LOCUS       NM_001289700            3710 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus proline-rich transmembrane protein 3 (Prrt3),
            transcript variant 2, mRNA.
ACCESSION   NM_001289700 XM_006505842
VERSION     NM_001289700.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3710)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031947.1, AC153910.6, BC058349.1 and AK136854.1.
            
            On Jan 25, 2014 this sequence version replaced XM_006505842.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the
            same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031947.1, SRR7974084.24759.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AK031947.1         4-451
            449-449             AC153910.6         173091-173091       c
            450-1751            AK031947.1         453-1754
            1752-3254           BC058349.1         1802-3304
            3255-3435           AK136854.1         3288-3468
            3436-3710           AK136854.1         3470-3744
FEATURES             Location/Qualifiers
     source          1..3710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.77 cM"
     gene            1..3710
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /note="proline-rich transmembrane protein 3"
                     /db_xref="GeneID:210673"
                     /db_xref="MGI:MGI:2444810"
     exon            1..82
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            83..1127
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..3058
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /note="isoform a precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 3 isoform a
                     precursor"
                     /protein_id="NP_001276629.1"
                     /db_xref="CCDS:CCDS85122.1"
                     /db_xref="GeneID:210673"
                     /db_xref="MGI:MGI:2444810"
                     /translation="MAPSPQACTSPLLLLLLPCLGAGPALGRGLPRPLENSEPHMIPS
                     ESQTFDLFWEKLRNESSWHSGDPQARAEGPKKPADPYLGPALHGPKAAPGVQGERLLR
                     ADDLQLARAFTSQGWTGPPDSQELLEPEAPEPHPVRAPRLTLVTTTPSSLLSAAILST
                     ASQKPGGTAGQQPARNEELIMVKAETHITQASPWDFQGSSHTPVPETDAVRTLVLGKQ
                     GGHEQGFQEAVQGPLLTQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGL
                     PAEPPKTGAGDTWEVSSLGPQPEQTDLLGGQDSPAPQPIPPSASDTSDGHLRPAVSSL
                     NGADPISPQRVRGAMEAPGTPKSFIPDLPNSAQAANGTESPVRALQPDEAEDWPGRPQ
                     SHPPAPPVQAPSTSRRGLVRVTTQRALGQPLPPEPSASSIVPIPASSPPANATAPPLR
                     WGPLRRVLSFSWELHVYGVGVLFLLPALLALVTVAAALAGPRLALVAAALVLVASGLR
                     SAYMLTDPYGSQARLGVRAGLVLYNLPFPLLLTALAALTLLGLGAGLPQPLQKPLLLG
                     IVAPVHGTCLLATDLFSTSPVLNLLTQGLSCAWGASVALGTLCLCRRRLLEGPRGWDA
                     SPGPRLLAVAGSLGLLASGLQLAASLWLYPGPGREGRFSWAWWGVHFWLRLLELTWAL
                     ALALAALAATRPRPPTEHACWAKLLRLACPAPTGKSEVPERPNNCYAGPSGLGTGGLD
                     ISKSLIRNAAGEAGLPVTPGSGPWGSAASLGRGRPGGQRMSRGSVGPAPSLSELDLRP
                     PSPINLSRSIDAALFREHLVRESVFQRCGLRGLASSPTGGALRPRRGSQPDAELDGAG
                     TSLLRGRCRSLTEVCLRTSLPQHVMEPPVGAAAAGTSGSSLDSFSKGSLKISWNPWRH
                     GLSSVDSLPLDELPSTVQLLPPPTPVPAPARAGEPQGEGQSRCKSSESHSASSDTIEL
                     "
     exon            1128..1283
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..3710
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3402..3407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3423
                     /gene="Prrt3"
                     /gene_synonym="6330505P20; B230206N24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcatctcg gaggatgcgc ctccgggagc ggctgcaggg acgcgcgcaa ggtgaacgca
       61 tggctgcgga tgcagcgcgc agacgggtcc agtgaagcct agaagtcaag ggctctacac
      121 tcaggcattg aattagacca tggcccccag cccacaggcc tgcacatctc ctcttctgct
      181 gttgctgctg ccatgcctgg gggctggccc tgccttgggc agaggccttc ccaggcccct
      241 ggagaactca gaacctcaca tgatcccatc agagtcacag acctttgacc tcttctggga
      301 gaagctgaga aatgagagtt cctggcacag cggtgaccct caggcccgtg ctgaggggcc
      361 caagaagccc gcagaccctt acctaggacc agccctgcat gggcccaagg cagcccctgg
      421 ggtccaaggt gaaagactac taagagctga tgacctccag ctggcccgag cattcacctc
      481 ccaaggctgg acaggacctc ctgactcaca ggagcttctg gagcctgagg caccagaacc
      541 ccaccctgtg cgagcacctc gtctcactct tgtcactaca actcccagct ccctactctc
      601 ggcagccata ctttccactg cctcccagaa gcctggaggc acagcagggc agcagccagc
      661 taggaacgag gagctaataa tggtcaaagc cgagacccac atcacacagg cttccccctg
      721 ggacttccag ggctcttccc acactccggt acccgagaca gatgctgtga ggacgctggt
      781 gttggggaag caggggggac atgaacaggg cttccaggag gctgtccagg gtcccctact
      841 cacccagcag gatccagtag tccctggggt cggctcaaca cccccagtta aagtggaatc
      901 caccccagag cctggagccc agctcgacct ggcattggtc agaagccttc ctcttcctga
      961 ggggctgcca gctgaacccc ccaaaactgg agctggggat acctgggaag tcagctctct
     1021 gggaccccaa ccagaacaga ccgatctcct tggaggacaa gattccccag caccccagcc
     1081 tataccacct tcagcctcag acacttctga tgggcaccta agaccagcag tatcctcgct
     1141 gaatggagcc gaccccatct ccccacaacg tgtgagagga gcgatggagg ccccaggaac
     1201 ccccaagtcc ttcatccctg accttccaaa ttctgctcaa gctgcaaatg gaacagagag
     1261 ccctgtgagg gccctgcagc cagatgaagc cgaggattgg ccgggtcgcc cacaaagcca
     1321 ccctccagca ccccctgtcc aggccccctc gacatctcgg cgtggtctcg ttagagtcac
     1381 cacacagaga gctctgggcc agccactccc tccggagccc tcagccagct ccatagtccc
     1441 catcccagct tctagccccc cagccaatgc caccgcacct cccctgcgtt ggggacccct
     1501 tcggcgggtg ctgagtttct cctgggagct tcatgtgtat ggggtggggg tgcttttcct
     1561 gcttccagca ttattggcat tggtcacagt ggcagccgcc ctagcgggac cccgattagc
     1621 actagtggct gccgcgctgg tattggtggc ttcagggctg cgatctgcct acatgctcac
     1681 ggatccttat ggctctcagg cgcgactggg agtacgtgca ggtctggtgc tatacaactt
     1741 gcccttcccc ttgctactca ctgcactggc agcactcacc ctgctgggct tgggtgctgg
     1801 tctgccacag cctctgcaga agccgctgct gctgggaatt gtggcaccgg tgcatggcac
     1861 atgtttgctg gctacagacc tgttctccac cagccctgtg ctcaaccttc taacacaagg
     1921 cttatcttgc gcctggggcg cctcagtggc tctgggcaca ctctgcctgt gccgtcgacg
     1981 cctgctggaa ggccctcggg gctgggatgc cagtccaggg ccccggctgt tggctgtggc
     2041 gggctcactg gggctgttgg ccagtggtct gcagttggcg gcctctctct ggctgtaccc
     2101 agggcctggc cgggagggtc gcttctcctg ggcttggtgg ggcgtgcact tctggctgcg
     2161 cctgctggaa ttgacctggg cactggccct ggcgctagct gccctggctg ccactcgtcc
     2221 caggccgccc acggagcacg cttgctgggc taagctgctg cgtctggcgt gccccgcgcc
     2281 tacagggaag agcgaagttc ccgagagacc caataactgc tatgcggggc ccagtggcct
     2341 gggcacaggc ggcctggaca tcagcaaaag tctcatccgc aacgctgctg gggaagctgg
     2401 gcttcctgtc actcctggtt ctggaccctg gggttcggct gcatcgctgg gtcgcggtcg
     2461 tccaggtggc cagaggatgt cccggggcag tgtggggccc gcaccgtcgc tgagcgagct
     2521 ggatctgcgg ccaccgtcac ctatcaattt gagccgcagc atcgacgccg cgctcttccg
     2581 ggagcacttg gttcgagaga gtgtgttcca acgctgtggt ctccgtggct tggcctcctc
     2641 gccgacaggg ggcgccctgc ggcctcgccg cggcagccag cccgatgccg agctcgacgg
     2701 cgcgggcaca tcattgctcc gaggccgctg ccgctcgctc accgaggtgt gcttgcgcac
     2761 gtcgctcccg cagcacgtga tggagccgcc cgtcggcgcg gcggccgcgg ggacttcggg
     2821 cagctccctg gacagtttct ccaagggctc gctgaagatc agctggaacc cgtggcgtca
     2881 cgggctgtca tccgtggaca gcctgcccct agatgaactg cccagcaccg tgcagctgct
     2941 gccaccacct accccagtcc ctgctcctgc ccgggcgggg gagcctcagg gcgagggcca
     3001 gtcgcgttgc aagtccagcg agtctcacag cgcctctagt gacactatag agctctaagc
     3061 acctacggag agaacctgta ccctctcctc aatgtccaca agaagaggct gagccaagac
     3121 agttgagcat ttgaaaaatt ggccctcccg ggcctccacc agactgcagc tcccgggtac
     3181 agccgggctt gaatttaccc aactcgtttt ttgtttttgt ttttttaata tctctatttt
     3241 tttcagcaga tattttgcac agaggccgtg agttacacgg aacacagggt ggatgtgcat
     3301 ggatttgatc atgggggcca ggggccaggt acccctgacc ctctcagtgt ggagagatgc
     3361 acctcacttg tccagactga ctgtcctctt tgtgccaaag aaataaaaac ccttccgatt
     3421 gggctcatgc ctcgctctgg tcaagccagg gtctctcctc acagcagaga cctctggctt
     3481 tggtaggtac agccacccct atctcactaa aaacccgtct gttgtggagt ccccacctcc
     3541 tgcaaacccc atataaggcc taatcggaaa gtatcctgcc cacttccgga aatgagaaca
     3601 gctggggttc aacccaggaa gaccgactcc taagctggtt cctctgtcat ctttcccctt
     3661 cctccatttc ttgctggttt ttatttaaaa acattgtttt ttgtagattt
//
