LOCUS       NM_053243                807 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus serine protease 1 (trypsin 1) (Prss1), mRNA.
ACCESSION   NM_053243
VERSION     NM_053243.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 807)
  AUTHORS   Yang,W.J., Cao,R.C., Xiao,W., Zhang,X.L., Xu,H., Wang,M.,
            Zhou,Z.T., Chen,H.J., Xu,J., Chen,X.M., Zeng,J.L., Li,S.J., Luo,M.,
            Han,Y.J., Yang,X.B., Feng,G.D., Lu,Y.H., Ni,Y.Y., Wu,C.G.,
            Bai,J.J., Yuan,Z.Q., Jin,J. and Zhang,G.W.
  TITLE     Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and
            clearance of inflammation during chronic pancreatitis development
  JOURNAL   Cell Death Dis 13 (10), 893 (2022)
   PUBMED   36273194
  REMARK    Erratum:[Cell Death Dis. 2022 Nov 7;13(11):930. doi:
            10.1038/s41419-022-05374-8. PMID: 36344486]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 807)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   4  (bases 1 to 807)
  AUTHORS   Heymans,C., Delcorte,O., Spourquet,C., Villacorte-Tabelin,M.,
            Dupasquier,S., Achouri,Y., Mahibullah,S., Lemoine,P., Balda,M.S.,
            Matter,K. and Pierreux,C.E.
  TITLE     Spatio-temporal expression pattern and role of the tight junction
            protein MarvelD3 in pancreas development and function
  JOURNAL   Sci Rep 11 (1), 14519 (2021)
   PUBMED   34267243
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 807)
  AUTHORS   Tan,J.H., Cao,R.C., Zhou,L., Zhou,Z.T., Chen,H.J., Xu,J.,
            Chen,X.M., Jin,Y.C., Lin,J.Y., Qi,Z.C., Zeng,J.L., Li,S.J., Luo,M.,
            Hu,G.D., Jin,J. and Zhang,G.W.
  TITLE     EMC6 regulates acinar apoptosis via APAF1 in acute and chronic
            pancreatitis
  JOURNAL   Cell Death Dis 11 (11), 966 (2020)
   PUBMED   33177505
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 807)
  AUTHORS   Krapp,A., Knofler,M., Ledermann,B., Burki,K., Berney,C.,
            Zoerkler,N., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     The bHLH protein PTF1-p48 is essential for the formation of the
            exocrine and the correct spatial organization of the endocrine
            pancreas
  JOURNAL   Genes Dev 12 (23), 3752-3763 (1998)
   PUBMED   9851981
REFERENCE   7  (bases 1 to 807)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 807)
  AUTHORS   Bucan,M., Yang-Feng,T., Colberg-Poley,A.M., Wolgemuth,D.J.,
            Guenet,J.L., Francke,U. and Lehrach,H.
  TITLE     Genetic and cytogenetic localisation of the homeo box containing
            genes on mouse chromosome 6 and human chromosome 7
  JOURNAL   EMBO J 5 (11), 2899-2905 (1986)
   PUBMED   2878803
REFERENCE   9  (bases 1 to 807)
  AUTHORS   Honey,N.K., Sakaguchi,A.Y., Lalley,P.A., Quinto,C., MacDonald,R.J.,
            Craik,C., Bell,G.I., Rutter,W.J. and Naylor,S.L.
  TITLE     Chromosomal assignments of genes for trypsin, chymotrypsin B, and
            elastase in mouse
  JOURNAL   Somat Cell Mol Genet 10 (4), 377-383 (1984)
   PUBMED   6589791
REFERENCE   10 (bases 1 to 807)
  AUTHORS   .
  TITLE     Abstracts of meeting presentations: Human gene mapping 7, Los
            Angeles Conference (1983), Seventh International Workshop on Human
            Gene Mapping
  JOURNAL   Cytogenet Cell Genet 37 (1-4), 399-616 (1984)
   PUBMED   6690234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153854.7.
            
            On Sep 7, 2007 this sequence version replaced NM_053243.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094921.1, CF580393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC153854.7         113666-113718
            54-213              AC153854.7         115917-116076
            214-467             AC153854.7         117271-117524
            468-604             AC153854.7         117921-118057
            605-807             AC153854.7         118320-118522
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.6 cM"
     gene            1..807
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /note="serine protease 1 (trypsin 1)"
                     /db_xref="GeneID:114228"
                     /db_xref="MGI:MGI:98839"
     exon            1..53
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..754
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /EC_number="3.4.21.4"
                     /note="trypsin 1; trypsinogen 16; protease, serine 1
                     (trypsin 1)"
                     /codon_start=1
                     /product="protease, serine, 1 precursor"
                     /protein_id="NP_444473.1"
                     /db_xref="CCDS:CCDS20049.1"
                     /db_xref="GeneID:114228"
                     /db_xref="MGI:MGI:98839"
                     /translation="MSALLFLALVGAAVAFPVDDDDKIVGGYTCRENSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNINVLEGNEQFIDAAKIIKHPNFNRK
                     TLNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQC
                     LDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGY
                     GCALPDNPGVYTKVCNYVDWIQDTIAAN"
     exon            54..213
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /inference="alignment:Splign:2.1.0"
     exon            214..467
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /inference="alignment:Splign:2.1.0"
     exon            468..604
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /inference="alignment:Splign:2.1.0"
     exon            605..807
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      784..789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /note="hexamer: AATAAA"
     polyA_site      807
                     /gene="Prss1"
                     /gene_synonym="Try-1; Try1; Trygn16"
                     /note="major polyA site"
ORIGIN      
        1 accttctgcc acaatgagtg cactcctgtt cctggccctt gtgggagctg ctgttgcttt
       61 ccctgtggat gatgatgaca agatcgttgg aggatacacc tgccgagaga attctgttcc
      121 ctaccaggtg tccctgaact ctggctacca cttctgtgga ggttccctca tcaatgacca
      181 gtgggtggtg tctgcagctc attgctacaa gacccgcatc caagtgagat tgggggagca
      241 caatatcaat gtcctggagg gcaatgagca gtttatcgat gctgccaaga tcatcaagca
      301 ccccaacttc aataggaaga ccctgaacaa tgacatcatg ttgatcaagc tctcatcccc
      361 tgtgaccctc aatgccagag tggccactgt ggctctgccc agctcctgtg cacctgctgg
      421 cactcagtgt ctcatctctg gctggggcaa cactcttagc tttggtgtca gtgaaccaga
      481 cctgctccag tgcctggatg ccccactgct gcctcaggct gactgtgagg cttcctatcc
      541 tgggaagatc actggtaaca tggtctgtgc tggcttccta gagggaggca aggattcctg
      601 ccagggtgac tctggtggcc ctgtggtctg caatggagag ctccagggca ttgtctcttg
      661 gggctatggc tgtgccctgc cagacaatcc tggtgtgtac accaaggtct gcaactatgt
      721 ggattggatt caggacacaa ttgctgccaa ctagagattc ccaatccctc tgcagtcact
      781 gtcaataaag tgaaatattc attacta
//
