LOCUS       NM_009430                826 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus serine protease 2 (Prss2), mRNA.
ACCESSION   NM_009430
VERSION     NM_009430.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 826)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 826)
  AUTHORS   Chen,Y., Wang,B., Zhao,Z., Li,M. and Wang,F.
  TITLE     PRSS2 overexpression relates to poor prognosis and promotes
            proliferation, migration and invasion in gastric cancer
  JOURNAL   Tissue Cell 79, 101949 (2022)
   PUBMED   36240716
  REMARK    GeneRIF: PRSS2 overexpression relates to poor prognosis and
            promotes proliferation, migration and invasion in gastric cancer.
REFERENCE   3  (bases 1 to 826)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   4  (bases 1 to 826)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 826)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 826)
  AUTHORS   Ohmura,K., Kohno,N., Kobayashi,Y., Yamagata,K., Sato,S.,
            Kashiwabara,S. and Baba,T.
  TITLE     A homologue of pancreatic trypsin is localized in the acrosome of
            mammalian sperm and is released during acrosome reaction
  JOURNAL   J Biol Chem 274 (41), 29426-29432 (1999)
   PUBMED   10506205
REFERENCE   7  (bases 1 to 826)
  AUTHORS   Krapp,A., Knofler,M., Ledermann,B., Burki,K., Berney,C.,
            Zoerkler,N., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     The bHLH protein PTF1-p48 is essential for the formation of the
            exocrine and the correct spatial organization of the endocrine
            pancreas
  JOURNAL   Genes Dev 12 (23), 3752-3763 (1998)
   PUBMED   9851981
REFERENCE   8  (bases 1 to 826)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
REFERENCE   9  (bases 1 to 826)
  AUTHORS   Petrucco,S., Wellauer,P.K. and Hagenbuchle,O.
  TITLE     The DNA-binding activity of transcription factor PTF1 parallels the
            synthesis of pancreas-specific mRNAs during mouse development
  JOURNAL   Mol Cell Biol 10 (1), 254-264 (1990)
   PUBMED   2294404
REFERENCE   10 (bases 1 to 826)
  AUTHORS   Stevenson,B.J., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     Sequence organisation and transcriptional regulation of the mouse
            elastase II and trypsin genes
  JOURNAL   Nucleic Acids Res 14 (21), 8307-8330 (1986)
   PUBMED   3641189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB841364.1 and AK003082.1.
            
            On Sep 7, 2007 this sequence version replaced NM_009430.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003082.1, CF581504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BB841364.1         2-12
            12-826              AK003082.1         1-815
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.67 cM"
     gene            1..826
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /note="serine protease 2"
                     /db_xref="GeneID:22072"
                     /db_xref="MGI:MGI:102759"
     exon            1..68
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..769
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /EC_number="3.4.21.4"
                     /note="anionic trypsin-2; trypsinogen 20; pretrypsinogen
                     II; anionic trypsin II; trypsin 2; protease, serine 2"
                     /codon_start=1
                     /product="anionic trypsin-2 precursor"
                     /protein_id="NP_033456.1"
                     /db_xref="CCDS:CCDS20050.1"
                     /db_xref="GeneID:22072"
                     /db_xref="MGI:MGI:102759"
                     /translation="MSALLILALVGAAVAFPVDDDDKIVGGYTCRESSVPYQVSLNAG
                     YHFCGGSLINDQWVVSAAHCYKYRIQVRLGEHNINVLEGNEQFVDSAKIIRHPNYNSW
                     TLDNDIMLIKLASPVTLNARVASVPLPSSCAPAGTQCLISGWGNTLSNGVNNPDLLQC
                     VDAPVLPQADCEASYPGDITNNMICVGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGY
                     GCAQPDAPGVYTKVCNYVDWIQNTIADN"
     exon            69..228
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /inference="alignment:Splign:2.1.0"
     exon            229..482
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /inference="alignment:Splign:2.1.0"
     exon            483..619
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /inference="alignment:Splign:2.1.0"
     exon            620..826
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      802..807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /note="putative"
     polyA_site      826
                     /gene="Prss2"
                     /gene_synonym="Ta; Tesp4; Try2; TRY8; TRYP"
                     /note="putative"
ORIGIN      
        1 ctttctgtgc tcatgacttt ctgtcaccat gagtgcactt ctgatcctag cccttgtggg
       61 agctgctgtt gctttccctg tggatgatga tgacaagatt gttggaggat acacctgccg
      121 agagagttct gtcccctatc aggtgtccct aaatgctggc taccacttct gtggaggttc
      181 cctcatcaat gaccagtggg tggtgtctgc agctcactgc tacaaatacc gcatccaagt
      241 gagactggga gagcacaaca tcaatgtcct ggagggcaat gagcagtttg ttgattctgc
      301 caagatcatc cggcacccca attataattc atggaccctg gacaatgaca tcatgctgat
      361 caaactggct tcccctgtga ccctcaatgc cagagtggcc tctgtacctc tgcccagctc
      421 ctgtgcacct gcaggcactc agtgcctcat ctctggctgg ggcaacaccc tcagcaatgg
      481 tgtgaacaac ccagacctgc tccagtgtgt tgatgcccca gtgctgcctc aggctgactg
      541 tgaggcctcc taccctgggg acatcaccaa caacatgatc tgtgttggct tcctggaggg
      601 aggcaaagat tcctgccagg gtgactctgg tggccctgtg gtctgcaatg gagagctgca
      661 gggcattgtc tcctggggct atggctgtgc ccagccagat gctcctggtg tatacaccaa
      721 ggtctgcaac tacgtggact ggattcagaa cacaattgct gacaactaga gaaccctagt
      781 ctctcttcaa tcagtattat caataaagtt catttgtcat cactgt
//
