LOCUS       NM_020487               1077 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus serine protease 21 (Prss21), mRNA.
ACCESSION   NM_020487
VERSION     NM_020487.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Peroutka,R.J., Buzza,M.S., Mukhopadhyay,S., Johnson,T.A.,
            Driesbaugh,K.H. and Antalis,T.M.
  TITLE     Testisin/Prss21 deficiency causes increased vascular permeability
            and a hemorrhagic phenotype during luteal angiogenesis
  JOURNAL   PLoS One 15 (6), e0234407 (2020)
   PUBMED   32511276
  REMARK    GeneRIF: Testisin/Prss21 deficiency causes increased vascular
            permeability and a hemorrhagic phenotype during luteal
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Conway,G.D., Buzza,M.S., Martin,E.W., Duru,N., Johnson,T.A.,
            Peroutka,R.J., Pawar,N.R. and Antalis,T.M.
  TITLE     PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes
            proangiogenic angiopoietins ANG2 and ANGPTL4
  JOURNAL   J Mol Med (Berl) 97 (5), 691-709 (2019)
   PUBMED   30911775
  REMARK    GeneRIF: Testisin inhibits metastatic ovarian tumor burden and
            ascites production. Testisin activity antagonizes ANG2 and ANGPTL4
            synthesis and secretion.
            Erratum:[J Mol Med (Berl). 2019 Sep;97(9):1375. doi:
            10.1007/s00109-019-01820-x. PMID: 31327018]
REFERENCE   4  (bases 1 to 1077)
  AUTHORS   Asano,A., Nelson-Harrington,J.L. and Travis,A.J.
  TITLE     Phospholipase B is activated in response to sterol removal and
            stimulates acrosome exocytosis in murine sperm
  JOURNAL   J Biol Chem 288 (39), 28104-28115 (2013)
   PUBMED   23943622
REFERENCE   5  (bases 1 to 1077)
  AUTHORS   Zhou,C., Kang,W. and Baba,T.
  TITLE     Functional characterization of double-knockout mouse sperm lacking
            SPAM1 and ACR or SPAM1 and PRSS21 in fertilization
  JOURNAL   J Reprod Dev 58 (3), 330-337 (2012)
   PUBMED   22362218
  REMARK    GeneRIF: ACR or PRSS21 or both may function cooperatively with
            SPAM1 in sperm/cumulus penetration
REFERENCE   6  (bases 1 to 1077)
  AUTHORS   Yamashita,M., Honda,A., Ogura,A., Kashiwabara,S., Fukami,K. and
            Baba,T.
  TITLE     Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is
            rescued by sperm exposure to uterine microenvironment
  JOURNAL   Genes Cells 13 (10), 1001-1013 (2008)
   PUBMED   18754795
  REMARK    GeneRIF: The reduced fertility of Prss21-null epididymal sperm was
            rescued by exposure of the sperm to the uterine microenvironment
            and by in vitro treatment of the sperm with uterine fluids.
REFERENCE   7  (bases 1 to 1077)
  AUTHORS   Wong,G.W., Yasuda,S., Morokawa,N., Li,L. and Stevens,R.L.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
REFERENCE   8  (bases 1 to 1077)
  AUTHORS   Honda,A., Yamagata,K., Sugiura,S., Watanabe,K. and Baba,T.
  TITLE     A mouse serine protease TESP5 is selectively included into lipid
            rafts of sperm membrane presumably as a
            glycosylphosphatidylinositol-anchored protein
  JOURNAL   J Biol Chem 277 (19), 16976-16984 (2002)
   PUBMED   11861648
REFERENCE   9  (bases 1 to 1077)
  AUTHORS   Wong,G.W., Li,L., Madhusudhan,M.S., Krilis,S.A., Gurish,M.F.,
            Rothenberg,M.E., Sali,A. and Stevens,R.L.
  TITLE     Tryptase 4, a new member of the chromosome 17 family of mouse
            serine proteases
  JOURNAL   J Biol Chem 276 (23), 20648-20658 (2001)
   PUBMED   11259427
REFERENCE   10 (bases 1 to 1077)
  AUTHORS   Scarman,A.L., Hooper,J.D., Boucaut,K.J., Sit,M.L., Webb,G.C.,
            Normyle,J.F. and Antalis,T.M.
  TITLE     Organization and chromosomal localization of the murine Testisin
            gene encoding a serine protease temporally expressed during
            spermatogenesis
  JOURNAL   Eur J Biochem 268 (5), 1250-1258 (2001)
   PUBMED   11231276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049588.1.
            
            On Aug 14, 2009 this sequence version replaced NM_020487.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049588.1, AB033822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              BC049588.1         15-1091
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.11 cM"
     gene            1..1077
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /note="serine protease 21"
                     /db_xref="GeneID:57256"
                     /db_xref="MGI:MGI:1916698"
     exon            1..126
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /inference="alignment:Splign:2.1.0"
     exon            127..153
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /inference="alignment:Splign:2.1.0"
     exon            154..319
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /inference="alignment:Splign:2.1.0"
     exon            320..603
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /inference="alignment:Splign:2.1.0"
     exon            604..758
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1077
                     /gene="Prss21"
                     /gene_synonym="1700023E12Rik; mT4; TESP5; testisin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaggtggc aggagaggtg gccatgggcg cgcggggcaa gacgttggtg ccactgctgg
       61 tggttgtggc gactgcggcg atggccttac agtcaaccta tttgcaggtg gatcctgaga
      121 aacccgaact gcaggaaccc gacctattgt cagggccctg cggtcacagg accatccctt
      181 cccgtatagt gggtggcgat gatgctgagc ttggccgctg gccgtggcaa gggagcctgc
      241 gtgtatgggg caaccactta tgtggcgcaa ccttgctcaa ccgccgctgg gtgcttacag
      301 ctgcccactg cttccaaaag gataacgatc cttttgactg gacagtccag tttggtgagc
      361 tgacatccag gccatctctc tggaacctac aggcctattc caaccgttac caaatagaag
      421 atattttcct gagccccaag tactcggagc agtatcccaa tgacatagcc ctgctgaagc
      481 tgtcatctcc agtcacctac aataacttca tccagcccat ctgcctcctg aactccacgt
      541 acaagtttga gaaccgaact gactgctggg tgaccggctg gggggctatt ggagaagatg
      601 agagtctgcc atctcccaac actctccagg aagtgcaggt agctattatc aacaacagca
      661 tgtgtaacca tatgtacaaa aagccagact tccgcacgaa catctgggga gacatggttt
      721 gcgctggcac tcctgaaggt ggcaaggatg cctgctttgg tgactcggga ggacccttgg
      781 cctgcgacca ggatacggtg tggtatcagg ttggagttgt gagctgggga ataggctgtg
      841 gtcgccccaa tcgccctgga gtctatacca acatcagtca tcactacaac tggatccagt
      901 caaccatgat ccgcaatggg ctgctcaggc ctgacccagt ccccctgcta ctgtttctca
      961 ctctggcctg ggcttcctct ttgctgaggc ctgcctgagc ccacacgtgt acgtcacacc
     1021 tgtgaggtca gggtgtgtct cttttgtatc ttgcttgcta ataaacctgt taatatt
//
