LOCUS       NM_001038997             824 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus serine protease 1 (trypsin 1) like (Prss1l), mRNA.
ACCESSION   NM_001038997
VERSION     NM_001038997.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 824)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   2  (bases 1 to 824)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 824)
  AUTHORS   Chen,F., Rowen,L., Hood,L. and Rothenberg,E.V.
  TITLE     Differential transcriptional regulation of individual TCR V beta
            segments before gene rearrangement
  JOURNAL   J Immunol 166 (3), 1771-1780 (2001)
   PUBMED   11160223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158659.6.
            
            On Sep 7, 2007 this sequence version replaced NM_001038997.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132030.1, CF580481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC158659.6         57882-57954         c
            74-230              AC158659.6         55492-55648         c
            231-484             AC158659.6         54064-54317         c
            485-621             AC158659.6         53518-53654         c
            622-824             AC158659.6         53054-53256         c
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.52 cM"
     gene            1..824
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /note="serine protease 1 (trypsin 1) like"
                     /db_xref="GeneID:436523"
                     /db_xref="MGI:MGI:3646222"
     exon            1..73
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..771
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /note="trypsinogen 12"
                     /codon_start=1
                     /product="trypsinogen 12 precursor"
                     /protein_id="NP_001034086.1"
                     /db_xref="CCDS:CCDS20048.1"
                     /db_xref="GeneID:436523"
                     /db_xref="MGI:MGI:3646222"
                     /translation="MSALLFLALVGAAVAFPVDDDKIVGGYTCRENSVPYQVSLNSGY
                     HFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFVNAAKIIKHPNFNRKT
                     LNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQCL
                     DAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYG
                     CALADNPGVYTKVCNYVDWIQDTIAAN"
     exon            74..230
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /inference="alignment:Splign:2.1.0"
     exon            231..484
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /inference="alignment:Splign:2.1.0"
     exon            485..621
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /inference="alignment:Splign:2.1.0"
     exon            622..824
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /inference="alignment:Splign:2.1.0"
     regulatory      801..806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /note="hexamer: AATAAA"
     polyA_site      824
                     /gene="Prss1l"
                     /gene_synonym="EG436523; Gm5771"
                     /note="major polyA site"
ORIGIN      
        1 gcttccatcc agggctcact agcttctacc acaatgagtg cactcctctt cctggccctt
       61 gtgggagctg ctgttgcttt ccctgtggat gatgataaga tcgttggagg atacacctgc
      121 cgagagaatt ctgttcccta ccaggtgtcc ctgaactctg gctaccactt ctgtggaggt
      181 tccctcatca atgaccagtg ggtggtgtct gcagctcatt gctacaaaac ccgcatccaa
      241 gtgagattgg gggagcacaa catcaaagtc ctggagggca atgagcagtt tgtcaatgct
      301 gccaagatca tcaagcaccc caacttcaat aggaagaccc tcaataacga catcatgttg
      361 atcaagctct cttcccctgt gaccctcaat gccagagtgg ccactgtggc tctgcccagc
      421 tcctgtgcgc cagctggcac tcagtgtctc atctctggct ggggcaacac tcttagcttt
      481 ggtgtcagtg aaccagacct gctccagtgc ctggatgccc cactgctgcc tcaggctgac
      541 tgtgaagcct cctatcctgg gaagatcact ggtaacatgg tctgtgctgg cttcctagag
      601 ggaggcaagg attcctgcca gggtgactct ggtggccctg tggtctgcaa tggagagctc
      661 cagggcattg tctcttgggg ctatggctgt gccctggcag acaatcctgg tgtgtacacc
      721 aaggtctgca actatgtgga ttggattcag gacacaattg ctgccaacta gagattccca
      781 atccctctgt agtcactgtc aataaagtga agtattcatt acta
//
