LOCUS       NM_019429               2152 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus serine protease 16 (thymus) (Prss16), mRNA.
ACCESSION   NM_019429
VERSION     NM_019429.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2152)
  AUTHORS   Serre,L., Girard,M., Ramadan,A., Menut,P., Rouquie,N., Lucca,L.E.,
            Mahiddine,K., Leobon,B., Mars,L.T. and Guerder,S.
  TITLE     Thymic-Specific Serine Protease Limits Central Tolerance and
            Exacerbates Experimental Autoimmune Encephalomyelitis
  JOURNAL   J Immunol 199 (11), 3748-3756 (2017)
   PUBMED   29061767
  REMARK    GeneRIF: these results show that TSSP increases experimental
            autoimmune encephalomyelitis severity by limiting central tolerance
            to myelin oligodendrocyte glycoprotein
REFERENCE   3  (bases 1 to 2152)
  AUTHORS   Viret,C., Mahiddine,K., Baker,R.L., Haskins,K. and Guerder,S.
  TITLE     The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to
            Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive
            to ChgA and IAPP Autoantigens
  JOURNAL   J Immunol 195 (5), 1964-1973 (2015)
   PUBMED   26209627
  REMARK    GeneRIF: Data indicate that T-cell receptors that react to
            chromogranin A (ChgA) and islet amyloid polypeptide precursor
            (IAPP) autoantigens were impaired when the thymic stromal cells
            lacked thymus-specific serine protease (TSSP).
REFERENCE   4  (bases 1 to 2152)
  AUTHORS   Serre,L., Fazilleau,N. and Guerder,S.
  TITLE     Central tolerance spares the private high-avidity CD4(+) T-cell
            repertoire specific for an islet antigen in NOD mice
  JOURNAL   Eur J Immunol 45 (7), 1946-1956 (2015)
   PUBMED   25884569
REFERENCE   5  (bases 1 to 2152)
  AUTHORS   Brisson,L., Pouyet,L., N'guessan,P., Garcia,S., Lopes,N.,
            Warcollier,G., Iovanna,J.L. and Carrier,A.
  TITLE     The thymus-specific serine protease TSSP/PRSS16 is crucial for the
            antitumoral role of CD4(+) T cells
  JOURNAL   Cell Rep 10 (1), 39-46 (2015)
   PUBMED   25543139
  REMARK    GeneRIF: our data demonstrate that antitumoral immune surveillance
            requires thymic TSSP-driven production of CD4(+) T cells
            contributing to inflammatory balance.
REFERENCE   6  (bases 1 to 2152)
  AUTHORS   Cheunsuk,S., Lian,Z.X., Yang,G.X., Gershwin,M.E., Gruen,J.R. and
            Bowlus,C.L.
  TITLE     Prss16 is not required for T-cell development
  JOURNAL   Mol Cell Biol 25 (2), 789-796 (2005)
   PUBMED   15632078
  REMARK    GeneRIF: Data suggest that Prss16 is not required for
            quantitatively normal T-cell development.
REFERENCE   7  (bases 1 to 2152)
  AUTHORS   Cheunsuk,S., Sparks,R., Noveroske,J.K., Hsu,T., Justice,M.J.,
            Gershwin,M.E., Gruen,J.R. and Bowlus,C.L.
  TITLE     Expression, genomic structure and mapping of the thymus specific
            protease prss16: a candidate gene for insulin dependent diabetes
            mellitus susceptibility
  JOURNAL   J Autoimmun 18 (4), 311-316 (2002)
   PUBMED   12144812
  REMARK    GeneRIF: role of Prss16 in T-cell development and susceptibility to
            autoimmunity in the mouse
REFERENCE   8  (bases 1 to 2152)
  AUTHORS   Carrier,A., Wurbel,M.A., Mattei,M.G., Kissenpfennig,A., Malissen,M.
            and Malissen,B.
  TITLE     Chromosomal localization of two mouse genes encoding
            thymus-specific serine peptidase and thymus-expressed acidic
            protein
  JOURNAL   Immunogenetics 51 (11), 984-986 (2000)
   PUBMED   11003393
REFERENCE   9  (bases 1 to 2152)
  AUTHORS   Carrier,A., Nguyen,C., Victorero,G., Granjeaud,S., Rocha,D.,
            Bernard,K., Miazek,A., Ferrier,P., Malissen,M., Naquet,P.,
            Malissen,B. and Jordan,B.R.
  TITLE     Differential gene expression in CD3epsilon- and RAG1-deficient
            thymuses: definition of a set of genes potentially involved in
            thymocyte maturation
  JOURNAL   Immunogenetics 50 (5-6), 255-270 (1999)
   PUBMED   10630289
REFERENCE   10 (bases 1 to 2152)
  AUTHORS   Bowlus,C.L., Ahn,J., Chu,T. and Gruen,J.R.
  TITLE     Cloning of a novel MHC-encoded serine peptidase highly expressed by
            cortical epithelial cells of the thymus
  JOURNAL   Cell Immunol 196 (2), 80-86 (1999)
   PUBMED   10527559
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL590614.8.
            
            On Mar 21, 2007 this sequence version replaced NM_019429.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131775.1, AK088019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AL590614.8         26987-27097         c
            112-278             AL590614.8         26746-26912         c
            279-378             AL590614.8         25935-26034         c
            379-508             AL590614.8         25686-25815         c
            509-632             AL590614.8         24499-24622         c
            633-710             AL590614.8         24244-24321         c
            711-758             AL590614.8         24103-24150         c
            759-1049            AL590614.8         23338-23628         c
            1050-1191           AL590614.8         22447-22588         c
            1192-1371           AL590614.8         20502-20681         c
            1372-1517           AL590614.8         20282-20427         c
            1518-2152           AL590614.8         19532-20166         c
FEATURES             Location/Qualifiers
     source          1..2152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 8.12 cM"
     gene            1..2152
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /note="serine protease 16 (thymus)"
                     /db_xref="GeneID:54373"
                     /db_xref="MGI:MGI:1859181"
     exon            1..111
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1574
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /note="thymus-specific serine protease; serine protease
                     16; protease, serine 16 (thymus)"
                     /codon_start=1
                     /product="thymus-specific serine protease precursor"
                     /protein_id="NP_062302.1"
                     /db_xref="CCDS:CCDS26303.1"
                     /db_xref="GeneID:54373"
                     /db_xref="MGI:MGI:1859181"
                     /translation="MAVKAPWLGFLLLVSLWGLSTPALLLRRLREHIQKFQESSSLHP
                     GFGLGHGPGAVPKQGWLEQPLDPFNASDRRTFLQRYWVNDQHRTGQDVPVFLHIGGEG
                     SLGPGSVMAGHPAALAPAWGALVISLEHRFYGLSMPAGGLDLALLRYLSSRHALADVA
                     SARQALSGLLNVSSSSPWICFGGSYAGSLATWARLKFPHLVFAAVASSAPLSAVVDFS
                     AYNQVVARSLTQVAIGGSLECLAAASTAFTEVERLLRAGPAAQAVLREELGACGSLDL
                     TEDQAELLGALQALVGGTVQYDGQAGAPLSVRQLCGLLLGKWGNRSRSTPYLGLRRAV
                     QIVLRSMGQKCLSFSRAETVAQLSNTEPQVSGVGDRQWLYQTCTEFGFYVTCEGLQCP
                     FSQLPALPFQLELCEQVFGLSPASVAQAVAQTNSYYGGQSPGATQVLFVNGDTDPWHV
                     LSVTQDLGLSEPALLIPSASHCFDMAPMRPSDSPSLRLGRQKISQQLQDWLKDIKKSQ
                     S"
     exon            112..278
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            279..378
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..508
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            509..632
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            633..710
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            711..758
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1049
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1191
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1371
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1517
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..2152
                     /gene="Prss16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagagtgc ctggaacact tcctaacaca gaatactggg gagaatggca gtcaaggctc
       61 catggttggg attcttgctt ctggtttccc tctggggact gtcaactcca gccttgcttc
      121 tcaggcgcct gagggaacac attcagaagt ttcaggagag ctctagccta cacccaggct
      181 ttggactagg ccatggtcct ggggctgtcc ccaaacaagg gtggttagaa cagccactgg
      241 atcccttcaa tgcatctgac agacgaacct tcctgcagcg gtactgggtg aatgatcaac
      301 acagaactgg ccaagatgta ccagtatttc tgcacatagg aggcgagggc agccttgggc
      361 ctggctcagt gatggcaggg catcctgcgg cactggcccc tgcctggggg gccctggtga
      421 taagcctaga acacagattc tatggtttga gtatgcctgc tgggggcctg gatctggccc
      481 tgcttcgcta cttgtccagc cgccatgcgt tggctgacgt ggcttccgct cgccaggcgc
      541 tctccggcct cctcaatgtg tcttcttcca gcccttggat ctgcttcgga ggctcctacg
      601 ctggctcgct ggcgacctgg gcccggctga agttccccca cctagtcttt gccgccgtcg
      661 cctcctcagc accgctgagc gctgtagtgg acttctccgc ctataaccag gtggtggcca
      721 gaagcctgac acaagtcgcc ataggaggat cattggagtg tctggcggcg gcctccaccg
      781 ccttcacgga ggtggagcgg ctgctgcgcg caggcccggc ggctcaggct gtgctgaggg
      841 aggaactggg cgcctgcggg tccctggacc ttacggaaga ccaggcggag ctgctgggag
      901 cgttgcaggc gctggtgggc ggcaccgtgc agtacgacgg gcaggcggga gcgccgctaa
      961 gcgtgcgcca gctctgcggt ctcctgctcg ggaagtgggg aaaccgcagc cgctccacgc
     1021 cctacttggg gcttcgccgg gctgtacaga tagtcttgcg cagcatggga cagaagtgtt
     1081 taagcttttc ccgggcagag acagtggcac agctgagcaa caccgaaccg caagtgtctg
     1141 gtgtggggga ccggcagtgg ttgtaccaga catgcactga gtttggcttc tatgtcacct
     1201 gtgagggtct tcagtgtcct ttttcccagc tcccagcact gcccttccag ctagagctgt
     1261 gtgaacaagt gtttggcctc tcacctgcat ctgttgccca ggctgtggcc cagacaaact
     1321 cctattatgg tggtcagagc cctggagcca cccaagtact gtttgttaat ggagacacag
     1381 atccttggca tgtattgagc gtaacacagg acttaggact gtctgagcca gcccttctaa
     1441 ttcctagtgc ttcccactgc ttcgatatgg cacctatgag gccttcagac tctcccagcc
     1501 tccgcctggg acgtcagaaa atctcccagc aattacagga ttggctcaaa gatataaaga
     1561 agagccagag ttgatgtggg atcaaaaccc agccctttga cagtcccatc acaggaactg
     1621 catcctggca tttttcttca ctgtagaaga gaaaacagct gtttggaagg aggaagttcc
     1681 tagacgtggg actcagtgcc tgttctgcct gcttgttctc aatttatctt cattgccaac
     1741 tagaagttct ttgtcacgga ttagtataaa tgtaggcaaa tgattactgt cctttgtagg
     1801 tagtgatatt ctgtatggta aatgtcaggg gaatgtggct ttccatgctg gagccgcctt
     1861 ctcccagata agaacctggc ttaaattctg tctcttcatt cttgactggc acctactgca
     1921 tagaactctt cacatcctga ctctgtctct cctgagtttt agtctgtggt agttgaactt
     1981 cattgtcagc ctacctgaat ttagaatcac atggaaacat aaccctggac tgactgacta
     2041 cctttgagca cgttttcagt aaagttatac tgaagaggaa agacccgcct gaaatggtgg
     2101 taacacccat tactgaactc ccagctgaat aaaagaaatg gtgagcaccg gc
//
