LOCUS       NM_030890               1909 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus proline-rich transmembrane protein 1 (Prrt1),
            transcript variant 1, mRNA.
ACCESSION   NM_030890
VERSION     NM_030890.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1909)
  AUTHORS   van der Spek,S.J.F., Pandya,N.J., Koopmans,F., Paliukhovich,I., van
            der Schors,R.C., Otten,M., Smit,A.B. and Li,K.W.
  TITLE     Expression and Interaction Proteomics of GluA1- and
            GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition
  JOURNAL   Cells 11 (22), 3648 (2022)
   PUBMED   36429079
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1909)
  AUTHORS   Troyano-Rodriguez,E., Mann,S., Ullah,R. and Ahmad,M.
  TITLE     PRRT1 regulates basal and plasticity-induced AMPA receptor
            trafficking
  JOURNAL   Mol Cell Neurosci 98, 155-163 (2019)
   PUBMED   31216424
  REMARK    GeneRIF: PRRT1 controls NMDA-induced trafficking of AMPA receptors
            in hippocampal neurons.
REFERENCE   3  (bases 1 to 1909)
  AUTHORS   Matt,L., Kirk,L.M., Chenaux,G., Speca,D.J., Puhger,K.R.,
            Pride,M.C., Qneibi,M., Haham,T., Plambeck,K.E., Stern-Bach,Y.,
            Silverman,J.L., Crawley,J.N., Hell,J.W. and Diaz,E.
  TITLE     SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and
            Plasticity Underlying Cognitive Function
  JOURNAL   Cell Rep 22 (9), 2246-2253 (2018)
   PUBMED   29490264
  REMARK    GeneRIF: SynDIG4 maintains a pool of extrasynaptic AMPARs necessary
            for synapse development and function underlying higher-order
            cognitive plasticity.
REFERENCE   4  (bases 1 to 1909)
  AUTHORS   Chenaux,G., Matt,L., Hill,T.C., Kaur,I., Liu,X.B., Kirk,L.M.,
            Speca,D.J., McMahon,S.A., Zito,K., Hell,J.W. and Diaz,E.
  TITLE     Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not
            Formation In Vivo
  JOURNAL   eNeuro 3 (5) (2016)
   PUBMED   27800545
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1909)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 1909)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   7  (bases 1 to 1909)
  AUTHORS   Kalashnikova,E., Lorca,R.A., Kaur,I., Barisone,G.A., Li,B.,
            Ishimaru,T., Trimmer,J.S., Mohapatra,D.P. and Diaz,E.
  TITLE     SynDIG1: an activity-regulated, AMPA- receptor-interacting
            transmembrane protein that regulates excitatory synapse development
  JOURNAL   Neuron 65 (1), 80-93 (2010)
   PUBMED   20152115
REFERENCE   8  (bases 1 to 1909)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   9  (bases 1 to 1909)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009767.6.
            
            On Feb 22, 2019 this sequence version replaced NM_030890.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2613795.1,
                                           SRR7652917.804629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               CT009767.6         186991-187131
            142-680             CT009767.6         188060-188598
            681-866             CT009767.6         189197-189382
            867-1909            CT009767.6         189511-190553
FEATURES             Location/Qualifiers
     source          1..1909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.21 cM"
     gene            1..1909
                     /gene="Prrt1"
                     /gene_synonym="Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5;
                     ORF31; SynDIG4"
                     /note="proline-rich transmembrane protein 1"
                     /db_xref="GeneID:260297"
                     /db_xref="MGI:MGI:1932118"
     exon            1..141
                     /gene="Prrt1"
                     /gene_synonym="Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5;
                     ORF31; SynDIG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1043
                     /gene="Prrt1"
                     /gene_synonym="Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5;
                     ORF31; SynDIG4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synapse differentiation-induced protein 4; dispanin
                     subfamily D member 1"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 1 isoform 1"
                     /protein_id="NP_112152.1"
                     /db_xref="CCDS:CCDS28653.1"
                     /db_xref="GeneID:260297"
                     /db_xref="MGI:MGI:1932118"
                     /translation="MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPIPPPQTAPSSHHHH
                     HHHYHQSGTATLPRLGAGGLASAAASAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCA
                     TLPRMPPDPYLQETRFEGPLPPPPPAAAAPPPPAPAPTAQAPGFVVPTHAGAVGTLPL
                     GGYVAPGYPLQLQPCTAYVPVYPVGTPYAGGTPGGPGVTSTLPPPPQGPGLALLEPRR
                     PPHDYMPIAVLTTICCFWPTGIIAIFKAVQVRTALARGDLVSAEIASREARNFSFISL
                     AVGIAAMVLCTILTVVIIIAAQHHENYWDP"
     exon            142..680
                     /gene="Prrt1"
                     /gene_synonym="Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5;
                     ORF31; SynDIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            681..866
                     /gene="Prrt1"
                     /gene_synonym="Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5;
                     ORF31; SynDIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1909
                     /gene="Prrt1"
                     /gene_synonym="Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5;
                     ORF31; SynDIG4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccgcgc tgctgctgct accgccgctg cgccatcccg gactgagaca ctaagactcc
       61 tgcgccagca gtcagggggc cctgactcca gcttcagaga ccctgtccca acgattgcaa
      121 acatgtcgtc agaaaagtca ggccttccag actcggttcc ccacacttca ccgccgccct
      181 acaatgcccc ccagccaccg gccgagcccc ccatcccgcc cccacaaacg gccccatcct
      241 cacatcacca ccaccaccac cattaccacc agtctggcac cgccaccctc ccgcgcttag
      301 gagcaggtgg cctggcctct gctgcggcca gtgctcaacg cggtccttcg tcttccgcca
      361 cgctaccgcg gcccccccac catgccccgc ccggccccgc cgctggggct cccccacccg
      421 gctgtgctac cttaccccgc atgccacccg acccttatct gcaggagact cgcttcgagg
      481 gtccacttcc cccaccaccg cctgcggccg ccgccccgcc cccaccagcg cctgccccga
      541 cggcccaagc cccgggcttc gtggttccca cgcacgcggg ggcggtgggc acgttgccgc
      601 tggggggcta cgtggcgccg ggctacccgc tgcagctgca gccgtgcact gcttatgtcc
      661 ctgtgtatcc ggtgggcacg ccctacgcag gcgggacccc cgggggtcct ggagtgacct
      721 ccactctgcc cccgccgccc cagggcccag gattggctct gttggagccc aggcgtccgc
      781 cacacgacta catgcccatc gctgtgctga ccaccatctg ctgcttctgg cccacaggca
      841 tcatcgccat cttcaaggcc gtgcaggtgc gcacggcttt ggcccgcgga gatttggtgt
      901 ctgccgagat cgcttcacgc gaagcccgga atttctcctt catctccctg gccgtgggca
      961 tcgcagccat ggtgctttgt accatcctca ctgtagtcat catcatcgcc gcccagcacc
     1021 acgaaaacta ctgggatccc taaaaacgtc cccatctcgg ccccactccg tgccccccaa
     1081 cctcccaggc gcgtcgcgca gttctgccgc ctacccaacg cgcgccctgc acagcctcct
     1141 gaggcgccgc tggacgtcca gacatcataa actccgcccc cacggaacct ctggcccaga
     1201 gagtacgctc agttcctcag gaacccctct aacacccaca tcctcagcgg cactggaatc
     1261 cgcgccaaac cccaatcctc cagtcgccct agtttcccac cccatcaaag tgcagtgcca
     1321 ggggaggagc tctcctcgtc tcctctcccc agtaggagtc aggtcccaga agccctgcct
     1381 catctatgag ctccacccca actcccacaa accccgcctc caggtcggca ggccccgcct
     1441 tctttttcgt cttttggggt gttcagtctg atgattgggt ctgtgaatcc aggcccagct
     1501 cacatacaga cggactcatt ccccctacct ccctaaaagg actcagcctt gggagaacta
     1561 cacccccact ctggctcgga ttttttgcca gtgaggattt ttcttttccc cccaccccat
     1621 ctctgcctat tttcttgcta attacagaac ttcccgtttt gctgcttttg gagtgagatg
     1681 tgggaagttc ctggtttagt acccctcacc ctggaaaaag aaccaagtcc ctgcaatgta
     1741 aatacccttt ctacctgtgc caacccctgg tcagtggggg cagaagagaa tccagggtta
     1801 aagggaggga gtcgacgctc cccggccctc ccctcagccc tagacttgtt ttgatctgtg
     1861 tgtgccgtgt gtgaacttcc acgagacagt attaaaaaca ttttagtgg
//
