LOCUS       NM_133731               1343 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus serine protease 22 (Prss22), mRNA.
ACCESSION   NM_133731
VERSION     NM_133731.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Sah,R.K., Yang,A., Bah,F.B., Adlat,S., Bohio,A.A., Oo,Z.M.,
            Wang,C., Myint,M.Z.Z., Bahadar,N., Zhang,L., Feng,X. and Zheng,Y.
  TITLE     Transcriptome profiling of mouse brain and lung under Dip2a
            regulation using RNA-sequencing
  JOURNAL   PLoS One 14 (7), e0213702 (2019)
   PUBMED   31291246
  REMARK    Erratum:[PLoS One. 2019 Nov 14;14(11):e0225570. doi:
            10.1371/journal.pone.0225570.. PMID: 31725791]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Wong,G.W., Yasuda,S., Morokawa,N., Li,L. and Stevens,R.L.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD773447.1, AB010778.1 and AK014645.1.
            
            On Nov 15, 2007 this sequence version replaced NM_133731.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055854.1, AK014645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               CD773447.1         5-423
            420-761             AB010778.1         403-744
            762-889             AK014645.1         762-889
            890-899             AB010778.1         873-882
            900-974             AK014645.1         900-974
            975-1199            AB010778.1         955-1179
            1200-1323           AK014645.1         1200-1323
            1324-1343           AB010778.1         1298-1317
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.18 cM"
     gene            1..1343
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /note="serine protease 22"
                     /db_xref="GeneID:70835"
                     /db_xref="MGI:MGI:1918085"
     exon            1..178
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1020
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /note="brain-specific serine protease 4; tryptase epsilon;
                     serine protease 26; protease, serine 22"
                     /codon_start=1
                     /product="brain-specific serine protease 4 precursor"
                     /protein_id="NP_598492.2"
                     /db_xref="CCDS:CCDS37482.1"
                     /db_xref="GeneID:70835"
                     /db_xref="MGI:MGI:1918085"
                     /translation="MMISRPPPALGGDQFSILILLVLLTSTAPISAATIRVSPDCGKP
                     QQLNRIVGGEDSMDAQWPWIVSILKNGSHHCAGSLLTNRWVVTAAHCFKSNMDKPSLF
                     SVLLGAWKLGSPGPRSQKVGIAWVLPHPRYSWKEGTHADIALVRLEHSIQFSERILPI
                     CLPDSSVRLPPKTDCWIAGWGSIQDGVPLPHPQTLQKLKVPIIDSELCKSLYWRGAGQ
                     EAITEGMLCAGYLEGERDACLGDSGGPLMCQVDDHWLLTGIISWGEGCAERNRPGVYT
                     SLLAHRSWVQRIVQGVQLRGYLADSGDTGSS"
     exon            179..205
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            206..377
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            378..655
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            656..813
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1324
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /note="hexamer: AATAAA"
     polyA_site      1324
                     /gene="Prss22"
                     /gene_synonym="4733401N09Rik; BSSP-4; SP001LA"
                     /note="major polyA site"
ORIGIN      
        1 acactacagc cacccgtcct gccagtctca agcaacacag cccttaggtc ctttgagccg
       61 gccagcagcc ttgctgggtc tccacccata ccagcaatga tgatctccag acctccccca
      121 gcactgggtg gggaccagtt cagcatctta atccttctgg tgctgctgac ttccacagct
      181 cccatcagtg ctgccaccat ccgagtgtcc ccagactgtg ggaagcctca gcagctgaac
      241 cggattgtgg gaggtgagga cagcatggat gcccagtggc cctggattgt tagcatcctc
      301 aagaatggct cccaccactg tgcaggctcc ctgctcacca accgctgggt ggtcacagcc
      361 gcgcactgct ttaagagcaa tatggacaaa ccatctctgt tctcagtatt gttgggggcc
      421 tggaagctgg ggagcccagg cccaaggtcc cagaaagtag gcattgcttg ggtgctgcct
      481 caccccaggt attcttggaa ggagggaacc catgcagaca ttgccctggt gcgcctggaa
      541 cactccatcc agttctctga gcggatcctg cccatctgcc tacctgactc ctctgtccgt
      601 ctccctccca agaccgactg ctggattgcc ggctggggaa gcatccagga tggagtgccc
      661 ctgccccacc ctcagaccct tcagaagctg aaggtgccca tcatcgactc cgaactctgc
      721 aaaagcttgt actggcgggg agccggtcag gaagccatca ccgagggcat gctgtgtgct
      781 ggttacctgg aaggggagcg ggatgcttgt ctgggcgact ctgggggtcc cctgatgtgc
      841 caggtggatg accactggct actgactggc ataatcagct ggggagaggg ctgcgcggag
      901 cgcaaccggc ccggtgtgta caccagcctc ctagctcacc gctcctgggt gcaaaggatc
      961 gttcaagggg tgcagctgcg cgggtacttg gcggacagtg gggacacagg aagctcctaa
     1021 tctaggatct gaagatgagc agcctcctgc aattctctct gctgtaaata tgtcttctac
     1081 ctccgggggg cgcccgcggc ctgagcgaga gaacaaggaa gttctggaac cgcccacata
     1141 gaggatccgc ccctcaatcg aggactctgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1201 gtgtgcctct gtgtgcgtgt gtatgcgcgc gcacgtgcgc gcgagagcaa tgattttttt
     1261 ttttacagtt atacgtaacc atgcccacat atttattcca gtttcaataa attatttatt
     1321 cttaaaaaaa aaaaaaaaaa aaa
//
