroma and the Maintenance of Epithelial Integrity in the Prostate
  JOURNAL   PLoS One 11 (4), e0154413 (2016)
   PUBMED   27120339
  REMARK    Erratum:[PLoS One. 2016 Jun 3;11(6):e0157283. doi:
            10.1371/journal.pone.0157283. PMID: 27257811]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Raman,K., Trivedi,N.N., Raymond,W.W., Ganesan,R., Kirchhofer,D.,
            Verghese,G.M., Craik,C.S., Schneider,E.L., Nimishakavi,S. and
            Caughey,G.H.
  TITLE     Mutational tail loss is an evolutionary mechanism for liberating
            marapsins and other type I serine proteases from transmembrane
            anchors
  JOURNAL   J Biol Chem 288 (15), 10588-10598 (2013)
   PUBMED   23447538
  REMARK    GeneRIF: Mutational tail loss is an evolutionary mechanism for
            liberating marapsins and other type I serine proteases from
            transmembrane anchors.
REFERENCE   4  (bases 1 to 1149)
  AUTHORS   Li,W., Danilenko,D.M., Bunting,S., Ganesan,R., Sa,S., Ferrando,R.,
            Wu,T.D., Kolumam,G.A., Ouyang,W. and Kirchhofer,D.
  TITLE     The serine protease marapsin is expressed in stratified squamous
            epithelia and is up-regulated in the hyperproliferative epidermis
            of psoriasis and regenerating wounds
  JOURNAL   J Biol Chem 284 (1), 218-228 (2009)
   PUBMED   18948266
  REMARK    GeneRIF: Marapsin's restricted expression, localization, and
            cytokine-inducible expression suggest a role in the terminal
            differentiation of keratinocytes in hyperproliferating squamous
            epithelia.
REFERENCE   5  (bases 1 to 1149)
  AUTHORS   Wong,G.W. and Stevens,R.L.
  TITLE     Identification of a subgroup of
            glycosylphosphatidylinositol-anchored tryptases
  JOURNAL   Biochem Biophys Res Commun 336 (2), 579-584 (2005)
   PUBMED   16143303
REFERENCE   6  (bases 1 to 1149)
  AUTHORS   Wong,G.W., Yasuda,S., Morokawa,N., Li,L. and Stevens,R.L.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
REFERENCE   7  (bases 1 to 1149)
  AUTHORS   Bhagwandin,V.J., Hau,L.W., Mallen-St Clair,J., Wolters,P.J. and
            Caughey,G.H.
  TITLE     Structure and activity of human pancreasin, a novel tryptic serine
            peptidase expressed primarily by the pancreas
  JOURNAL   J Biol Chem 278 (5), 3363-3371 (2003)
   PUBMED   12441343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT010502.14.
            
            On May 2, 2007 this sequence version replaced NM_175440.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080281.1, BC117009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               CT010502.14        151184-151302       c
            120-146             CT010502.14        147465-147491       c
            147-309             CT010502.14        146581-146743       c
            310-581             CT010502.14        145014-145285       c
            582-751             CT010502.14        144517-144686       c
            752-1149            CT010502.14        143596-143993       c
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.21 cM"
     gene            1..1149
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /note="serine protease 27"
                     /db_xref="GeneID:213171"
                     /db_xref="MGI:MGI:2450123"
     exon            1..119
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /inference="alignment:Splign:2.1.0"
     exon            120..146
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /inference="alignment:Splign:2.1.0"
     exon            147..309
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /inference="alignment:Splign:2.1.0"
     exon            310..581
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /inference="alignment:Splign:2.1.0"
     exon            582..751
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1149
                     /gene="Prss27"
                     /gene_synonym="CAPH2; marapsin; Mpn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagtactaa ggagagcttc tgccacctct gaccaggact caaacgtcca ccaagccaga
       61 gaacatgagg cagccccaca tcgctgccct gctgctgctg ccgctgctgc tcagatctgg
      121 gactgaaggg gccaggactc tgagagcctg tgggcatcca aagatgttca accggatggt
      181 gggcggggag aacgccttag aaggtgagtg gccctggcag gtcagcatcc agcgcaacgg
      241 aatccacttc tgtgggggca gtctcatcgc accaacatgg gtcctcactg ctgcacactg
      301 cttctccaac acttcggaca tatccatata ccaggtcctg ctgggggcac tgaagctgca
      361 gcagccagga ccacacgcct tgtatgtccc cgtgaagcag gtgaaaagca atcctcagta
      421 ccaaggcatg gcctccagtg ccgacgtggc tctggtggag ctgcaggggc cggtgacctt
      481 caccaattac atccttcctg tgtgccttcc tgatccctcg gtcatctttg agtcgggcat
      541 gaactgctgg gtcactggct ggggcagccc cagtgaacaa gaccgactac ccaacccacg
      601 ggtcctgcag aaacttgctg tgcccatcat tgacacgccc aagtgcaacc tgctgtacaa
      661 caaagatgtt gagtctgact tccagctcaa aaccatcaag gatgacatgc tgtgtgcagg
      721 cttcgcagag ggcaagaagg acgcctgtaa gggtgactct ggaggcccac tggtgtgcct
      781 tgtggaccag tcgtgggtgc aggctggggt gatcagctgg ggagagggtt gtgcccgtcg
      841 gaatcgccca ggtgtctaca tccgtgtgac ttctcatcac aaatggatcc accaaatcat
      901 cccagaactg cagtttcagg ggagagcagg cacccagcag caacaaaaag actcccaagg
      961 tcagcagcgc ctggcgggga actccgcccc ttgcctggct gcccatgcaa tggtgctggc
     1021 cctgggagca ctgctgctca ggatcgtcta gggctgccca gccccacagg tggagcccca
     1081 cccactgtac atttgtaaat actgtgttcc cgtctgccat gccagctgct tttatatatg
     1141 ttcaccacc
//
