LOCUS       NM_011127               4911 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus paired related homeobox 1 (Prrx1), transcript variant
            1, mRNA.
ACCESSION   NM_011127
VERSION     NM_011127.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4911)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   2  (bases 1 to 4911)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   3  (bases 1 to 4911)
  AUTHORS   Ning,Y., Duo,S., Lin,X., Zhang,H., Fei,J., Zhang,B., Zeng,Y.,
            Xie,D., Chen,J., Liu,X. and Han,C.
  TITLE     Transcription factor PBX4 regulates limb development and
            haematopoiesis in mice
  JOURNAL   Cell Prolif 57 (5), e13580 (2024)
   PUBMED   38230761
REFERENCE   4  (bases 1 to 4911)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   5  (bases 1 to 4911)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4911)
  AUTHORS   Uelmen,P.J., Oka,K., Sullivan,M., Chang,C.C., Chang,T.Y. and
            Chan,L.
  TITLE     Tissue-specific expression and cholesterol regulation of
            acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice.
            Molecular cloning of mouse ACAT cDNA, chromosomal localization, and
            regulation of ACAT in vivo and in vitro
  JOURNAL   J Biol Chem 270 (44), 26192-26201 (1995)
   PUBMED   7592824
REFERENCE   7  (bases 1 to 4911)
  AUTHORS   Leussink,B., Brouwer,A., el Khattabi,M., Poelmann,R.E.,
            Gittenberger-de Groot,A.C. and Meijlink,F.
  TITLE     Expression patterns of the paired-related homeobox genes MHox/Prx1
            and S8/Prx2 suggest roles in development of the heart and the
            forebrain
  JOURNAL   Mech Dev 52 (1), 51-64 (1995)
   PUBMED   7577675
REFERENCE   8  (bases 1 to 4911)
  AUTHORS   Weiss,K.M., Ruddle,F.H. and Bollekens,J.
  TITLE     Dlx and other homeobox genes in the morphological development of
            the dentition
  JOURNAL   Connect Tissue Res 32 (1-4), 35-40 (1995)
   PUBMED   7554933
REFERENCE   9  (bases 1 to 4911)
  AUTHORS   Kern,M.J., Witte,D.P., Valerius,M.T., Aronow,B.J. and Potter,S.S.
  TITLE     A novel murine homeobox gene isolated by a tissue specific PCR
            cloning strategy
  JOURNAL   Nucleic Acids Res 20 (19), 5189-5195 (1992)
   PUBMED   1383943
REFERENCE   10 (bases 1 to 4911)
  AUTHORS   Cserjesi,P., Lilly,B., Bryson,L., Wang,Y., Sassoon,D.A. and
            Olson,E.N.
  TITLE     MHox: a mesodermally restricted homeodomain protein that binds an
            essential site in the muscle creatine kinase enhancer
  JOURNAL   Development 115 (4), 1087-1101 (1992)
   PUBMED   1360403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084387.1 and BC092372.1.
            
            On Jul 16, 2005 this sequence version replaced NM_011127.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59725.1, AB221686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1614              AK084387.1         19-1632
            1615-4911           BC092372.1         1036-4332
FEATURES             Location/Qualifiers
     source          1..4911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.53 cM"
     gene            1..4911
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="paired related homeobox 1"
                     /db_xref="GeneID:18933"
                     /db_xref="MGI:MGI:97712"
     exon            1..1256
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1016..1753
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="isoform a is encoded by transcript variant 1;
                     paired mesoderm homeobox protein 1; homeobox protein K-2;
                     homeobox protein mHox; paired-related homeobox protein 1;
                     muscle homeobox protein"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 1 isoform a"
                     /protein_id="NP_035257.1"
                     /db_xref="CCDS:CCDS15427.1"
                     /db_xref="GeneID:18933"
                     /db_xref="MGI:MGI:97712"
                     /translation="MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEE
                     AGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFN
                     SSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANK
                     NASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGI
                     NMANSIANLRLKAKEYSLQRNQVPTVN"
     exon            1257..1432
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1614
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..4892
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="hexamer: ATTAAA"
     polyA_site      3972
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="major polyA site"
     regulatory      4870..4875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="hexamer: AATAAA"
     polyA_site      4892
                     /gene="Prrx1"
                     /gene_synonym="A230024N07Rik; K-2; mHox; MHox1; Pmx; Pmx1;
                     Prx1"
                     /note="major polyA site"
ORIGIN      
        1 gaggaaaagg aggtaggaga ttgtgatgga gaaagggggt ctgtaaaacg tcaggcgccg
       61 cacaaaggct ttgccacgta attacaggct cctattaagt ggagatctgc cctcccaggg
      121 gtctccaatt ttcttgtatt ccctacaaag cctcctctcc atgccagcct gtgccttttg
      181 aagtgccaga gagcttcttg atccaactga gaagggaaaa ggagctccgc acggagaagg
      241 gggagagagc ggagggaagg gggaccgcca cccttctgca gactcttgaa gccccgcttc
      301 tttatttctt attttttttt cctccttacg aagagtaaag tgagaatcct gctctctaat
      361 acatctgcaa gacatcactc tcctgaaatt ctagtcactc ccgagaatcc acaggagtgc
      421 agagaggggg aacgcgcttt cttgaagaca ttttaaagct ggaacaagcc ttcttctgtt
      481 ggcgcttgaa ctcttgccgg gggaataact ttttttaacc tctttctcta atttttttaa
      541 agccactttg attcttctct ccaccccttc ttctctcttc tgtttgccta actcccccgc
      601 cccgctggcc tcccctttcc tcgctccccc ttattattat ttttagtgtc tgcgagtgga
      661 cgctttttaa gagttgaaag ggatattttt tttctttttg atctaagcat aggttgtttg
      721 ttttgttttt atttttgaac tttttggtgt ggattatctc tctggaccgc gctggacttg
      781 gctttagcga agtaaccgag gctgcaggga aagttacttg tcccgaaagt tctacacttc
      841 agaaggggtc ccaccctctg tttctctctc tctctctctc tctctctctc tctctctctc
      901 tctctccact cccccctctt tcttccccac tcggctcctc tcccccctca cgcccacagc
      961 gtttggtgtt gattcgagcg ggaagagggg ggtgggtggg attggagggg agaccatgac
     1021 ctccagctac gggcacgttc tggagcggca accggcgctg ggcggccgct tggacagccc
     1081 gggcaacctc gacaccctgc aggcgaaaaa gaacttctcc gtcagtcacc tgctagacct
     1141 ggaggaggcc ggggacatgg tggcggcaca agcagacgaa agtgtgggcg aggcgggccg
     1201 gagcctgctg gagtcaccgg gactgaccag tggcagcgac acccctcagc aggacaatga
     1261 ccagttgaac tctgaggaga agaagaagag aaagcagcgg agaaacagga caacattcaa
     1321 cagcagccaa ctgcaggcct tggagcgtgt ctttgagcgg acacattacc cggatgcttt
     1381 tgttcgagaa gatctcgcac gtcgggtgaa cctcactgag gccagagtgc aggtgtggtt
     1441 tcagaaccga agagccaagt tccgcaggaa tgagcgagcc atgctggcca ataaaaacgc
     1501 ttctctcctc aagtcctact caggagacgt gactgctgtg gagcaaccca tcgtacctcg
     1561 tcctgctccc agaccaaccg attatctctc ctgggggaca gcctctccgt acagcgccat
     1621 ggctacttat tctgccacat gtgccaacaa tagccctgca cagggtatca acatggccaa
     1681 cagcattgcc aacctgagac tgaaggccaa ggaatatagt ttacagagga accaggtgcc
     1741 aacagtcaac tgaggaaaaa aaaataatta aacaggccta agaagaaatc aaaaaccata
     1801 agacacctat cctgttctgt catatcttca tccgccgggg aaaaaaaaat aaaagcaaac
     1861 aaacaaagcc agaactaaaa tattgggacc atggcggagc aaagcaggag aggaacaaaa
     1921 tgaaaattag ttaacaaatg tttcttcttg ctctcggata cctaccatca ccatttgctt
     1981 ttgtgtgtgt attttgtttt ccttctatcc atgcttagct aattatactc caggcttctt
     2041 ctgttaggct cagcccaccc attcctataa ttgtatgaga ataaaagaaa tctccagcag
     2101 ccaaagaaat atatatatga gaaagatcac ttctcggtaa cctgcttgac ttcagtgcct
     2161 tactctgtct ccttccaagt ctctctagga gatttttgaa aatccaaagt ctttctgaag
     2221 aatctgtatt attgtgtcca tgttggtcat ggtaaggttt ttctatcagt gacaggaaaa
     2281 aaataaatgt acgcatgttc tggtcactga ccagtctgat caatgtggtt ggtcatgtct
     2341 ggtgtactct aagctctaag ctctaggtta tgatgtcacc gttaacccta ccccttaccc
     2401 aacccaaaca ataaaagatc ctaagttaaa gatactcatc gtttttaaac aattgtttca
     2461 cttgttcttt ggtagaagaa atcctttcag ttttagagat ggaaaaaaat tttgtaggaa
     2521 gaaaaatact gagttgtgaa aggcatagtc tatatttctt tggtgcctta gaggtggtca
     2581 gatgcacact tttatatata catatatatg ctgtatatat ttatatatat tatatataaa
     2641 atattgaaag cttgagtttg cagtttctca aaaactataa aagcaaactc tctgccatca
     2701 ccactgccct tatttacaca ataattatat gttaatgcgg catcttgttt tcatagtcta
     2761 tataaaatcc tcattaaggt cagagagcaa ttagccaggc agctgtttga gaacagcttc
     2821 catttttatg ttagggcttt aataaaatta ggaattattt gatgctatag agttgacctt
     2881 gagtttggac tctgatcttg agtgtaaagt ctatatcatc tgacttatca tgagaaatac
     2941 agttggaagg gtgagggaag acagcactct ttctctactt cataggaata tgaaagacaa
     3001 tatgttgaag tgaagtgttt aaagccttgc ttaaatttta aaaattaaat acaatcatac
     3061 tcttacattt tagttgtttt gaaatgaggt ttagcatcga gggtgggagg cagagctggt
     3121 atttctttgt ttctctttgt tcccagcttt gctttggcaa ttttcctggt gaacttgacc
     3181 aaaccacgtt gccatgctgt gtctagttta cctgtttata aaatggttta acaattccta
     3241 cctcacaggg atgttgtgag gctacatcca tttgttttct ctctctctct ctctctctct
     3301 ctctctctct ctctctctcc tcttccctcc ctccctccct ttccttcctt ccttccttcc
     3361 ttccttcctt ccttccttcc ttccttgttc ctggtttgtc cagcactttg tagccgtgaa
     3421 aggagaaggg acattaagag catacaatat tcatggatta acacggtatt tgaaagcttt
     3481 gttttctagt aaggaaatgg tatctgactg tacataaata taaccttcta tttggaaatg
     3541 ataaataggt ttatattttc aaatatctca acaataacat catttgacca aagaataatt
     3601 taaggcacaa agtatagaga tattttttaa cttatatttt catcaacagc tcgattttat
     3661 taaccatagt tctcagtgaa tgaaaatctt cagagtgatt ttggccaaat atgtcaacat
     3721 tgcaatatgc gtgtcagtca aagtatttgg cgtataagat tcacttttag cacatacttg
     3781 ttcttccctt ggcatatctg gctgtgttaa tggtgatttt ttttccccag tctaacaggc
     3841 acccatctga aaatatattt caagtgattt tgtactttgt tcagtaataa gaaggaagat
     3901 catcttgtgt actttgatct catgaagtga ttccttctca acaactacta ttaaagcatt
     3961 tctttcagaa tagtttatgt ggtctggctt aatatacatt acttgttttt atctccactc
     4021 atgtatttgt cccatcgatt gctgcgtgtt atcacatttc aaaaaaacca gtacatcctt
     4081 attgtaaaaa tgttttttga tttgtaagtg agtacaggtc caagagactg gtaaaccggg
     4141 aatttagcgt ttgtagagaa tagcttaaat atttggatta taggcaagga agagaaatta
     4201 taaatgaaaa gtgttttcta aggagagcag aatcttggaa ggcagttgtt ggaagtcatc
     4261 tgaaaccttc atcctggcat ccatttccag tggacgtcaa acaaacctga tcccataaac
     4321 tcaaaggagg aagtgggatg ttgtgtctga tgcttcgtac aagcagcttc gcggaatttc
     4381 acagaataac ccctgctagt taatcatagg aatgtctgca gctggtagac ccacagcaca
     4441 gcagctttat ctgagcacgt accaggaaat acacctgaag cactgacgct caattttgtt
     4501 catttgtggt aaactttgtg aaagaatata agtttaacaa gtggtttgga gggttagata
     4561 tctagcttgt aagtcaatta ccagaggaga gtctcagtgt cagactcaag gcatatagct
     4621 actgcgctcc atcaatatac ccagatgaag gcattagaac tatcaatgtc cacactccct
     4681 taccaaagaa gaggccaatt agttcagcac gtgggaggtt aaattaaacc agaagtaatg
     4741 acctaattac aaaaaaggga atggcatatg gtaataaaga tctcataaga aatgtaatat
     4801 gtaaattata tcttgcttta tgatgtaaaa tatacattgt ttgtgctaga atagaaatga
     4861 tttcttttca ataaaatgaa agagtgataa taaaaaaaaa aaaaaaaaaa a
//
