LOCUS       NM_001384148            3532 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus serine protease 23 (Prss23), transcript variant 7,
            mRNA.
ACCESSION   NM_001384148 XM_030243078
VERSION     NM_001384148.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3532)
  AUTHORS   Li,Y., Zhong,X. and Yang,F.
  TITLE     Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice
            by regulating the C3/MMPs/prss axis
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (7), 4823-4831 (2024)
   PUBMED   38157023
  REMARK    GeneRIF: Silencing HE4 alleviates the renal fibrosis in lupus
            nephritis mice by regulating the C3/MMPs/prss axis.
REFERENCE   2  (bases 1 to 3532)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   3  (bases 1 to 3532)
  AUTHORS   Kolla,L., Kelly,M.C., Mann,Z.F., Anaya-Rocha,A., Ellis,K.,
            Lemons,A., Palermo,A.T., So,K.S., Mays,J.C., Orvis,J., Burns,J.C.,
            Hertzano,R., Driver,E.C. and Kelley,M.W.
  TITLE     Characterization of the development of the mouse cochlear
            epithelium at the single cell level
  JOURNAL   Nat Commun 11 (1), 2389 (2020)
   PUBMED   32404924
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3532)
  AUTHORS   Bayoumi,A.S., Teoh,J.P., Aonuma,T., Yuan,Z., Ruan,X., Tang,Y.,
            Su,H., Weintraub,N.L. and Kim,I.M.
  TITLE     MicroRNA-532 protects the heart in acute myocardial infarction, and
            represses prss23, a positive regulator of
            endothelial-to-mesenchymal transition
  JOURNAL   Cardiovasc Res 113 (13), 1603-1614 (2017)
   PUBMED   29016706
  REMARK    GeneRIF: Suggest a pivotal role for miR-532-prss23 axis in
            regulating cardiac endothelial cell function after myocardial
            infarction.
REFERENCE   5  (bases 1 to 3532)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 3532)
  AUTHORS   Wahlberg,P., Nylander,A., Ahlskog,N., Liu,K. and Ny,T.
  TITLE     Expression and localization of the serine proteases
            high-temperature requirement factor A1, serine protease 23, and
            serine protease 35 in the mouse ovary
  JOURNAL   Endocrinology 149 (10), 5070-5077 (2008)
   PUBMED   18566130
  REMARK    GeneRIF: HtrA1 and PRSS35 may be involved in ovulation and corpus
            luteum formation and regression, and that PRSS23 may play a role in
            follicular atresia
REFERENCE   7  (bases 1 to 3532)
  AUTHORS   Miyakoshi,K., Murphy,M.J., Yeoman,R.R., Mitra,S., Dubay,C.J. and
            Hennebold,J.D.
  TITLE     The identification of novel ovarian proteases through the use of
            genomic and bioinformatic methodologies
  JOURNAL   Biol Reprod 75 (6), 823-835 (2006)
   PUBMED   16870946
  REMARK    GeneRIF: Prss23 mRNA levels decreased transiently after ovulation
            induction and again in the postovulatory period
REFERENCE   8  (bases 1 to 3532)
  AUTHORS   Chen,H.W., Chen,J.J., Yu,S.L., Li,H.N., Yang,P.C., Su,C.M.,
            Au,H.K., Chang,C.W., Chien,L.W., Chen,C.S. and Tzeng,C.R.
  TITLE     Transcriptome analysis in blastocyst hatching by cDNA microarray
  JOURNAL   Hum Reprod 20 (9), 2492-2501 (2005)
   PUBMED   15919778
REFERENCE   9  (bases 1 to 3532)
  AUTHORS   Norman,B., Davis,J. and Piatigorsky,J.
  TITLE     Postnatal gene expression in the normal mouse cornea by SAGE
  JOURNAL   Invest Ophthalmol Vis Sci 45 (2), 429-440 (2004)
   PUBMED   14744882
REFERENCE   10 (bases 1 to 3532)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116326.5.
            
            On Jan 11, 2023 this sequence version replaced NM_001384148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.5094976.1,
                                           SRR17253012.1056691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               AC116326.5         30807-31247
            442-3532            AC116326.5         37489-40579
FEATURES             Location/Qualifiers
     source          1..3532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 49.9 cM"
     gene            1..3532
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
                     /note="serine protease 23"
                     /db_xref="GeneID:76453"
                     /db_xref="MGI:MGI:1923703"
     exon            1..441
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
                     /inference="alignment:Splign:2.1.0"
     exon            442..3532
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
                     /note="hexamer: AATAAA"
     polyA_site      2208
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
                     /note="major polyA site"
     regulatory      3510..3515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
                     /note="hexamer: AATATA"
     polyA_site      3532
                     /gene="Prss23"
                     /gene_synonym="2310046G15Rik; 4930479H08Rik; Spuve"
ORIGIN      
        1 actcggccac tctgcggagc aggcatggga gccgcgcgcg tcctccgggc gcccacacct
       61 gtctgagcgg cgcacggccg cggccccggc gggctgctcc acgcgggtga gtgcgatgcg
      121 gggacccggc gtctcccgct gggtccgaag gaccaggcgt gtgccggagc cggacaaaga
      181 gtcgggtgcg cgcggggtgg ggtggctgcg ggtaacaccg gggagtttgc cgtggcttcc
      241 gcacagactc tgggcttagg acaagagcct gaaagagcct ccctccccgg acaccggctc
      301 tgtacagcgt ttggattcac tcagtgtctc tcttaaagtg gatggggaaa agaaggtttt
      361 gaaagcgctg tcttggatgc aaggtgttgt ctaggggtca agtggagctg tgtatggcaa
      421 ggtgtccctg gagaggtcaa gtagcactca gcatggctgg aatcccgggg ctcttcatcc
      481 ttcttgtcct gctctgtgtg ttcatgcagg tgagtcccta caccgttccg tggaaaccca
      541 catggccggc ttatcgcctc cctgtagtct tgcctcagtc taccctcaac ttagctaagg
      601 cagacttcga cgccaaagcg aaattggagg tgtcctcctc atgtggacct cagtgtcaca
      661 agggaacacc actgcccacc tacgaagagg ccaagcagta cctttcctat gaaacccttt
      721 atgccaatgg cagccgcaca gagactcggg tgggcatcta catcctcagc aatggtgaag
      781 gcagggcacg aggcagagac tcggaggcca cagggagatc tcgcaggaag aggcagattt
      841 atggctacga tggcaggttt agcatttttg ggaaggactt cctgctcaat tatcctttct
      901 caacatcggt gaagttgtct actggctgca ctggcaccct ggtggcagag aagcacgtcc
      961 tcactgctgc ccactgcata cacgatggga aaacctatgt gaaagggaca cagaaactcc
     1021 gagtgggctt cctgaagccc aagtataaag atggtgccgg aggggacaac agctcgagct
     1081 cagccatgcc agacaagatg aagtttcagt ggatccgcgt gaaacgcacc catgtgccca
     1141 aggggtggat caagggcaat gccaatgaca tcggcatgga ttatgactac gccctgctgg
     1201 aactcaagaa accccacaaa agacagttca tgaagattgg tgtgagtcct ccagcgaagc
     1261 agctcccagg gggcaggatc cacttctctg gttatgacaa tgaccggccc ggcaatttgg
     1321 tgtaccgctt ctgtgatgtc aaagatgaga cctacgacct tctctaccag cagtgtgacg
     1381 cccagcccgg ggccagtggt tcaggggtct atgtgaggat gtggaagaga ccacagcaga
     1441 aatgggaaag aaaaattatc ggcatctttt cagggcacca gtgggtggac atgaatggct
     1501 ctccacagga tttcaacgtg gcagttagaa tcacgcctct taaatatgcc cagatttgct
     1561 attggattaa aggaaactac ctagattgca gggaggggtg acatgcgtct tcttgccagc
     1621 accaatggtc tttttgcact cattgtagga gaggctagct ttttatcatt gactcttgtg
     1681 gtgtgagtca catagtatct tttacctagt attcttcaaa tggcaaaaat tattggctat
     1741 attattttaa aactgttgtg tgcgttatag catttaagca gtctgaaagc atacttttgc
     1801 atagagactt taaagtattc gggtaatagg gcctatttga caaggaagtt aaactttcag
     1861 tttttggaga attctaattt ttgtctgatc caaacttgct tcagaggttt atatcaaata
     1921 cgtgacacac agggaatatg aattcttatg tttgtatatg tatatgtttt cttctgagag
     1981 tcatatattg atatttttgt aatgtgtggt tattatgctt ccagataatg atagcaaagt
     2041 cttcaatagg caatttataa tgttttggat tcaaacattt acgtagtagt ccttgaagag
     2101 aacaataatt tattggctat attgataccc atataagact gtatcttaca gtgcacagaa
     2161 ttcccacgct gcttttagtt ttgaaaataa aactttccct tgtaaaaact gctgttctgc
     2221 ttttgtggga cgtctgtata cagttctgca aagcttgcta tcacaccaga gtgggcaaga
     2281 ccattaattc caatcctcct cttggcaagg ttttattcgc atgtctgaag ctaacagttt
     2341 ctcgaaagac agtaagtgga gcctaattag aacaggctga aaagcttccc agctagcact
     2401 tgtggctaca ataaaaaaca attcttggat tttctcccca cagtgaggca catctcacag
     2461 tttatcattt ggatgagtaa tttaaaatga attaaattcc agagaacaat ggatgcactg
     2521 ctccatagat gtcactgcag agtaaccact tgtttgaagc ctagcataat cgcacagcct
     2581 aatccagatt tattctgctt agtttttcaa cgtttccaga gagctttaca tttgtttagt
     2641 tggtaaactt ttctctctca ctgcacttat tctatagttt aaaaaaaaag tttgaaagta
     2701 gctttaggaa aaccagtata gctttatttt cccgacttca aagtggcatc tcgtgctgga
     2761 atggtctagg ctataggaac ataaaaccag acatagcagt cagaaaaaca actggaggtg
     2821 gtgggtgaga tggcccagca ggcaaggata tttgctgcca agcctgccag cctgagtgca
     2881 attcgtggga cccaaatgtg gaagaggaga actgactccc acaggttgac ctctgacctc
     2941 cactggcaca ccagtgcaat cccataaata cacaaatgta atttcaaaat cagagggctg
     3001 gagaatggct aagtagtgaa gaatgtttgc tgaggaaaca tgtggactga gattcaattc
     3061 ctcctggaac ataagatgaa cagacatgta atcccagtac tatcagggac aaagatagga
     3121 ggactgatgg tccttgctgg cttctggccc aactccaagt tcagagagag actttgctac
     3181 agaggaataa ggcagagaat aataaagcag aacactggat gtcctcctct ggcaatacac
     3241 acacacacac acacacacac ccagacacac tacataaaat aattcaaaca atgggggaga
     3301 atacaaaaac taacaagaat catacattct agtaaatgtt atgtaaacag aatcacagca
     3361 ttagggagaa attactgact tattttgtag tttcatcttg tgactcttag tctaaatcta
     3421 tcagcgagga gacaagcaac atgaggtcga tgtttgaggg gttgcatgct gggtaatttt
     3481 agcttacatt gtagctctaa gaacattcaa atataacact gtcaattaag ca
//
